|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Immunopathobiology and therapeutic targets related to cytokines in liver diseases显示文摘Chronic liver injury with any etiology can progress to fibrosis and the end-stage diseases cirrhosis and hepatocellular carcinoma.The progression of liver disease is controlled by a variety of factors,including liver injury,inflammatory cells,inflammatory mediators,cytokines,and the gut microbiome.In the current review,we discuss recent data on a large number of cytokines that play important roles in regulating liver injury,inflammation,fibrosis,and regeneration,with a focus on interferons and T helper(Th)1,Th2,Th9,Th17,interleukin(IL)-1 family,IL-6 family,and IL-20 family cytokines.Hepatocytes can also produce certain cytokines(such as IL-7,IL-11;and IL-33),and the functions of these cytokines in the liver are briefly summarized.Several cytokines have great therapeutic potential,and some are currently being tested as therapeutic targets in clinical trials for the treatment of liver diseases,which are also described. | Yong He Seonghwan Hwang Yeni Ait Ahmed Dechun Feng Na Li Marcelle Ribeiro Fouad Lafdil Tatiana Kisseleva Gyongyi Szabo Bin Gao | 2021 | Cellular & Molecular Immunology2021，18，1： | 14 |
| 2 | Guillain–Barré syndrome, transverse myelitis and infectious diseases显示文摘Guillain–Barrésyndrome(GBS)and transverse myelitis(TM)both represent immunologically mediated polyneuropathies of major clinical importance.Both are thought to have a genetic predisposition,but as of yet no specific genetic risk loci have been clearly defined.Both are considered autoimmune,but again the etiologies remain enigmatic.Both may be induced via molecular mimicry,particularly from infectious agents and vaccines,but clearly host factor and co-founding host responses will modulate disease susceptibility and natural history.GBS is an acute inflammatory immune-mediated polyradiculoneuropathy characterized by tingling,progressive weakness,autonomic dysfunction,and pain.Immune injury specifically takes place at the myelin sheath and related Schwann-cell components in acute inflammatory demyelinating polyneuropathy,whereas in acute motor axonal neuropathy membranes on the nerve axon(the axolemma)are the primary target for immune-related injury.Outbreaks of GBS have been reported,most frequently related to Campylobacter jejuni infection,however,other agents such as Zika Virus have been strongly associated.Patients with GBS related to infections frequently produce antibodies against human peripheral nerve gangliosides.In contrast,TM is an inflammatory disorder characterized by acute or subacute motor,sensory,and autonomic spinal cord dysfunction.There is interruption of ascending and descending neuroanatomical pathways on the transverse plane of the spinal cord similar to GBS.It has been suggested to be triggered by infectious agents and molecular mimicry.In this review,we will focus on the putative role of infectious agents as triggering factors of GBS and TM. | Yhojan Rodríguez Manuel Rojas Yovana Pacheco Yeny Acosta-Ampudia Carolina Ramírez-Santana Diana M Monsalve M Eric Gershwin Juan-Manuel Anaya | 2018 | Cellular & Molecular Immunology2018，15，6： | 7 |
| 3 | Kupffer cell restoration after partial hepatectomy is mainly driven by local cell proliferation in IL-6-dependent autocrine and paracrine manners显示文摘Kupffer cells(KCs),which are liver-resident macrophages,originate from the fetal yolk sac and represent one of the largest macrophage populations in the body.However,the current data on the origin of the cells that restore macrophages during liver injury and regeneration remain controversial.Here,we address the question of whether liver macrophage restoration results from circulating monocyte infiltration or local KC proliferation in regenerating livers after partial hepatectomy(PHx)and uncover the underlying mechanisms.By using several strains of genetically modified mice and performing immunohistochemical analyses,we demonstrated that local KC proliferation mainly contributed to the restoration of liver macrophages after PHx.Peak KC proliferation was impaired in Il6-knockout(KO)mice and restored after the administration of IL-6 protein,whereas KC proliferation was not affected in Il4-KO or Csf2-KO mice.The source of IL-6 was identified using hepatocyte-and myeloid-specific Il6-KO mice and the results revealed that both hepatocytes and myeloid cells contribute to IL-6 production after PHx.Moreover,peak KC proliferation was also impaired in myeloid-specific Il6 receptor-KO mice after PHx,suggesting that IL-6 signaling directly promotes KC proliferation.Studies using several inhibitors to block the IL-6 signaling pathway revealed that sirtuin 1(SIRT1)contributed to IL-6-mediated KC proliferation in vitro.Genetic deletion of the Sirt1 gene in myeloid cells,including KCs,impaired KC proliferation after PHx.In conclusion,our data suggest that KC repopulation after PHx is mainly driven by local KC proliferation,which is dependent on IL-6 and SIRT1 activation in KCs. | Yeni Ait Ahmed Yaojie Fu Robim M.Rodrigues Yong He Yukun Guan Adrien Guillot Ruixue Ren Dechun Feng Juan Hidalgo Cynthia Ju Fouad Lafdil Bin Gao | 2021 | Cellular & Molecular Immunology2021，18，9： | 2 |
| 4 | Biomechanical Analysis of Different Techniques in Revision Spinal Instrumentation: Larger Diameter Screws Versus Cement Augmentation显示文摘 | Dirk W. Kiner Christopher D. Wybo William Sterba Yener N. Yeni Stephen W. Bartol Rahul Vaidya | 2008 | Spine2008，，24： | 2 |
| 5 | Free air gravity map of Tai- wan and its applications显示文摘 | YenY H Yeh Y H LinCH | 1990 | TAO1990，1，2： | 1 |
| 6 | Comparison of the linear finite element prediction of deformation and strain of human cancellous bone to 3D digital volume correlation measurements显示文摘 | Zauel R Yeni YN Bay BK | | 0，，01： | 1 |
| 7 | Electrochemical glucose bio- sensing by pyranose oxidase immobilized in gold nanoparticle-polyani- line/AgC1/gelatin nanocomposite matrix显示文摘 | OZDEMIR C YENI F ODACI D | 2010 | Food Chem2010，119，1： | 1 |
| 8 | Visual field defects in selective amygdalohippocampectomy for hippocampal sclerosis:the fate of Meyer's loop during the transsylvian approach to the temporal horn显示文摘 | Yeni S N Tanriover N Uyanik O | 2008 | Neurosurgery2008，63，3： | 1 |
| 9 | The KLEAN study of fos- amprenavir-ritonavir versus lopinavir-ritonavir, each in combina- tion with abacavir-lamivudine, for initial treatment of HIV infec- tion over 48 weeks: A randomised non-inferiority trial显示文摘 | Eron J Jr Yeni P Gathe J Jr | 2006 | Lan- cet2006，368，： | 1 |
| 10 | Variability of trabecular microstructure is age-, gender-, race- and anatomic site-dependent and affects stiffuess and stress distribution properties of human vertebral cancellous bone显示文摘 | Yeni YN Zinno MJ Yerramshetty JS | 2011 | Bone2011，49，4： | 1 |
| 11 | Update on HAART in HIV显示文摘 | Yeni P | 2006 | J Hepatol2006，44，1： | 1 |
| 12 | Fast digital image stabilization using one bit transform based sub-image motion estimation显示文摘 | Yeni A A Erttirk S | 2005 | IEEE Transactions on Consumer Electron2005，51，3： | 1 |
| 13 | Electrochemical glucose biosensing by pyranose oxidase immobilized in gold nanoparticale-polyaniline/AgCl/gelatin nanocomposite matrix显示文摘 | Caglar Ozdemir Fatma Yeni Dliek Odaci | | 0，，1： | 1 |
| 14 | Correction of lung boundary using t he gradient and intensity distribution显示文摘 | Yeny Y Helen H Joon B S | | 0，，3： | 1 |
| 15 | Antiretroviral treatment for adult HIV infection in 2002:updated recommendations of the International A IDSSociety-USA Panel显示文摘 | Yeni P G Hammer S M Carpenter C C | 2002 | J Am Med Assoc2002，288，： | 1 |
| 16 | Antiretvoviral treatment for adult HIV infection in 2002:updated recommendations of the international AIDS Society-USA Panel显示文摘 | Yeni PG Hammer Sm Carpenter CC | 2002 | JAMA2002，288，2： | 1 |
| 17 | Idiopathic retroperitoneal fibrosismimicking a pelvic tumor: a case of peficystitis plastica显示文摘 | Verit A Yeni E Unal D | 2003 | Yonsei Med J2003，44，3： | 1 |
| 18 | Purification and characterization of a novel antitumor protein with antioxidant and deoxyribonuclease activity from edible mushroom Pholiota nameko显示文摘 | Yeni Zhang Zhaokun Liu Tzi Bun Ng Zhihui Chen Wentao Qiao Fang Liu | 2013 | Biochimie2013，，： | 1 |
| 19 | Finite element calculated uniaxial apparent stiffness is a consistent predictor of uniaxial apparent strength in human vertebral cancellous bone tested with different boundary conditions 显示文摘 | Yeni Y Fyhrie D | 2001 | J Biomech2001，34，： | 1 |
| 20 | Influence of sperm con-centration on the motility, morphology, membrane and DNA in-tegrity along with oxidative stress parameters of ram sperm dur-ing liquid storage 显示文摘 | Gundogan M Yeni D Avdatek F | 2010 | Anim Reprod Sci2010，122，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员