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| 1 | Therapeutic effects of the artemisinin analog SM934 on lupus-prone MRLIIpr mice via inhibition of TLR-triggered B-cell activation and plasma cell formation显示文摘我们以前报导了那 SM934,水溶性的 artemisinin 衍生物,是在鼠科的豺狼座模型的一个可行处理。在当前的学习,我们进一步在豺狼座容易的 MRL/lpr 老鼠上调查了 SM934 的修改剂量政体的治疗学的效果并且在 B 房间回答上探索了它的效果,在全身的豺狼座 erythematosus (SLE ) 的一个中央病原的事件。当口头上地管理了时两次每日, SM934 显著地延长了 MRL/lpr 老鼠的寿命,改善 lymphadenopathy 症状并且减少浆液的层次反原子的抗体(言论集) 并且病原的 cytokines IL-6, IL-10 和 IL-21。而且, SM934 处理由增加静止 B 房间数字在 MRL/lpr 老鼠的怒气恢复了 B 房间分隔空间,维持幼芽的中心 B 房间数字,减少激活的 B 房间数字和减少的血浆房间(PC ) 数字。前 vivo, SM934 压制了触发的像使用费的受体(TLR ) B 房间的激活和增长,以及抗体分泌物。而且,现在的学习证明 SM934 由 downregulating TLR7/9 mRNA 表示, MyD88 蛋白质表示和 NF-κ 防碍 B 房间内在的小径; B phosphorylation。在人的外部血 mononuclear 房间(PBMC ) ,与在 MRL/lpr 鼠标的结果一致, SM934 禁止了联系 TLR 的 B 房间激活和 PC 区别。在结论, SM934 的两次每日的 dosing 政体由压制 B 房间激活和血浆房间形成在豺狼座容易的 MRL/lpr 老鼠上有治疗学的效果。 | Yanwei Wu Shijun He Bingxin Bai Luyao Zhang Lu Xue Zemin Lin Xiaoqian Yang Fenghua Zhu Peilan He Wei Tang Jianping Zuo | 2016 | Cellular & Molecular Immunology2016，13，3： | 31 |
| 2 | miR-124 suppresses multiple steps of breast cancer metastasis by targeting a cohort of pro-metastatic genes in vitro显示文摘Metastasis is a multistep process involving modification of morphology to suit migration, reduction of tumor cell adhesion to the extracellular matrix, increase of cell mobility, tumor cell resistance to anoikis, and other steps. MicroRNAs are well-suited to regulate tumor metastasis due to their capacity to repress numerous target genes in a coordinated manner, thereby enabling their intervention at multiple steps of the invasion-metastasis cascade. In this study, we identified a microRNA exemplifying these attributes, miR-124, whose expression was reduced in aggressive MDA-MB-231 and SK-3rd breast cancer cells. Down-regulation of miR-124 expression in highly aggressive breast cancer cells contributed in part to DNA hypermethylation around the promoters of the three genes encoding miR-124. Ectopic expression of miR-124 in MDA-MB-231 cells suppressed metastasis-related traits including formation of spindle-like morphology, migratory capacity, adhesion to fibronectin, and anoikis. These findings indicate that miR-124 suppresses multiple steps of metastasis by diverse mechanisms in breast cancer cells and suggest a potential application of miR-124 in breast cancer treatment. | Xiao-Bin Lv Yu Jiao Yanwei Qing Haiyan Hu Xiuying Cui Tianxin Lin Erwei Song Fengyan Yu | 2011 | Chinese Journal of Cancer2011，30，12： | 6 |
| 3 | TCP7 functions redundantly with several Class Ⅰ TCPs and regulates endoreplication in Arabidopsis显示文摘TCP(TEOSINTE BRANCHED1/CYCLOIDEA/PROLIFERATING CELL FACTOR) proteins, a family of plantspecific transcription factors, play important roles in many developmental processes. However, genetic and functional redundancy among class I TCP limits the analysis of their biological roles. Here, we identified a dominantnegative mutant of Arabidopsis thaliana TCP7 named leaf curling-upward(lcu), which exhibits smaller leaf cells and shorter hypocotyls than the wild type, due to defective endoreplication. A septuple loss-of-function mutant of TCP7, TCP8, TCP14, TCP15, TCP21, TCP22, and TCP23 displayed similar developmental defects to those of lcu.Genome-wide RNA-sequencing showed that lcu and the septuple mutant share many misexpressed genes.Intriguingly, TCP7 directly targets the CYCLIN D1;1 (CYCD1;1) locus and activates its transcription. We determined that the C-terminus of TCP7 accounts for its transcriptional activation activity. Furthermore, the mutant protein LCU exhibited reduced transcriptional activation activity due to the introduction of an EAR-like repressive domain at its C-terminus. Together, these observations indicate that TCP7 plays important roles during leaf and hypocotyl development, redundantly, with at least six class I TCPs, and regulates the expression of CYCD1;1 to affect endoreplication in Arabidopsis. | Guofang Zhang Hongtao Zhao Chunguang Zhang Xiaoyun Li Yuanyuan Lyu Dongmei Qi Yanwei Cui Lin Hu Zhenjie Wang Zheng Liang Sujuan Cui | 2019 | Journal of Integrative Plant Biology2019，61，11： | 5 |
| 4 | Epidemiological Investigation of an Inhalational Anthrax Patient Traveling for Medical Treatment in Beijing Municipality,China,August 2021显示文摘Summary What is already known about this topic?Inhalational anthrax,also known as pulmonary anthrax,is an infectious disease caused by Bacillus anthracis.The patients are usually infected by inhaling aerosolized B.anthracis spores from dead animals or animal products.Compared to cutaneous anthrax,inhalational anthrax is rare and deadly and few cases in China were reported.What is added by this report?This report covers all information of clinical features,laboratory testing,and epidemiological characteristics as well as exposure history of a recent primary inhalational anthrax patient who was seeking medical treatment in Beijing Municipality in August 2021.New laboratory techniques,including second-generation sequencing,polymerase chain reaction,and rapid test for serum antibody,played an important role in the process.What are the implications for public health practice?The information provided in this report,including the correct sample type,epidemiological investigation details,and application of the new diagnostic criteria of anthrax,could assist public health professionals in dealing with anthrax epidemics. | Changying Lin Xiangfeng Dou Daitao Zhang Yinqi Sun Huiqiang Han Chunzhi Chen Xiaojun Zhang Shuang Li Yanwei Chen Hongbin Zhang Bin Wang Zhichao Liang Xin Zhang Feng Wei Jiangli Wang Feng Liu Quanyi Wang Jian Shi Peng Yang | 2022 | China CDC weekly2022，4，1： | 3 |
| 5 | Bi-level Coordinated Planning of Active Distribution Network Considering Demand Response Resources and Severely Restricted Scenarios显示文摘Due to the uncertainty and fluctuation of distributed generation(DG)and load,the operation of active distribution network(ADN)is affected by multi-dimension factors which are described by massive operation scenarios.Efficient and accurate screening of severely restricted scenarios(SRSs)has become a new challenge in ADN planning.In this paper,a novel bi-level coordinated planning model which combines the short-time-scale operation problem with the long-time-scale planning problem is proposed.At the upper level,the demand response(DR)resource,an effective non-component planning resource characterized by low capacity price,high energy price,and short contract term,is co-optimized with the configuration of lines and energy storage systems(ESSs)to achieve the economic trade-off between the investment cost and the operation cost under SRSs.At the lower level,with the planning scheme obtained from the upper level,massive operation problems are optimized to minimize the daily operation cost;and the SRSs are provided to the upper level through a shadow-price-based scenario screening method,which simulates the planning information(i.e.,the restricted degrees of operation scenarios)feedback process from ADN operators to ADN planners.Case studies on a 62-node distribution system in Jianshan New District,Zhejiang Province,China,illustrate the effectiveness of the proposed bi-level coordinated planning model considering DR resources and SRSs. | Huang Yixin Lin Zhenzhi Liu Xinyi Yang Li Dan Yangqing Zhu Yanwei Ding Yi Wang Qin | 2021 | Journal of Modern Power Systems and Clean Energy2021，9，5： | 3 |
| 6 | CO flux of soil respiration in natural recovering karst abandoned farmland in Southwest China显示文摘To estimate carbon sequestration potential in the karst area,soil respiration in a natural recovering karst abandoned farmland in Shawan,Puding,Guizhou,southwest China was continuously and automatically monitored for more than two years.The results show that the CO2flux of soil respiration(2.63±1.89 lmol m^-2s-^1)is higher in the karst area than in non-karst areas under similar conditions but that regional value(1.32 lmol m-2s-1)is lower because of larger rock fragment coverage(~50%).A the same time,the temperature sensitivity of soil respiration(Q10)in this study area is significantly higher than that of non-karst areas under similar conditions.Soil respiration has an obvious temporal variation,which is reflected in a significant exponential relationship between soil respiration and soil temperature,but the relationship between soil respiration and soil moisture is very complex.Especially soil respiration has an obvious spatial variation,which is likely affected by different diffusion or water-rock reaction processes. | Yanwei Wang Weijun Luo Guangneng Zeng Hanling Yang Meifang Wang Yina Lyu Anyun Cheng Lin Zhang Xianli Cai Jia Chen Shijie Wang | 2020 | Acta Geochimica2020，39，4： | 2 |
| 7 | Li-ion battery material under high pressure:amorphization and enhanced conductivity of Li_4Ti_5O_(12)显示文摘Lithium titanium oxide(Li_4Ti_5O_(12),LTO),a‘zero-strain’anode material for lithium-ion batteries,exhibits excellent cycling performance.However,its poor conductivity highly limits its applications.Here,the structural stability and conductivity of LTO were studied using in situ high-pressure measurements and first-principles calculations.LTO underwent a pressure-induced amorphization(PIA)at 26.9 GPa.The impedance spectroscopy revealed that the conductivity of LTO improved significantly after amorphization and that the conductivity of decompressed amorphous LTO increased by an order of magnitude compared with its starting phase.Furthermore,our calculations demonstrated that the different compressibility of the Li O_6 and Ti O_6 octahedra in the structure was crucial for the PIA.The amorphous phase promotes Li^+ diffusion and enhances its ionic conductivity by providing defects for ion migration.Our results not only provide an insight into the pressure depended structural properties of a spinel-like material,but also facilitate exploration of the interplay between PIA and conductivity. | Yanwei Huang Yu He Howard Sheng Xia Lu Haini Dong Sudeshna Samanta Hongliang Dong Xifeng Li Duck Young Kim Ho-kwang Mao Yuzi Liu Heping Li Hong Li Lin Wang | 2019 | National Science Review2019，6，2： | 2 |
| 8 | Ceria supported Ru^(0)-Ru^(δ+) clusters as efficient catalyst for arenes hydrogenation显示文摘Selective hydrogenation of aromatic amines,especially chemicals such as aniline and bis(4-aminocyclohexyl)methane for non-yellowing polyurethane,is of particular interests due to the extensive applications.To conquer the existing difficulties,in selective hydrogenation,,the Ru^(0)-Ru^(δ+)/CeO2 catalyst with solid frustrated Lewis pairs was developed for aromatic amines hydrogenation with excellent activity and selectivity under relative milder conditions.The morphology,electronic and chemical properties,especially the Ru^(O)-Ru^(δ+) clusters and reducible ceria were characterized by X-ray diffraction(XRD),transmission electron microscopy(TEM),sca nning electronic microscopy(SEM),X-ray photoelectron sp ectroscopy(XPS),CO_(2) tempe rature programmed deso rption(CO_(2)-TPD),H_(2) tempe rature programmed reduction(H_(2)-TPR),H_(2) diffuse reflectance Fourier transform infrared spectroscopy(H_(2)-DRIFT),Raman,etc.The 2% Ru/CeO_(2) catalyst exhibited good conversion of 95% and selectivity greater than 99% toward cyclohexylamine.The volcano curve describing the activity and Ru state was found.Owning to the 'acidic site isolation' by surrounding alkaline sites,condensation between the neighboring amine molecules could be effectively suppressed.The catalyst also showed good stability and applicability for other aromatic amines and heteroarenes containing different functional groups. | Yanwei Cao Huan Zheng Gangli Zhu Haihong Wu Lin He | 2021 | Chinese Chemical Letters2021，32，2： | 2 |
| 9 | A study on melanoma treatment using dendritic cells loaded with antigens purified from melanoma cell lines显示文摘Objective The aim of this study was to purify effective tumor peptide complexes from human melanoma cell lines to enhance the treatment effects on melanoma.Methods We purified heat shock protein 70(HSP70)-peptide complexes(PCs)from human melanoma cell lines A375,A875,M21,M14,WM-35,and SK-HEL-1.We named the purified product as M-HSP70-PCs and determined its immunological activities.Autologous HSP70-PCs purified from primary tumor cells of melanoma patients(9 cases)were used as controls.These two tumor antigenic complexes were loaded into dendritic cells(DCs)and used to stimulate an antitumor response against tumor cells in the corresponding patients.Results Mature DCs pulsed with M-HSP70-PCs stimulated autologous T cells to secrete the same levels of type I cytokines as the autologous HSP70-PCs.Moreover,DCs pulsed with M-HSP70-PCs endued CIK cells with an equal ability as autologous HSP70-PCs to kill melanoma cells in the patients.Conclusion M-HSP70-PCs may be used as an efficient and generalized tumor antigen in the treatment of DC-based malignant melanoma. | Yanwei Gao Xia Chen Weishi Gao Xiangji Lu Lin Peng | 2020 | Oncology and Translational Medicine2020，6，1： | 2 |
| 10 | Nanoporous polystyrene fibers for oil spill cleanup显示文摘 | Jinyou Lin Yanwei Shang Bin Ding Jianmao Yang Jianyong Yu Salem S. Al-Deyab | 2011 | Marine Pollution Bulletin2011，，2： | 2 |
| 11 | Nanoporous polystyrene fibers for oil spill cleanup显示文摘 | Lin Jinyou Shang Yanwei Ding Bin | 2012 | Mar Pollut Bull2012，64，2： | 1 |
| 12 | IL-22 + CD4 + T Cells Promote Colorectal Cancer Stemness via STAT3 Transcription Factor Activation and Induction of the Methyltransferase DOT1L显示文摘 | Ilona Kryczek Yanwei Lin Nisha Nagarsheth Dongjun Peng Lili Zhao Ende Zhao Linda Vatan Wojciech Szeliga Yali Dou Scott Owens Witold Zgodzinski Marek Majewski Grzegorz Wallner Jingyuan Fang Emina Huang Weiping Zou | 2014 | Immunity2014，，5： | 1 |
| 13 | 显示文摘 | Lin Jinyou Shang Yanwei Ding Bin | 2012 | Marine Pollution Bulletin2012，64，2： | 1 |
| 14 | Analysis of Tibetan Cities and Towns in Sichuan——A Case Study of Traditional Tibetan Settlements in Gengqing Town, Dege County显示文摘Tibetan area is a region consisting of different nationalities and cultures,it has special settlement forms.Dege is a historic and cultural center of Kangba area,local architecture has profound cultural background,it is an important representative of traditional Tibetan buildings in Sichuan.This paper explored the forms of Tibetan forms and architectural spaces,summarized architectural features of Tibetan folk dwellings in Sichuan,and studied formation and evolution of traditional settlements in Gengqing Town in an all-around way. | YANG Yanwei QIAO Yaqian LI Lin | 2014 | Journal of Landscape Research2014，6，4： | 1 |
| 15 | 显示文摘 | Lin Jinyou Tian Feng shang Yanwei | 2012 | Nanoscale2012，4，： | 1 |
| 16 | 显示文摘 | Lin Jinyou Tian Feng Shang Yanwei | 2013 | Nanoscale2013，5，7： | 1 |
| 17 | Nanoporous polystyrene fibers for oil spill cleanup显示文摘 | Lin Jinyou Shang Yanwei Ding Bin | 2012 | Marine Pollution Bulletin2012，64，： | 1 |
| 18 | Commercial MPT64-based tests for rapid identification of Mycobacterium tuberculosis complex: A meta-analysis显示文摘 | Xiaomao Yin Lei Zheng Li Lin Yarong Hu Fen Zheng Yanwei Hu Qian Wang | 2013 | Journal of Infection2013，，： | 1 |
| 19 | Energy-efficient Wake-up Scheduling for Data Collection and Aggregation显示文摘 | Wu Yanwei Li Xiangyang Lin Yunhao | 2010 | IEEE Transactions on Parallel and Distributed Systems2010，21，2： | 1 |
| 20 | Eudragit? S100 coated calcium pectinate microspheres of curcumin for colon targeting显示文摘 | Lin Zhang Fengliang Cao Buyun Ding Qilu Li Yanwei Xi Guangxi Zhai | 2011 | Journal of Microencapsulation2011，，7： | 1 |
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