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| 1 | Spatial and temporal distribution of Neolithic sites in coastal China:Sea level changes, geomorphic evolution and human adaption显示文摘The East China coastal plain is one of the most important Neolithic culture areas in China, where rich archaeological sites including those producing the earliest domesticated rice are observed. It is also a place where landscape has experienced dramatic evolution during the Holocene when both sea level and climate changed, such that it is an ideal place for studying human-environment interaction. This study investigated over 2000 sites of pre-history and Shang and Zhou Dynasties, with 655 of which being Neolithic ages, by using DEM and GIS methods. The results suggest that the spatial and temporal distribution of Neolithic sites has largely been controlled by landscape evolution(particularly changes in coastal line), which ultimately governed by sea level changes. During early Holocene, Neolithic sites sparsely distributed in the intermountain basins of east Zhejiang Province, far from the influence of ocean. Over the period of 9–7 ka, the coastal plain(including the shelf) was largely submerged,only the feet of low hills to the south and southwest of the study area, and islands protruding the estuary, cradled limited number of settlements with characteristic 'maritime components'. At about 7 ka, sea level rise decelerated prominently, while sediments supply in the drainage remained high value, the combination of which led to land formation and propagation. Vast space during this period facilitated the growth of settlements in both size and number. In the mean time, however, the coastal plain was vulnerable to extreme environmental events such as storms and flooding owning to its geomorphic nature, which exerted great influence on the rise and fall of Neolithic culture. | ZHENG HongBo ZHOU YouSheng YANG Qing HU ZhuJun LING GuangJiu ZHANG JuZhong GU ChunGuang WANG YingYing CAO YeTing HUANG XianRong CHENG Yue ZHANG XiaoYu WU WenXiang | 2018 | Science China Earth Sciences2018，61，2： | 7 |
| 2 | An improved and practical route for the synthesis of enzalutamide and potential impurities study显示文摘An improved and practical synthesis of enzalutamide was accomplished in five steps.Starting from 4-bromo-2-fluoro-benzonic acid,a methyl esterification,Ullmann ligation,methyl esterification,ring closing reaction and final methyl amidation provided the target in 35% total yield with 99.8% purity.Five identified impurities were also synthesized.This efficient and economical procedure avoids the use of highly toxic reagents and multiple recrystallization operations,which is suitable for further industrialization. | Ai-Nan Zhou Bonan Li Lejun Ruan Yeting Wang Gengli Duan Jianqi Li | 2017 | Chinese Chemical Letters2017，28，2： | 2 |
| 3 | Components Simulation of Viral Envelope via Amino Acid Modified Chitosans for Efficient Nucleic Acid Delivery: In Vitro and In Vivo Study显示文摘 | Jing Chang Xianghui Xu Haiping Li Yeting Jian Gang Wang Bin He Zhongwei Gu | 2013 | Adv Funct Mater2013，，21： | 1 |
| 4 | Neuroendocrine Differentiation Is a Prognostic Factor for Stage II Poorly Differentiated Colorectal Cancer显示文摘 | Yue Liu Jinghong Xu Yurong Jiao Yeting Hu Chenghao Yi Qiong Li Zhou Tong Xiaowei Wang Lifeng Hu Qian Xiao Jun Li Kefeng Ding Hanlin L. Wang | 2014 | BioMed Research International2014，，： | 1 |
| 5 | BBX11 promotes red light-mediated photomorphogenic development by modulating phyB-PIF4 signaling显示文摘phytochrome B(phyB)acts as the red light photoreceptor and negatively regulates the growth-promoting factor PHYTOCHROME INTERACTING 4(PIF4)through a direct physical interaction,which in turn changes the expression of a large number of genes.phyB-PIF4 module regulates a variety of biological and developmental processes in plants.In this study,we demonstrate that B-BOX PROTEIN 11(BBX11)physically interacts with both phyB and PIF4.BBX11 negatively regulates PIF4 accumulation as well as its biochemical activity,consequently leading to the repression of PIF4-controlled genes’expression and promotion of photomorphogenesis in the prolonged red light.This study reveals a regulatory mechanism that mediates red light signal transduction and sheds a light on phyB-PIF4 module in promoting red light-dependent photomorphognenesis. | Zhaoqing Song Yueqin Heng Yeting Bian Yuntao Xiao Jiujie Liu Xianhai Zhao Yan Jiang Xing Wang Deng Dongqing Xu | 2021 | aBIOTECH2021，2，2： | 1 |
| 6 | Proximity-enabled covalent binding of IL-2 to IL-2Rα selectively activates regulatory T cells and suppresses autoimmunity显示文摘Interleukin-2(IL-2)is a pleiotropic cytokine that orchestrates bidirectional immune responses via regulatory T cells(Tregs)and effector cells,leading to paradoxical consequences.Here,we report a strategy that exploited genetic code expansion-guided incorporation of the latent bioreactive artificial amino acid fluorosulfate-L-tyrosine(FSY)into IL-2 for proximity-enabled covalent binding to IL-2Rαto selectively promote Treg activation.We found that FSY-bearing IL-2 variants,such as L72-FSY,covalently bound to IL-2Rαvia sulfur-fluoride exchange when in proximity,resulting in persistent recycling of IL-2 and selectively promoting the expansion of Tregs but not effector cells.Further assessment of L72-FSY-expanded Tregs demonstrated that L72-FSY maintained Tregs in a central memory phenotype without driving terminal differentiation,as demonstrated by simultaneously attenuated expression of lymphocyte activation gene-3(LAG-3)and enhanced expression of programmed cell death protein-1(PD-1).Subcutaneous administration of L72-FSY in murine models of pristane-induced lupus and graft-versus-host disease(GvHD)resulted in enhanced and sustained therapeutic efficacy compared with wild-type IL-2 treatment.The efficacy of L72-FSY was further improved by N-terminal PEGylation,which increased its circulatory retention for preferential and sustained effects.This proximity-enabled covalent binding strategy may accelerate the development of pleiotropic cytokines as a new class of immunomodulatory therapies. | Bo Zhang Jiaqi Sun Yeshuang Yuan Dezhong Ji Yeting Sun Yudong Liu Shengjie Li Xingxing Zhu Xunyao Wu Jin Hu Qiu Xie Ling Wu Lulu Liu Boyang Cheng Yuanjie Zhang Lingjuan Jiang Lidan Zhao Fei Yu Wei Song Min Wang Yue Xu Shiliang Ma Yunyun Fei Lihe Zhang Demin Zhou Xuan Zhang | 2023 | Signal Transduction and Targeted Therapy2023，8，2： | 0 |
| 7 | Friction measurement of aircraft wing based on optimized FlowNet2.0显示文摘Few studies have applied the deep optical flows model to global friction measurements of aircraft wing.This study used an optimized FlowNet2.0 model to measure friction of wing based on fluorescent oil film,which achieved the first integration of deep learning and friction measurement.Two input images of the traditional FlowNet2.0 model were extended to multiple images so that more flow features and details could be with them.It is the specific part of optimization that will also further improve the measurement accuracy of FlowNet2.0.Simulation experimental results show that the optimized FlowNet2.0 model reduces the Mean Absolute Percentage Error(MAPE)error by 8.51%and increases Root Mean Square Error(RMSE)by only 0.0138 when compared to the hybrid optical flow method,which indicate that the optimized FlowNet2.0 model has great potential for friction measurement.Measurements in continuous transonic wind tunnel tests demonstrate that FlowNet2.0 can calculate clearer and more accurate flow velocity than hybrid optical flow,and the solved friction magnitude distribution is consistent with the actual flow,which will be of great practical application in wind tunnel engineering. | Hongjiang QIAN Zhiyong HUANG Jian WANG Yeting XU Xiucheng DONG Jiebin SHEN | 2023 | Chinese Journal of Aeronautics2023，36，11： | 0 |
| 8 | Insight analysis of the cross-sensitization of multiple fish parvalbumins via the Th1/Th2 immunological balance and cytokine release from the perspective of safe consumption of fish显示文摘Objectives:Parvalbumin(PV)is the primary allergen found in fish and is highly conserved.According to some studies,some patients with fish allergy are allergic to only one species of fish but are tolerant to others;however,the underlying mechanism has not been identified.Materials and Methods:The cross-reactivity of these seven fish parvalbumins based on turbot PV-treated mice was determined using BALB/c mouse and RBL-2H3 cell models.Meanwhile,immunoinformatic tools were used to assess cross-reactivity.Results:The results indicated that the seven species of fishes(turbot,large yellow croaker,sea bass,grass carp,common carp,conger eel and Japanese eel)studied exhibited varying degrees of cross-reactivity,with the highest cross-reactivity being between turbot and bass and the lowest being between turbot and conger eel.The bioinformatics analysis revealed that the sequence homology of parvalbumin between conger eel and turbot was the lowest,which may account for the conger eel and turbot cross-reaction being so limited.Parvalbumin was a potent cross-reactive allergen found in turbot,large yellow croaker,sea bass,grass carp,common carp,conger eel and Japanese eel,and the cross-reactivity between conger eel and turbot parvalbumin was the weakest.Conclusion:This study demonstrated that the cross-reactivity between conger eel PV and turbot PV was the weakest. | Yeting Wu Youyou Lu Yuhao Huang Hong Lin Xuewen Dang Yujie Jing Zhaocheng Meng Xiangchen Wang Zhenxing Li | 2022 | Food Quality and Safety2022，6，4： | 0 |
| 9 | Urban Land Use Efficiency and Contributing Factors in the Yangtze River Delta Under Increasing Environmental Restrictions in China显示文摘Evaluating urban land use efficiency(ULUE) provides insights into the interactions between land use systems and their external environment. Specifically, changes in ULUE are important for monitoring urban transformation in developing countries. In this study, using a traditional input-output index model, we incorporated slack-based measurements and undesirable outputs into a SBM-UN(slack-based measure-undesirable) model to investigate ULUE within the context of increasing environmental restrictions in China. The model was used to estimate the ULUE of 26 cities in the highly developed urban agglomeration of the Yangtze River Delta from 2000 to2018. The average ULUE in the Yangtze River Delta was relatively low compared to that of developed city regions in the European Union(EU) and North America and exhibited a U-shaped curve over the study period. Incorporating undesirable outputs, such as environmental pollution, into the model reduced ULUE by 19.06%. ULUE varied spatially, with the kernel density estimation exhibiting a bimodal distribution. Efficiency decomposition analysis showed that scale efficiency made a greater contribution to ULUE than pure technical efficiency. Based on our findings, recommended approaches to improve ULUE include optimizing factor allocation, reducing undesirable outputs, and increasing the effective output per land unit. The study suggests that ULUE and the SBM-UN model are useful planning tools for sustainable urban development. | YANG Qingke WANG Lei QIN Xianhong FAN Yeting WANG Yazhu DING Linlin | 2022 | Chinese Geographical Science2022，32，5： | 0 |
| 10 | Trimetaphosphate-induced chiral selection between amino acid and nucleoside using ^(15)N-^(31)P coupling NMR显示文摘Life on Earth uses a common set of L-amino acids(L-aa)to construct proteins and D-nucleosides(D-Nu)to form nucleic acids,which serve as the carrier of genetic information.Herein,we reveal the in-trinsic mechanism of chiral selection of L-aa and D-Nu from the perspective of chemical origin of life.This work employed^(15)N-labeled L-aa and performed one-pot synthesis of nucleotide amidate of amino acid(N-aa-NMP)using equal amounts of L-^(15)N-aa and D-^(14)N-aa with D-/L-Nu in the aqueous solution of trimetaphosphate,generating L-^(15)N-aa-NMP and D-^(14)N-aa-NMP,respectively.The ^(31)P-NMR data indicated that L-aa was preferentially selected during the formation of N-aa-NMP in the presence of D-Nu.Surpris-ingly,D-aa was preferred over L-aa in the presence of L-Nu.Further analysis revealed that L-^(15)N-aa-D-NMP vs.D-^(14)N-aa-L-NMP and D-^(14)N-aa-D-NMP vs.L-^(15)N-aa-L-NMP were mirror isomers of each other,respec-tively.These data suggest that there could be a set of chiral systems opposite to that on Earth,which infers there might be a world of life that is a mirror image of the Earth. | Jianxi Ying Ruiwen Ding Yumeng Zhang Bowen Han Yeting Guo Ning Wang Dandan Guo Yile Wu Junwei Huang Yan Liu Feng Ni Shaohua Huang Yufen Zhao | 2022 | Chinese Chemical Letters2022，33，2： | 0 |
| 11 | Influence Mechanism of New-type Urbanization on Urban Land Use Efficiency in the Yangtze River Delta, China显示文摘Rapid urbanization in China has led to inefficient use of urban land and spatial structure disorder,attracting attention from academia and society.Taking the Yangtze River Delta,China as an example,this study constructed an index evaluation system that quantitatively analyses the impact of new-type urbanization(NTU)on urban land use efficiency(ULUE)from 2000 to 2020 using a panel data vector autoregressive model.The results show that NTU in the Yangtze River Delta promotes ULUE improvement.However,the promotion of NTU to ULUE is limited,and the level of urban economic development also plays a role in promoting the change of ULUE.Moreover,the study further analyzed the results of urbanization decomposition and found that population urbanization(PU),economic urbanization(EU),spatial urbanization(SU),and social urbanization(SCU)can explain changes in ULUE in the Yangtze River Delta to a certain extent.In terms of variance decomposition,PU contributed the most to ULUE,followed by EU,SU,and SCU.Some necessary measures should be taken to coordinate the development of different types of urbanization,improve the sustainable utilization level of land resources,and provide a reference for high-quality development in the Yangtze River Delta. | YANG Qingke DING Linlin WANG Lei LIU Chao FAN Yeting LI Ying WANG Yazhu | 2023 | Chinese Geographical Science2023，33，3： | 0 |
| 12 | COP1 SUPPRESSOR 6 represses the PIF4 and PIF5 action to promote light-inhibited hypocotyl growth显示文摘Light signaling precisely controls photomorphogenic development in plants.PHYTOCHROME INTERACTING FACTOR 4 and 5(PIF4 and PIF5)play critical roles in the regulation of this developmental process.In this study,we report CONSTITUTIVELY PHOTOMORPHOGENIC 1 SUPPRESSOR 6(CSU6)functions as a key regulator of light signaling.Loss of CSU6 function largely rescues the cop1-6 constitutively photomorphogenic phenotype.CSU6 promotes hypocotyl growth in the dark,but inhibits hypocotyl elongation in the light.CSU6 not only associates with the promoter regions of PIF4 and PIF5 to inhibit their expression in the morning,but also directly interacts with both PIF4 and PIF5 to repress their transcriptional activation activity.CSU6 negatively controls a group of PIF4-and PIF5-regulated gene expressions.Mutations in PIF4 and/or PIF5 are epistatic to the loss of CSU6,suggesting that CSU6 acts upstream of PIF4 and PIF5.Taken together,CSU6 promotes light-inhibited hypocotyl elongation by negatively regulating PIF4 and PIF5 transcription and biochemical activity. | Hongxia Lan Yueqin Heng Jian Li Mengdi Zhang Yeting Bian Li Chu Yan Jiang Xuncheng Wang Dongqing Xu Xing Wang Deng | 2022 | Journal of Integrative Plant Biology2022，64，11： | 0 |
| 13 | MHC class Ⅱ in renal tubules plays an essential role in renal fibrosis显示文摘Immunomodulation has been considered a potential therapeutic approach for chronic kidney disease(CKD).Although it has been previously reported that CD4+T cells contribute to the development of renal fibrosis after UUO,the role of MHC class Ⅱ(MHCII)in UUO-induced renal fibrosis remains largely uncharacterized.The present study reports that the expressions of MHCII molecules in renal cortical tubules are upregulated in a mouse unilateral ureter obstruction(UUO)model.Global or renal tubule-specific ablation of MHCII significantly alleviates renal fibrosis following UUO.Additionally,renal expression of profibrotic genes showcased consistent reduction in both MHCII gene deficient mouse lines.These results demonstrate that renal tubular MHCII plays an important role in pathogenesis of renal fibrosis. | Yunfeng Zhou Zhaokang Luo Chenghui Liao Rong Cao Zain Hussain Jie Wang Yeting Zhou Tie Chen Jie Sun Zhong Huang Baohua Liu Xiaoyan Zhang Youfei Guan Tuo Deng | 2021 | Cellular & Molecular Immunology2021，18，11： | 0 |
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