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| 1 | Generation of iPSCs from mouse fibroblasts with a single gene, Oct4, and small molecules显示文摘由病毒的 transduction 的四抄写因素 Oct4, Klf4, Sox2 和 c-Myc 的介绍能导致体的房间的 reprogramming 进导致的 pluripotent 干细胞(iPSCs ) ,但是 iPSCs 的使用被病毒的交货系统的使用妨碍。导致化学药品的 reprogramming 把一条新奇途径提供给没有任何病毒的基于向量的基因修正,产生 iPSCs。尽管,以前的报告证明几个小分子能代替一些 reprogramming 因素至少二个抄写因素, Oct4 和 Klf4,仍然被要求从老鼠产生 iPSCs 胚胎的成纤维细胞。这里,我们识别特定的化学联合,它是足够的面对一个单个抄写因素从胚胎的老鼠和成年成纤维细胞允许 reprogramming, Oct4 在 20 天以内,代替 Sox2, Klf4 和 c-Myc。用这个处理产生的 iPSCs 类似于胚胎的干细胞以全球基因表示介绍的老鼠,在 vitro 并且在 vivo 的 epigenetic 地位和 pluripotency。我们也发现那 8 天 Oct4 正式就职是足够的面对小分子启用导致 Oct4 的 reprogramming,它建议 reprogramming 在开始的 8 天以内被开始并且独立于连续外长的 Oct4 表示。没有基因修正,这些发现将帮助 iPSCs 的未来产生,以及阐明位于 reprogramming 过程下面的分子的机制。 | Yanqin Li Qiang Zhang Xiaolei Yin Weifeng Yang Yuanyuan Du Pingping Hou Jian Ge Chun Liu Weiqi Zhang Xu Zhang Yetao Wu Honggang Li Kang Liu Chen Wu Zhihua Song Yang Zhao Yan Shi Hongkui Deng | 2011 | Cell Research2011，21，1： | 51 |
| 2 | Preparation and coagulation efficiency of polyaluminium ferric silicate chloride composite coagulant from wastewater of high-purity graphite production显示文摘The aim of the present work was to produce a polyaluminium ferric silicate chloride (PAFSiC) coagulant from acidic and alkaline wastewater of purifying graphite by roasting, and subsequently to evaluate coagulation efficiency of the reagent by treating surface water from the Yellow River as well as municipal wastewater in comparison with the conventional coagulant polyaluminium chloride (PAC). The PAFSiC coagulant was prepared by co-polymerization. The effects of (Al+Fe)/Si molar ratio, OH/(Al+Fe) molar ratio (i.e., γ value), coagulant dosage and pH value of test suspension on the coagulation behavior of FAFSiC and the stability of the PAFSiC were also examined. Results showed that PAFSiC performed more efficiently than PAC in removing turbidity, chemical oxygen demand (COD), and total phosphate (TP). The PAFSiC with a γ value of 2.0 and (Al+Fe)/Si ratio of 5 (PAFSiC 2.0/5) showed excellent coagulation effect for both turbidity and COD, while PAFSiC 1.0/5 was the best for TP. The optimum coagulation pH range of PAFSiC 2.0/5 was 5.0–9.0, slightly wider than that of PAC (6.0–8.0). The process can be easily incorporated into high-purity graphite production plants, thereby reducing wastewater pollution and producing a valuable coagulant. | Xiaoxia Niu Xili Li Jihong Zhao Yigang Ren Yanqin Yang | 2011 | Journal of Environmental Sciences2011，23，7： | 23 |
| 3 | Compliance Modeling and Analysis of a 3-RPS Parallel Kinematic Machine Module显示文摘The compliance modeling and rigidity performance evaluation for the lower mobility parallel manipulators are still to be remained as two overwhelming challenges in the stage of conceptual design due to their geometric complexities. By using the screw theory, this paper explores the compliance modeling and eigencompliance evaluation of a newly patented 1T2R spindle head whose topological architecture is a 3-RPS parallel mechanism. The kinematic definitions and inverse position analysis are briefly addressed in the first place to provide necessary information for compliance modeling. By considering the 3-RPS parallel kinematic machine(PKM) as a typical compliant parallel device, whose three limb assemblages have bending, extending and torsional deflections, an analytical compliance model for the spindle head is established with screw theory and the analytical stiffness matrix of the platform is formulated. Based on the eigenscrew decomposition, the eigencompliance and corresponding eigenscrews are analyzed and the platform's compliance properties are physically interpreted as the suspension of six screw springs. The distributions of stiffness constants of the six screw springs throughout the workspace are predicted in a quick manner with a piece-by-piece calculation algorithm. The numerical simulation reveals a strong dependency of platform's compliance on its configuration in that they are axially symmetric due to structural features. At the last stage, the effects of some design variables such as structural, configurational and dimensional parameters on system rigidity characteristics are investigated with the purpose of providing useful information for the structural design and performance improvement of the PKM. Compared with previous efforts in compliance analysis of PKMs, the present methodology is more intuitive and universal thus can be easily applied to evaluate the overall rigidity performance of other PKMs with high efficiency. | ZHANG Jun ZHAO Yanqin DAI Jiansheng | 2014 | Chinese Journal of Mechanical Engineering2014，27，4： | 11 |
| 4 | Multi-level denoising and enhancement method based on wavelet transform for mine monitoring显示文摘Based on low illumination and a large number of mixed noises contained in coal mine, denoising with one method usually cannot achieve good results, so a multi-level image denoising method based on wavelet correlation relevant inter-scale is presented. Firstly, we used directional median filter to effectively reduce impulse noise in the spatial domain, which is the main cause of noise in mine. Secondly, we used a Wiener filtration method to mainly reduce the Gaussian noise, and then finally used a multi-wavelet transform to minimize the remaining noise of low-light images in the transform domain. This multi-level image noise reduction method combines spatial and transform domain denoising to enhance benefits, and effectively reduce impulse noise and Gaussian noise in a coal mine, while retaining good detailed image characteristics of the underground for improving quality of images with mixing noise and effective low-light environment. | Yanqin Zhao | 2013 | International Journal of Mining Science and Technology2013，23，1： | 9 |
| 5 | Kinetostatic Modeling and Analysis of an Exechon Parallel Kinematic Machine(PKM) Module显示文摘As a newly invented parallel kinematic machine(PKM), Exechon has found its potential application in machining and assembling industries due to high rigidity and high dynamics. To guarantee the overall performance, the loading conditions and deflections of the key components must be revealed to provide basic mechanic data for component design. For this purpose, a kinetostatic model is proposed with substructure synthesis technique. The Exechon is divided into a platform subsystem, a fixed base subsystem and three limb subsystems according to its structure. By modeling the limb assemblage as a spatial beam constrained by two sets of lumped virtual springs representing the compliances of revolute joint, universal joint and spherical joint, the equilibrium equations of limb subsystems are derived with finite element method(FEM). The equilibrium equations of the platform are derived with Newton's 2nd law. By introducing deformation compatibility conditions between the platform and limb, the governing equilibrium equations of the system are derived to formulate an analytical expression for system's deflections. The platform's elastic displacements and joint reactions caused by the gravity are investigated to show a strong position-dependency and axis-symmetry due to its kinematic and structure features. The proposed kinetostatic model is a trade-off between the accuracy of FEM and concision of analytical method, thus can predict the kinetostatics throughout the workspace in a quick and succinct manner. The proposed modeling methodology and kinetostatic analysis can be further expanded to other PKMs with necessary modifications, providing useful information for kinematic calibration as well as component strength calculations. | ZHAO Yanqin JIN Yan ZHANG Jun | 2016 | Chinese Journal of Mechanical Engineering2016，29，1： | 6 |
| 6 | Pluripotent Stem Cells Induced from Mouse Somatic Cells by Small-Molecule Compounds显示文摘 | Pingping Hou Yanqin Li Xu Zhang Chun Liu Jingyang Guan Honggang Li Ting Zhao Junqing Ye Weifeng Yang Kang Liu Jian Ge Jun Xu Qiang Zhang Yang Zhao Hongkui Deng | 2013 | Science2013，，6146： | 4 |
| 7 | Three Tiaobu Feishen therapies protect human alveolar epithelial cells against cigarette smoking and tumor necrosis factor-mlear factor-kappa B pathwayα-induced inflamation by nuc显示文摘OBJECTIVE: To investigate the efficacy of Tiaobu Feishen formulae(TBFS), including Bufei Jianpi formula(BJF), Bufei Yishen formula(BYF), and Yiqi Zishen formula(YZF), on inflammatory response, protease-anti-protease imbalance and collagen deposition in rats.METHODS: In present work, we used an in vitro model of cigarette smoking extract(CSE)-and tumor necrosis factor-α(TNF-α)-induced A549 cellsto examine the efficacy of BJF, BYF and YZF on the production of inflammatory cytokines, including TNF-α and interleukin(IL)-8, IL-6, matrix metalloproteinases(MMP)-9, and IL-10 in CSE or TNF-ls. And their related transcripα-induced A549 celtion factors and signaling pathway were also analyzed.RESULTS: The results showed that BJF, BYF and YZF could significantly decrease the expression levels of the pro-inflammatory cytokines induced by CSE or TNF-α. Furthermore, BJF, BYF and YZF could suppress CSE-or TNF-α-induced activation of nuclear factor-kappa B(NF-κB) transcription factors and its corresponding pathways. Taken together, these data implied that BJF, BYF and YZF effectively inhibited CSE-or TNF-α-induced inflammatory response in alveolar epithelial cell, which was due to their inhibition effect on NF-κB pathways.CONCLUSION: Our findings suggest that the Tiaobu Feishen therapies may protect human alveolar epithelial cells against cigarette smoking and TNF-α-induced inflammation. NF-κB pathway may involve in the actions. | Chen Yulong Wu Yaosong Li Jiansheng Feng Suxiang Hao Lili Liu Xuefang Zheng Wanchun Dong Haoran Qin Yanqin Yin Sugai Zhao Peng | 2019 | Journal of Traditional Chinese Medicine2019，39，1： | 4 |
| 8 | Propofol effectively inhibits lithium-pilocarpine-induced status epilepticus in rats via downregulation of N-methyl-D-aspartate receptor 2B subunit expression显示文摘Status epilepticus was induced via intraperitoneal injection of lithium-pilocarpine.The inhibitory effects of propofol on status epilepticus in rats were judged based on observation of behavior,electroencephalography and 24-hour survival rate.Propofol(12.5-100 mg/kg) improved status epilepticus in a dose-dependent manner,and significantly reduced the number of deaths within 24 hours of lithium-pilocarpine injection.Western blot results showed that,24 hours after induction of status epilepticus,the levels of N-methyl-D-aspartate receptor 2A and 2B subunits were significantly increased in rat cerebral cortex and hippocampus.Propofol at 50 mg/kg significantly suppressed the increase in N-methyl-D-aspartate receptor 2B subunit levels,but not the increase in N-methyl-D-aspartate receptor 2A subunit levels.The results suggest that propofol can effectively inhibit status epilepticus induced by lithium-pilocarpine.This effect may be associated with downregulation of N-methyl-D-aspartate receptor 2B subunit expression after seizures. | Henglin wang Zhuoqiang Wang Weidong Mi Cong Zhao Yanqin Liu Yongan Wang Haipeng Sun | 2012 | Neural Regeneration Research2012，7，11： | 3 |
| 9 | Application of the back-error propagation artificial neural network(BPANN) on genetic variants in the PPAR-γ and RXR-α gene and risk of metabolic syndrome in a Chinese Han population显示文摘This study was aimed to explore the associations between the combined effects of several polymorphisms in the PPAR-γ and RXR-α gene and environmental factors with the risk of metabolic syndrome by back-error propagation artificial neural network(BPANN).We established the model based on data gathered from metabolic syndrome patients(n = 1012) and normal controls(n = 1069) by BPANN.Mean impact value(MIV) for each input variable was calculated and the sequence of factors was sorted according to their absolute MIVs.Generalized multifactor dimensionality reduction(GMDR) confirmed a joint effect of PPAR-γ and RXR-α based on the results from BPANN.By BPANN analysis,the sequences according to the importance of metabolic syndrome risk factors were in the order of body mass index(BMI).serum adiponectin,rs4240711,gender,rs4842194,family history of type 2 diabetes,rs2920502,physical activity,alcohol drinking,rs3856806,family history of hypertension,rsl045570,rs6537944,age,rsl7817276,family history of hyperlipidemia,smoking,rs1801282 and rs3132291.However,no polymorphism was statistically significant in multiple logistic regression analysis.After controlling for environmental factors,A_1,A_2,B_1 and B_2(rs4240711,rs4842194,rs2920502 and rs3856806) models were the best models(cross-validation consistency 10/10,P = 0.0107) with the GMDR method.In conclusion,the interaction of the PPAR-γ and RXR-α gene could play a role in susceptibility to metabolic syndrome.A more realistic model is obtained by using BPANN to screen out determinants of diseases of multiple etiologies like metabolic syndrome. | Xu Zhao Kang Xu Hui Shi Jinluo Cheng Jianhua Ma Yanqin Gao Qian Li Xinhua Ye Ying Lu Xiaofang Yu Juan Du Wencong Du Qing Ye Ling Zhou | 2014 | The Journal of Biomedical Research2014，28，2： | 3 |
| 10 | Pluripotent Stem Cells Induced from Mouse Somatic Cells by Small-Molecule Compounds显示文摘 | Pingping Hou Yanqin Li Xu Zhang Chun Liu Jingyang Guan Honggang Li Ting Zhao Junqing Ye Weifeng Yang Kang Liu Jian Ge Jun Xu Qiang Zhang Yang Zhao Hongkui Deng | 2013 | Science . 2013 (6146)2013，，： | 2 |
| 11 | Gene expression profiling under different photoperiod/temperature conditions in a photoperiod-/thermo-sensitive genic male sterile line of rice(Oryza sativa L.)显示文摘Peiai 64S is a photoperiod- and thermo- sensitive genic male sterile (PTSGMS) line of rice, which is male sterile at long day/high temperature and partial fertile at short day/low temperature. A cDNA array representing 3328 unique rice genes was used to profile the gene expression patterns in the young panicles of Peiai 64S under these two condi- tions. The statistical data showed that up to 14.60% of genes exhibited up-or down-regulated expressions in the plants at long day/high temperature compared with plants at short day/low temperature. Only four genes were up-regulated while 482 genes down-regulated. Real-time PCR with all the up-regulated and 9 randomly selected down-regulated genes confirmed the differential expressions detected by the array, indicating that the constructed cDNA array is reliable. These differently expressed genes participated in almost all cell biological responses. Analysis of up- and down-regulated genes revealed distinctive changes between the mRNA abundances of MMK1 and MMK2, both of which are analogs ofMAPK, and significant down-regulation of several transcription factors. It was suggested that changes that occurred in the MAPK signal transduction path- way might disturb the transcription control necessary for morphogenesis of pollens and corresponding phys- iological functions. | GUO Xiaoqin DONG Haitao ZHENG Kangle LUO Hongmei TAN Xuelin FANG Yongqi WANG Yanqin DENG Ye DAI Chengen LOU Yichun SHAO Jing SHI Wenqin ZHAO Dong LI Debao | 2006 | Chinese Science Bulletin2006，51，2： | 2 |
| 12 | Pluripotent Stem Cells Induced from Mouse Somatic Cells by Small-Molecule Compounds显示文摘 | Pingping Hou Yanqin Li Xu Zhang Chun Liu Jingyang Guan Honggang Li Ting Zhao Junqing Ye Weifeng Yang Kang Liu Jian Ge Jun Xu Qiang Zhang Yang Zhao Hongkui Deng | 2013 | Science2013，，6146： | 2 |
| 13 | A New Image Enhancement Algorithm for Low Il- lumination Environment 显示文摘 | ZHAO YANQIN WANG ZHENCHONG FU XIHUI | 2011 | International Conference on Computer Science and Automation Engineering CSAE2011，1，： | 1 |
| 14 | Pluripotent Stem Cells Induced from Mouse Somatic Cells by Small-Molecule Compounds显示文摘 | Pingping Hou Yanqin Li Xu Zhang Chun Liu Jingyang Guan Honggang Li Ting Zhao Junqing Ye Weifeng Yang Kang Liu Jian Ge Jun Xu Qiang Zhang Yang Zhao Hongkui Deng | 2013 | 2013 (6146)2013，，6146： | 1 |
| 15 | An analytical poroelastic model for laboratorial mechanical testing of the articular cartilage (AC)显示文摘The articular cartilage(AC) can be seen as a biphasic poroelastic material.The cartilage deformation under compression mainly leads to an interstitial fluid flow in the porous solid phase.In this paper,an analytical poroelastic model for the AC under laboratorial mechanical testing is developed.The solutions of interstitial fluid pressure and velocity are obtained.The results show the following facts.(i) Both the pressure and fluid velocity amplitudes are proportional to the strain loading amplitude.(ii) Both the amplitudes of pore fluid pressure and velocity in the AC depend more on the loading amplitude than on the frequency.Thus,in order to obtain the considerable fluid stimulus for the AC cell responses,the most effective way is to increase the loading amplitude rather than the frequency.(iii) Both the interstitial fluid pressure and velocity are strongly affected by permeability variations.This model can be used in experimental tests of the parameters of AC or other poroelastic materials,and in research of mechanotransduction and injury mechanism involved interstitial fluid flow. | Xiaogang WU Kuijun CHEN Zhaowei WANG Ningning WANG Teng ZHAO Yanan XUE Yanqin WANG Weiyi CHEN | 2018 | Applied Mathematics and Mechanics(English Edition)2018，39，6： | 1 |
| 16 | Direct Conversion of Glucose to 5-Hydroxymethylfurfural over Zirconium Phosphate Catalyst in a Biphasic System显示文摘Efficient and selective production of 5-hydroxymethylfurfural(HMF) from glucose was achieved in the presence of zirconium phosphate(ZrPO) catalyst in a biphasic system.With the use of this catalyst,a high HMF yield of 56.8% was obtained from glucose in a water-tetrahydrofuran(THF) biphasic system.Characterization results showed that such catalyst had weak to strong acid sites and contained both Lewis and Br?nsted acid sites.The results of comparative experiments over some other solid acid catalysts demonstrated that the Lewis acid sites on the ZrPO catalyst played a crucial role in the isomerization of glucose to fructose and the Br?nsted ones were active in the dehydration of generated fructose to HMF.Moreover,less levulinic acid(LA) and formic acid(FA)(0.5%) were detected in the reaction solution,indicating that this ZrPO catalyst exhibited high selectivity towards the formation of HMF.Furthermore,the ZrPO catalyst was very stable and could maintain its activity after being used for six times. | Zhao Hong Ye Xinxin Yan Rui Liu Xiaohui Guo Yong Wang Yanqin | 2018 | China Petroleum Processing & Petrochemical Technology2018，20，2： | 1 |
| 17 | Two Supporting Factors Greatly Improve the Efficiency of Human iPSC Generation显示文摘 | Yang Zhao Xiaolei Yin Han Qin Fangfang Zhu Haisong Liu Weifeng Yang Qiang Zhang Chengang Xiang Pingping Hou Zhihua Song Yanxia Liu Jun Yong Pengbo Zhang Jun Cai Meng Liu Honggang Li Yanqin Li Xiuxia Qu Kai Cui Weiqi Zhang Tingting Xiang Yetao Wu Yiding Zh | 2008 | Cell Stem Cell2008，，5： | 1 |
| 18 | Contrast-en- hanced ultrasound with SonoVue could accurately assess the renal microvascular perfusion in diabetic kidney dam- age显示文摘 | Fang Ma Yanqin Cang Baozhen Zhao | 2012 | Nephrol Dial Transplant2012，10，： | 1 |
| 19 | 超表面三维彩色全息显示文摘全息光学是近代光学领域的一个重要分支。全息技术充分利用完整的电磁场振幅和位相信息实现对电磁场的重构。近些年来发展起来的计算全息技术通过电磁算法来计算得到包含振幅和位相信息的全息图,在外界光源的照射下可以产生预先设计的、虚拟的物体图像。现有的基于二元光学元件或空间光调制器等实现的位相型计算全息图,通常存在像元尺寸大和位相调控能力有限等限制,使得全息的视场角受限,难以实现大视场三维彩色全息。 | Li, Xiong Chen, Lianwei Li, Yang Zhang, Xiaohu Pu, Mingbo Zhao, Zeyu Ma, Xiaoliang Wang, Yanqin Hong, Minghui Luo, Xiangang | 2017 | 光电工程2017，44，1： | 1 |
| 20 | Simulating potential outbreaks of Delta and Omicron variants based on contact-tracing data:A modelling study in Fujian Province,China显示文摘Although studies have compared the relative severity of Omicron and Delta variants by assessing the relative risks,there are still gaps in the knowledge of the potential COVID-19 burden these variations may cause.And the contact patterns in Fujian Province,China,have not been described.We identified 8969 transmission pairs in Fujian,China,by analyzing a contact-tracing database that recorded a SARS-CoV-2 outbreak in September 2021.We estimated the waning vaccine effectiveness against Delta variant infection,contact patterns,and epidemiology distributions,then simulated potential outbreaks of Delta and Omicron variants using a multi-group mathematical model.For instance,in the contact setting without stringent lockdowns,we estimated that in a potential Omicron wave,only 4.7%of infections would occur in Fujian Province among individuals aged>60 years.In comparison,58.75%of the death toll would occur in unvaccinated individuals aged>60 years.Compared with no strict lockdowns,combining school or factory closure alone reduced cumulative deaths of Delta and Omicron by 28.5%and 6.1%,respectively.In conclusion,this study validates the need for continuous mass immunization,especially among elderly aged over 60 years old.And it confirms that the effect of lockdowns alone in reducing infections or deaths is minimal.However,these measurements will still contribute to lowering peak daily incidence and delaying the epidemic,easing the healthcare system's burden. | Yichao Guo Wenjing Ye Zeyu Zhao Xiaohao Guo Wentao Song Yanhua Su Benhua Zhao Jianming Ou Yanqin Deng Tianmu Chen | 2023 | Infectious Disease Modelling2023，8，1： | 1 |
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