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| 1 | Mlkl knockout mice demonstrate the indispensable role of Mlkl in necroptosis显示文摘像域的蛋白质(Mlkl ) 最近被发现与受体交往交往的混合的系 kinase 蛋白质 3 (Rip3 ) 并且导致的坏死因素(TNF ) 在有教养的房间线规划了坏死(necroptosis ) 为肿瘤必要。我们由抄写产生了 Mlkl 缺乏的老鼠像使活跃之物的受动器核酸酶(TALEN ) 调停了基因混乱和发现 Mlkl 到为象有免疫力的房间开发一样的正常老鼠开发非必需。胚胎的成纤维细胞(MEF ) 和巨噬细胞两个都显示出的 Mlkl 缺乏的老鼠抵抗到坏死然而并非 apoptotic 刺激。Mlkl 缺乏的 MEF 和巨噬细胞与处于他们激活 NF-κ 的能力的野类型的房间难区分;响应 TNF 和 lipopolysaccharides (LPS ) 的 B,英皇家空军之阶级最低之兵, JNK,和 p38 分别地。一致地, Mlkl 缺乏的巨噬细胞和老鼠展出了正常 interleukin-1β(IL-1β) ,在 LPS 处理以后的 IL-6,和 TNF 生产。Mlkl 缺乏保护老鼠免受导致天蓝色的尖锐胰腺炎的伤害,坏死相关的疾病,但是没在 polymicrobial 上有效果腐败导致吃惊的动物死亡。我们的结果在 necroptosis 为 Mlkl 的角色提供基因证据。 | Jianfeng Wu Zhe Huang Junming Ren Zhirong Zhang Peng He Yangxin Li Jianhui Ma Wanze Chen Yingying Zhang Xiaojuan Zhou Zhentao Yang Su-Qin Wu Lanfen Chen Jiahuai Han | 2013 | Cell Research2013，23，8： | 35 |
| 2 | On a nonlinear elliptic problem with critical potential in R^2显示文摘Consider the existence of nontrivial solutions of homogeneous Dirichlet problem for a nonlinear elliptic equation with the critical potential in R2. By establishing a weighted inequality with the best constant, determine the critical potential in R2, and study the eigenvalues of Laplace equation with the critical potential. By the Pohozaev identity of a solution with a singular point and the Cauchy-Kovalevskaya theorem, obtain the nonexistence result of solutions with singular points to the nonlinear elliptic equation. Moreover, for the same problem, the existence results of multiple solutions are proved by the mountain pass theorem. | SHEN Yaotian YAO Yangxin HEN Zhihui | 2004 | Science China Mathematics2004，47，5： | 6 |
| 3 | Epicardial adipose tissue: the accomplice implicated in the genesis and maintenance of atrial fibrillation显示文摘 | Fang Mingcheng Chen Yangxin Wang Jingfeng | 2014 | Chinese Medical Journal2014，，14： | 4 |
| 4 | The complicated role of NF-κB in T-cell selection显示文摘原子因素(NF )- 魏 B 抄写因素家庭戏在免疫系统的重要角色。发信号的异常 NF-魏 B 经常与发炎和自体免疫的疾病被联系,但是内在的机制充分没被理解。最近的研究证明 NF-魏 B 在 T 房间中央忍耐起一个关键作用。二 NF-魏 B 发信号小径被识别了:正规小径和其他的小径。在 T 房间中央忍耐的建立,其他的小径看起来是在为他们的发展和功能的 thymic stromal 房间的关键发信号部件,当正规小径在自治 T 房间选择更施加它的功能时。这评论打算总结为未来的未解决的吸引人的问题工作的在建立 T 房间中央忍耐和热点的 NF-魏 B 的角色的当前的理解。 | Mingzhao Zhu Yangxin Fu | 2010 | Cellular & Molecular Immunology2010，7，2： | 3 |
| 5 | Inflammasomes as therapeutic targets in human diseases显示文摘Inflammasomes are protein complexes of the innate immune system that initiate inflammation in response to either exogenous pathogens or endogenous danger signals.Inflammasome multiprotein complexes are composed of three parts:a sensor protein,an adaptor,and pro-caspase-1.Activation of the inflammasome leads to the activation of caspase-1,which cleaves pro-inflammatory cytokines such as IL-ip and IL-18,leading to pyroptosis.Effectors of the inflammasome not only provide protection against infectious pathogens,but also mediate control over sterile insults.Aberrant inflammasome signaling has been implicated in the development of cardiovascular and metabolic diseases,cancer,and neurodegenerative disorders.Here,we review the role of the inflammasome as a double-edged sword in various diseases,and the outcomes can be either good or bad depending on the disease,as well as the genetic background.We highlight inflammasome memory and the two-shot activation process.We also propose the M-and N-type inflammation model,and discuss how the inflammasome pathway may be targeted for the development of novel therapy. | Yangxin Li Hui Huang Bin Liu Yu Zhang Xiangbin Pan Xi-Yong Yu Zhenya Shen Yao-Hua Song | 2021 | Signal Transduction and Targeted Therapy2021，6，8： | 3 |
| 6 | Bioinformatic analysis for potential biological processes and key targets of heart failure-related stroke显示文摘This study aimed to uncover underlying mechanisms and promising intervention targets of heart failure(HF)-related stroke.HF-related dataset GSE42955 and stroke-related dataset GSE58294 were obtained from the Gene Expression Omnibus(GEO)database.Weighted gene co-expression network analysis(WGCNA)was conducted to identify key modules and hub genes.Gene Ontology(GO)and pathway enrichment analyses were performed on genes in the key modules.Genes in HF-and stroke-related key modules were intersected to obtain common genes for HF-related stroke,which were further intersected with hub genes of stroke-related key modules to obtain key genes in HF-related stroke.Key genes were functionally annotated through GO in the Reactome and Cytoscape databases.Finally,key genes were validated in these two datasets and other datasets.HF-and stroke-related datasets each identified two key modules.Functional enrichment analysis indicated that protein ubiquitination,Wnt signaling,and exosomes were involved in both HF-and stroke-related key modules.Additionally,ten hub genes were identified in stroke-related key modules and 155 genes were identified as common genes in HF-related stroke.OTU deubiquitinase with linear linkage specificity(OTULIN)and nuclear factor interleukin 3-regulated(NFIL3)were determined to be the key genes in HF-related stroke.Through functional annotation,OTULIN was involved in protein ubiquitination and Wnt signaling,and NFIL3 was involved in DNA binding and transcription.Importantly,OTULIN and NFIL3 were also validated to be differentially expressed in all HF and stroke groups.Protein ubiquitination,Wnt signaling,and exosomes were involved in HF-related stroke.OTULIN and NFIL3 may play a key role in HF-related stroke through regulating these processes,and thus serve as promising intervention targets. | Chiyu LIU Sixu CHEN Haifeng ZHANG Yangxin CHEN Qingyuan GAO Zhiteng CHEN Zhaoyu LIU Jingfeng WANG | 2021 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2021，22，9： | 3 |
| 7 | Stem cell-derived exosomes repair ischemic muscle injury by inhibiting the tumor suppressor Rbl-mediated NLRP3 inflammasome pathway显示文摘Dear Editor,Lower-limb ischemia is a serious clinical condition affecting many patients world-wide and there is no effective therapy.Ischemia activates the NLRP3 inflammasome,which triggers tissue damage by releasing inflammatory cytokines including IL-1β and IL-18.1 However,the molecular mechanisms underlying activation of the NLRP3 inflammasome remain largely unknown. | Yanli Wang Wenping Xie Bin Liu Hui Huang Wei Luo Yu Zhang Xiangbin Pan Xi-Yong Yu Zhenya Shen Yangxin Li | 2021 | Signal Transduction and Targeted Therapy2021，6，4： | 3 |
| 8 | DENSITY FUNCTIONAL FOR STRUCTURES OF COLLOIDS CONFINED IN A SLIT-LIKE PORE显示文摘A density functional theory is applied to calculating the local density profiles of colloids confined in a slit-like pore as well as the radial distribution functions of bulk colloids. The interaction between the colloidal particles is described using a hard-core Yukawa model. The excess Helmholtz energy functional is a combination of the modified fundamental measure theory of Yu and Wu (2002) for the hard-core contribution and a corrected mean-field theory for the attractive contribution. Comparison with the results from the Monte Carlo simulations shows that the corrected theory improves the density profiles of colloids in the vicinity of contact over the original mean-field theory. Both the present corrected theory and simulations suggest that there are depletion and desorption for the colloid with strong attraction between particles at low temperature. | Fengqi You Sheng Fu Yangxin Yu Guanghua Gao | 2005 | China Particuology2005，3，5： | 2 |
| 9 | Ni(OH)_2-Ni/C for hydrogen oxidation reaction in alkaline media显示文摘The development of the hydrogen electrode is vital for the application of alkaline polymer electrolyte fuel cells(APEFCs).In this study,a series of Ni(OH)_2 decorated Ni/C catalysts(Ni(OH)_2-Ni/C) were prepared by a three-step electrochemical treatment of Ni/C.The existence of Ni(OH)_2 was demonstrated by X-ray photoelectron spectroscopy(XPS),and the surface molar ratio of Ni(OH)_2/Ni of the samples was estimated via an electrochemical method.The HOR catalytic activity of the catalysts was evaluated by a rotation disk electrode(RDE) method,and a 'volcano plot' was established between the HOR exchange current(j0) and the surface molar ratio of Ni(OH)_2/Ni.On top of the 'volcano',the surface molar ratio of Ni(OH)_2/Ni is1.1:1,the j0 of which was 6.8 times of that of Ni/C.The stability of the samples toward HOR was evaluated to be good.Our study added a systematic experimental evidence to the HOR research,showing that the HOR catalytic activity of Ni can be deliberately controlled via decoration of Ni(OH)_2,which may help understanding the HOR mechanism on Ni. | Yangxin Pan Gaohe Hu Juntao Lu Li Xiao Lin Zhuang | 2019 | Journal of Energy Chemistry2019，28，2： | 2 |
| 10 | Hollow click-based porous organic polymers for heterogenization of [Ru(bpy)3]2+ through electrostatic interactions显示文摘为用在空基于按的多孔的器官的聚合物(H-CPPs ) 的非共有原子价相互作用的转变金属催化剂的 heterogenization 的一条灵巧的途径被介绍。催化地活跃的 cationic 种,[Ru (bpy )3]2+(bpy = 2,2-bipyridyl ) ,经由静电的相互作用在 H-CPPs 被使不能调动。内在的性质[Ru (bpy )3]2+ 很好被保留。当在可见光的照耀下面为 4-methoxyphenylboronic 酸的氧化 hydroxylation 使用了到 4-methoxyphenol 时,产生 Rucontaining 空聚合物展出了优秀催化活动,提高的稳定性,和好再循环能力。吸引人的催化表演主要从有效集体转移和 cationic Ru 建筑群的化学性质的维护导致了 H-CPPs。 | Liuyi Li Caiyan Cui Wenyue Su Yangxin Wang Ruihu Wang | 2016 | Nano Research2016，9，3： | 2 |
| 11 | Effective femtosecond laser shock peening on a Mg-3Gd alloy at low pulse energy 430 μJ of 1 kHz显示文摘In this paper,microstructure evolution and hardness of Mg-3 Gd alloy treated by femtosecond(fs)laser shock peening(LSP)with direct and confined ablation m odes were investigated in detail.Under a relatively low pulse energy of 430μJ with a repetition of 1 kHz,the surface hardness of sample has been enhanced by 70%effectively.Comp a r e d with ns-LSP with pulse fluence of 71.7J/cm2,fs-LSP with pulse fluence of 34.2 J/cm2 is superior in the hardness increment,both of which are in the same order of magnitude.A distinct grain refinement of surface layer has been discovered and results in the increase of hardness.Nonuse of absorption and confining layers and the employment of the industry commercial fs laser with high repetition can inspire big potential L S P application in special metal material.©2019 Published by Elsevier B.V.on behalf of Chongqing University. | Chenghao Lu Licheng Ge Bing Zhu Yangxin Li Xianfeng Chen Xiaoqin Zeng Yuping Chen | 2019 | Journal of Magnesium and Alloys2019，7，3： | 2 |
| 12 | The effect of basal dislocation on {11■1} twin boundary evolution in a Mg-Gd-Y-Zr alloy显示文摘This study aims to understand the features of{11■1}twin boundaries in a high strain rate compressed Mg-10 Gd-3Y-0.4Zr using electron backscatter diffraction(EBSD)and transmission electron microscopy(TEM).Based on the Schmid factor calculations,the basal dislocations are easily activated within the{11■1}twin and suppressed in the surrounding matrix.The consequent basal dislocation-twin interaction during deformation can lead to the misorentiation deviation of{11■1}twin boundaries,accompanying with the formation of a step at the twin boundary.Such a{11■1}twin boundary evolution mechanism provides a new vision of twinning behavior in Mg alloys. | Huan Zhang Yangxin Li Yuxuan Liu Qingchun Zhu Xixi Qi Gaoming Zhu Jinhui Wang Peipeng Jin Xiaoqin Zeng | 2021 | Journal of Materials Science & Technology2021，，22： | 2 |
| 13 | Short-term intensive atorvastatin therapy improves endothelial function partly via attenuating perivascular adipose tissue inflammation through 5-lipoxygenase pathway in hyperlipidemic rabbits显示文摘 | Wang Xiaoqiao Lin Yongqin Luo Niansang Chen Zhongqing Gu Miaoning Wang Jingfeng Chen Yangxin | 2014 | Chinese Medical Journal2014，，16： | 2 |
| 14 | Eeigenvalue problem of elliptic equations with Hardy potential 显示文摘 | XIE Chaodong SHEN Yaotian YAO Yangxin | 2009 | Acta Mathematica Scientia2009，29，： | 1 |
| 15 | 显示文摘 | YangXin(杨鑫) XiZhengping(奚正平) LiuYong(刘咏)eta1 | 2012 | 稀有金属材料与工程2012，41，6： | 1 |
| 16 | Expression Profiles of Six Circulating MicroRNAs Critical to Atherosclerosis in Patients With Subclinical Hypothyroidism: A Clinical Study显示文摘 | Xinhuan Zhang Shanshan Shao Houfa Geng Yong Yu Chenggang Wang Zhanfeng Liu Chunxiao Yu Xiuyun Jiang Yangxin Deng Ling Gao Jiajun Zhao | 2014 | The Journal of Clinical Endocrinology & Metabolism2014，，： | 1 |
| 17 | The modelling of NC-electrochemical contour evolution machining using a rotary tool-cathod显示文摘 | XU Jiawen YUN Naizhang TANG Yangxin | 2005 | Journal of Materials Processing Technology2005，159，2： | 1 |
| 18 | 显示文摘 | ZHANGHua WANGZhen-yu YANGXin etal(张华 王振宇 杨鑫 等) | 2014 | 食品化学2014，147，15： | 1 |
| 19 | Simulation study on dynamics of A- to B-form transition in aqueous DNA solution:Effect of alkali metal counterions显示文摘DNA and its conformational transition can be used to design nanometer-scale structures,nano-tweezers and nanomechanical devices.Experiments and molecular simulations have been used to study the concentration effect on the A-DNA→B-DNA conformational transition,but a systematical investigation on counterion effect on the dynamics of this transition has not been reported up to now.In present work,restrained and unrestrained molecular dynamics(MD)simulations have been performed to characterize the stability of DNA conformations and the dynamics of A-DNA→B-DNA transitions in aqueous solutions with different alkali metal counterions.The DNA duplex d(CGCGAATTCGCG)2,coion Cl and counterions Li+,Na+,K+,Rb+and Cs+as well as water molecule were considered using the PARM99 force field in the AMBER8 package.It was found that B-form DNA is more stable than A-form DNA in aqueous electrolyte solutions with different alkali metal counterions.Increasing KCl concentration in solution hinders the A-DNA→B-DNA transition and the transition times for different alkali metal counterions conform to neither the simple sequence related to naked ion size nor to hydrated diameter,but an apparently abnormal sequence of K+ | YU YangXin FUJIMOTO Shintaro | 2013 | Science China Chemistry2013，56，12： | 1 |
| 20 | The modelling of NC - electrochemical contour evolution machining using a rotary tool -cathode显示文摘 | XU Jiawen YUN Naizhang TANG Yangxin | 2005 | Journal of Materials Processing Technology2005，159，： | 1 |
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