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| 1 | PARylation regulates stress granule dynamics, phase separation, and neurotoxicity of disease-related RNA-binding proteins显示文摘Mutations in RNA-binding proteins (RBPs) localized in ribonucleoprotein (RNP) granules, such as hnRNP A1 and TDP-43, promote aberrant protein aggregation, which is a pathological hallmark of various neurodegenerative diseases, such as amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Protein posttranslational modifications (PTMs) are known to 佗gulate RNP granules. In this study, we investigate the function of poly(ADP-ribosyl)ation (PARylation), an important PTM involved in DNA damage repair and cell death, in RNP granule-related neurodegeneration. We reveal that PARylation levels are a major regulator of the assembly-disassembly dynamics of RNP granules containing disease-related RBPs, hnRNP A1 and TDP-43. We find that hnRNP A1 can both be PARylated and bind to PARylated proteins or poly(ADP-ribose)(PAR). We further uncover that PARylation of hnRNP A1 at K298 controls its nucleocytoplasmic transport, whereas PAR-binding via the PAR-binding motif (PBM) of hnRNP Al regulates its association with stress granules. Moreover, we reveal that PAR not only dramatically enhances the liquid-liquid phase separation of hnRNP A1, but also promotes the co-phase separation of hnRNP A1 and TDP-43 in vitro and their interaction in vivo. Finally, both genetic and pharmacological inhibition of PARP mitigates hnRNP Al- and TDP-43-mediated neurotoxicity in cell and Drosophila models of ALS. Together, our findings suggest a novel and crucial role for PARylation in regulating the dynamics of RNP granules, and that dysregulation in PARylation and PAR levels may con tribute to ALS disease pathoge nesis by promoting protei n aggregation. | Yongjia Duan Aiying Du Jinge Gu Gang Duan Chen Wang Xinrui Gui Zhiwei Ma Beituo Qian Xue Deng Kai Zhang Le Sun Kuili Tian Yaoyang Zhang Hong Jiang Cong Liu Yanshan Fang | 2019 | Cell Research2019，29，3： | 13 |
| 2 | Process mineralogy of Weishan rare earth ore by MLA显示文摘Mineral liberation analyser(MLA) was applied to quantitatively analyze the rare earth ore from Weishan in Shandong. Mineralogy parameters, such as mineral composition, occurrence states of rare earth elements(REEs) and valuable elements, mineral embedded grain size distribution, mineral association and liberation, are obtained. Results show that the contents of REEs and other valuable elements mainly contained in the ore were La 1.02 wt%, Ce 4.29 wt%, Pr 0.34 wt%, Nd 0.84 wt%, Sr 3.4 wt%and Ba 26.53 wt%, respectively. The REEs mainly occur in bastnaesite and carbocernaite in the form of independent mineral and the contents of bastnaesite and carbocernaite in the ore were 5.96 wt% and12.30 wt%, respectively. 67.34% of strontium occurs in carbocernaite and the rest occurs in celestobarite and strontianite mineral. 92.71% of barium occurs in barite. Liberation of main rare-earth minerals such as bastnaesite and carbocernaite is more than 80% when the grinding fineness is78.42% passing 74 μm. The research results could be employed to provide detailed basic theoretical data for further improvement of the beneficiation process flow and the processing index of rare earth ore, the recycling of other valuable minerals and the comprehensive utilization of tailings. | Caili Xu Chengbin Zhong Renliang Lyu Yaoyang Ruan Zhenyue Zhang Ru'an Chi | 2019 | Journal of Rare Earths2019，37，3： | 12 |
| 3 | Cryo-EM structure of full-length α-synuclein amyloid fibril with Parkinson’s disease familial A53T mutation显示文摘Dear Editor,α-Synuclein(α-Syn)forms amyloid fibrils accumulating in Lewy bodies(LB)and Lewy neuritis(LN);which is a common histological hallmark of Parkinson’s disease(PD)and other synudeinopathies.1 Moreover,α-syn amyloid fibrils spread in the patient's brain via cell-to-cell transmission,which accounts for the disease progression.2 Several single amino-acid mutations of αa-syn,including A53T,E46K,H50Q,G51D,A30P and A53E,have been identified from familial PD patients,which are causative to the early-onset pathology with different clinical symptoms. | Yunpeng Sun Shouqiao Hou Kun Zhao Houfang Long Zhenying Liu Jing Gao Yaoyang Zhang Xiao-Dong Su Dan Li Cong Liu | 2020 | Cell Research2020，30，4： | 2 |
| 4 | Modeling maximum lipid productivity of microalgae: Review and next step显示文摘 | XU Yaoyang BOEING W J | 2014 | Renewable and Sustainable Energy Reviews2014，32，： | 1 |
| 5 | Tailored ZnF_(2)/ZnS-rich interphase for reversible aqueous Zn batteries显示文摘The urgent need for highly safe and sustainable large-scale energy storage systems for residential buildings has led to research into aqueous zinc ion batteries.However,when zinc is used in aqueous zinc ion batteries,it suffers from severe irreversibility due to its low Coulombic efficiency,dendrite growth,and side reactions.To address these challenges,we take advantage of organic cation to induce trifluoromethanesulfonate decomposition to build zinc fluoride/zinc sulfide-rich solid electrolyte interphase(SEI)that not only can adapt to a high areal capacity of deposition/stripping disturbance but also adjust zinc ion deposition path to eliminate dendrite.As a result,the unique interface can promote the Zn battery to achieve excellent electrochemical performance:high levels of plating/stripping Coulombic efficiency(99.8%),stability life(6,600 h),and cumulative capacity(66,000 mAh·cm^(−2))at 68%zinc utilization(20 mAh·cm^(−2)).More importantly,the SEI significantly enhances the cyclability of full battery under limited Zn,lean electrolyte,and high areal capacity cathode conditions. | Junmin Ge Yaoyang Zhang Zhengkun Xie Huabin Xie Weihua Chen Bingan Lu | 2023 | Nano Research2023，16，4： | 1 |
| 6 | Generic amyloid fibrillation of TMEM106B in patient with Parkinson’s disease dementia and normal elders显示文摘Dear Editor,Protein amyloid aggregation is a histological hallmark of neurodegenerative diseases(NDs).1,2 In synucleinopathies including Parkinson’s disease(PD),Parkinson’s disease dementia(PDD),dementia with Lewy body and multiple system atrophy,αsynuclein(α-syn)is commonly characterized to form amyloid aggregates presenting distinct pathological activities in diseased brains.3,4 Structural characterization ofα-syn amyloid fibrils formed in different diseases could provide mechanistic understanding of heterogeneousα-syn pathologies. | Yun Fan Qinyue Zhao Wencheng Xia Youqi Tao Wenbo Yu Mingjia Chen Yiqi Liu Jue Zhao Yan Shen Yunpeng Sun Chenfang Si Shenqing Zhang Yaoyang Zhang Wensheng Li Cong Liu Jian Wang Dan Li | 2022 | Cell Research2022，32，6： | 1 |
| 7 | Diel vertical migration of Peridiniopsis niei, Liu et al., a new species of dinoflagellates in an eutrophic bay of Three-Gorge Reservoir, China显示文摘 | Yaoyang Xu Qinghua Cai Lan Wang Linghui Kong Daofeng Li | 2010 | Aquatic Ecology2010，，2： | 1 |
| 8 | MOF-derived zinc manganese oxide nanosheets with valence-controllable composition for high-performance Li storage显示文摘Zinc manganese oxide(ZMO)system represents a notable family of mixed transition metal oxides(MTMOs)because of their superiority of the high theoretical capacity,adequacy of natural content,and low cost.However,the methods to match both the reliable synthesis and the designable construction of large-sized two-dimensional(2D)ZMO nanosheets are still considered as grand challenges.Herein,we have successfully realized the preparation of 2D ZMO nanosheets with large lateral sizes up to~20 mm by simple pyrolysis of 2D metal–organic framework(MOF)nanosheets precursor.The growth mechanism of 2D MOF is proposed to be based on the lamellar micelles formed by polyvinyl pyrrolidone(PVP).The obtained 2D and porous ZMO nanosheets exhibit high specific capacity as well as good rate capability.More importantly,the as-prepared ZMO electrode shows a remarkable capacity increment upon cycling(from 832 mAh g^(-1) at the 2nd cycle to 1418 mAh g^(-1) at the 700th cycle,at 1 A g^(-1)).Through simple adjustment of the calcination temperature,the valence state of Mn species in the yielding ZMO samples can be fine-tuned.Through systematic investigation towards these ZMOs containing different Mn species,the extra specific capacity is revealed to be chiefly on account of the arising of the valence state of Mn upon the cycling process.Moreover,it is disclosed that the higher-valent Mn the pristine ZMO contains,the more additional capacity it gains upon cycling.We believe that this work will inspire more detailed analysis on the relationship between the valence state of Mn and extra capacity. | Yu Du Yihan Xu Weiwei Zhou Yaoyang Yu Xinzhou Ma Fei Liu Jinglong Xu Yongming Zhu | 2021 | Green Energy & Environment2021，6，5： | 1 |
| 9 | Weekly dynamics ofphytoplankton functional groups under high water level fluctuations ina subtropica reservoir-bay显示文摘 | Lan Wang Qinghua Cai Yaoyang Xu | 2011 | Aquat Ecol2011，45，： | 1 |
| 10 | Faddeev-Jackiw Quantization of the Gauge Invariant Version of the Linear Self-Dual constrained Theory显示文摘The Faddeev-Jackiw quantization procedure is applied to the gauge invariant version of the linear self-dual constrained theory.The equivalence of the gauge invariant and the gauge noninvariant versions is discussed. | MIAO Yangang LIU Yaoyang | 1993 | Chinese Physics Letters1993，10，1： | 0 |
| 11 | Calculation of Process t→Wbgg显示文摘We presented the calculation of the decay width for the massive top quark accompanied by a emission of two hard gluons.It is shown that the top quark decay channel with two-gluon bremsstrahlung increases its total width by 2%to 7%,so that this contribution is non-negligible and should be included in considering top decay. | YU Zenghui SUN Lazhen MA Wengan LIU Yaoyang | 1994 | Chinese Physics Letters1994，11，11： | 0 |
| 12 | Crustal Electrical Structure of the Wuwei Basin,Lower Yangtze Region of China,and Its Geological Implications显示文摘The Wuwei Basin is one of the most important oil-and gas-bearing basins in the Meso-Cenozoic basin groups in the Lower Yangtze River region.It has great shale gas resource prospects.The formation mechanism of this basin is poorly studied for lack of constraining data for deep structures.In this paper,a crustal electrical structure model of the Wuwei Basin and the adjacent areas is constructed based on the two-dimensional inversion of a magnetotelluric(MT)sounding profile achieved with the nonlinear conjugate gradient method.The results show that large-scale low-resistance bodies have developed in the underlying middle and lower crust of the Wuwei Basin,and are different from the uplifts on the two sides according to their high-resistance electrical characteristics.The electrical structure and regional geological and geophysical data suggest that the peak zone of the Chuzhou-Chaohu foreland fold-and-thrust belt is located on the east bank of the Yangtze River(Wuhu Section),which,together with the main thrust fault belt in the east,forms a typical thrust structure belt.An early Yanshanian sinistral strike-slip fault developed in the deep part of the Wuwei Basin,which may have controlled the formation and evolution of the basin,whereas the tectonic inversion of the early-developed thrust faults is relatively weak.These findings provide a geophysical basis for future studies of basin tectonic evolution and regional tectonic frameworks. | Xiaobo Zhang Penghui Zhang Meixing He Dashuang He Fagen Pei Yaoyang Zhang Yan Peng | 2023 | Journal of Earth Science2023，34，6： | 0 |
| 13 | An Artemisinin Derivative ART1 Induces Ferroptosis by Targeting the HSD17B4 Protein Essential for Lipid Metabolism and Directly Inducing Lipid Peroxidation显示文摘Artemisinin and its derivatives,commonly known as antimalarial drugs,have gradually come to be regarded as potential antitumor agents,although their cytotoxic efficacy and mechanisms of action remain to be settled.Herein,we report that an artemisinin analog,ART1,can potently induce ferroptosis in a subset of cancer cell lines.Structure–activity relationship(SAR)analysis reveals that both the endoperoxide moiety and the artemisinin skeleton are required for the antitumor activity of ART1.Aided with ART1-based small-molecule tools,chemical proteomic analysis identified the HSD17B4 protein as a direct target of ART1.HSD17B4 resides in peroxisomes and is an essential enzyme in the catabolism of very-long-chain fatty acids.Our results demonstrate that ART1 initiates ferroptosis through selective oxidation of the fatty acids in peroxisomes by hijacking the HSD17B4 protein without disturbing its enzymatic function,providing a promising mechanism to develop therapeutics for cancer treatment. | Jingjing Xie Guangya Zhu Ming Gao Jie Xi Ge Chen Xinxin Ma Yu Yan Zhiyuan Wang Ze-Jun Xu Hui-Jun Chen Hong-Dong Hao Yaoyang Zhang Zhu-Jun Yao Jidong Zhu | 2022 | CCS Chemistry2022，4，1： | 0 |
| 14 | Tunable multicolor luminescence in vanadates from yttrium to indium with enhanced luminous efficiency and stability for its application in WLEDs and indoor photovoltaics显示文摘The preparation of high-efficiency phosphor is the key to the construction of white light-emitting diode(WLED)devices and their application in indoor photovoltaics.Compared with YVO_(4),InVO_(4)is not suitable as the host material of lanthanide ions because of its strong self-luminescence.Here,the work focused on combining the broadband emission from InVO_(4)and the red luminescence from YVO_(4):Eu^(3+)to obtain enhanced and stable multicolor luminescence.The band structure,density of state,and optical properties were studied by density functional theory.The spectral configuration of YVO_(4):In^(3+)/Eu^(3+)with(112)surface appears to be broadening and redshifts with increasing layer number.When the In^(3+)concentration is 3.5 mol%,the YVO_(4):30%Eu^(3+)/In^(3+)emits the strongest light.The Judd-Ofelt parameterΩ2 of YVO_(4):In^(3+)/Eu^(3+)increases with increaing In^(3+)concentration,indicating that the symmetry decreases.By adjusting In^(3+)/Eu^(3+)contents,the YVO_(4):In^(3+)/Eu^(3+)not only can emit white light with a color rendering index of 95,but also can be used as high-efficiency red phosphor to build WLED devices with blue emitting N/Tb codoped carbon quantum dots(CQDs-N:Tb^(3+))and green emitting MOF:Tb^(3+)(MOF=metal organic framework),for which the color rendering index can also reach 95 and the color temperature is 5549 K.The manufactured WLED devices were further used to excite the silicon solar cell and make it show good photoelectric characteristics. | Yaoyang Zhang Jing Mao Peifen Zhu Guofeng Wang | 2023 | Nano Research2023，16，8： | 0 |
| 15 | Approaching the upper boundary of driver-response relationships:identifying factors using a novel framework integrating quantile regression with interpretable machine learning显示文摘The identification of factors that may be forcing ecological observations to approach the upper boundary provides insight into potential mechanisms affecting driver-response relationships,and can help inform ecosystem management,but has rarely been explored.In this study,we propose a novel framework integrating quantile regression with interpretable machine learning.In the first stage of the framework,we estimate the upper boundary of a driver-response relationship using quantile regression.Next,we calculate“potentials”of the response variable depending on the driver,which are defined as vertical distances from the estimated upper boundary of the relationship to observations in the driver-response variable scatter plot.Finally,we identify key factors impacting the potential using a machine learning model.We illustrate the necessary steps to implement the framework using the total phosphorus(TP)-Chlorophyll a(CHL)relationship in lakes across the continental US.We found that the nitrogen to phosphorus ratio(N:P),annual average precipitation,total nitrogen(TN),and summer average air temperature were key factors impacting the potential of CHL depending on TP.We further revealed important implications of our findings for lake eutrophication management.The important role of N:P and TN on the potential highlights the co-limitation of phosphorus and nitrogen and indicates the need for dual nutrient criteria.Future wetter and/or warmer climate scenarios can decrease the potential which may reduce the efficacy of lake eutrophication management.The novel framework advances the application of quantile regression to identify factors driving observations to approach the upper boundary of driver-response relationships. | Zhongyao Liang Yaoyang Xu Gang Zhao Wentao Lu Zhenghui Fu Shuhang Wang Tyler Wagner | 2023 | Frontiers of Environmental Science & Engineering2023，17，6： | 0 |
| 16 | A Survey on Recent Advances in Privacy Preserving Deep Learning显示文摘Deep learning based on neural networks has made new progress in a wide variety of domain,however,it is lack of protection for sensitive information.The large amount of data used for training is easy to cause leakage of private information,thus the attacker can easily restore input through the representation of latent natural language.The privacy preserving deep learning aims to solve the above problems.In this paper,first,we introduce how to reduce training samples in order to reduce the amount of sensitive information,and then describe how to unbiasedly represent the data with respect to specific attributes,clarify the research results of other directions of privacy protection and its corresponding algorithms,summarize the common thoughts and existing problems.Finally,the commonly used datasets in the privacy protection research are discussed in this paper. | Siran Yin Leiming Yan Yuanmin Shi Yaoyang Hou Yunhong Zhang | 2020 | Journal of Information Hiding and Privacy Protection2020，2，4： | 0 |
| 17 | The development of roadside green swales in the Chinese Sponge City Program:Challenges and opportunities显示文摘Roadside green swales have emerged as popular stormwater management infrastructure in urban areas,serving to mitigate stormwater pollution and reduce urban surface water discharge.However,there is a limited understanding of the various types,structures,and functions of swales,as well as the potential challenges they may face in the future.In recent years,China has witnessed a surge in the adoption of roadside green swales,especially as part of the prestigious Sponge City Program(SCP).These green swales play a crucial role in controlling stormwater pollution and conserving urban water resources by effectively removing runoff pollutants,including suspended solids,nitrogen,and phosphorus.This review critically examines recent research findings,identifies key knowledge gaps,and presents future recommendations for designing green swales for effective stormwater management,with a particular emphasis on ongoing major Chinese infrastructure projects.Despite the growing global interest in bioswales and their significance in urban development,China's current classification of such features lacks a clear definition or specific consideration of bioswales.Furthermore,policymakers have often underestimated the adverse environmental effects of road networks,as reflected in existing laws and planning documents.This review argues that the construction and maintenance of roadside green swales should be primarily based on three critical factors:Wellthought-out road planning,suitable construction conditions,and sustainable long-term funding.The integration of quantitative environmental standards into road planning is essential to effectively address the challenge of pollution from rainfall runoff.To combat pollution associated with roads,a comprehensive assessment of potential pollution loadings should be carried out,guiding the appropriate design and construction of green swales,with a particular focus on addressing the phenomenon of first flush.One of the major challenges faced in sustaining funds for ongoing maintenance after swale construction.To address this issue,the implementation of a green finance platform is proposed.Such a platform would help ensure the availability of funds for continuous maintenance,thus maximizing the long-term effectiveness of green swales in stormwater management.Ultimately,the findings of this review aim to assist municipal governments in enhancing and implementing future urban road designs and SCP developments,incorporating effective green swale strategies. | Lingwen Lu Faith Ka Shun Chan Matthew Johnson Fangfang Zhu Yaoyang Xu | 2023 | Frontiers of Engineering Management2023，10，4： | 0 |
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