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| 1 | Spatial Distribution of Traditional Villages and Influence Factors in Hunan Province显示文摘To develop and protect traditional villages reasonably, this paper applied Arc GIS Spatial Analyst Tools to analyze spatial distribution and infl uence factors of 101 traditional villages in Hunan Province. The research showed the agglomerate distribution of traditional villages in Hunan; from the city scale, distribution of traditional villages was concentrated mainly in West Hunan Tujia Nationality Autonomous Prefecture, Chenzhou, Yongzhou, Huaihua and Shaoyang; concentrated distribution of traditional villages in the fi ve major geographic regions showed poor equilibrium, West Hunan had the most concentrated traditional villages, and South Hunan has the second most; relatively closed regional environment, perilous hills, inconvenient transportation, and underdeveloped social economy contributed to the protection of traditional villages, and they were all signifi cant infl uence factors for the distribution of traditional villages in Hunan. | LI Bohua YIN Sha LIU Peilin DOU Yindi | 2016 | Journal of Landscape Research2016，8，2： | 4 |
| 2 | Conophylline Promotes the Proliferation of Immortalized Mesenchymal Stem Cells Derived from Fetal Porcine Pancreas (iPMSCs)显示文摘Conophylline, is a bis (indole) alkaloid consisting of two pentacyclic aspidosperma skeletons, isolated from Tabernaemontana divaricata, which has been found to induce β-cell differentiation in rat pancreatic acinar carcinoma cells and in cultured rat pancreatic tissue. However, the precise role of conophylline in the growth and survival of immortalized pancreatic mesenchymal stem cells (iPMSCs) derived from fetal porcine pancreas were not understood at present. To determine whether this molecule is involved in controlling the proliferation of iPMSCs, we examined the effects of conophylline on iPMSCs. We found that conophylline can robustly stimulate iPMSCs proliferation, even promote their potential differentiation into islet-like clusters analyzed by cell counting, morphology, RT-PCR and real-time PCR, Western blotting, glucose-stimulated insulin release and insulin content analysis. The effects of conophylline were inhibited by LY294002, which is the inhibitor of the PI3K pathway. These results suggest that conophylline plays a key role in the regulation of cell mass proliferation, maintenance of the undifferentiated state of iPMSCs and also promotes iPMSCs differentiated into insulin-producing cells. | ZHANG Hui-ru LI Dan CAO Hui Lü Xiao CHU Yuan-kui BAI Yao-fu JIN Ya-ping PENG Sha DOU Zhong-ying HUA Jin-lian | 2013 | Journal of Integrative Agriculture2013，12，4： | 3 |
| 3 | Combined detection and subclass characteristics analysis of CTCs and CTECs by SE-iFISH in ovarian cancer显示文摘Objective:Hematogenous metastasis is essential for the progression of ovarian cancer(OC),and circulating tumor cells(CTCs)are part of the metastatic cascade.However,the detection rate of CTC is low due to the use of less sensitive detection methods.Therefore,this study aimed to detect CTCs and circulating tumorigenic endothelial cells(CTECs)in patients with OC using subtraction enrichment and immunostaining and fluorescence in situ hybridization(SE-iFISH).Methods:We enrolled a total of 56 subjects,including 20 OC patients and 36 ovarian benign tumor patients.CTCs and CTECs were captured by subtraction enrichment(SE)and counted and classified according to immunofluorescence staining of tumor markers(TMs)carbohydrate antigen 125(CA125)and human epididymis protein 4(HE4)combined with fluorescence in situ hybridization(iFISH)of chromosome 8(Chr8)aneuploidy.The diagnostic value and subtype characteristics of CTCs and CTECs were investigated.Results:The detection rate of CTCs by SE-iFISH was high.Compared with CA125 and HE4,Chr8 aneuploidy was the major identification feature of CTC.CTC counts in OC were statistically higher than those in benign groups.CTC and CTEC with≥pentaploidy were detected in both groups,illustrating the poor diagnostic value of CTC or CTEC.Distributions of triploid and tetraploid CTC subtypes were significantly different,and combined detection of triploid and tetraploid CTCs showed the best diagnostic value.In contrast,the distribution of CTECs in the OC and benign groups had no statistically significant difference.Small CTCs accounted for over 1/3 of the total CTC count.We also found that small CTCs and CTECs primarily comprised triploid cells,while large CTCs and CTECs mainly comprised pentaploidy and beyond.Conclusions:The application of SE-iFISH offered a more comprehensive understanding of heterogeneous CTCs and CTECs in OC.Analysis of subclass characteristics of the CTCs and CTECs according to Chr8 aneuploidy and cell size may broaden their potential clinical utility and deepen mechanistic studies in OC. | Hongyan Cheng Shang Wang Wenqing Luan Xue Ye Sha Dou Zhijian Tang Honglan Zhu Peter Ping Lin Yi Li Heng Cui Xiaohong Chang | 2021 | Chinese Journal of Cancer Research2021，33，2： | 3 |
| 4 | A study on the reaction kinetics of HCI removal from high-temperature coal gas显示文摘 | Dou B L Gao J S Sha X Z | 2001 | Fuel Processing Technology2001，72，1： | 1 |
| 5 | Catalytic cracking of tar component from high-temperature fuel gas显示文摘 | DOU Bin-lin GAO Jin-sheng SHA Xing-zhong | 2003 | Applied Thermal Engineering2003，23，17： | 1 |
| 6 | A New Method to Construct Traveling Wave Solutions for the Klein-Gordon-Zakharov Equations显示文摘 | Zai-Yun Zhang Juan Zhong Sha Sha Dou Jiao Liu Dan Peng Ting Gao | 2013 | Romanian Journal of Physics2013，，： | 1 |
| 7 | Study on the reaction kinetics of HC1 removal from a high-temperature coal gas 显示文摘 | Dou B L Gao J S Sha X Z | 2001 | Fuel Processing Technology2001，72，1： | 1 |
| 8 | Notch Signaling Activation Promotes Seizure Activity in Temporal Lobe Epilepsy显示文摘 | Longze Sha Xiaofeng Wu Yuan Yao Bo Wen Jing Feng Zhiqiang Sha Xueqin Wang Xiaoliang Xing Wanchen Dou Liri Jin Wenting Li Naili Wang Yan Shen Jinhui Wang Liwen Wu Qi Xu | 2014 | Molecular Neurobiology2014，，2： | 1 |
| 9 | Study of Imidazolium Ionic Liquids:Temperature-dependent Fluorescence and Molecular Dynamics Simulation显示文摘The steady-state fluorescence spectra and molecular dynamics simulations were explored to investigate the temperature dependent organization in some imidazolium ionic liquids:1-butyl-3-methylimidazolium hexafluo-rophosphate([bmim][PF6]),1-ethyl-3-methylimidazolium ethylsulfate([emim][EtSO4]) and 1-butyl-3-methylimida-zolium tetrafluoroborate([bmim][BF4]).The pure room temperature ionic liquids(ILs) exhibit a large red shift at more than an excitation wavelength of around 340 nm,which demonstrates the heterogeneous nature of the liquids.Furthermore,the fluorescence spectra of the ionic liquids were found to be temperature-dependent.The emission intensity gradually decreased with increasing temperature for the neat ionic liquids and the mixed solutions of [bmim][BF4]-H2O,which was the special phenomena induced by not only the local structure but also the viscosity.The molecular dynamics simulation further confirms that the structures of ionic liquids are sensitive to the surroun-ding environment because of the aggregation degree of ILs. | FU Hai-ying ZHU Guang-lai WU Guo-zhong SHA Mao-lin DOU Qiang | 2011 | Chemical Research in Chinese Universities2011，27，4： | 1 |
| 10 | A monoclonal antibody targeting neuropilin-1 inhibits adhesion of MCF7 breast cancer cells to fibronectin by suppressing the FAK/p130cas signaling pathway显示文摘 | Fanwei Zeng Fanghong Luo Sha Lv Haipeng Zhang Chang Cao Xiaoli Chen Shengyu Wang Zhe Li Xianjiang Wang Xiaofeng Dou Yujuan Dai Mingjun He Yafei Zhang Haiyan Lv Jianghua Yan Yuqiang Chen | 2014 | Anti-Cancer Drugs2014，，： | 1 |
| 11 | Catalytic cracking of tar component from high-temperature fuel gas显示文摘 | Binlin Dou Jinsheng Gao Xingzhong Sha | 2003 | Applied thermal engineering2003，23，： | 1 |
| 12 | A study on the reaction kinetics of HCl removal from high-temperature coal gas显示文摘 | GAO Jin-sheng SHA Xing-zhong | 2001 | Fuel Process Technol2001，72，1： | 1 |
| 13 | Catalytic cracking of tar component from high-temperature fuel gas显示文摘 | Dou B Gao J Sha X | 2003 | Applied Thermal Engineering2003，23，17： | 1 |
| 14 | High temperature removal of NH3, organic sulfur, HCl and tar component from coal derived gas显示文摘 | DOU B ZHANG M GAO J SHEN W SHA X | 2002 | Ind Eng Chem Res2002，41，17： | 1 |
| 15 | Catalytic cracking of tar component from high-temperature fuel gas 显示文摘 | Dou B L Gao J S Sha X Z | 2003 | Applied Thermal Engineering2003，23，： | 1 |
| 16 | Dynamic modeling of fluid-conveying pipes restrained by a retaining clip显示文摘Although most pipes are restrained by retaining clips in aircraft,the influence of the clip parameters on the vibration of the fluid-conveying pipe has not been revealed.By considering the clip width,a new dynamic model of a fluid-conveying pipe restrained by an intermediate clip is established in this paper.To demonstrate the necessity of the proposed model,a half pipe model is established by modeling the clip as one end.By comparing the two models,it is found that the half pipe model overestimates the critical velocity and may estimate the dynamical behavior of the pipe incorrectly.In addition,with the increase in the clip stiffness,the conversion processes of the first two modes of the pipe are shown.Furthermore,by ignoring the width of the clip,the effect of the flow velocity on the accuracy of a concentrated restraint clip model is presented.When the flow velocity is close to the critical velocity,the accuracy of the concentrated restraint clip model significantly reduces,especially when the width of the clip is large.In general,the contribution of this paper is to establish a dynamic model of the fluid-conveying pipe which can describe the influence of the clip parameters,and to demonstrate the necessity of this model. | Bo DOU Hu DING Xiaoye MAO Sha WEI Liqun CHEN | 2023 | Applied Mathematics and Mechanics(English Edition)2023，44，8： | 0 |
| 17 | Risk factors of major intraoperative blood loss at primary debulking surgery for ovarian cancer显示文摘Objective:The goal of this study was to find the risk factors for major intraoperative blood loss(MBL)of pr imary debulking surgery(PDS)for ovarian cancer.Methods:Patients wi th ovarian cancer who underwent PDS in our hospital,from 2010 to 2017,were enrolled.The association between risk factors and MBL was modeled with the use of logisde regr ession.Receiver operating characteristic(ROC)curve analysis was used to determine the predictive value of the logi stic regression model.Results:A total of 346 padients met the inclusion criteria.There were 150 patients with MBL.Tumor stage 3/4(P<0.001),American Society of Aneshesiologists(ASA)score 23(P=0.044),ascites volume≥500 ml(P=0.002),radical or ultra radical surgery(P=0.002),and diabetes(P=0.035)were independent risk factors for MBL in patients with ovarian cancer.The logistic regression combined model of these five factors is more reliable in the prediction of MBL with an area under the ROC curve of 0.729 than the tumor stage(ROC curve=0.645)and surgical complexity(ROC curve=0.568).Conclusion:In padients with ovarian cancer,five risk factors for major intraoperative bleeding were identified.Planned surgical procedures and preoperative risk factors can be used to predict perioperative blood requir ements. | Sha Dou Junchen Chen Yuanfen Wang Chongyuan Zhu Heng Cui Yi Li | 2022 | Gynecology and Obstetrics Clinical Medicine2022，2，1： | 0 |
| 18 | High-quality chromosome-level genome assembly of Tibetan fox(Vulpes ferrilata)显示文摘DEAR EDITOR,Using Oxford Nanopore and Hi-C sequencing technology,we successfully assembled a chromosome-level genome of the Tibetan fox(Vulpes ferrilata),with a total size of 2.38 Gb and N50 length of 133960477 bp.The 157 contigs were further assembled into 18 chromosomes with a sequence length of2378.42 Mb,accounting for 99.95%of the total length. | Tian-Shu Lyu Qin-Guo Wei Li-Dong Wang Sheng-Yang Zhou Lu-Peng Shi Yue-Huan Dong Hua-Shan Dou Wei-Lai Sha Ta Ga Hong-Hai Zhang | 2022 | Zoological Research2022，43，3： | 0 |
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