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| 1 | Regulating cost for renewable energy integration in power grids显示文摘To address the issue of climate change caused by the use of polluting, non-renewable energy sources, the use of renewable energy has gained momentum worldwide. Consequently, the increased integration of renewable energy sources into power grids has necessitated the inclusion of flexible capacities in the power systems to solve problems of intermittent and fluctuating characteristics associated with renewable generation outputs. In this work, we study the regulating cost of a power system with high renewable penetration using an improved time-series system production simulation analysis method. The operational cost of the system is considered as the objective function. Three different methods to increase regulating capacities, including using interconnection lines, building additional flexible power capacities, and retrofitting existing thermal power plants, are adopted and simulated to compare the costs of accommodating renewable energy in the system in these cases. Our results indicate that increasing the flexibility of thermal power plants and developing crossregional connection lines are cost-effective methods of increasing renewable energy consumption. | Dong Zhang Peiyu You Fan Liu Yuhong Zhang Yantao Zhang Chao Feng | 2018 | Global Energy Interconnection2018，1，5： | 3 |
| 2 | Spatial distribution characteristics of bacterial community structure and gene abundance in sediments of the Bohai Sea显示文摘This study investigated differences in the community structure and environmental responses of the bacterial community in sediments of the Bohai Sea.Illumina high-throughput sequencing technology and real-time PCR were used to assay the bacterial 16S rRNA genes in the surface sediments of 13 sampling stations in the Bohai Sea.The results showed that sediments at the majority of the 13 sampling stations were contaminated by heavy metal mercury.The main phyla of bacteria recorded included Proteobacteria(52.92%),Bacteroidetes(11.76%),Planctomycetes(7.39%),Acidobacteria(6.53%)and Chloroflexi(4.97%).The genus with the highest relative abundance was Desulfobulbus(4.99%),which was the dominant genus at most sampling stations,followed by Lutimonas and Halioglobus.The main factors influencing bacterial community structure were total organic carbon,followed by depth and total phosphorus.The content of lead,cadmium,chromium,copper and zinc had a consistent effect on community structure.Arsenic showed a negative correlation with bacterial community structure in most samples,while the impact of mercury on community structure was not significant.The bacterial community in sediment samples from the Bohai Sea was rich in diversity and displayed an increase in diversity from high to low latitudes.The data indicated that the Bohai Sea had abundant microbial resources and was rich in bacteria with the potential to metabolize many types of pollutants. | Quanrui Chen Jingfeng Fan Jie Su Hongxia Ming Zhihao Sun Mengfei Li Xiaohui Zhao Yantao Wang Yingxue Zhang Huizhen Zhang Yuan Jin Xiaowan Ma Bin Wang | 2020 | Acta Oceanologica Sinica2020，39，2： | 2 |
| 3 | A drug-loaded composite coating to improve osteogenic and antibacterial properties of Zn-1Mg porous scaffolds as biodegradable bone implants显示文摘Zinc(Zn)alloy porous scaffolds produced by additive manufacturing own customizable structures and biodegradable functions,having a great application potential for repairing bone defect.In this work,a hydroxyapatite(HA)/polydopamine(PDA)composite coating was constructed on the surface of Zn-1Mg porous scaffolds fabricated by laser powder bed fusion,and was loaded with a bioactive factor BMP2 and an antibacterial drug vancomycin.The microstructure,degradation behavior,biocompatibility,antibacterial performance and osteogenic activities were systematically investigated.Compared with as-built Zn-1Mg scaffolds,the rapid increase of Zn2+,which resulted to the deteriorated cell viability and osteogenic differentiation,was inhibited due to the physical barrier of the composite coating.In vitro cellular and bacterial assay indicated that the loaded BMP2 and vancomycin considerably enhanced the cytocompatibility and antibacterial performance.Significantly improved osteogenic and antibacterial functions were also observed according to in vivo implantation in the lateral femoral condyle of rats.The design,influence and mechanism of the composite coating were discussed accordingly.It was concluded that the additively manufactured Zn-1Mg porous scaffolds together with the composite coating could modulate biodegradable performance and contribute to effective promotion of bone recovery and antibacterial function. | Zhenbao Zhang Aobo Liu Jiadong Fan Menglin Wang Jiabao Dai Xiang Jin Huanze Deng Xuan Wang Yijie Liang Haixia Li Yantao Zhao Peng Wen Yanfeng Li | 2023 | Bioactive Materials2023，，9： | 2 |
| 4 | Efficacy,safety and immunogenicity of hexavalent rotavirus vaccine in Chinese infants显示文摘A randomized,double-blind,placebo-controlled multicenter trial was conducted in healthy Chinese infants to assess the efficacy and safety of a hexavalent live human-bovine reassortant rotavirus vaccine(HRV)against rotavirus gastroenteritis(RVGE).A total of 6400 participants aged 6-12 weeks were enrolled and randomly assigned to either HRV(n?3200)or placebo(n?3200)group.All the subjects received three oral doses of vaccine four weeks apart.The vaccine efficacy(VE)against RVGE caused by rotavirus serotypes contained in HRV was evaluated from 14 days after three doses of administration up until the end of the second rotavirus season.VE against severe RVGE,VE against RVGE hospitalization caused by serotypes contained in HRV,and VE against RVGE,severe RVGE,and RVGE hospitalization caused by natural infection of any serotype of rotavirus were also investigated.All adverse events(AEs)were collected for 30 days after each dose.Serious AEs(SAEs)and intussusception cases were collected during the entire study.Our data showed that VE against RVGE caused by serotypes contained in HRV was 69.21%(95%CI:53.31-79.69).VE against severe RVGE and RVGE hospitalization caused by serotypes contained in HRV were 91.36%(95%CI:78.45-96.53)and 89.21%(95%CI:64.51-96.72)respectively.VE against RVGE,severe RVGE,and RVGE hospitalization caused by natural infection of any serotype of rotavirus were 62.88%(95%CI:49.11-72.92),85.51%(95%CI:72.74-92.30)and 83.68%(95%CI:61.34-93.11).Incidences of AEs from the first dose to one month post the third dose in HRV and placebo groups were comparable.There was no significant difference in incidences of SAEs in HRV and placebo groups.This study shows that this hexavalent reassortant rotavirus vaccine is an effective,well-tolerated,and safe vaccine for Chinese infants. | Zhiwei Wu Qingliang Li Yan Liu Huakun Lv Zhaojun Mo Fangjun Li Qingchuan Yu Fei Jin Wei Chen Yong Zhang Teng Huang Xiaosong Hu Wei Xia Jiamei Gao Haisong Zhou Xuan Bai Yueyue Liu Zhenzhen Liang Zhijun Jiang Yingping Chen Jiuwei Zhang Jialiang Du Biao Yang Bo Xing Yantao Xing Ben Dong Qinghai Yang Chen Shi Tingdong Yan Bo Ruan Haiyun Shi Xingliang Fan Dongyang Feng Weigang Lv Dong Zhang Xiangchu Kong Liuyifan Zhou Dinghong Que Hong Chen Zhongbing Chen Xiang Guo Weiwei Zhou Cong Wu Qingrong Zhou Yuqing Liu Jian Qiao Ying Wang Xinguo Li Kai Duan Yuliang Zhao Gelin Xu Xiaoming Yang | 2022 | Virologica Sinica2022，37，5： | 2 |
| 5 | Effect of the hyaluronic acid-poloxamer hydrogel on skin-wound healing: in vitro and in vivo studies显示文摘Background: Recent research into skin injury and wound healing has focused mainly on post‐trauma hemostasis, infection prevention, dermal regeneration and angiogenesis. However, less attention has been paid to air permeability and moisture loss prevention which also play important roles in injury healing. Methods: In the present work, we prepared a hyaluronic acid‐poloxamer (HA‐POL) hydrogel and tested the therapeutic effect of the hydrogel on skin‐wound healing. Results: The HA‐POL hydrogel transformed from sol to gel at 30°C, close to body temperature, and had stable moisturizing properties. HA‐POL hydrogel promoted skin‐wound healing and increased protein accumulation in the wound area. HA‐POL hydrogel allowed greater air permeability than Band‐aid, a typical wound covering. Results from transwell assays showed that the HA‐POL hydrogel effectively isolated skin‐wounds from bacterial invasion. Conclusion: This work demonstrates the advantages of using HA‐POL gel materials in the treatment of cutaneous wounds. | Xiaojuan Li Aimin Li Fan Feng Qiyu Jiang Huiwei Sun Yantao Chai Ruichuang Yang Zhijie Wang Jun Hou Ruisheng Li | 2019 | Animal Models and Experimental Medicine2019，2，2： | 1 |
| 6 | c-Myc regulates neural stem cell quiescence and activation by coordinating the cell cycle and mitochondrial remodeling显示文摘Dear Editor,In the adult brain,the transition from neural stem cell(NSC)quiescence to activation is a focal regulatory point for neural regeneration and dysregulations in the transition lead to brain disorders.1,2 During this transition,both cell cycle states and metabolism including mitochondria undergo extensive reprogramming.A deep understanding of such comprehensive changes is a prerequisite for a holistic picture of physiology and may aid disease combats. | Chunhui Cai Xinyu Hu Peibin Dai Tianran Zhang Mei Jiang Liefu Wang Wanhao Hua Yantao Fan Xin-Xin Han Zhengliang Gao | 2021 | Signal Transduction and Targeted Therapy2021，6，9： | 1 |
| 7 | Water in granulites: implications for the nature and evolution of the lower continental crust显示文摘更低的大陆人外壳是在深地球中的最重要的范围层之一并且是外壳披风相互作用发生的直接地方。 Granulites 是在更低的外壳中的统治岩石并且有批评含意因为深外壳液体的作文,自然和进化的知识是影响许多 geochemical 的重要媒介,更低的外壳的地球物理、地球动力学的特征并且可以也在 granulites 和更低的外壳的形成的 petrogenesis 起一个基本作用。在这篇论文,我们考察涉及深大陆人外壳 granulites 和液体和一些长期的争论的最近的进展。与Fourier变换红外线的光谱学结合了( FTIR 分析从华东在更低的外壳的 granulite 捕虏体和地面(暴露的节)表现在矿物质集合( cpx , opx , plag 和 grt )上,结构的水统治了由,这被建议哦在这些,有名无实地无水的阶段可以在深外壳中组成最重要的水水库。这 structual 水可以帮助理解许多降低外壳的地质的过程和现象(例如地震活动和电的传导性的异例) 并且从这些水的影响必须被考虑。 | YANG Xiaozhi XIA Qunke Etienne DELOULE FAN Qieheng HAO Yantao | 2007 | Progress in Natural Science:Materials International2007，17，2： | 1 |
| 8 | Quantitative examination of the inhibitory activation of molecular targeting agents in hepatocellular carcinoma patient-derived cell invasion via a novel in vivo tumor model显示文摘Background: The outcomes for patients with advanced hepatocellular carcinoma(HCC) receiving sorafenib are far from satisfactory because of treatment resistance to sorafenib. However, the exact mechanism of resistance to sorafenib remains unclear and it is valuable to establish a novel mouse model to quantitatively analyze the inhibition rates of sorafenib on the invasive growth of HCC cells in the liver.Methods: HCC tissue microblocks derived from patients were cultured and mixed with hydrogel drops. Then, hydrogel drops containing microblocks of HCC tissue were attached onto the surface of the livers of nude mice to form lesions or nodules of HCC. The mice received molecular targeting agents through oral administration. Livers with tumor nodules were harvested for H&E staining(hematoxylin-eosin staining) analysis and H&E staining images were quantitatively analyzed using image J software. The invasive growth of HCC cells into the liver was calculated using the depth of the lesions compared with the total thickness of the liver.Results: Microblocks containing cells derived from HCC patients can form lesions in the liver of nude mice. Oral administration of molecular targeting agents inhibited the invasive growth of HCC cells in the liver of nude mice.Conclusions: The model established in this study involves the invasive growth of HCC cells in the liver of nude mice, and the model allows for the quantitative analysis of the inhibitory effect of molecular targeting agents on the invasion of HCC cells in vivo. | Huiwei Sun Fan Feng Hui Xie Xiaojuan Li Qiyu Jiang Yantao Chai Zhijie Wang Ruichuang Yang Ruisheng Li Jun Hou | 2019 | Animal Models and Experimental Medicine2019，2，4： | 1 |
| 9 | The influence of earthquakes on Zhubi Reef in the Nansha Islands of the South China Sea显示文摘It is exceedingly important to estimate the stability of coral reefs. In recent years, growing construction projects have been carried out on the reef flat in the South China Sea. As a special marine geotechnical medium, it is made of the reef debris underwent overwhelmingly long geological age. Reefs grow thickly on the carbonate platform after the Late Oligocene and have five to six main sedimentary facies. It can be used as a recorder to measure the occurrence time of recent earthquake. A model of reef body is presented to study the influence of earthquakes according to the geological structure characteristic of reefs in the Nansha Islands. Furthermore, Geo Studio is used to simulate stress and deformation situations within it under various earthquake intensities. A safety factor is calculated by the limit equilibrium method, and the possible scenarios of earthquake-induced landslides and sliding scale are defined with a Newmark sliding block method, as well as stress distribution and deformation behaviors. Therefore, the numerical results suggest that the connections between the coral reef and the earthquake are as follows:(1) the reef body has a good stability under self-gravity state;(2) after the earthquake, it may cause slope's instability and bring out slumping when the safety factor is smaller than 1(FS<1);(3) the safety factor decreases with the increasing earthquake intensity, and fluctuates around a particular value after a while;and(4) as a new developed part of the reef, the smaller shallow landslide will be easily subject to collapse caused by the earthquake. It is concluded that it is feasible to provide a reference for evaluating the stability of coral reef using a geotechnical engineering simulation method. This can help the engineering constructions in the South China Sea. | GUO Lei ZHAN Wenhuan ZHANG Fan ZHANG Jinchang YAO Yantao LI Jian FENG Yingci CHEN Mei CHENG Gong | 2017 | Acta Oceanologica Sinica2017，36，3： | 1 |
| 10 | Weak Fiber Bragg Grating Based Sensing System for Cryogenic Static Test of Launch Vehicle Oxygen Tank显示文摘In this paper,a weak fiber Bragg grating(WFBG)based sensing system applied to the cryogenic static test of launch vehicle oxygen tanks has been developed and the results of an evaluation are reported.A customized sensor encapsulation and installation method allow for precise strain measurement at cryogenic temperatures.The reflection peaks of series-connected WFBGs with low optical loss are obtained,ensuring high system reliability in harsh environments.The experimental results show that the maximum full-scale error is less than 0.81%full-scale error.The temperature is as low as−193℃ during the test.This study also demonstrates a practical method in which WFBG can be used to obtain critical parameters for structural monitoring in a cryogenic environment. | Zhang Xuezhi Chen Guanlong Jiang Junfeng Fan Xiaojun Liu Kun Wang Shuang Liu Yantao Ni Jingda Liu Tiegen | 2021 | 激光与光电子学进展2021，58，21： | 0 |
| 11 | Ultrasensitive and Signal-on Electrochemiluminescence Aptasensor Using the Multi-tris(bipyridine)ruthenium(Ⅱ)- β-cyclodextrin Complexes显示文摘An ultrasensitive and signal-on electrochemiluminescence(ECL)aptasensor to detect target protein(thrombin or lysozyme)was developed using the host-guest recognition between a metallocyclodextrin complex and single-stranded DNA(ss-DNA).The aptasensor uses both the photoactive properties of the metallocyclodextrins named multi-tris(bipyridine)ruthenium(Ⅱ)-β-cyclodextrin complexes and their specific recognition with ss-DNA,which amplified the ECL signal without luminophore labeling.After investigating the ECL performance of different multi-tris(bipyridine)ruthenium(Ⅱ)-β-cyclodextrin(multi-Ru-β-CD)complexes,tris-tris(bipyridine)-ruthenium(Ⅱ)-β-cyclodextrin(tris(bpyRu)-β-CD)was selected as a suitable host molecule to construct an atasensor.First,double-stranded DNA(ds-DNA)formed by hybridization of the aptamer and its target DNA was attached to a glassy carbon electrode via coupling interaction,which showed low ECL intensity with 2-(dibutylamino)ethanol(DBAE)as coreactant,because of the weak recognition between ds-DNA and tris(bpyRu)-β-CD.Upon addition of the corresponding protein,the ECL intensity increased when target ss-DNA was released because of the higher stability of the aptamer-protein complex than the aptamer-DNA one.A linear relationship was observed in the range of 0.01 pmol/L to 100 pmol/L between ECL intensity and the logarithm of thrombin concentrations with a limited detection of 8.5 fmol/L(S/N=3).Meanwhile,the measured concentration of lysozyme was from 0.05 pmol/L to 500 pmol/L and the detection limit was 33 fmol/L(S/N=3).The investigations of proteins in human serum samples were also performed to demonstrate the validity of detection in real clinical samples.The simplicity,high sensitivity and specificity of this aptasensor show great promise for practical applications in protein monitoring and disease diagnosis. | Yingying Zhao Hong Chen Qiong Chen Yantao Qi Fan Yang Jie Tang Pingang He Fan Zhang | 2014 | Chinese Journal of Chemistry2014，32，11： | 0 |
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