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| 1 | Sodium oligomannate therapeutically remodels gut microbiota and suppresses gut bacterial amino acids-shaped neuroinflammation to inhibit Alzheimer's disease progression显示文摘Recently,increasing evidence has suggested the association between gut dysbiosis and Alzheimer's disease(AD)progression,yet the role of gut microbiota in AD pathogenesis remains obscure.Herein,we provide a potential mechanistic link between gut microbiota dysbiosis and neuroinflammation in AD progression.Using AD mouse models,we discovered that,during AD progression,the alteration of gut microbiota composition leads to the peripheral accumulation of phenylalanine and isoleucine,which stimulates the differentiation and proliferation of pro-inflammatory T helper 1(Thl)cells.The brain-infiltrated peripheral Th1 immune cells are associated with the Ml microglia aaivation,contributing to AD-associated neuroinflammation.Importantly,the elevation of phenylalanine and isoleucine concentrations and the increase of Th1 cell frequency in the blood were also observed in two small independent cohorts of patients with mild cognitive impairment(MCI)due to AD.Furthermore,GV-971,a sodium oligomannate that has demonstrated solid and consistent cognition improvement in a phase 3 clinical trial in China,suppresses gut dysbiosis and the associated phenylalanine/isoleucine accumulation,harnesses neuroinflammation and reverses the cognition impairment.Together,our findings highlight the role of gut dysbiosis-promoted neuroinflammation in AD progression and suggest a novel strategy for AD therapy by remodelling the gut microbiota. | Xinyi Wang Guangqiang Sun Teng Feng Jing Zhang Xun Huang Tao Wang Zuoquan Xie Xingkun Chu Jun Yang Huan Wang Shuaishuai Chang Yanxue Gong Lingfei Ruan Guanqun Zhang Siyuan Yan Wen Lian Chen Du Dabing Yang Qingli Zhang Feifei Lin Jia Liu Haiyan Zhang Changrong Ge Shifu Xiao Jian Ding Meiyu Geng | 2019 | Cell Research2019，29，10： | 192 |
| 2 | Zircon U-Pb dating for the earliest Neoproterozoic mafic magmatism in the southern margin of the North China Block显示文摘Huge diabase occurs within the Pro- terozoic strata in the southern margin of the North China Block, geographically in the northern parts of Anhui and Jiangsu provinces, where no strata younger than Neoproterozoic have been found. Zir- cons from the diabase show three different structures from cathodoluminesecence imaging, but they are all of magmatic origin. SHRIMP U-Pb dating yields a range of 206Pb/238U ages from 2600 to 124 Ma, but two geological events can clearly be identified from both concordant and discordant ages. One gives two weighted mean 207Pb/206Pb ages of 976 ± 24 and 1038 ± 26 Ma which are interpreted as timing of dia- base crystallization, and the other has a weighted mean 207Pb/206Pb age of 2523 ± 52 Ma that repre- sents formation time of inherited zircon from the old crust. The dating results indicate that the mafic magmatic event occurred in a transition period from the latest Mesoproterozoic to the earliest Neopro- terozoic, consistent with global subduction of Grenvill ocean crust to result in the assembly of superconti- nent Rodinia. Therefore, the North China Block needs to be taken into account when reconstructing the position of China continents within the framework of Rodinia supercontinent. | LIU Yongqing GAO Linzhi LIU Yanxue SONG Biao WANG Zongxiu | 2006 | Chinese Science Bulletin2006，51，19： | 36 |
| 3 | Plant-derived phosphocholine facilitates cellular uptake of anti-pulmonary fibrotic HJT-sRNA-m7显示文摘Pulmonary fibrosis, a progressive chronic disease with a high mortality rate, has limited treatment options. Currently, lung transplantation remains the only effective treatment. Here we report that a small RNA, HJT-sRNA-m7, from a Chinese herbal medicine Hong Jing Tian(HJT, RHODIOHAE CRENULATAE RADIX ET RHIZOMA, Rhodiola crenulata) can effectively reduce the expressions of fibrotic hallmark genes and proteins both in alveolar in vitro and in mouse lung tissues in vivo. We also discovered over one hundred oil-soluble chemicals from HJT decoctions, most of which are found in lipid extracts from other Chinese herbals decoctions, including Pu Gong Ying(PGY, TARAXACI HERBA, Taraxacum mongolicum), Chuan Xin Lian(CXL, changed to 'ANDROGRAPHIS HERBA, Andrographis paniculata'), and Jin Yin Hua(JYH, lonicera japonica or Honeysuckle). We identified the active component in these decoctions as two forms of phosphocholines, PC(18:0/18:2) and PC(16:0/18:2). These PCs potentially could form liposomes with small RNAs to enter human alveolar and gastric cells. Our experimental results suggest an unprecendent lipid complex route through which botanic small RNA can enter human bodies.Our results provide an innovative treatment strategy for oral delivery of siRNAs as therapeutic medication. | Jianchao Du Zhu Liang Jiantao Xu Yan Zhao Xiaoyun Li Yanli Zhang DANDan Zhao Ruxuan Chen Yang Liu Trupti Joshi Jiahui Chang Zhiqing Wang Yanxu Zhang Jindong Zhu Qiang Liu Dong Xu Chengyu Jiang | 2019 | Science China(Life Sciences)2019，62，3： | 21 |
| 4 | Using Impervious Surfaces to Detect Urban Expansion in Beijing of China in 2000s显示文摘The change of impervious surface area(ISA) can effectively reveal the gradual process of urbanization and act as a key index for monitoring urban expansion. Experiencing rapid growth of the built environment in the 2000 s, urban expansion of Beijing has not been fully characterized through ISA. In this study, Landsat TM images of Beijing in 2001 and 2009 were obtained, and the eight-year urban expansion process in Beijing was analyzed using the ISA extracted by means of the vegetation-imperious surface-soil(V-I-S) model. From the spatial variation in ISA, the ring structure of urban expansion in Beijing was significant during the study period, with decreasing urban density from the city center to the periphery. In the ring road analysis, the most dramatic changes of ISA were found between the fifth ring and the sixth ring. This area has experienced the most new residential development, and is currently the main source of urban expansion. The typical profile lines revealed the directional characteristics of urban expansion. The east-west profile was the most urbanized axes in Beijing, while ISA change in the east-north profile was more significant than in the other five profiles. Moreover, the transition matrix of ISA levels revealed an increase in urban density in the low density built areas; the Moran′s I index showed a clear expansion of the central urban area, which spread contiguously; and the standard deviational ellipse indicated the northeast was the dominant direction of urban expansion. These findings can provide important spatial control guidelines in the next round of national economic and social development planning, overall urban and rural planning, and land use planning. | PENG Jian LIU Yanxu SHEN Hong XIE Pan HU Xiaoxu WANG Yanglin | 2016 | Chinese Geographical Science2016，26，2： | 11 |
| 5 | Self-triggered Consensus Control for Linear Multi-agent Systems With Input Saturation显示文摘In this paper, we study the consensus problem for a class of linear multi-agent systems(MASs) with consideration of input saturation under the self-triggered mechanism. In the context of discrete-time systems, a self-triggered strategy is developed to determine the time interval between the adjacent triggers. The triggering condition is designed by using the current sampled consensus error. Furthermore, the consensus control protocol is designed by means of a state feedback approach. It is shown that the considered multi-agent systems can reach consensus with the presented algorithm. Some sufficient conditions are proposed in the form of linear matrix inequalities(LMIs) to show the positively invariant property of the domain of attraction(DOA). Moreover, some sufficient conditions of controller synthesis are provided to enlarge the volume of the DOA and obtain the control gain matrix. A numerical example is simulated to demonstrate the effectiveness of the theoretical analysis results. | Yanxu Su Qingling Wang Changyin Sun | 2020 | IEEE/CAA Journal of Automatica Sinica2020，7，1： | 11 |
| 6 | Arbuscular mycorrhizal fungi ameliorate the chemical properties and enzyme activities of rhizosphere soil in reclaimed mining subsidence in northwestern China显示文摘In semi-arid region of northwestern China, underground mining subsidence often results in decreased vegetation coverage, impoverishment of soil fertility and water stress. In addition, the physical-chemical and biological properties of soil also change, resulting in more susceptible to degradation. In particular, subsidence causes disturbance of the symbioses of plant and microbe that can play a beneficial role in the establishment of vegetation communities in degraded ecosystems. The objective of this study was to evaluate the effects of revegetation with exotic arbuscular mycorrhizal fungi(AMF) inoculum on the chemical and biological properties of soil over time in mining subsidence areas. Soils were sampled at a depth up to 30 cm in the adjacent rhizosphere of Amorpha fruticose Linn. from five reclaimed vegetation communities in northwestern China. In August 2015, a field trial was set up with five historical revegetation experiments established in 2008(7-year), 2011(4-year), 2012(3-year), 2013(2-year) and 2014(1-year), respectively. Each reclamation experiment included two treatments, i.e., revegetation with exotic AMF inoculum(AMF) and non-AMF inoculum(the control). Root mycorrhizal colonization, glomalin-related soil protein(GRSP), soil organic carbon(SOC), soil nutrients, and enzyme activities were also assessed. The results showed that mycorrhizal colonization of inoculated plants increased by 33.3%–163.0% compared to that of non-inoculated plants(P<0.05). Revegetation with exotic AMF inoculum also significantly improved total GRSR(T-GRSP) and easily extracted GRSP(EE-GRSP) concentrations compared to control, besides the T-GRSP in 1-year experiment and the EE-GRSP in 2-year experiment. A significant increase in SOC content was only observed in 7-year AMF reclaimed soils compared to non-AMF reclaimed soils. Soil total N(TN), Olsen phosphorus(P) and available potassium(K) were significantly higher in inoculated soil after 1–7 years of reclamation(except for individual cases), and increased with reclamation time(besides soil Olsen P). The exotic AMF inoculum markedly increased the average soil invertase, catalase, urease and alkaline phosphatase by 23.8%, 21.3%, 18.8% and 8.6%, respectively(P<0.01), compared with the control. Root mycorrhizal colonization was positively correlated with soil parameters(SOC, TN and soil available K) and soil enzyme activities(soil invertase, catalase, urease and alkaline phosphatase) in both AMF and non-AMF reclaimed soils(P<0.05), excluding availableK in non-AMF reclaimed soils. T-GRSP(P<0.01) and EE-GRSP(P<0.05) were significantly correlated with the majority of edaphic factors, except for soil Olsen P. The positive correlation between root mycorrhizal colonization and available K was observed in AMF reclaimed soils, indicating that the AMF reclaimed soil with a high root mycorrhizal colonization could potentially accumulate available K in soils. Our findings concluded that revegetation with exotic AMF inoculum influenced soil nutrient availability and enzyme activities in the semi-arid ecosystem, suggesting that inoculating AMF can be an effective method to improve soil fertility and support restoration of vegetation communities under poor conditions like soil nutrient deficiency and drought. | QIU Lang BI Yinli JIANG Bin WANG Zhigang ZHANG Yanxu Yryszhan ZHAKYPBEK | 2019 | Journal of Arid Land2019，11，1： | 11 |
| 7 | Glass modified barium strontium titanate ceramics for energy storage capacitor at elevated temperatures显示文摘A glass with composition of B_(2)O_(3)-Bi_(2)O_(3)-SiO_(2)-CaO-BaO-Al_(2)O_(3)-ZrO_(2)(BBSZ)modified Ba_(x)Sr_(1-x)TiO_(3)(BST,x=0.3 and 0.4)ceramics were prepared by a conventional solid state reaction method abided by a formula of BST+y%BBSZ(y=0,2,4,7,and 10,in mass).The effect of BBSZ glass content on the structure,dielectric properties and energy storage characteristics of the ceramics was investigated.The dielectric constant reduced but the endurable electrical strength enhanced due to the BBSZ glass addition in BST ceramics.In particular,the dielectric loss of the ceramics at elevated temperature(e.g.200℃)can be strongly suppressed from tanδ>20%to tanδ<3% after BBSZ glass modification.For Ba_(0.3)Sr_(0.7)TiO_(3)+2%BBSZ ceramics,an optimized energy storage density(γ=0.63 J/cm^(3))and efficiency(η=91.6%)under an applied electric field of 160 kV/cm was obtained at room temperature.Meanwhile,the temperature dependent polarization-electric field(P-E)hysteresis loops were measured to evaluate the energy storage characteristics of the ceramics potential for high voltage capacitor application at elevated temperatures. | Zong-Yang Shen Yu Wang Yanxue Tang Yuanying Yu Wen-Qin Luo Xingcai Wang Yueming Li Zhumei Wang Fusheng Song | 2019 | Journal of Materiomics2019，5，4： | 9 |
| 8 | Tauroursodeoxycholic acid(TUDCA) inhibits influenza A viral infection by disrupting viral proton channel M2显示文摘Influenza is a persistent threat to human health and there is a continuing requirement for updating antiinfluenza strategies. Initiated by observations of different endoplasmic reticulum(ER) responses of host to seasonal H1N1 and highly pathogenic avian influenza(HPAI) A H5N1 infections, we identified an alternative antiviral role of tauroursodeoxycholic acid(TUDCA), a clinically available ER stress inhibitor, both in vitro and in vivo. Rather than modulating ER stress in host cells, TUDCA abolished the proton conductivity of viral M2 by disrupting its oligomeric states, which induces inefficient viral infection. We also showed that M2 penetrated cells, whose intracellular uptake depended on its proton channel activity,an effect observed in both TUDCA and M2 inhibitor amantadine. The identification and application of TUDCA as an inhibitor of M2 proton channel will expand our understanding of IAV biology and complement current anti-IAV arsenals. | Ning Li Yanxu Zhang Shuangxiu Wu Ruodan Xu Zhiqing Li Jindong Zhu Hongliang Wang Xiao Li Mingyao Tian Huijun Lu Ningyi Jin Chengyu Jiang | 2019 | Science Bulletin2019，64，3： | 6 |
| 9 | TCMSTD 1.0: a systematic analysis of the traditional Chinese medicine system toxicology database显示文摘Dear Editor,The safety and modernization of traditional Chinese medicine (TCM) are significant concerns for users’ lives and health. Recently, the adverse effects caused by TCM and traditional nontoxic TCM have been frequently reported (Joo et al., 2020;Liu et al., 2021). As the safety of TCM continues to attract widespread attention, many researchers have been investigating the toxicity of TCM in regard to the toxic ingredients, effects, mechanisms, and detoxification strategies in TCM (Figure S1 in Supporting Information). Although some TCMs cause toxic reactions, they also play key roles in treating certain unignorable diseases (Fang et al., 2022).Therefore, toxicity research is crucial and urgently needed to develop and safely use TCM. | Lili Song Wenxiu Qian Hongqing Yin Yu Sun Xiuyan Sun Guohui Li Junjie He Yanxue Zheng Yue Zhang Jiayi Wang Yubo Li | 2023 | Science China(Life Sciences)2023，66，9： | 3 |
| 10 | Using nerve segment insert grafting to reconstruct neural pathways of brain-derived paralysis显示文摘Since 1992,task groups have used free nerve auto grafts to bridge partially transected nerves from the dominant area of the normal cerebral cortex to nerves that innervate spastic muscles from a diseased cerebral cortex,using transplanting sutures to alleviate the muscle spasm of cerebral palsy caused by different diseases. This has facilitated rebuilding of some of its neurological function. In this study,80 such patients were followed up,including 20 patients with traumatic brain injury,32 patients with stroke,and 28 pediatric patients with cerebral palsy. After postoperative follow-up of 3 to 21 years,the efficacy rate of this operation was 100% and the excellent and good spasm relief rate was 82.5%. | Wenbin Ding Shaocheng Zhang Zhuo Wang Lin Chen Chuansen Zhang Ping Huang Shunfa Liu Laiqing Sun Yuhai Ma Jun Yang Fei Huang Chengjing Xue Yanxue Zhong Lei Yin Yongtai Pan Dajiang Wu | 2017 | Translational Neuroscience and Clinics2017，3，4： | 2 |
| 11 | Research on China's high-grade highway design index of asphalt pavement with granular base显示文摘Based on the 2006 Chinese asphalt pavement deflection value design index, we used KENLAYER Pavement Analysis and Design software and 1stOpt statistical analysis software to carry on the nonlinear regression, this paper establish high-grade highway design equations for the compressive strain of soil sub-base top (CSSBT) and the radial compressive stress of semi-rigid base top (RCSRBT). The correlation coefficients inspection standard to get precise proof, which means that our granular base design equations have high credibility and can be used in the Chinese design index of asphalt pavement with granular base (APGB). | XiuShan Wang TaoTao Fan YanXu Gao Yi Hu | 2013 | Research in Cold and Arid Regions2013，5，4： | 2 |
| 12 | Optimization of sampling frequency for routine river water quality monitoring显示文摘Sampling frequency is an important factor to be considered during the design of a water monitoring network,and the cost-effective selection of possible ways and means for the optimization of sampling frequency is still needed.This paper introduces water pollution index deviation ratio comparison(WPI DRC),a procedure for the optimization of sampling frequency for a routine river water quality monitoring system.Sampling frequency optimized using WPI DRC at monitoring station X5 in the mainstream of Xiangjiang River is compared with that established using the traditional Statistical Algorithm method.The result of comparison indicates that WPI DRC is more feasible than the traditional one.And then,the sampling frequencies for other 16 monitoring stations also have been optimized,and the results show the sampling frequencies of all the stations except that X4 are reduced,and there is no unacceptable difference between water quality evaluation results at 17 stations before and after the optimization.Therefore,it is concluded that WPI DRC is an effective optimization process with operable results,which can be used to fulfill the requirement of practical monitoring work. | LIU Yan ZHENG BingHui WANG Mei XU YanXue QIN YanWen | 2014 | Science China Chemistry2014，57，5： | 2 |
| 13 | Enhance- ment of signal denoising and multiple fault signatures detecting in rotating machinery using dual-tree com- plex wavelet transform 显示文摘 | Wang Yanxue He Zhengjia Zi Yanyang | 2010 | Mechanical Systems and Signal Processing2010，24，1： | 1 |
| 14 | Enhancement of signal denoising and multiple fault signatures detecting in rotating machinery using dual-tree complex wavelet transform显示文摘 | WANG Yanxue HE Zhengjia ZI Yanyang | 2010 | Mechanical Systems and Signal Processing2010，24，1： | 1 |
| 15 | Enhancement of signal denoising and multiple fault signatures detecting in rotating machinery using dual-tree complex wavelet transform显示文摘 | Wang Yanxue He Zhengjia Zi Yanyang | 2010 | Mechanical Systems and Signal Processing2010，2，1： | 1 |
| 16 | Displacement amplification and electric characteristics of modified rectangular cymbal transducers using electroactive materials显示文摘 | Luo Laihui Tang Yanxue Wang Feifei | 2007 | Solid State Communications2007，143，： | 1 |
| 17 | Single‐atomic Co‐B_(2)N_(2)sites anchored on carbon nanotube arrays promote lithium polysulfide conversion in lithium-sulfur batteries显示文摘Due to low cost,high capacity,and high energy density,lithium–sulfur(Li–S)batteries have attracted much attention;however,their cycling performance was largely limited by the poor redox kinetics and low sulfur utilization.Herein,predicted by density functional theory calculations,single‐atomic Co‐B2N2 site‐imbedded boron and nitrogen co‐doped carbon nanotubes(SA‐Co/BNC)were designed to accomplish high sulfur loading,fast kinetic,and long service period Li–S batteries.Experiments proved that Co‐B2N2 atomic sites can effectively catalyze lithium polysulfide conversion.Therefore,the electrodes delivered a specific capacity of 1106 mAh g−1 at 0.2 C after 100 cycles and exhibited an outstanding cycle performance over 1000 cycles at 1 C with a decay rate of 0.032%per cycle.Our study offers a new strategy to couple the combined effect of nanocarriers and single‐atomic catalysts in novel coordination environments for high‐performance Li–S batteries. | Zhifeng Wang Yajing Yan Yongguang Zhang Yanxu Chen Xianyun Peng Xin Wang Weimin Zhao Chunling Qin Qian Liu Xijun Liu Zhongwei Chen | 2023 | Carbon Energy2023，5，11： | 1 |
| 18 | A comparative study on the local mean decomposition and empirical mode decomposition and their applications to rotating machinery health diagnosis显示文摘 | Wang Yanxue He Zhengjia Zi Yanyang | 2010 | Journal of Vibration and Acoustics2010，132，2： | 1 |
| 19 | Enhance ment of signal denoising and multiple fault signatures detecting in rotating machinery using dual-tree complex wavelet transform 显示文摘 | WANG Yanxue HE Zhengjia ZI Yanyang | 2010 | Mechanical Systems and Signal Processing2010，24，1： | 1 |
| 20 | A demodulation method based on local mean decomposition and its application in rub-impact fault diagnosis显示文摘 | Wang Yanxue He Zhengjia Zi Yanyang | 2009 | Measurement Science and Technology2009，20，2： | 1 |
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