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| 1 | Effectiveness of probiotic therapy for the prevention of relapse in patients with inactive ulcerative colitis显示文摘AIM: to evaluate the effectiveness of probiotic therapy for suppressing relapse in patients with inactive ulcerative colitis(UC).METHODS: Bio-Three tablets, each containing 2 mg of lactomin(Streptococcus faecalis T-110), 10 mg of Clostridium butyricum TO-A, and 10 mg of Bacillus mesentericus TO-A, were used as probiotic therapy.Sixty outpatients with UC in remission were randomly assigned to receive 9 Bio-Three tablets/day(BioThree group) or 9 placebo tablets/day(placebo group)for 12 mo in addition to their ongoing medications.Clinical symptoms were evaluated monthly or on the exacerbation of symptoms or need for additional medication. Fecal samples were collected to analyze bacterial DNA at baseline and 3-mo intervals. Terminal restriction fragment length polymorphism and cluster analyses were done to examine bacterial components of the fecal microflora.RESULTS: Forty-six patients, 23 in each group,completed the study, and 14 were excluded. The relapse rates in the Bio-Three and placebo groups were respectively 0.0% vs 17.4% at 3 mo(P = 0.036), 8.7%vs 26.1% at 6 mo(P = 0.119), and 21.7% vs 34.8%(P = 0.326) at 9 mo. At 12 mo, the remission rate was 69.5% in the Bio-Three group and 56.6% in the placebo group(P = 0.248). On cluster analysis of fecal flora, 7 patients belonged to cluster Ⅰ, 32 to cluster Ⅱ,and 7 to cluster Ⅲ.CONCLUSION: Probiotics may be effective formaintaining clinical remission in patients with quiescent UC, especially those who belong to cluster Ⅰ on fecal bacterial analysis. | Yasushi Yoshimatsu Akihiro Yamada Ryuichi Furukawa Koji Sono Aisaku Osamura Kentaro Nakamura Hiroshi Aoki Yukiko Tsuda Nobuo Hosoe Nobuo Takada Yasuo Suzuki | 2015 | World Journal of Gastroenterology2015，21，19： | 21 |
| 2 | Rapid flow injection analysis method for successive determination of ammonia,nitrite,and nitrate in water by gas-phase chemiluminescence显示文摘 | Toyoaki Aoki Shinji Fukuda Yasuo Hosoi | 1997 | Anal Chimica Acta1997，，349： | 1 |
| 3 | Fabrication of high strength PVA/SWCNT composite fibers by gel spinning显示文摘 | Xuezhu Xu Ahmed Jalal Uddin Kenta Aoki Yasuo Gotoh Takeshi Saito Motoo Yumura | 2010 | Carbon2010，，7： | 1 |
| 4 | Load Sensing Fluid Power System显示文摘 | Yasuo Aoki Kazuo Ue hara Ka zu yu ki Hirose | | SAE paper0，，： | 1 |
| 5 | Effect of Additive on Crystal Shape and Control of Xonotlite显示文摘 | Yasuo ARAI Tamotsu YASUE shigeti Aoki | 1995 | Inorganic Material1995，2，258： | 1 |
| 6 | Load Sensing Fluid Power System显示文摘 | Yasuo Aoki Kazuo Ue hara Ka zu yu ki Hirose | | SAE paper0，，： | 1 |
| 7 | Coefficients of friction of TiN coatings with preferred grain orientations under dry condition显示文摘 | Akira Azushima Yasuo Tanno Hiroyuki Iwata Kohshiro Aoki | 2008 | Wear2008，，7： | 1 |
| 8 | Clinical effectiveness of probiotics therapy (BIO-THREE) in patients with ulcerative colitis refractory to conventional therapy显示文摘 | Yukiko Tsuda Yasushi Yoshimatsu Hiroshi Aoki Kentaro Nakamura Masaki Irie Katsuyuki Fukuda Nobuo Hosoe Nobuo Takada Koji Shirai Yasuo Suzuki | 2007 | Scandinavian Journal of Gastroenterology2007，，11： | 1 |
| 9 | Clinical effectiveness of probiotics therapy (BIO-THREE) in patients with ulcerative colitis refractory to conventional therapy显示文摘 | Yukiko Tsuda Yasushi Yoshimatsu Hiroshi Aoki Kentaro Nakamura Masaki Irie Katsuyuki Fukuda Nobuo Hosoe Nobuo Takada Koji Shirai Yasuo Suzuki | 2007 | Scandinavian Journal of Gastroenterology2007，，11： | 1 |
| 10 | Rapid flow injection analysis method for successivedetermination of ammonia, nitrite, and nitrate in water bygas-phase chemiluminescence 显示文摘 | TOYOAKI AOKI SHINJI FUKUDA YASUO HOSOI etal | 1997 | Analytica Chimica Acta1997，349，13： | 1 |
| 11 | Load Sensing Fluid Power System显示文摘 | Yasuo Aoki Kazuo Ue hara Ka zu yu ki Hirose | | SAE paper0，，： | 1 |
| 12 | Load Sensing Fluid Power System显示文摘 | Yasuo Aoki Kazuo Uehara Kazuyuki Hirose | | SAE paper0，，： | 1 |
| 13 | Lnsd Sensing Fluid Power Systems显示文摘 | Yasuo Aoki Kazuo Uehara | 1994 | SAE(Society of Automotive Engineers)Transactions1994，2，： | 1 |
| 14 | An Elevated level of Autoantibidies Against 48 - to 50 - kd keratins in the serum of patients with psoriasis显示文摘 | Shigenobu Aoki Hideo Yaoiya Yasuo Kitajima | 1992 | J Invest Dermatol1992，92，： | 1 |
| 15 | Diet-Induced Adipose Tissue Inflammation and Liver Steatosis Are Prevented by DPP-4 Inhibition in Diabetic Mice显示文摘 | Shirakawa Jun Fujii Hideki Ohnuma Kei Sato Koichiro Ito Yuzuru Kaji Mitsuyo Sakamoto Eri Koganei Megumi Sasaki Hajime Nagashima Yogi Amo Kikuko Aoki Kazutaka Morimoto Chikao Takeda Eiji Terauchi Yasuo | 2011 | Diabetes2011，，4： | 1 |
| 16 | Effect of additive on crystal shape and control of xonotlite 显示文摘 | Yasuo ARAI Tamotsu YASUE Shigeti Aoki | 1995 | Inorganic Material1995，258，2： | 1 |
| 17 | Rapid flow injection analysis method for successivedetermination of ammonia, nitrite, and nitrate in water bygas-phase chemiluminescence 显示文摘 | TOYOAKI AOKI SHINJI FUKUDA YASUO HOSOI etal | 1997 | Analytica Chimica Acta1997，349，13： | 1 |
| 18 | Decomposition and removal of dental model plaque by using toothpaste containing dextranase显示文摘Objective:The purpose of this study is to demonstrate the decomposition and removal effects of dextranase-containing toothpaste on dental plaque. Method:In the decomposition test,the supernatant of three times diluted toothpaste was applied to a dextran solution (as a dental model plaque),and samples were evaluated by colorimetric reaction with Fehling’s test solution. In the removal test,the supernatant of three times diluted toothpaste was applied to a dental model plaque prepared with Streptococcus mutans and the optical density at 550nm (hereinafter referred to as OD_(550)) was measured as the remaining plaque. Results:In the test solution of toothpaste containing dextranase,a red-brown precipitate was observed. On the other hand,a precipitate was not observed in the test solution of the placebo toothpaste which did not contain dextranase. The plaque removal effect of the test toothpaste was 2. 7 times higher than that of the placebo toothpaste. Conclusion:Our findings suggest that the test toothpaste containing dextranase has a higher plaque removal effect by cuttingα-1,6-linkages inside the plaque. Therefore,the test toothpaste might be helpful to prevent dental caries. | Yuko Aoki Zheng Sujiang Yasuo Nomura Kenichiro Shibasaki Gotaro Iiizumi Liu Jing Li Debao An Fengbao | 2018 | 口腔护理用品工业2018，28，4： | 0 |
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