|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Staged angioplasty versus regular carotid artery stenting in patients with carotid artery stenosis at high risk of hyperperfusion:a randomised clinical trial显示文摘Background and purpose Hyperperfusion(HP)is a devastating complication associated with carotid artery stenting(CAS)or endarterectomy.The efficacy and safety of staged angioplasty(SAP)in patients with CAS at high risk of HP remains unclear.We sought to determine whether SAP is superior to regular CAS in patients with high risk of HP.Methods A randomised,multicentre open-label clinical trial with blinded outcome assessment(STEP)was conducted.Patients with severe carotid stenosis at high risk of HP were randomly assigned(1:1)to the SAP or regular CAS group.The primary endpoint was hyperperfusion syndrome(HPS)and intracerebral haemorrhage(ICH)within 30 days after the procedure.Results From November 2014 to January 2017,a total of 64 patients were enrolled in 11 centres.33 patients were allocated to the SAP group and 31 to the regular CAS group.At 30 days,the rate of primary endpoint was 0.0%(0/33)in the SAP group and 9.7%(3/31)in the regular CAS group(absolute risk reduction(ARR),9.7%;95%CI−20.1% to 0.7%;p=0.11).As one of the secondary endpoints,the incidence of HP phenomenon(HPP)was lower in the SAP group than the regular CAS group(0.0%vs 22.6%,ARR,−22.6%;95% CI−36.8%to−10.2%;p=0.04).Conclusion The rate of HPS and ICH was not significantly lower in SAP group;the extended secondary endpoint of HPP,however,significantly reduced,which suggested that SAP may be a safe and effective carotid revascularisation procedure to prevent HP. | Dapeng Mo Baixue Jia Huaizhang Shi Yaxuan Sun Qingan Liu Chengzhe Fan Jianping Deng Jinglin Yuan Wei Wu Changchun Jiang Guilian Zhang Hanjun Du Ning Ma Feng Gao Xuan Sun Ligang Song Lian Liu Guangge Peng Yongjun Wang Yilong Wang Zhongrong Miao the STEP Study Group | 2021 | Stroke & Vascular Neurology2021，6，1： | 3 |
| 2 | Protective Effects of Vitamin E against Oxidative Damage Induced by Aβ(1-40)Cu(Ⅱ)Complexes显示文摘贝它淀粉的肽(贝它)被认为为老年的匾的形成负责,它是 Alzheimer 的疾病(广告)的特点 .Oxidativestress ,每氧化由蛋白质氧化和类脂化合物表明了在另外的改变之中,广告 brain.A 的一个特征种证据的身体在 beta1-40forming 的支持被介绍了在建筑群产生的 CuZn 超级氧化物象dismutase一样绑定 site.Abeta1-40 Cu ( II )绑铜的 oligomeric 建筑群从经由 Cu2+reduction 的 O2 的毒害神经的氢过氧化物( H2O2 ),尽管精确反应机制是不清楚的。 beta1-40 或 Abeta1-40Cu ( II )的毒性当(+) -alpha-tocopherol ( 维生素 E )在数据从版本和 H2O2 的形成证实了的乳酸脱氢酶( LDH )导出的 100 muM.The 的集中作为免费激进的抗氧化剂被增加时,到有教养的主要外皮的神经原的建筑群部分被稀释结果从 MTT 试金。这些调查结果显示到 beta1-40 的那铜绑定能产生 H2O2 的更大的生产,它在质膜和随后的 neuronal 死亡的完整导致一个故障。与维生素 E 对待的组展出了许多更细微的损坏,建议维生素 E 起在保护 neuronal 房间免受机能障碍或死亡的伤害的一个关键作用。 | Xueling DAI~1 Yaxuan SUN~2 and Zhaofeng JIANG~2 ~1College of Life Science,Capital Normal University,Bejing 100037,China ~2College of Applied Sciences Humanities of Beijing Union University,Beijing 100083,China | 2007 | Acta Biochimica et Biophysica Sinica2007，39，2： | 1 |
| 3 | The lectin gene TRpL1 of tetraploid Robinia pseudoacacia L.response to salt stress显示文摘Lectins are natural proteins in animals,plants,and microorganisms and can be divided into 12 families.These lectins play important roles in various environmental stresses.Some polyploid plants show tolerance to environmental stresses and to insect pests.However,the mechanism of stress tolerance is unclear.Tetraploid Robinia pseudoacacia(4×)under salt stress showed higher tolerance than diploid R.pseudoacacia(2×).As lectin can improve stress tolerance,it was questioned whether the stress resistance of polyploid plants was related to the lectin protein.In this study,salt resistance of lectin gene TRpL1 was verified by its over-expression in plants.In addition,salt resistance of lectin protein by E.coli strains was detected.The data revealed that the over-expression transgenic plants of TRpL1 showed better salt tolerance than control plants under salt stress,and the TRpL1-expressing strain also grew better in the medium with added NaCl.Therefore,tetraploid plants can resist salt stress through TRpL1 protein regulation. | Shuo Liu Yaxuan Jiang Xinyu Guo Liping Xu Pei Lei Qiuxiang Luo Jianxin Liu Wei Li Lei Tao Fanjuan Meng | 2023 | Journal of Forestry Research2023，34，2： | 0 |
| 4 | 前额叶皮质中兴奋性神经元集合编码短期记忆显示文摘文章简介短期记忆(STM)对于动物在一小段时间内保存信息来说至关重要。已经知道,持续性或复发性的神经活动和神经振荡在细胞水平上编码STM。然而,微回路级的编码机制仍然是一个谜。在本文中,我们对行为小鼠进行了双光子成像以监测神经元微回路的活动。 | Yonglu Tian Chaojuan Yang Yaxuan Cui Feng Su Yongjie Wang Yangzhen Wang Peijiang Yuan Shujiang Shang Hao Li Jizong Zhao Desheng Zhu Shiming Tang Peng Cao Yunbo Liu Xunli Wang Liecheng Wang Wenbo Zeng Haifei Jiang Fei Zhao Minhua Luo Wei Xiong 仇子龙 李相尧 张晨 | 2019 | 科学新闻2019，0，2： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员