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| 1 | Ampullary carcinoma:Effect of preoperative biliary drainage on surgical outcome显示文摘AIM: To evaluate the influence of preoperative biliary drainage on morbidity and mortality after surgical resection for ampullary carcinoma. METHODS: We analyzed retrospectively data for 82 patients who underwent potentially curative surgery for ampullary carcinoma between September 1993 and July 2007 at the Singapore General Hospital, a tertiary referral hospital. Diagnosis of ampullary carcinoma was confirmed histologically. Thirty-five patients underwent preoperative biliary drainage (PBD group), and 47 were not drained (non-PBD group). The mode of biliary drainage was endoscopic retrograde cholangiopancreatography (n = 33) or percutaneous biliary drainage (n = 2). The following parameters were analyzed: wound infection, intra-abdominal abscess, intra-abdominal or gastrointestinal bleeding, septicemia, biliary or pancreatic leakage, pancreatitis, gastroparesis, and re-operation rate. Mortality was assessed at 30 d (hospital mortality) and also longterm. The statistical endpoint of this study was patient survival after surgery. RESULTS: The groups were well matched for demographic criteria, clinical presentation and operative characteristics, except for lower hemoglobin in the non-PBD group (10.9 ± 1.6 vs 11.8 ± 1.6 in the PBD group).Of the parameters assessing postoperative morbidity, incidence of wound infection was signif icantly less in the PBD than the non-PBD group [1 (2.9%) vs 12 (25.5%)]. However, the rest of the parameters did not differ signif icantly between the groups, i.e. sepsis [10 (28.6%) vs 14 (29.8%)], intra-abdominal bleeding [1 (2.9%) vs 5 (10.6%)], intra-abdominal abscess [1 (2.9%) vs 8 (17%)], gastrointestinal bleeding [3 (8.6%) vs 5 (10.6%)], pancreatic leakage [2 (5.7%) vs 3 (6.4%)], biliary leakage [2 (5.7%) vs 3 (6.4%)], pancreatitis [2 (5.7%) vs 2 (4.3%)], gastroparesis [6 (17.1%) vs 10 (21.3%)], need for blood transfusion [10 (28.6%) vs 17 (36.2%)] and re-operation rate [1 (2.9%) vs 5 (10.6%)]. There was no early mortality in either group. Median survival was 44 mo (95% CI: 34.2-53.8) in the PBD group and 41 mo (95% CI: 27.7-54.3; P = 0.86) in the non-PBD group. CONCLUSION: Biliary drainage before surgery for ampullary cancer significantly reduced postoperative wound infection. Overall mortality was not influenced by preoperative drainage. | Sheikh Anwar Abdullah Tarun Gupta Khairul Azhar Jaafar Yaw Fui Alexander Chung London Lucien Peng Jin Ooi Steven Joseph Mesenas | 2009 | World Journal of Gastroenterology2009，15，23： | 16 |
| 2 | 基于人工神经网络的注水开发油藏产量预测显示文摘针对传统注水开发油藏产量预测方法存在的问题,提出了基于人工神经网络的预测模型,阐述了模拟工作流程,并进行了算例分析。提出了基于流体物理学和测量数据随机组合的特征提取方法,以提高模型的预测效果。优选贝叶斯正则化算法作为模型的训练算法,该算法一般耗时较长,但能对产油量、产气量、产水量等嘈杂数据集进行良好泛化。通过计算均方误差及决定系数、绘制误差分布直方图及模拟数据-验证数据交会图等方式进行模型评价。用90%的历史数据训练、验证、测试目标模型结构,然后用其余10%数据进行盲测。研究表明,提出的流体产量预测模型决定系数超过0.9,模拟结果与实际数据吻合程度高,输入信息少,计算成本低。 | NEGASH Berihun Mamo YAW Atta Dennis | 2020 | 石油勘探与开发2020，47，2： | 15 |
| 3 | Systematic review of the outcomes of surgical resection for intermediate and advanced Barcelona Clinic Liver Cancer stage hepatocellular carcinoma:A critical appraisal of the evidence显示文摘AIM To perform a systematic review to determine the survival outcomes after curative resection of intermediate and advanced hepatocellular carcinomas(HCC).METHODS A systematic review of the published literature was performed using the PubM ed database from 1 st January 1999 to 31 st Dec 2014 to identify studies that reported outcomes of liver resection as the primary curative treatment for Barcelona Clinic Liver Cancer(BCLC) stage B or C HCC. The primary end point was to determine the overall survival(OS) and disease free survival(DFS) of liver resection of HCC in BCLC stage B or C in patients with adequate liver reserve(i.e., Child's A or B status). The secondary end points were to assess the morbidity and mortality of liver resection in large HCC(defined as lesions larger than 10 cm in diameter) and to compare the OS and DFS after surgical resection of solitary vs multifocal HCC.RESULTS We identified 74 articles which met the inclusion criteria and were analyzed in this systematic review. Analysis of the resection outcomes of the included studies were grouped according to(1) BCLC stage B or C HCC,(2) Size of HCC and(3) multifocal tumors. The median 5-year OS of BCLC stage B was 38.7%(range 10.0-57.0); while the median 5-year OS of BCLC stage C was 20.0%(range 0.0-42.0). The collective median 5-year OS of both stages was 27.9%(0.0-57.0). In examining the morbidity and mortality following liver resection in large HCC, the pooled RR for morbidity [RR(95%CI) = 1.00(0.76-1.31)] and mortality [RR(95%CI) = 1.15(0.73-1.80)] were not significant. Within the spectrum of BCLC B and C lesions, tumors greater than 10 cm were reported to have median 5-year OS of 33.0% and multifocal lesions 54.0%.CONCLUSION Indication for surgical resection should be extended to BCLC stage B lesions in selected patients. Further studies are needed to stratify stage C lesions for resection. | Ye Xin Koh Hwee Leong Tan Weng Kit Lye Juinn Huar Kam Adrian Kah Heng Chiow Siong San Tan Su Pin Choo Alexander Yaw Fui Chung Brian Kim Poh Goh | 2018 | World Journal of Hepatology2018，10，6： | 10 |
| 4 | Contents of four active components in different commercial crude drugs and preparations of Danshen (Salvia miltiorrhiza)显示文摘AIM:To detect the contents of four active components of Salvia miltiorrhiza in various commercially available danshen crude drugs and preparations.METHODS:Commercially available danshen crude drugs from different sources,as well as danshen pills and intravenous injection preparations containing danshen alone or in combination with other herbs were collected.The composition of these danshen samples was analyzed using HPLC.Specifically,the amounts of magnesium tanshinoate B(MTB),danshensu,isotanshinone IIA,and cryptotanshinone were determined.In some of these samples,the content of MTB was further confirmed by liquid chromatography-tandem mass spectrometer (LC-MS)/MS method.RESULTS:There were great variations in the amount of the four active ingredients in the commercially available danshen crude drugs and drug preparations in this study.The amount of MTB was the highest among the four components measured in the crude drugs.However,the amounts of MTB in all danshen preparations were much lower than those in crude drugs.The 2 lipophilic components,isotanshinone IIA and cryptotanshinone,were very low or not detectable in both injection and oral preparations.CONCLUSION:MTB can be used to standardize the various forms of danshen crude drugs and drug preparations from different sources.In view of the variation in the amounts of MTB and other components,improvement in the production methods of danshen preparations is essential to ensure consistent amount of its active ingredients and reproducible pharmacological actions. | Susan Wai Sum LEUNG Yaw Loong SIOW Ricky Ying Keung MAN | 2002 | Acta Pharmacologica Sinica2002，23，12： | 6 |
| 5 | Anatomy of Mdm2 and Mdm4 in evolution显示文摘老鼠双分钟(Mdm ) 基因从古老的真核细胞的 placozoa Trichoplax adhaerens 跨越进化 timeframe,全部暗示一个重要、可能保存的细胞的角色人现代人的历史。到 DNA 损坏的 DNA 正直和反应的维护包含许多关键规章的小径,包括对瘤 suppressor 蛋白质 p53 的精确控制。在大多数脊椎动物,通过指向的 proteasomal 的 p53 的降级被 Mdm2 和 Mdm2 相关的蛋白质 Mdm4 的 heterodimers 首先调停(也作为 MdmX 知道) 。Mdm2 和 Mdm4 让 p53 有约束力的区域,酸的领域,锌手指,和 C 终端包围在整个进化被保存的领域。当无脊椎的种类的定序的染色体的分析识别了单个 Mdm 基因时,脊椎动物典型地有 Mdm2 和 Mdm4 基因,建议一个复制事件百万年以前发生在关于 550-440 的无颚的脊椎动物的出现以前。在在 T 的 Mdm 和 p53 之间的功能的关系。adhaerens,存在 10 亿年了的一个有机体,暗示这二蛋白质一起演变维持保存并且调整的功能。 | Ban Xiong Tan Hoe Peng Liew Joy S. Chua Farid J. Ghadessy Yaw Sing Tan David P. Lane Cynthia R. Coffill | 2017 | Journal of Molecular Cell Biology2017，9，1： | 3 |
| 6 | Predictors and consequences of pneumonia in critically ill patients with stroke显示文摘 | Anupama Upadya Natalya Thorevska Kanaga N Sena Constantine Manthous Yaw Amoateng-Adjepong | 2004 | Journal of Critical Care2004，，1： | 3 |
| 7 | 膝关节多发韧带损伤的手术时机选择和术后功能锻炼的系统性综述显示文摘背景:膝关节外伤性脱位导致的多发韧带损伤并不常见,相关研究也较少。由于缺乏前瞻性数据资料,所以对于手术时机选择以及术后康复方案的选择仍存在争议。本篇综述旨在对比早期、延期和分期手术的结果以及各种康复方案的疗效。方法:收集检索24篇回顺性研究,共计396个膝关节,侧重于严重多发韧带损伤的外科治疗。韧带损伤包括前、后十字韧带和(或)内单侧或内外双侧副韧带。数据采集后,按照手术时间(早期、延期和分期)将患者分组。同时我们也将术后早期功能锻炼和术后制动进行对比。 | William R.Mook, MD Mark D.Miller, MD David R. Diduch, MD JayHertel, PhD ATC, Yaw Boachie-Adjei, MD Joseph M.Hart, PhD, ATC 韦祎(译) 冯华(译) | 2010 | 中华骨科杂志2010，30，3： | 2 |
| 8 | An investigation of the microstructural effects on the mechanical and electrochemical properties of a friction stir processed equiatomic CrMnFeCoNi high entropy alloy显示文摘The electrochemical properties of a friction stir processed(FSPed)equiatomic CrMnFeCoNi high-entropy alloy(HEA)was investigated in an aerated 0.5 M Na_(2)SO_(4) electrolyte solution at room temperature.The microstructural analysis reveals a highly refined stir zone(SZ)with an average grain size that decreases from the top region of the SZ to the bottom region of the SZ(also known as shear-processed zone;SPZ).However,the region below the SPZ,(i.e.below the plunge depth)experienced an increase in average grain size and dislocation densities compared to the other regions.There is no secondary phase observed in the FSPed region,however,the microstructural evolution in the FSPed region affects the electrochemical behavior of the HEA.Cr_(2)O_(3) passive layer was observed to form on the FSPed HEA,leading to excellent corrosion properties from the polarization corrosion tests.Grain refinement in the SZ enhances the rapid formation of the passive layer,thus,leading to better corrosion properties in the front surface of the FSPed HEA.The localized corrosion behavior of the FSPed HEA was predicted to be caused by the micro-galvanic nature of the HEA,which leads to an increase in polarization at the anodic sites(pits).A numerical model was established using the corrosion parameters from the experiment to simulate the localized corrosion behavior on the surface of the FSPed HEA in a neutral environment.The predicted initial pitting potential and corresponding current density agree well with the experimental results.The model is also capable of tracking the dissolution of the pits over longer periods. | Sam Yaw Anaman Solomon Ansah Hoon-Hwe Cho Min-Gu Jo Jin-Yoo Suh Minjung Kang Jong-Sook Lee Sung-Tae Hong Heung Nam Han | 2021 | Journal of Materials Science & Technology2021，，28： | 2 |
| 9 | Oil removal from aqueous state by natural fibrous sorbent: An overview显示文摘 | Rafeah Wahi Luqman Abdullah Chuah Thomas Shean Yaw Choong Zainab Ngaini Mohsen Mobarekeh Nourouzi | 2013 | Separation and Purification Technology2013，，： | 2 |
| 10 | Dovitinib demonstrates antitumor and antimetastatic activities in xenograft models of hepatocellular carcinoma显示文摘 | Hung Huynh Pierce Kah Hoe Chow Wai Ming Tai Su Pin Choo Alexander Yaw Fui Chung Hock Soo Ong Khee Chee Soo Richard Ong Ronald Linnartz Michael Ming Shi | 2011 | Journal of Hepatology2011，，3： | 2 |
| 11 | Abusive Supervision and Contextual Performance: The Mediating Role of Emotional Exhaustion and the Moderating Role of Work Unit Structure显示文摘 | SamuelAryee Li‐YunSun Zhen Xiong GeorgeChen Yaw A.Debrah | 2008 | Management and Organization Review2008，，3： | 2 |
| 12 | Influence of Shim Layers on Progressive Failure of a Composite Componentin Composite-Aluminum Bolted Joint in Aerospace Structural Assembly显示文摘The influence of varying shim layers on the progressive damage/failure of a composite component in a bolted composite-aluminum aerospace structural assembly was investigated using a non-linear three-dimensional(3 D)structural solid elements assembled model of a carbon fiber-reinforced polymer(CFRP)-aluminum single-lap joint with a titanium(Ti-6 Al-4 V)fastener and a washer generated with the commercial finite element(FE)software package,ABAQUS/Standard.A progressive failure algorithm written in Fortran code with a set of appropriate degradation rules was incorporated as a user subroutine in ABAQUS to simulate the non-linear damage behavior of the composite component in the composite-aluminum bolted aerospace structure.The assembled 3 DFE model simulated,as well as the specimen for the experimental testing consisted of a carbon-epoxy IMS-977-2 substrate,aluminum alloy 7075-T651 substrate,liquid shim(Hysol EA 9394),solid peelable fiberglass shim,a titanium fastener,and a washer.In distinction to previous investigations,the influence of shim layers(liquid shim and solid peelable fiberglass shim)inserted in-between the faying surfaces(CFRP and aluminum alloy substrates)were investigated by both numerical simulations and experimental work.The simulated model and test specimens conformed to the standard test configurations for both civil and military standards.The numerical simulations correlated well with the experimental results and it has been found that:(1)The shimming procedure as agreed upon by the aerospace industry for the resolution of assembly gaps in bolted joints for composite materials is the same for a composite-aluminum structure;liquid shim series(0.3,0.5 and 0.7 mm thicknesses)prolonged the service life of the composite component whereas a solid peelable fiberglass shim most definitely had a better influence on the 0.9 assembly gap compared with the liquid shim;(2)The shim layers considerably influenced the structural strength of the composite component by delaying its ultimate failure thereby increasing its service life;and(3)Increasing the shim layer′s thickness led to a significant corresponding effect on the stiffness but with minimal effect on the ultimate load. | Cephas Yaw Attahu An Luling Li Zhaoqing Gao Guoqiang | 2018 | Transactions of Nanjing University of Aeronautics and Astronautics2018，35，1： | 2 |
| 13 | Catalytic gasification of coal using eutectic salts: identification of eutectics 显示文摘 | YAW D Y XU Y ATUL S | 2003 | Carbon2003，41，2： | 1 |
| 14 | A monolithic buck DC - DC converter with on chip PWM circuit显示文摘 | Yeong Tsair Lin Mei Chu Jen Wen Yaw Chung | 2007 | Micro-electronics2007，38，89： | 1 |
| 15 | Expression of the E- cadherin/catenin (a-, β-, γ-) complex correlates with the macroscopic appearance of early gastric cancer 显示文摘 | Yaw O A Masao N Mikolash P | 2000 | J Pathol2000，192，4： | 1 |
| 16 | Arrest of replication forks by drug-stabilized Topoisomerase I-DNA cleavable complexes as a mechanism of cell killing by Camptothecin显示文摘 | Michelle GL Leroy FL | 1989 | Cancer Res1989，49，18： | 1 |
| 17 | The Determinants of Investor Valuation of R&D Expenditure in the Software Industry 显示文摘 | C Catherine Chiang & Yaw M Mensah | 2004 | Review of Quantitative Finance and Accounting2004，，22： | 1 |
| 18 | SINGLE IMAGING MODALITY EVALUATION OF LIVING DONORS IN LIVER TRANSPLANTATION: MAGNETIC RESONANCE IMAGING1显示文摘 | Yu Fan Cheng Chao Long Chen Tung Liang Huang Tai Yi Chen Tze Yu Lee Yaw Sen Chen Chih Chi Wang Vanessa de Villa Shigeru Goto Yuan Cheng Chiang Hock Liew Eng Bruno Jawan Hak Kim Cheung | 2001 | Transplantation2001，，9： | 1 |
| 19 | Chemical modification of sago starch by solventless esterification with fatty acid chlorides显示文摘 | Dzulkefly K See Yaw Koon | | 0，，02： | 1 |
| 20 | Henry's law constants for organic compounds in water显示文摘 | Yaws C Yang H C Pan X | 1991 | Chemical Engineering1991，11，： | 1 |
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