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| 1 | Nano silver oxide (AGO) as a super high charge/discharge rate cathode material for rechargeable alkaline batteries 显示文摘 | Junqing Pan Yanzh Zihao Wang | 2007 | Journal of Materials Chem- istry2007，17，： | 1 |
| 2 | Criteria and regulatory considerations for the conditional approval of innovative antitumor drugs in China:from the perspective of clinical reviewers显示文摘1 BACKGROUND Before the State Council of the People’s Republic of China issued the“Opinions on the Reform of the Examination and Approval System of Pharmaceutical and Medical Devices”[1],several problems existed in China’s drug evaluation and approval system.The long approval time and low efficiency of new drug marketing seriously affected the enthusiasm for drug innovation.To this end,the current“Drug Registration Regulation”(DRR)[2]was initiated by the National Medical Products Administration of China and officially implemented on July 1,2020.To encourage clinical value-oriented drug innovation,four expedited drug programs were first proposed,including breakthrough therapy drugs,conditional approval,priority review,and special approval procedures.For drugs listed in the expedited programs,the drug regulatory authorities and professional technical institutions should provide policy and technical support,prioritize the allocation of communication and review resources,and thereafter shorten the review time as much as possible. | Limin Zou Yueli Qi Yongling Jiang Ling Tang Yu Du Boyuan Zhao Yanzhe Sun Meiyi Xiang Jun Ma Zhimin Yang | 2023 | Cancer Communications2023，43，2： | 0 |
| 3 | Two-dimensional layered In_(2)P_(3)S_(9): A novel superior anode material for sodium-ion batteries显示文摘Developing reliable and efficient anode materials is essential for the successfully practical application of sodium-ion batteries.Herein,employing a straightforward and rapid chemical vapor deposition technique,two-dimensional layered ternary indium phosphorus sulfide(In_(2)P_(3)S_(9)) nanosheets are prepared.The layered structure and ternary composition of the In_(2)P_(3)S_(9) electrode result in impressive electrochemical performance,including a high reversible capacity of 704 mA h g^(-1) at 0.1 A g^(-1),an outstanding rate capability with 425 mA h g^(-1) at 5 A g^(-1),and an exceptional cycling stability with a capacity retention of88% after 350 cycles at 1 A g^(-1).Furthermore,sodium-ion full cell also affords a high capacity of 308 and114 mA h g^(-1) at 0.1 and 5 A g^(-1).Ex-situ X-ray diffraction and ex-situ high-resolution transmission electron microscopy tests are conducted to investigate the underlying Na-storage mechanism of In_(2)P_(3)S_(9).The results reveal that during the first cycle,the P-S bond is broken to form the elemental P and In_(2)S_(3),collectively contributing to a remarkably high reversible specific capacity.The excellent electrochemical energy storage results corroborate the practical application potential of In_(2)P_(3)S_(9) for sodium-ion batteries. | Longsheng Zhong Hongneng Chen Yanzhe Sheng Yiting Sun Yanhe Xiao Baochang Cheng Shuijin Lei | 2024 | Journal of Energy Chemistry2024，90，3： | 0 |
| 4 | Therapy of replenishing Yin and regulating Yang for manic episode in bipolar disorder:study protocol for a prospective,double-blind,randomized controlled trial显示文摘Bipolar disorder(BD) is a chronic and recurrent disorder characterized by biphasic mood episodes of mania or hypomania and depression.It affects more than 1% of the global population and is a leading cause of disability in young people.Currently available treatments for BD are still fairly limited in terms of efficacy,with high rates of non-adherence,non-response,and undesirable side effects.Traditional Chinese medicine(TCM) has a long history and rich experience in stabilizing mania and improving quality of life.Aiming at rebalancing Yin and Yang in BD,therapy of replenishing Yin and regulating Yang(RYRY therapy) has been in clinical use for years in China.The present prospective,double-blind,randomized controlled trial is designed to investigate the efficacy and safety of RYRY therapy for bipolar mania and its possible mechanism from the point of regulating gut microbiota and anti-inflammation.A total of 60 eligible participants will be recruited from Beijing Anding Hospital.They will be randomized to either the study group or the control group in a ratio of 1∶1.Participants allocated to the study group will receive RYRY granule,while placebo granule will be applied in the control group.Participants in both groups will be prescribed conventional therapy for manic episode in BD.Four scheduled visits will be conducted over 4 weeks.Outcome measurements include Young Mania Rating Scale,TCM Symptom Pattern Rating Scale,Treatment Emergent Symptom Scale,levels of C-reactive protein,interleukin-6 and tumor necrosis factor-α and the gut microbial community profile of stool samples.Safety outcomes and adverse events will also be recorded.In this study,we set a number of scientific and objective assessments to evaluate the efficacy of RYRY therapy and study into its possible mechanism,hopefully offering clinicians an alternative approach to BD. | YANG Yang YUAN Haining JIA Hongxiao NING Yanzhe WANG Di ZHANG Lei YAN Kaijuan GUO Yumeng WANG Fei SUN Weishuang CHEN Pei | 2023 | Journal of Traditional Chinese Medicine2023，43，3： | 0 |
| 5 | Measuring the elasticity of liquid–liquid phase separation droplets with biomembrane force probe显示文摘Numerous biomacromolecules undergo liquid–liquid phase separation(LLPS)inside living cells and LLPS plays important roles in their functions.The droplets formed by LLPS molecules are complex fluids and their behavior follows fluid mechanics,thus studies on rheological and material properties are required to gain full insight into the biophysical mechanism of these droplets.Biophysical force spectroscopy techniques are particularly useful in this aspect.Indeed,atomic force microscopy and optical tweezers have been used to quantify the elasticity and the viscoelasticity of LLPS droplets.The Biomembrane Force Probe(BFP)is a single-molecule technique designed to investigate liquid-like objects and is more suitable to quantify the material properties of LLPS droplets,but its usage on LLPS droplets is not yet described.Here we present an experimental protocol to measure the Young’s modulus of LLPS droplets using BFP,we believe that the application of BFP on phase separation studies can be expanded and will be very helpful in deciphering the underlying principles of LLPS. | Min Sun Hui Chen Qinghua Ji Jianhui Xiao Yanzhe Hou Jizhong Lou | 2022 | Biophysics Reports2022，8，2： | 0 |
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