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| 1 | Liver injury in COVID-19:Detection,pathogenesis,and treatment显示文摘In the early December 2019,a novel coronavirus named severe acute respiratory syndrome coronavirus 2 was first reported in Wuhan,China,followed by an outbreak that spread around the world.Numerous studies have shown that liver injury is common in patients with coronavirus disease 2019(COVID-19),and may aggravate the severity of the disease.However,the exact cause and specific mechanism of COVID-associated liver injury needs to be elucidated further.In this review,we present an analysis of the clinical features,potential mechanisms,and treatment strategies for liver injury associated with COVID-19.We hope that this review would benefit clinicians in devising better strategies for management of such patients. | Yue Cai Li-Ping Ye Ya-Qi Song Xin-Li Mao Li Wang Yan-Zhi Jiang Wei-Tao Que Shao-Wei Li | 2021 | World Journal of Gastroenterology2021，27，22： | 5 |
| 2 | A Teosinte-derived Allele of a MYB Transcription Repressor Confers Multiple Disease Resistance in Maize.显示文摘Natural alleles controlling multiple disease resistances (MDR) are valuable for crop breeding. However, only one MDR gene have been cloned in maize, and molecular mechanisms of MDR are not clear. By map-based cloning, we have cloned a teosinte-derived allele of a resistance gene, Mexicana lesion mimic 1 (ZmMM1), which has a lesion mimic phenotype and confers resistance to northern leaf blight (NLB), gray leaf spot (GLS) and southern corn rust (SCR). Strong MDR conferred by the teosinte allele is linked with the polymorphisms in the 3' untranslated region of the ZmMM1 gene that cause increased accumulation of ZmMM1 protein. ZmMM1 acts as a transcription repressor and negatively regulates transcription of specific target genes including ZmMM1-target gene 3 (ZmMT3), which functions as a negative regulator of plant immunity and associated cell death. The successful isolation of the ZmMM1 resistance gene will help not only in developing broad-spectrum and durable disease resistance but also in understanding the molecular mechanisms underlying MDR. | Hongze Wang Jiabao Hou Pei Ye Long Hu Junshi Huang Zhikang Dai Bao Zhang Sha Dai Jiamin Que Haoxuan Min Gengshen Chen Yanbo Wang Min Jiang Yan Liang Lin Li Xuecai Zhang Zhibing Lai | 2021 | Molecular Plant2021，14，11： | 4 |
| 3 | Varicella-zoster virus ORF7 interacts with ORF53 and plays a role in its trans-Golgi network localization显示文摘Varicella-zoster virus(VZV) is a neurotropic alphaherpesvirus that causes chickenpox and shingles. ORF7 is an important virulence determinant of VZV in both human skin and nerve tissues,however, its specific function and involved molecular mechanism in VZV pathogenesis remain largely elusive. Previous yeast two-hybrid studies on intraviral protein-protein interaction network in herpesviruses have revealed that VZV ORF7 may interact with ORF53, which is a virtually unstudied but essential viral protein. The aim of this study is to identify and characterize VZV ORF53, and to investigate its relationship with ORF7. For this purpose, we prepared monoclonal antibodies against ORF53 and, for the first time, characterized it as a ~40 k Da viral protein predominantly localizing to the trans-Golgi network of the infected host cell. Next, we further confirmed the interaction between ORF7 and ORF53 by co-immunoprecipitation and co-localization studies in both plasmid-transfected and VZV-infected cells. Moreover, interestingly, we found that ORF53 lost its trans-Golgi network localization and became dispersed in the cytoplasm of host cells infected with an ORF7-deleted recombinant VZV, and thus ORF7 seems to play a role in normal subcellular localization of ORF53. Collectively, these results suggested that ORF7 and ORF53 may function as a complex during infection, which may be implicated in VZV pathogenesis. | Wei Wang Wenkun Fu Dequan Pan Linli Cai Jianghui Ye Jian Liu Che Liu Yuqiong Que Ningshao Xia Hua Zhu Tong Cheng | 2017 | Virologica Sinica2017，32，5： | 1 |
| 4 | Influence of annealing atmosphere and temperature on photoluminescence of Tb 3+ or Eu 3+ -activated zinc silicate thin film phosphors via sol–gel method显示文摘 | Q.Y Zhang K Pita W Ye W.X Que | 2002 | Chemical Physics Letters2002，，3： | 1 |
| 5 | Effectiveness of acu- puncture intervention for neck pain caused by cervical spon- dylosis :study protocol for a randomized controlled trial 显示文摘 | Que Q Ye x Su Q Weng Y | 2013 | Trials2013，14，： | 1 |
| 6 | Pretreatment of Cylindrical Coconut Activated Carbon and Performance as Catalyst Support显示文摘 | PAN Chong-gen YE Lin-qin WANG Ju-hua BAO Li-xia QUE Yong-sheng | 2013 | Chemical Research in Chinese Universities2013，29，5： | 0 |
| 7 | Statistical estimation in partially nonlinear models with random effects显示文摘In this article, a partially nonlinear model with random effects is proposed and its new estimation procession is provided. In order to estimate the link function, we propose generalised leastsquare estimate and B-splines estimate methods. Further, we also use the Gauss–Newton methodto construct the estimates of unknown parameters. Finally, we also consider the estimation forthe variance components. The consistency and the asymptotic normality of the estimator will beproved. Simulated and real examples are given to illustrate our proposed methodology, whichshows that our methods give effective estimation. | Ye Que Zhensheng Huang Riquan Zhang | 2017 | Statistical Theory and Related Fields2017，1，2： | 0 |
| 8 | Endoscopy demand among county people in southeast China:A cross-sectional study显示文摘Objective The popularization of gastroenteroscopy and the introduction of comfortable medical care have further promoted the growth of people's demand,especially the demand for painless endoscopy.This cross-sectional study aims to investigate the current situation and change in county people's demand for endoscopy to promote the development of endoscopy centers in county hospitals in southeast China.Methods From October to December 2021,patients and their family members who came to the Gastroenterology Department in Suichang County People's Hospital of Zhejiang Province were randomly selected to complete the questionnaire.A total of 838 valid questionnaires were collected.Additionally,the original software data of the Endoscopy Center were sampled and retrieved(from October to December every year from 2018 to 2021)for statistical analysis of real-world data.Those who would choose painless endoscopy the next time in the valid questionnaires were included in the painless endoscopy group,while those who would choose ordinary endoscopy the next time were included in the ordinary endoscopy group.Results The stepwise forward binary logistic regression model analysis showed that,patients with“secondhand smoke exposure”were more willing to choose painless endoscopy(OR=1.459,95%CI:1.050-2.028,p=0.025).However,patients with an education level of“primary and below”and“junior high school”,and patients who are suffering from“currently experiencing abdominal distension”,were more willing to choose ordinary endoscopy(OR=0.270,95%CI:0.149-0.488,p<0.001;OR=0.528,95%CI:0.330-0.845,p=0.008;OR=0.536,95%CI:0.334-0.861,p=0.010).Patients with previous experience in painless endoscopy tended to choose painless endoscopy the next time,while patients with previous experience in ordinary endoscopy tended to choose ordinary endoscopy the next time(χ^(2)=140.97,p<0.001).From 2018 to 2021,the proportion of painless endoscopy has increased yearly(p<0.001).Most patients indicated that they would“regularly review gastroenteroscopy”(477/838,56.9%).Conclusions With Suichang County of Zhejiang Province as the representative,the demand for painless endoscopy for people's gastrointestinal cancer detection in southeast China has been increasing yearly.The development of endoscopy centers in county-level hospitals can basically meet the demand growth.Meanwhile,advanced concepts such as comfortable medical care and regular follow-up are gradually popularized at the grassroots level in southeast China. | Huihui Yan Zhenghua Lin Shuangjing Gao Chenyu Fan Mengyue Jiang Liying Que Lanfang Zhou Yingdi Weng Jing Shu Tongyun Zhang Jian Hu Zhiqiang Liu Xi Ye Jianting Cai Guangfa Liao | 2023 | Laparoscopic, Endoscopic and Robotic Surgery2023，6，1： | 0 |
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