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| 1 | Numerical Simulation and Analysis of Solid-liquid Two-phase Flow in Centrifugal Pump显示文摘The flow with solid-liquid two-phase media inside centrifugal pumps is very complicated and the relevant method for the hydraulic design is still immature so far.There exist two main problems in the operation of the two-phase flow pumps,i.e.,low overall efficiency and severe abrasion.In this study,the three-dimensional,steady,incompressible,and turbulent solid-liquid two-phase flows in a low-specific-speed centrifugal pump are numerically simulated and analyzed by using a computational fluid dynamics(CFD) code based on the mixture model of the two-phase flow and the RNG k-two-equation turbulence model,in which the influences of rotation and curvature are fully taken into account.The coupling between impeller and volute is implemented by means of the frozen rotor method.The simulation results predicted indicate that the solid phase properties in two-phase flow,especially the concentration,the particle diameter and the density,have strong effects on the hydraulic performance of the pump.Both the pump head and the efficiency are reduced with increasing particle diameter or concentration.However,the effect of particle density on the performance is relatively minor.An obvious jet-wake flow structure is presented near the volute tongue and becomes more remarkable with increasing solid phase concentration.The suction side of the blade is subject to much more severe abrasion than the pressure side.The obtained results preliminarily reveal the characteristics of solid-liquid two-phase flow in the centrifugal pump,and are helpful for improvement and empirical correction in the hydraulic design of centrifugal pumps. | ZHANG Yuliang LI Yi CUI Baoling ZHU Zuchao DOU Huashu | 2013 | Chinese Journal of Mechanical Engineering2013，26，1： | 55 |
| 2 | Intravoxel incoherent motion diffusion-weighted magnetic resonance imaging for predicting histological grade of hepatocellular carcinoma:Comparison with conventional diffusion-weighted imaging显示文摘AIM To compare intravoxel incoherent motion(IVIM)-derived parameters with conventional diffusion-weighted imaging(DWI) parameters in predicting the histological grade of hepatocellular carcinoma(h CC) and to evaluate the correlation between the parameters and the histological grades.METHODS A retrospective study was performed. Sixty-two patients with surgically confirmed h CCs underwent diffusion-weighted magnetic resonance imaging with twelve b values(10-1200 s/mm^2). The apparent diffusion coefficient(ADC), pure diffusion coefficient(D), pseudo-diffusion coefficient(D*), and perfusion fraction(f) were calculated by two radiologists. The IVIM and conventional DWI parameters were compared among the different grades by using analysis of variance(ANOVA) and the Kruskal-Wallis test. Receiver operating characteristic(ROC) analysis was performed to evaluate the diagnostic efficiency of distinguishing between low-grade(grade 1, G1) and high-grade(grades 2 and 3, G2 and G3) hC C. The correlation between the parameters and the histological grades was assessed by using the Spearman correlation test. Bland-Altman analysis was used to evaluate the reproducibility of the two radiologists' measurements.RESULTS The differences in the ADC and D values among the groups with G1, G2, and G3 histological grades of HCCs were statistically significant(P < 0.001). The D* and f values had no significant differences among the different histological grades of h CC(P > 0.05). The ROC analyses demonstrated that the D and ADC values had better diagnostic performance in differentiating the low-grade h CC from the high-grade h CC, with areas under the curve(AUCs) of 0.909 and 0.843, respectively, measured by radiologist 1 and of 0.911 and 0.852, respectively, measured by radiologist 2. The following significant correlations were obtained between the ADC, D, and D~* values and the histological grades: r =-0.619(P < 0.001), r =-0.628(P < 0.001), and r =-0.299(P = 0.018), respectively, as measured by radiologist 1; r =-0.622(P < 0.001), r =-0.633(P < 0.001), and r =-0.303(P = 0.017), respectively, as measured by radiologist 2. The intra-class correlation coefficient(ICC) values between the two observers were 0.996 for ADC, 0.997 for D, 0.996 for D*, and 0.992 for f values, which indicated excellent interobserver agreement in the measurements between the two observers.CONCLUSION The IVIM-derived D and ADC values show better diagnostic performance in differentiating high-grade hC C from low-grade hC C, and there is a moderate to good correlation between the ADC and D values and the histological grades. | Shao-Cheng Zhu Yue-Hua Liu Yi Wei Lin-Lin Li She-Wei Dou Ting-Yi Sun Da-Peng Shi | 2018 | World Journal of Gastroenterology2018，24，8： | 33 |
| 3 | Clinical significance of diabetes on symptom and patient delay among patients with acute myocardial infarction——an analysis from China Acute Myocardial Infarction(CAMI) registry显示文摘Background Diabetes is frequently associated with poor prognosis among acute myocardial infarction(AMI)patients.Patients with these comorbidities often have atypical symptoms and subsequent delay in treatment.Few studies have reported detailed AMI symptoms in patients with diabetes.This study compared AMI symptoms and presentation characteristics between diabetics and non-diabetics.Methods We included patients from the China AMI registry diagnosed with AMI between January 2013 and September 2014.Baseline characteristics,symptomology,and delay in treatment were compared between diabetics and non-diabetics.Multivariable logistic regression analysis was used to explore independent predictors of atypical symptoms.Results A total of 4450(20.2%)patients had diabetes.They were older,more often women,higher in body mass index,and more likely to have non-ST segment elevation myocardial infarction.Fewer diabetic patients presented with persistent precordial chest pain(63.1%vs.68%,P<0.0001),diaphoresis(60.1%vs.65.6%,P<0.0001),fatigue(16.7%vs.18.3%,P=0.0123),and incontinence(0.4%vs.0.7%,P=0.0093).Time to hospital presentation was longer among patients with diabetes than those without.In multivariable analysis,diabetes was identified as an independent predictor of atypical symptoms(OR:1.112,95%CI:1.034?1.196).Conclusions Our study is the first large-scale study providing evidence that diabetics are less likely to present with typical chest pain and more likely to experience treatment delay when suffering from an AMI.Our results may increase clinician awareness of recognizing AMI patients rapidly to reduce diagnosis and treatment delay,particularly in the context of diabetes. | Rui FU Si-Dong LI Chen-Xi SONG Jing-Ang YANG Hai-Yan XU Xiao-Jin GAO Yi XU Jian-Ping ZENG Jun-Nong LI Ke-Fei DOU Yue-Jin YANG on behalf of the CAMI Registry study group Beijing,China | 2019 | Journal of Geriatric Cardiology2019，16，5： | 21 |
| 4 | Qualitative and Quantitative Analysis of Alkaloids in Cortex Phellodendri by HPLC-ESI-MS/MS and HPLC-DAD显示文摘A combined method of high performance liquid chromatograph-elecrtrospray-ionization mass spectrometer(HPLC-ESI-MS/MS) coupled with a photodiode array detector(HPLC-DAD) and principal component analysis(PCA) was applied to the qualitative and quantitative analyses of alkaloids in Cortex Phellodendri(CP) samples, and to the differentiation of two species of CP, Cortex Phellodendri Chinensis(CPC) and Cortex Phellodendri Amurensis(CPA). Twenty-two peaks appeared in the HPLC-MS base peak chromatogram of CP detected by the HPLC-ESI-MS/MS analysis, and the alkaloids were identified according to the MSn data, the known MS fragmentation rules and the literature data. Five alkaloids including berberine, palmatine, jatrorrhizine, phellodendrine and magnoflorine were simultaneously determinated by the HPLC-DAD. Berberine was the primary component in all CP samples, and the contents of berberine and palmatine were exploited to be two critical parameters for effective discrimination between the two species of CP. The average content of berberine in CPC(58.75 mg/g) was higher than that in CPA(9.16 mg/g), while the content of palmatine was less, only 0.25 mg/g in CPC and 4.19 mg/g in CPA. With the use of PCA, samples datasets were separated successfully into two different clusters corresponding to the two species, and berberine, palmatine, phellodendrine and magnoflorine contribute most to the above mentioned calssifying. The proposed method proved to be a useful tool in the quality control of Chinese herbal medicines. | ZHU Shuang-lai DOU Sheng-shan LIU Xin-ru LIU Run-hui ZHANG Wei-dong HUANG Hong-lin ZHANG Yi HU Yao-hua WANG Shu-ping | 2011 | Chemical Research in Chinese Universities2011，27，1： | 19 |
| 5 | Protein kinase A-mediated cardioprotection of Tongxinluo relates to the inhibition of myocardial inflammation, apoptosis, and edema in reperfused swine hearts显示文摘 | LI Xiang-dong YANG Yue-jin CHENG Yu-tong DOU Ke-fei TIAN Yi MENG Xian-min | 2013 | Chinese Medical Journal2013，，8： | 18 |
| 6 | H2A.Z Represses Gene Expression by Modulating Promoter Nucleosome Structure and Enhancer Histone Modifications in Arabidopsis显示文摘 | Xiaozhuan Dai Youhuang Bai Lihua Zhao Xianying DOU Yanhui Liu Lulu Wang Yi Li Weimin Li Yanan Hui Xinyu Huang Zonghua Wang Yuan Qin | 2017 | Molecular Plant2017，10，10： | 14 |
| 7 | Expression of somatostatin mRNA in various differentiated types of gastric carcinoma显示文摘ExpressionofsomatostatinmRNAinvariousdiferentiatedtypesofgastriccarcinomaZHANGQinXian,DOUYingLi,SHIXueYiandDINGYiSubjecth... | ZHANG Qin-Xian DOU Ying-Li SHI Xue-Yi DING Yi | 1998 | World Journal of Gastroenterology1998，4，1： | 10 |
| 8 | Structural, optical, and electrical properties of phase- controlled cesium lead iodide nanowires显示文摘铯铅碘化物(在它的黑 perovskite 阶段的 CsPbI 3), ,为光电的应用有合适的 bandgap 和高量效率。然而, CsPbI 3 趋于到 crystalize 进一个黄 non-perovskite 阶段,它有差的 optoelectronic 性质,在房间温度。因此,在 CsPbI 3 控制阶段转变为这材料的实际申请是批评的。这里,我们报导一个维的 CsPbI 3 nanowires 和他们的相应结构、光、电的性质的阶段转变的系统的研究。我们通过快速的热熄灭从 non-perovskite 黄阶段显示出 perovskite 黑人阶段 CsPbI 3 nanowires 的形成。transformed 以后黑阶段 CsPbI 3 nanowires 展览与一从 2.78 ~ 1.76 eV 缩小 bandgap 增加了光致发光排放紧张。perovskite nanowires 是光导的并且在房间温度显示出快 photoresponse 和优秀稳定性。这些有希望的光、电的性质为许多 nanoscale optoelectronic 设备使 perovskite CsPbI3 nanowires 吸引人。 | Minliang Lai Qiao Kong Connor G. Bischak Yi Yu Letian Dou Samuel W. Eaton Naomi S. Ginsberg Peidong Yang | 2017 | Nano Research2017，10，4： | 8 |
| 9 | A Local Cluster of Omicron Variant COVID-19 Likely Caused by Internationally Mailed Document——Beijing Municipality,China,January 2022显示文摘On January 15,2022,a 26 years old female(Case A)went to a sampling site for coronavirus disease 2019(COVID-19)testing due to excessive fatigue and fever for two days.This patient preliminarily tested positive for severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)using a quantitative real-time reverse transcription polymerase chain reaction(qRT-PCR)method. | Daitao Zhang Shuangsheng Wu Zhenyong Ren Ying Sun Xiangfeng Dou Zhaomin Feng Fu Li Yi Tian Shujuan Cui Baiwei Liu Bing Lyu Xiaoli Wang Feng Liu Lina Jin Chu Jiang Lina Tian Zhenjiang Xin Zhichao Liang Lei Jia Quanyi Wang Yang Pan Peng Yang | 2022 | China CDC weekly2022，4，14： | 6 |
| 10 | Epigenetic modification in histone deacetylase deletion strain of Calcarisporium arbuscula leads to diverse diterpenoids显示文摘Epigenetic modifications have been proved to be a powerful way to activate silent gene clusters and lead to diverse secondary metabolites in fungi. Previously, inactivation of a histone H3 deacetylase in Calcarisporium arbuscula had led to pleiotropic activation and overexpression of more than 75% of the biosynthetic genes and isolation of ten compounds. Further investigation of the crude extract of C. arbuscula Δhda A strain resulted in the isolation of twelve new diterpenoids including three cassanes(1-3), one cleistanthane(4), six pimaranes(5-10), and two isopimaranes(11 and 12) along with two know cleistanthane analogues. Their structures were elucidated by extensive NMR spectroscopic data analysis. Compounds 2 and 4 showed potent inhibitory effects on the expression of MMP1 and MMP2(matrix metalloproteinases family) in human breast cancer(MCF-7) cells. | Jian Bai Rong Mu Man Dou Daojiang Yan Bingyu Liu Qian Wei Jun Wan Yi Tang Youcai Hu | 2018 | Acta Pharmaceutica Sinica B2018，8，4： | 5 |
| 11 | Experimental Study on a Centrifugal Pump with an Open Impeller during Startup Period显示文摘Transient performance of fluid machinery during transient operating periods,such as startup and stopping,has been drawn more attentions recently due to the growing engineering needs.In this paper,the transient behavior of a prototype centrifugal pump with an open impeller during rapid startup period is studied experimentally.The variations of the rotational speed,flow rate,head,and shaft power during rapid startup period are recorded in experiments at different discharge valve openings.In addition,the non-dimensional flow rate and head are also used to analyze the transient behavior.The research result shows that the rise characteristic of the rotational speed is not basically changed by working points,while mainly depends on the startup characteristics of the driving motor.Compared with the rapid rise of the rotational speed,the flow rate rises slowly in the initial stage of startup.Moreover,the flow rate lags behind the rotational speed to rise to final stable value,and the delay becomes more severe with the increase of the discharge valve opening.The shaft power impact phenomenon generally exists in the process of startup.The non-dimensional analysis shows that the non-dimensional head is very high at the very beginning of startup,and quickly falls to the minimum,then gradually rises to final stable value,while the non-dimensional flow rate always shows the rise tendency during whole startup period.In conclusion,it is found from the non-dimensional results that the quasi-steady analysis is unable to accurately assess the transient flow during startup period. | Yuliang Zhang Zuchao Zhu Yingzi Jin Baoling Cui Yi Li Huashu Dou | 2013 | Journal of Thermal Science2013，22，1： | 5 |
| 12 | WBC27,an Adenosine Tri-phosphate-binding Cassette Protein,Controls Pollen Wall Formation and Patterning in Arabidopsis显示文摘In flowering plants,the exine components are derived from tapetum.Despite its importance to sexual plant reproduction,little is known about the translocation of exine materials from tapetum to developing microspores.Here we report functional characterization of the arabidopsis WBC27 gene.WBC27 encodes an adenosine tri-phosphate binding cassette(ABC) transporter and is expressed preferentially in tapetum.Mutation of WBC27 disrupted the exine formation.The wbc27 mutant microspores began to degenerate once released from tetrads and most of the microspores collapsed at the uninucleate stage.Only a small number of wbc27-1 microspores could develop into tricellular pollen grains.These survival pollen grains lacked exine and germinated in the anther before anthesis.All of these results suggest that the ABC transporter,WBC27 plays important roles in the formation of arabidopsis exine,possibly by translocation of lipidic precursors of sporopollenin from tapetum to developing microspores. | Xiao-Ying Dou Ke-Zhen Yang Yi Zhang Wei Wang Xiao-Lei Liu Li-Qun Chen Xue-Qin Zhang De Ye | 2011 | Journal of Integrative Plant Biology2011，53，1： | 5 |
| 13 | Pt/WO_3/C nanocomposite with parallel WO_3 nanorods as cathode catalyst for proton exchange membrane fuel cells显示文摘Pt/WO3/C nanocomposites with parallel WO3 nanorods were synthesized and applied as the cathode catalyst for proton exchange membrane fuel cells(PEMFCs). Electrochemical results and single cell tests show that an enhanced activity for the oxygen reduction reaction(ORR) is obtained for the Pt/WO3/C catalyst compared with Pt/C. The higher catalytic activity might be ascribed to the improved Pt dispersion with smaller particle sizes. The Pt/WO3/C catalyst also exhibits a good electrochemical stability under potential cycling. Thus, the Pt/WO3/C catalyst can be used as a potential PEMFC cathode catalyst. | Meiling Dou Ming Hou Zhilin Li Feng Wang Dong Liang Zhigang Shao Baolian Yi | 2015 | Journal of Energy Chemistry2015，24，1： | 4 |
| 14 | Synergistic impact of cocatalysts and hole scavenger for promoted photocatalytic H2 evolution in mesoporous TiO2–NiSx hybrid显示文摘Photocatalytic solar energy conversion to hydrogen is sustainable and attractive for addressing the global energy and environmental issue. Herein, a novel photocatalytic system (NiS/Ni3S4 cocatalysts modified mesoporous TiO2) with superior photocatalytic hydrogen evolution capability through the synergistic impact of NiS/Ni3S4 (NiSx) cocatalyst and efficient hole scavenger has been demonstrated. The photocatalytic hydrogen evolution of TiO2-NiSx hybrids with the different content of NiSx and upon different organic hole scavengers was both investigated. The hybrid of TiO2 decorated with 3%(mole ratio of Ni^2+) NiSx cocatalyst in methanol solution showed the optimal photocatalytic hydrogen evolution rate of 981.59 μmol h^-1 g^-1 which was about 20 times higher than that of bare mesoporous TiO2. Our results suggested that the boosted hydrogen production performance is attributed to both the improved photoinduced electrons migration between NiS and Ni3S4 in cocatalyst and the high hole captured efficiency by hole scavengers of methanol. | Yi Wei Gang Cheng Jinyan Xiong Jiaxin Zhu Yixin Gan Mengmeng Zhang Zhen Li Shixue Dou | 2019 | Journal of Energy Chemistry2019，28，5： | 3 |
| 15 | Combined detection and subclass characteristics analysis of CTCs and CTECs by SE-iFISH in ovarian cancer显示文摘Objective:Hematogenous metastasis is essential for the progression of ovarian cancer(OC),and circulating tumor cells(CTCs)are part of the metastatic cascade.However,the detection rate of CTC is low due to the use of less sensitive detection methods.Therefore,this study aimed to detect CTCs and circulating tumorigenic endothelial cells(CTECs)in patients with OC using subtraction enrichment and immunostaining and fluorescence in situ hybridization(SE-iFISH).Methods:We enrolled a total of 56 subjects,including 20 OC patients and 36 ovarian benign tumor patients.CTCs and CTECs were captured by subtraction enrichment(SE)and counted and classified according to immunofluorescence staining of tumor markers(TMs)carbohydrate antigen 125(CA125)and human epididymis protein 4(HE4)combined with fluorescence in situ hybridization(iFISH)of chromosome 8(Chr8)aneuploidy.The diagnostic value and subtype characteristics of CTCs and CTECs were investigated.Results:The detection rate of CTCs by SE-iFISH was high.Compared with CA125 and HE4,Chr8 aneuploidy was the major identification feature of CTC.CTC counts in OC were statistically higher than those in benign groups.CTC and CTEC with≥pentaploidy were detected in both groups,illustrating the poor diagnostic value of CTC or CTEC.Distributions of triploid and tetraploid CTC subtypes were significantly different,and combined detection of triploid and tetraploid CTCs showed the best diagnostic value.In contrast,the distribution of CTECs in the OC and benign groups had no statistically significant difference.Small CTCs accounted for over 1/3 of the total CTC count.We also found that small CTCs and CTECs primarily comprised triploid cells,while large CTCs and CTECs mainly comprised pentaploidy and beyond.Conclusions:The application of SE-iFISH offered a more comprehensive understanding of heterogeneous CTCs and CTECs in OC.Analysis of subclass characteristics of the CTCs and CTECs according to Chr8 aneuploidy and cell size may broaden their potential clinical utility and deepen mechanistic studies in OC. | Hongyan Cheng Shang Wang Wenqing Luan Xue Ye Sha Dou Zhijian Tang Honglan Zhu Peter Ping Lin Yi Li Heng Cui Xiaohong Chang | 2021 | Chinese Journal of Cancer Research2021，33，2： | 3 |
| 16 | Cholecystectomy is associated with higher risk of recurrence after microwave ablation of hepatocellular carcinoma:a propensity score matching analysis显示文摘Objective:To explore the association between cholecystectomy and the prognostic outcomes of patients with hepatocellular carcinoma(H CC)who underwent microwave ablation(MWA).Methods:Patients with HCC(«=921)who underwent MWA were included and divided into cholecystectomy(n=114)and non-cholecystectomy groups(n=807).After propensity score matching(PSM)at a 1:2 ratio,overall survival(OS)and disease-free survival(DFS)rates were analyzed to compare prognostic outcomes between the cholecystectomy(«=114)and non-cholecystectomy groups(n=228).Univariate and multivariate Cox analyses were performed to assess potential risk factors for OS and DFS.Major complications were also compared between the groups.Results:After matching,no significant differences between groups were observed in baseline characteristics.The 1-,3-,and 5-year OS rates were 96.5%,82.1%,and 67.1%in the cholecystectomy group,and 97.4%,85.2%,and 74.4%in the non-cholecystectomy group(P=0.396);the 1-,3-,and 5-year DFS rates were 58.4%,34.5%,and 26.6%in the cholecystectomy group,and 73.6%,44.7%,and 32.2%in the non-cholecystectomy group(P=0.026),respectively.The intrahepatic distant recurrence rate in the cholecystectomy group was significantly higher than that in the non-cholecystectomy group(P=0.026),and the local tumor recurrence and extrahepatic recurrence rates did not significantly differ between the groups(P=0.609 and P=0.879).Multivariate analysis revealed that cholecystectomy(HR=1.364,95%Cl 1.023-1.819,P=0.035),number of tumors(2 vs.1:HR=2.744,95%Cl 1.925-3.912,P<0.001;3 vs.1:HR=3.411,95%Cl 2.021-5.759,P<0.001),and y-GT levels(HR=1.003,95%Cl 1.000-1.006,P<0.024)were independent risk factors for DFS.The best y-GT level cut-off value for predicting median DFS was 39.6 U/L(area under the curve=0.600,P<0.05).A positive correlation was observed between cholecystectomy and y-GT level(r=0.108,95%Cl-0.001-0.214,P=0.047).Subgroup analysis showed that the DFS rates were significantly higher in the non-cholecystectomy group than the cholecystectomy group when Y-GT>39.6 U/L(i3=0.044).The 5-,10-,15-,20-,and 25-year recurrence rates from the time of cholecystectomy were 2.63%,21.93%,42.11%,58.77%,and 65.79%,respectively.A significant positive correlation was observed between cholecystectomy and the time from cholecystectomy to recurrence(r=0.205,95%Cl 0.016-0.379,P=0.029).There were no significant differences in complications between groups(P=0.685).Conclusions:Patients with HCC who underwent cholecystectomy were more likely to develop intrahepatic distant recurrence after MWA,an outcome probably associated with increased y-GT levels.Moreover,the recurrence rates increased with time. | Hongcai Yang Yi Yang Jianping Dou Rui Cui Zhigang Cheng Zhiyu Han Fangyi Liu Xiaoling Yu Xiang Zhou Jie Yu Ping Liang | 2020 | Cancer Biology & Medicine2020，17，2： | 3 |
| 17 | Preparation of Ultrafine Water-soluble Polymers Nanofiber Mats via Electrospinning显示文摘A series of water-soluble polymers such as poly(ethylene oxide)(PEO),polyacrylamide(PAM) and poly(vinyl pyrrilidone)(PVP) was successfully prepared via the electrospinning of their aqueous solutions without the use of a surfactant.The effects of solution properties on the electrospinning of PEO,PAM and PVP solutions were investigated.The viscosity of the solution,charge density carried by the jet,and the surface tension of the solution are the key factors that influence the morphology and diameter size of the fibers.The viscosity of the solution was measured on a modular compact rheometer.The morphology and the diameter size distribution of the fibers were observed under an environmental scanning electron microscope(ESEM).The results show that the diameters of the nanofibers electrospun from the solutions of these water soluble polymers were uniform and less than 300 nm. | SUN Guo-en TENG Hong ZHANG Chun-ling DOU Yan-li LI Yi | 2010 | Chemical Research in Chinese Universities2010，26，2： | 3 |
| 18 | Three new diarylheptanoids and their antioxidant property显示文摘三新 diarylheptanoids,即,钠(5S,2E )-1,7-bis(4-hydroxyphenyl)-1-hydroxy-2-hepten-5-sulfonate (1 ) ,钠(5R,2E )-1,7-bis(4-hydroxyphenyl)-1-hydroxy-2-hepten-5-sulfonate (2 ) 和 3,5-diacetoxy-1-(3-methoxy-4,5-dihydroxyphenyl )-7-(4-hydroxy-3-methoxyphenyl)heptane (3 ) 从姜 officinale 的根茎被孤立。新混合物的结构根据分光镜的方法被阐明。3 的抗氧化剂活动在包含 DPPH 自由激进分子和超级氧化物阴离子激进分子的 vitro 模型旁边是 assayed。 | Chang Xin Zhou Xiang Yi Zhang Xiao Wu Dong Qiao Feng Tao Hui Dou Rong Ping Zhang Ke Xin Huang Xiao Kun Li Chang Xiang Chen Su Zeng Yu Zhao | 2007 | Chinese Chemical Letters2007，18，10： | 2 |
| 19 | Application of Scanning Tunneling Microscopy in Electrocatalysis and Electrochemistry显示文摘Scanning tunneling microscopy(STM)has gained increasing attention in the field of electrocatalysis due to its ability to reveal electrocatalyst surface structures down to the atomic level in either ultra-high-vacuum(UHV)or harsh electrochemical conditions.The detailed knowledge of surface structures,surface electronic structures,surface active sites as well as the interaction between surface adsorbates and electrocatalysts is highly beneficial in the study of electrocatalytic mechanisms and for the rational design of electrocatalysts.Based on this,this review will discuss the application of STM in the characterization of electrocatalyst surfaces and the investigation of electrochemical interfaces between electrocatalyst surfaces and reactants.Based on different operating conditions,UHV-STM and STM in electrochemical environments(EC-STM)are discussed separately.This review will also present emerging techniques including high-speed EC-STM,scanning noise microscopy and tip-enhanced Raman spectroscopy. | Haifeng Feng Xun Xu Yi Du Shi Xue Dou | 2021 | Electrochemical Energy Reviews2021，4，2： | 2 |
| 20 | Identification of novel molecular markers of mastitis caused by Staphylococcus aureus using gene expression profiling in two consecutive generations of Chinese Holstein dairy cattle显示文摘Background: Mastitis in dairy cows caused by Staphylococcus aureus is a major problem hindering economic growth in dairy farms worldwide. It is difficult to prevent or eliminate due to its asymptomatic nature and long persistence of infection. Although transcriptomic responses of bovine mammary gland cells to pathogens that cause mastitis have been studied, the common responses of peripheral blood leukocytes to S. aureus infection across two consecutive generations of dairy cattle have not been investigated.Methods: In the current study, RNA-Seq was used to profile the transcriptomes of peripheral blood leukocytes sampled from S. aureus-infected mothers and their S. aureus-infected daughters, and also healthy non-infected mothers and their healthy daughters. Differential gene expression was evaluated as follows: 1) S. aureus-infected cows versus healthy non-infected cows(S vs. H, which include all the mothers and daughters), 2) S. aureus-infected mothers versus healthy non-infected mothers(SM vs. HM), and 3) S. aureus-infected daughters versus healthy noninfected daughters(SMD vs. HMD).Results: Analysis of all identified expressed genes in the four groups(SM, SMD, HM, and HMD) showed that EPOR,IL9, IFNL3, CCL26, IL26 were exclusively expressed in both the HM and HMD groups, and that they were significantly(P < 0.05) enriched for the cytokine-cytokine receptor interaction pathway. A total of 17, 13 and 10 differentially expressed genes(DEGs)(FDR Padj. < 0.1 and |FC| > 1.2) were detected in the three comparisons, respectively. DEGs with P < 0.05 and |FC| > 2 were used for functional enrichment analyses. For the S vs. H comparison, DEGs detected included CCL20, IL13 and MMP3, which are associated with the IL-17 signaling pathway. In the SM vs. HM and SMD vs. HMD comparisons, five(BLA-DQB, C1 R, C2, FCGR1 A, and KRT10) and six(BLA-DQB, C3 AR1, CFI, FCAR, FCGR3 A, and LOC10498484) genes, respectively, were involved in the S. aureus infection pathway.Conclusions: Our study provides insights into the transcriptomic responses of bovine peripheral blood leukocytes across two generations of cattle naturally infected with S. aureus. The genes highlighted in this study could serve as expression biomarkers for mastitis and may also contain sequence variation that can be used for genetic improvement of dairy cattle for resilience to mastitis. | Di Wang Lei Liu Serafino M.A.Augustino Tao Duan Thomas J.Hall David E.MacHugh Jinhuan Dou Yi Zhang Yachun Wang Ying Yu | 2021 | Journal of Animal Science and Biotechnology2021，12，1： | 2 |
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