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| 1 | Clinical study using mesenchymal stem cells for the treatment of patients with severe COVID-19显示文摘The coronavirus disease 2019(COVID-19)caused by SARS-CoV-2 was identified in December 2019.The symptoms include fever,cough,dyspnea,early symptom of sputum,and acute respiratory distress syndrome(ARDS).Mesenchymal stem cell(MSC)therapy is the immediate treatment used for patients with severe cases of COVID-19.Herein,we describe two confirmed cases of COVID-19 in Wuhan to explore the role of MSC in the treatment of COVID-19.MSC transplantation increases the immune indicators(including CD4 and lymphocytes)and decreases the inflammation indicators(interleukin-6 and C-reactive protein).High-flow nasal cannula can be used as an initial support strategy for patients with ARDS.With MSC transplantation,the fracrion of inspired O2(Fi02)of the two patients gradually decreased while the oxygen saturation(Sa02)and partial pressure of oxygen(P02)improved.Additionally,the patients9 chest computed tomography showed that bilateral lung exudate lesions were adsorbed after MSC infusion.Results indicated that MSC transplantation provides clinical data on the treatment of COVID-19 and may serve as an alternative method for treating COVID-19,particularly in patients with ARDS. | Lingling Tang Yingan Jiang Mengfei Zhu Lijun Chen Xiaoyang Zhou Chenliang Zhou Peng Ye Xiaobei Chen Baohong Wang Zhenyu Xu Qiang Zhang Xiaowei Xu Hainv Gao Xiaojun Wu Dong Li Wanli Jiang Jingjing Qu Charlie Xiang Lanjuan Li | 2020 | Frontiers of Medicine2020，14，5： | 8 |
| 2 | A novel requirement analysis approach for periodic control systems显示文摘 | Zheng WANG Geguang PU Jiangwen LI Yuxiang CHEN Yongxin ZHAO Mingsong CHEN Bin GU Mengfei YANG Jifeng HE | 2013 | Frontiers of Computer Science2013，7，2： | 3 |
| 3 | A leaf shape mutant provides insight into PINOID Serine/Threonine Kinase function in cucumber(Cucumis sativus L.)显示文摘Optimizing leaf shape is a major challenge in efforts to develop an ideal plant type. Cucumber leaf shapes are diverse;however, the molecular regulatory mechanisms underlying leaf shape formation are unknown. In this study, we obtained a round leaf mutant(rl) from an ethyl methanesulfonate-induced mutagenesis population. Genetic analysis revealed that a single recessive gene, rl, is responsible for this mutation. A modified Mut Map analysis combined linkage mapping identified a single nucleotide polymorphism within a candidate gene,Csa1 M537400, as the mutation underlying the trait.Csa1 M537400 encodes a PINOID kinase protein involved in auxin transport. Expression of Csa1 M537400 was significantly lower in the rl mutant than in wild type, and it displayed higher levels of IAA(indole-3-acetic acid) in several tissues. Treatment of wild-type plants with an auxin transport inhibitor induced the formation of round leaves,similar to those in the rl mutant. Altered expression patterns of several auxin-related genes in the rl mutant suggest that rl plays a key role in auxin biosynthesis,transport, and response in cucumber. These findings provide insight into the molecular mechanism underlying the regulation of auxin signaling pathways in cucumber,and will be valuable in the development of an ideal plant type. | Mengfei Song Feng Cheng Jing Wang Qingzhen Wei Wenyuan Fu Xiaqing Yu Ji Li Jinfeng Chen Qunfeng Lou | 2019 | Journal of Integrative Plant Biology2019，61，9： | 3 |
| 4 | Health-related quality of life among rural residents aged 45-69 years in Hua County, Henan Province, China: Results of ESECC Trial for esophageal cancer screening with endoscopy显示文摘Objective: There have been few population-based studies evaluating health related quality of life(HRQOL) in rural populations in China, and this study aimed to assess the current status of and risk factors for HRQOL in a general rural population in high risk region of esophageal cancer in China.Methods: From November 2015 to September 2016, 12,085 permanent residents aged 45–69 years from 257 villages in the Endoscopic Screening for Esophageal Cancer in China(ESECC) trial(Clinical Trials.gov:NCT01688908) randomly selected from Hua County, Henan Province, China were interviewed. The EQ-5 D-3 L,a generic measure of HRQOL, and a questionnaire were used to assess their HRQOL and potential risk factors.Results: Among all the participants, 30.62% of the participants reported problems in at least one EQ-5 D dimension. Pain/discomfort(25.52%) was the most frequently reported problem followed by anxiety/depression(7.97%), mobility(5.82%), usual activities(2.61%) and self-care(1%). These rural residents had a mean EQ-5 D index score of 0.948, and lower EQ-5 D index scores were associated with older age, female gender, lower levels of household annual per capita income, living alone, using shallow wells as main source of drinking water, exposure to family members smoking, testiness, unhealthy dietary habits, overweight or obesity, upper gastrointestinal cancer related symptoms and chronic diseases.Conclusions: Rural residents in China have a relatively low quality of life. Health promotion programs in this population should focus on the elderly, especially elderly women and the elderly living alone. Improving basic living circumstances and primary medical care services should be priorities. Results of this study will also serve as the basis for the cost-utility evaluation in our ESECC screening trial. | Hui Wang Yaqi Pan Chuanhai Guo Fenglei Li Ruiping Xu Mengfei Liu Zhen Liu Fangfang Liu Hong Cai Yang Ke Zhonghu He | 2018 | Chinese Journal of Cancer Research2018，30，2： | 3 |
| 5 | p190A inactivating mutations cause aberrant RhoA activation and promote malignant transformation via the Hippo-YAP pathway in endometrial cancer显示文摘The Rho family of GTPases is strictly regulated by a large family of GTPase-activating proteins(GAPs)that stimulate the relatively weak intrinsic GTP-hydrolyzing activity of Rho GTPases.p190A is a potent and widely expressed GAP that acts on RhoA GTPases.p190A is frequently mutated in endometrial cancer,but the contribution of p190A mutations to endometrial tumorigenesis remains unclear.Here we identified that p190A is an upstream regulator of the Hippo-YAP signaling pathway,which is a critical regulator of cell proliferation,apoptosis,and cell fate.p190A knockout in endometrial cancer cells promoted cell proliferation,migration,and epithelial–mesenchymal transition(EMT),which were partially dependent on YAP activation.Wild-type p190A,but not endometrial cancer-associated mutants,suppressed the nuclear localization,transcriptional activity,and malignant transformation function of YAP.Moreover,the nuclear localization of YAP was enhanced in p190A-mutated endometrial cancer.These findings reveal novel molecular mechanisms underlying Hippo-YAP pathway-driven endometrial tumorigenesis and elucidate the potential for therapy targeting the Hippo-YAP pathway in p190A-mutated endometrial cancer. | Xiaoli Wen Jing Wan Qizhi He Mengfei Wang Shuangdi Li Mei Jiang Zhen Qian Binya Liu Wen Lu Kai Wang Kun Gao Xiaoping Wan | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 3 |
| 6 | Oral microbiome and risk of malignant esophageal lesions in a high-risk area of China:A nested case-control study显示文摘Objective:We aimed to prospectively evaluate the association of oral microbiome with malignant esophageal lesions and its predictive potential as a biomarker of risk.Methods:We conducted a case-control study nested within a population-based cohort with up to 8 visits of oral swab collection for each subject over an 11-year period in a high-risk area for esophageal cancer in China.The oral microbiome was evaluated with 16 S ribosomal RNA(rRNA)gene sequencing in 428 pre-diagnostic oral specimens from 84 cases with esophageal lesions of severe squamous dysplasia and above(SDA)and 168 matched healthy controls.DESeq analysis was performed to identify taxa of differential abundance.Differential oral species together with subject characteristics were evaluated for their potential in predicting SDA risk by constructing conditional logistic regression models.Results:A total of 125 taxa including 37 named species showed significantly different abundance between SDA cases and controls(all P<0.05&false discovery rate-adjusted Q<0.10).A multivariate logistic model including 11 SDA lesion-related species and family history of esophageal cancer provided an area under the receiver operating characteristic curve(AUC)of 0.89(95%CI,0.84-0.93).Cross-validation and sensitivity analysis,excluding cases diagnosed within 1 year of collection of the baseline specimen and their matched controls,or restriction to screenendoscopic-detected or clinically diagnosed case-control triads,or using only bacterial data measured at the baseline,yielded AUCs>0.84.Conclusions:The oral microbiome may play an etiological and predictive role in esophageal cancer,and it holds promise as a non-invasive early warning biomarker for risk stratification for esophageal cancer screening programs. | Fangfang Liu Mengfei Liu Ying Liu Chuanhai Guo Yunlai Zhou Fenglei Li Ruiping Xu Zhen Liu Qiuju Deng Xiang Li Chaoting Zhang Yaqi Pan Tao Ning Xiao Dong Zhe Hu Huanyu Bao Hong Cai Isabel Dos Santos Silva Zhonghu He Yang Ke | 2020 | Chinese Journal of Cancer Research2020，32，6： | 3 |
| 7 | Identification of cancer patients using claims data from health insurance systems: A real-world comparative study显示文摘Objective: To evaluate the accuracy of identifying cancer patients by use of medical claims data in a health insurance system in China, and provide the basis for establishing the claims-based cancer surveillance system in China.Methods: We chose Hua County, Henan Province as the study site, and randomly selected 300 and 1,200 qualified inpatient electronic medical records(EMRs) as well as the New Rural Cooperative Medical Scheme(NCMS) claims records for cancer patients in Hua County People’s Hospital(HCPH) and Anyang Cancer Hospital(ACH) in 2017. Diagnostic information for NCMS claims was evaluated on an individual level, and sensitivity and positive predictive value(PPV) were calculated taking the EMRs as the gold standard.Results: The sensitivity of NCMS was 95.2%(93.8%-96.3%) and 92.0%(88.3%-94.8%) in ACH and HCPH,respectively. The PPV of the NCMS was 97.8%(96.7%-98.5%) in ACH and 89.0%(84.9%-92.3%) in HCPH.Overall, the weighted and combined sensitivity and PPV of NCMS in Hua County was 93.1% and 92.1%,respectively. Significantly higher sensitivity and PPV in identifying patients with common cancers than noncommon cancers were detected in HCPH and ACH separately(P<0.01).Conclusions: Identification of cancer patients by use of the NCMS is accurate on individual level, and it is therefore feasible to conduct claims-based cancer surveillance in areas not covered by cancer registries in China. | Hongrui Tian Ruiping Xu Fenglei Li Chuanhai Guo Lixin Zhang Zhen Liu Mengfei Liu Yaqi Pan Zhonghu He Yang Ke | 2019 | Chinese Journal of Cancer Research2019，31，4： | 3 |
| 8 | Spatial distribution characteristics of bacterial community structure and gene abundance in sediments of the Bohai Sea显示文摘This study investigated differences in the community structure and environmental responses of the bacterial community in sediments of the Bohai Sea.Illumina high-throughput sequencing technology and real-time PCR were used to assay the bacterial 16S rRNA genes in the surface sediments of 13 sampling stations in the Bohai Sea.The results showed that sediments at the majority of the 13 sampling stations were contaminated by heavy metal mercury.The main phyla of bacteria recorded included Proteobacteria(52.92%),Bacteroidetes(11.76%),Planctomycetes(7.39%),Acidobacteria(6.53%)and Chloroflexi(4.97%).The genus with the highest relative abundance was Desulfobulbus(4.99%),which was the dominant genus at most sampling stations,followed by Lutimonas and Halioglobus.The main factors influencing bacterial community structure were total organic carbon,followed by depth and total phosphorus.The content of lead,cadmium,chromium,copper and zinc had a consistent effect on community structure.Arsenic showed a negative correlation with bacterial community structure in most samples,while the impact of mercury on community structure was not significant.The bacterial community in sediment samples from the Bohai Sea was rich in diversity and displayed an increase in diversity from high to low latitudes.The data indicated that the Bohai Sea had abundant microbial resources and was rich in bacteria with the potential to metabolize many types of pollutants. | Quanrui Chen Jingfeng Fan Jie Su Hongxia Ming Zhihao Sun Mengfei Li Xiaohui Zhao Yantao Wang Yingxue Zhang Huizhen Zhang Yuan Jin Xiaowan Ma Bin Wang | 2020 | Acta Oceanologica Sinica2020，39，2： | 2 |
| 9 | Taking advantage of glass:capturing and retaining the helium gas on the moon显示文摘Helium-3(3He)is a noble gas that has critical applications in scientific research and promising application potential as clean fusion energy.It is thought that the lunar regolith contains large amounts of helium,but it is challenging to extract because most helium atoms are reserved in defects of crystals or as solid solutions.Here,we find large amounts of helium bubbles in the glassy surface layer of ilmenite particles that were brought back by the Chang’E-5 mission.The special disordered atomic packing structure of glasses should be the critical factor for capturing the noble helium gas.The reserves in bubbles do not require heating to high temperatures to be extracted.Mechanical methods at ambient temperatures can easily break the bubbles.Our results provide insights into the mechanism of helium gathering on the moon and offer guidance on future in situ extraction. | Ao Li Xiao Chen Lijian Song Guoxin Chen Wei Xu Juntao Huo Meng Gao Ming Li Lei Zhang Bingnan Yao Min Ji Yan Zhang Shaofan Zhao Wei Yao Yanhui Liu Jun-Qiang Wang Haiyang Bai Zhigang Zou Mengfei Yang Weihua Wang | 2022 | Materials Futures2022，1，3： | 2 |
| 10 | Reliable sensors based on graphene textile with negative resistance variation in three dimensions显示文摘The weft-knitted reduced graphene oxide(r-GO)textile that is made up of many conductive r-GO coated fibers was successfully prepared dependent on the electrospray deposition technique.Interestingly,the r-GO textile presents negative resistance variation not only in axial direction as the pressure increases but also in transverse direction as the lateral stretch increases which makes it has the advantage to fabricate the reliable sensors based on strain-resistance effect.The transverse-strain and pressure sensors based on the r-GO textiles all show the excellent sensing characteristics such as high sensitivity,reliability,and good durability,etc.The maximum gauge factors(GF)of the transverse-sensor are 27.1 and 153.5 in the x-and/-direction,respectively.And the practical detection range can up to 40%in the x-direction and 35%in the y-direction,respectively.The r-GO textile pressure sensor also shows high sensitivity for a broad pressure range that with a GF up to 716.8 kPa-1 for less than 4.5 kPa region and still has more sensitive pressure sensing characteristics even the pressure goes up to 14 kPa.Based on those good performances of r-GO textile sensors,its potential applications in human body states monitoring have been studied. | Wenpeng Han Yijun Wu He Gong Linxin Liu Junxiang Yan Mengfei Li Yunze Long Guozhen Shen | 2021 | Nano Research2021，14，8： | 2 |
| 11 | A Promising Anti-Cytokine-Storm Targeted Therapy for COVID-19:The Artificial-Liver Blood-Purification System显示文摘The coronavirus disease 2019(COVID-19)pan-epidemic,resulting from infection with the 2019 novel coronavirus(2019-nCoV),also known as severe acute respiratory syndrome-coronavirus-2(SARS-CoV-2),is currently the source of public health concern worldwide;however,treatment of this infection has been clinically challenging in many patients[1].Importantly,2019-nCoV is the third fatal coronavirus that has emerged in the past two decades,following SARS-CoV and the Middle East respiratory syndrome(MERS)-CoV[2].The numbers of confirmed cases of COVID-19 infection and related deaths are still rising.As of 9 March 2020. | Yimin Zhang Liang Yu LingLing Tang Mengfei Zhu Yanqi Jin Zhouhan Wang Lanjuan Li | 2021 | Engineering2021，7，1： | 2 |
| 12 | The partitioning behavior of trace elements in subduction zones:Advances and prospects显示文摘The partitioning behavior of trace elements is of key importance for understanding the geochemical process and material cycle mechanism in subduction zones.This paper focuses on the advances and prospects on the studies of trace element partitioning in subduction zones from the following four aspects.(1)The properties of fluids derived from subducting slabs and their ability in element transport.How slab-derived solute-rich fluids and supercritical fluids are formed and what the roles and key control factors of these fluids are in transferring of elements(especially the high field strength elements)from slab to wedge are discussed.We point out that the detailed investigations of supercritical fluids may provide a new perspective for the element migration mechanism,material cycle process,arc magma genesis and so on.(2)The behavior of transition elements during mantle wedge melting.The behavior of the first row transition elements(Sc,Ti,V,Cr,Mn,Fe,Co,Ni,Cu,Zn)in the mantle partial melting process is compatible or incompatible,depending on residual mineral assemblage and physicochemical conditions.The partitioning behavior of the elements such as Sc,Ti,Co,Ni and Zn whose valence states do not change in the melting process mainly depends on the residual mineral assemblage and temperature,whereas the partitioning behavior of the multivalent elements such as V and Fe is also the function of oxygen fugacity(fO_(2))in addition to mineral assemblage and temperature.Therefore,the partitioning behavior of transition elements has important applications in tracing lithologic inhomogeneity and fO_(2)of the mantle wedges.(3)The specificity of element partitioning behavior during arc magma evolution.Garnet has Dy/Yb partitioning behavior different from amphibole,and rutile has Nb/Ta partitioning behavior different from amphibole.Dy/Yb and Nb/Ta partitioning differences for these minerals enable to distinguish the specific evolution process of arc magmas.The Dy/Yb and Nb/Ta generally decrease with the increase of SiO_(2)in arc magmas,indicating that amphibole fractionation should be the most important during arc magma differentiation.(4)The behavior of sulfur and chalcophile elements and porphyry metallogeny.In subduction zones,the behavior of chalcophile elements such as Cu and Au is controlled by sulfide and fluid.Therefore,the stability of sulfide,the time at which the fluid exsolves from the melt relative to sulfide saturation,the fluid/sulfide mass ratio and fluid/melt Cu and Au partition coefficients in intermediate-felsic magma-H_(2)O systems are especially important in understanding Cu and Au enrichment in magma-hydrothermal processes.Intermediate-felsic magmas mainly originate from the differentiation of arc magmas at lower crustal reservoirs,and thus the fluid exsolution from the lower crustal reservoirs and the fluid/melt and fluid/sulfide partition coefficients of Cu and Au should be the keys to understanding quantitatively how Cu and Au are migrated from the deep crust to the shallow site of mineralization. | Xiaolin Xiong Xingcheng Liu Li Li Jintuan Wang Wei Chen Mengfei Ruan Ting Xu Zhongxing Sun Fangfang Huang Jianping Li&Lei Zhang | 2020 | Science China Earth Sciences2020，63，12： | 2 |
| 13 | Tacrine-6-Ferulic Acid,a Novel Multifunctional Dimer,Inhibits Amyloid-b-Mediated Alzheimer's Disease-Associated Pathogenesis In Vitro and In Vivo显示文摘 | Rongbiao Pi X M Xiaojuan Chao Zhiyi Cheng Mengfei Liu Xiaolu Duan Mingzhong Ye X C Zhengrong Mei Peiqing Liu Wenming Li Yifan Han | 2012 | PLo S ONE2012，7，2： | 1 |
| 14 | Highly Selective Gas-phase Synthesis of 1,1-Dichloroethylene from 1,1,2-Trichloroethane over Supported Amine Catalysts显示文摘 | TANG Cen JIN Yanxia WANG Xiaoxia HU Gengshen XIE Guanqun LI Xiaonian LUO Mengfei | 2015 | Chemical Research in Chinese Universities2015，31，5： | 1 |
| 15 | Concentration and size distribution of bioaerosols in an outdoor environment in the Qingdao coastal region显示文摘 | LI Mengfei QI Jianhua ZHANG Haidong | 2011 | Sci Total Environ2011，409，19： | 1 |
| 16 | Concentration and size distribution of bioaerosols in an outdoor environment in the Qingdao coastal region显示文摘 | Mengfei Li Jianhua Qi Haidong Zhang Shuai Huang Lin Li Dongmei Gao | 2011 | Science of the Total Environment2011，，19： | 1 |
| 17 | Novel CaBi 6 O 10 photocatalyst for methylene blue degradation under visible light irradiation显示文摘 | Yongjiao Wang Yiming He Tingting Li Jun Cai Mengfei Luo Leihong Zhao | 2011 | Catalysis Communications2011，，： | 1 |
| 18 | Diverse structures and antihepatoma effect of sesquiterpenoid dimers from Artemisia eriopoda by AKT/STAT signaling pathway显示文摘Dear Editor,Liver cancer as a common malignant tumor has become a major source of morbidity and mortality worldwide.1 Currently,four synthetic drugs and three monoclonal antibody drugs have been approved for the treatment of hepatocellular carcinoma(HCC)since 2007.Whereas,the disadvantages of the above drugs such as low response rates,severe side effects,and drug resistance hamper their therapeutic effects.Structurally and biologically diverse natural products are a major source in the search for novel antihepatoma agents. | Xiaofeng He Wenjing Ma Jing Hu Tianze Li Changan Geng Yunbao Ma Mengfei Wang Kexin Yang Xuemei Zhang Ji-Jun Chen | 2023 | Signal Transduction and Targeted Therapy2023，8，3： | 1 |
| 19 | Stable Ir/SiO 2 catalyst for selective hydrogenation of crotonaldehyde显示文摘 | Xiao Hong Bo Li Yuejuan Wang Jiqing Lu Gengshen Hu Mengfei Luo | 2013 | Applied Surface Science2013，，： | 1 |
| 20 | Strong Tracking Particle Filter Based on the Chi-Square Test for Indoor Positioning显示文摘In recent years,a number of wireless indoor positioning(WIP),such as Bluetooth,Wi-Fi,and Ultra-Wideband(UWB)technologies,are emerging.However,the indoor environment is complex and changeable.Walls,pillars,and even pedestrians may block wireless signals and produce non-line-of-sight(NLOS)deviations,resulting in decreased positioning accuracy and the inability to provide people with real-time continuous indoor positioning.This work proposed a strong tracking particle filter based on the chi-square test(SPFC)for indoor positioning.SPFC can fuse indoor wireless signals and the information of the inertial sensing unit(IMU)in the smartphone and detect the NLOS deviation through the chi-square test to avoid the influence of the NLOS deviation on the final positioning result.Simulation experiment results show that the proposed SPFC can reduce the positioning error by 15.1%and 12.3% compared with existing fusion positioning systems in the LOS and NLOS environment. | Lingwu Qian Jianxiang Li Qi Tang Mengfei Liu Bingjie Yuan Guoli Ji | 2023 | Computer Modeling in Engineering & Sciences2023，，8： | 1 |
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