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| 1 | TD-AltBOC:A new COMPASS B2 modulation显示文摘AltBOC(15,10) is the baseline of COMPASS B2 signal modulation.It is a BOC-like signal having different PN codes in the lower and the upper main split lobes,which allow one signal service per lobe.The two lobes can be received and processed separately like two BPSK(10) signals,or coherently processed to achieve better performance.Interoperability among COMPASS B2,Galileo E5 and GPS L5 is also achievable using AltBOC modulation.However,Galileo's 4-code AltBOC has drawbacks such as low efficiency and great receiver complexity.This paper presents a new modulation type named TD-AltBOC (Time Division AltBOC).The signal generation scheme and receiving method are presented,and are compared with AltBOC in the areas of power spectrum,ranging accuracy,anti-multipath performance,anti-interference performance,processing flexibility and complexity.Analysis results show TD-AltBOC has similar spectrum characteristics,interoperability,flexibility and anti-interference performance with AltBOC.When the frontend bandwidth is more than 50 MHz,TD-AltBOC can achieve better ranging accuracy and anti-multipath performance.It also has such advantages as high efficiency and low receiver complexity.TD-AltBOC could be a good solution to COMPASS B2 navigation signal. | TANG ZuPing ZHOU HongWei WEI JiaoLong YAN Tao LIU YuQi RAN YiHang ZHOU YanLing | 2011 | Science China(Physics,Mechanics & Astronomy)2011，54，6： | 20 |
| 2 | High-speed and high-efficiency three-dimensional shape measurement based on Gray-coded light显示文摘Fringe projection profilometry has been increasingly sought and applied in dynamic three dimensional(3D)shape measurement.In this work,a robust,high-efficiency 3D measurement based on Gray-coded light is proposed.Unlike the traditional method,a tripartite phase unwrapping method is proposed to avoid the jump errors on the boundary of code words,which are mainly caused by the defocusing of the projector and the motion of the tested object.Subsequently,the time overlapping coding strategy is presented to greatly increase the coding ef-ficiency,decreasing the projected number in each group from seven(i.e.,3+4)to four(i.e.,3+1)for one restored 3D frame.The combination of two proposed techniques allows the reconstruction of a pixel-wise and unambiguous 3D geometry of dynamic scenes with strong noise using every four projected patterns.To the best of our knowledge,the presented techniques for the first time preserve the high anti-noise ability of a method based on the Gray code while overcoming the drawbacks of jump errors and low coding efficiency.Experiments have demonstrated that the proposed method can achieve robust,high efficiency 3D shape measurement of high speed dynamic scenes even polluted by strong noise. | ZHOUJIE WU WENBO GUO YUEYANG LI YIHANG LIU QICAN ZHANG | 2020 | Photonics Research2020，8，6： | 17 |
| 3 | A carbon nanofiber network for stable lithium metal anodes with high Coulombic efficiency and long cycle life显示文摘李金属在 high-energy-density Li 离子电池被认为阳极材料的最有希望的候选人之一。然而,李金属的树枝状的生长能严重地在 plating/stripping 过程期间减少 Coulombic 效率和原因安全问题,它是限制李金属阳极的申请的一个关键问题。此处,我们在场为由与三维的碳 nanofiber (CNF ) 修改 Cu 当前的收集者的李的没有树突的免职的新奇策略网络。由于大表面区域和 CNF 网络的高电导率,李金属被插入到并且直接,并且不扔了到 CNF 上树枝状的李金属被观察,离开扁平的李金属表面。与是的李金属为李免职的相反的电极,99.9%的平均 Coulombic 效率为超过 300 个周期被完成,逍遥法外 1.0 和 2.0 妈的当前的密度??????????????????????? | Anyi Zhang Xin Fang Chenfei Shen Yihang Liu Chongwu Zhou | 2016 | Nano Research2016，9，11： | 14 |
| 4 | Downregulation of serum mi R-17 and mi R-106b levels in gastric cancer and benign gastric diseases显示文摘Altered micro RNA(mi RNA) associated with gastric cancer(GC) development and mi R-17 and mi R-106 b were differentially expressed in GC tissues. This study detected serum levels of mi R-17 and mi R-106 b expression in GC, benign gastric disease(BGD) and healthy controls to assess them as tumor markers for GC. Serum samples from 40 GC, 32 BGD(10 gastric ulcer, 14 gastric polyps, and 8 gastric ulcer with polyps) and 36 healthy individuals were subjected to quantitative reverse transcription polymerase chain reaction(q RT-PCR) analysis of mi R-17 and mi R-106 b expression. The data showed that the serum levels of mi R-17 and mi R-106 b were significantly reduced in healthy individuals and BGD patients compared to GC patients. There was a significant association of mi R-17 and mi R-106 b expression with age, but not with other clinicopathological features, such as gender, tumor differentiation, stage and lymphatic metastasis. Further analysis showed that, in discriminating GC patients from healthy controls, mi R-17 could yield a receiver-operating characteristic(ROC) area under the curve(AUC) of 0.879 with 80.6% sensitivity and 87.5% specificity and mi R-106 b could yield an AUC of 0.856 with 75.0% sensitivity and 92.5% specificity. The combined AUC of mi R-17 and mi R-106 b was 0.913 with 83.3% sensitivity and 87.5% specificity. Collectively, these data suggest that detection of serum mi R-17 and mi R-106 b levels should be further evaluated as novel non-invasive biomarkers in early GC detection and surveillance of disease progression. | Qinghai Zeng Cuihong Jin Wenhang Chen Fang Xia Qi Wang Fan Fan Juan Du Yihang Guo Changwei Lin Kaiyan Yang Jingjing Li Xiaowei Peng Xiaorong Li Ke Cao | 2014 | Chinese Journal of Cancer Research2014，26，6： | 12 |
| 5 | Inhibition of Mcl-1 enhances cell death induced by the Bcl-2-selective inhibitor ABT-199 in acute myeloid leukemia cells显示文摘Acute myeloid leukemia(AML)is a serious disease.The 5-year survival rates remain frustratingly low(65%for children and 26%for adults).Resistance to frontline chemotherapy(usually cytarabine)often develops;therefore a new treatment modality is needed.Bcl-2 family proteins play an important role in balancing cell survival and apoptosis.The antiapoptotic Bcl-2 family proteins have been found to be dysregulated in AML.ABT-199,a BH3 mimetic,was developed to target antiapoptotic protein Bcl-2.Although ABT-199 has demonstrated promising results,resistance occurs.Previous studies in AML show that ABT-199 alone decreases the association of proapoptotic protein Bim with Bcl-2,but this is compensated by increased association of Bim with prosurvival protein Mcl-1,stabilizing Mcl-1,resulting in resistance to ABT-199.In this study,we investigated the antileukemic activity of the Mcl-1-selective inhibitor A-1210477 in combination with ABT-199 in AML cells.We found that A-1210477 synergistically induced apoptosis with ABT-199 in AML cell lines and primary patient samples.The synergistic induction of apoptosis was decreased upon Bak,Bax and Bim knockdown.While A-1210477 treatment alone also increased Mcl-1 protein levels,combination with ABT-199 reduced binding of Bim to Mcl-1.Our results demonstrate that sequestration of Bim by Mcl-1,a mechanism of ABT-199 resistance,can be abrogated by combined treatment with the Mcl-1 inhibitor A-1201477. | Daniel A Luedtke Xiaojia Niu Yihang Pan Jianyun Zhao Shuang Liu Holly Edwards Kang Chen Hai Lin Jeffrey W Taub Yubin Ge | 2017 | Signal Transduction and Targeted Therapy2017，2，1： | 11 |
| 6 | Wireless whispering-gallery-mode sensor for thermal sensing and aerial mapping显示文摘The Internet of Things(IoT)1,2 employs a large number of spatially distributed wireless sensors to monitor physical environments,e.g.,temperature,humidity,and air pressure,and has many applications,including environmental monitoring3,health care monitoring4,smart cities5,and precision agriculture.A wireless sensor can collect,analyze,and transmit measurements of its environment1,2.Currently,wireless sensors used in the IoT are predominately based on electronic devices that may suffer from electromagnetic interference in many circumstances.Being immune to the electromagnetic interference,optical sensors provide a significant advantage in harsh environments6.Furthermore,by introducing optical resonance to enhance light–matter interactions,optical sensors based on resonators exhibit small footprints,extreme sensitivity,and versatile functionalities7,8,which can significantly enhance the capability and flexibility of wireless sensors.Here we provide the first demonstration of a wireless photonic sensor node based on a whisperinggallery-mode(WGM)optical resonator,in which light propagates along the circular rim of such a structure like a sphere,a disk,or a toroid by continuous total internal reflection.The sensor node is controlled via a customized iOS app.Its performance was studied in two practical scenarios:(1)real-time measurement of the air temperature over 12 h and(2)aerial mapping of the temperature distribution using a sensor node mounted on an unmanned drone.Our work demonstrates the capability of WGM optical sensors in practical applications and may pave the way for the large-scale deployment of WGM sensors in the IoT. | Xiangyi Xu Weijian Chen Guangming Zhao Yihang Li Chenyang Lu Lan Yang | 2018 | Light(Science & Applications)2018，7，1： | 8 |
| 7 | Potential and policy issues for sustainable development of wind power in China显示文摘This paper presents a macroscopic view on the prevailing policy and potential issues in respect of the sustainable wind power development in China.It starts by analyzing the characteristics of wind power resources and pin-pointing the relationship between the regulatory policies and various economic,taxation,legal and grid integration attributes relating to the wind power development.Then it follows by analyzing the status quo and capabilities of the wind power manufacturing industry in China including its operational efficiency and grid integration standards.The economic and environmental benefits are estimated by relating to the associated costing analysis in respect of the major contributing factors such as manufacturing,operational and financial factors.Results of the associated benefits analysis indicate that the use of the wind power generation helps to save a significant equivalent amount of standard coal consumption resulting to reduction of emission effectively.Finally,the potential of wind power development in China is shown to be affirmative and the sustainable energy policy is effectively implemented in China. | Zhongfu TAN H.W.NGAN Yang WU Huijuan ZHANG Yihang SONG Chao YU | 2013 | Journal of Modern Power Systems and Clean Energy2013，1，3： | 7 |
| 8 | Y_(4)GeO_(8):Er^(3+),Yb^(3+) up-conversion phosphors for optical temperature sensor based on FIR technique显示文摘Herein,we reported novel Y_(4)GeO_(8):Er^(3+),Yb^(3+)phosphors elaborated via conventional solid-state reaction.and we further explored their properties as optical thermometer by using fluorescence intensity ratio(FIR)method complemented by detailed analysis on crystal structure,up-conversion luminescence and energy transfer from Yb^(3+)to Er^(3+).Upon 980 nm laser excitation,Y_(4)GeO_(8):Er^(3+),Yb^(3+)phosphors present525,547 and 659 nm emission bands assigned to the characteristic transitions of Er^(3+).Furthermore,Y_(4)GeO_(8):Er^(3+),Yb^(3+)samples show outstanding temperature sensing performances.To be specific,the minimal temperature resolution is 0.03 K(303 K),and the relative sensitivity of FIR can be up to 1.152%/K(303 K).Hence,Y_(4)GeO_(8):Er^(3+),Yb^(3+)phosphors can be possible candidates for thermometry devices. | Yihang Chen Jing Chen Ye Tong Wenna Zhang Xiusha Peng Hai Guo Daxing Huang | 2021 | Journal of Rare Earths2021，39，12： | 5 |
| 9 | Quantifying urbanization levels on the Tibetan Plateau with high-resolution nighttime light data显示文摘The Tibetan Plateau(TP)is undergoing rapid urbanization.To improve urban sustainability and construct eco-logical security barriers,it is essential to quantify the spatial patterns of urbanization level on the TP,but the existing studies on the topic have been limited by the lack of socioeconomic data.This study aims to quantify the urbanization level on the TP in 2018 with Luojia1-01(LJ1-01)high-resolution nighttime light(NTL)data.Specifically,the compounded night light index is used to quantify spatial patterns of urbanization level at mul-tiple scales.The results showed that the TP had a low overall urbanization level with a large internal difference.The urbanization level in the northeast,southeast and south of the TP was relatively high,forming three hotspots centered in Xining City,Lhasa City and Shangri-La City,while the urbanization level in the central and western regions was relatively low.The analysis of influencing factors,based on the random forest model,showed that transportation and topography were the main factors affecting the TP’s spatial patterns of urbanization level.The comparison analysis with socioeconomic statistics and traditional NTL data showed that LJ1-01 NTL data can be used to more effectively quantify the urbanization level since it is more advantageous for reflecting the spatial extent of urban land and describing the spatial structure of socioeconomic activities within urban areas.These advantages are attributed to the high spatial resolution of the data,appropriate imaging time and unaf-fected by saturation phenomena.Thus,the proposed LJ1-01 NTL-based urbanization level measurement method has the potential for wide applications around the world,especially in less-developed regions lacking statistical data.Using this method,we refined the measurement of the TP’s urbanization level in 2018 for multiple scales including the region,basin,prefecture and county levels,which provides basic information for the further urban sustainability research on the TP. | Yihang Wang Zhifeng Liu Chunyang He Pei Xia Ziwen Liu Haimeng Liu | 2020 | Geography and Sustainability2020，1，3： | 5 |
| 10 | Cotidal charts and tidal power input atlases of the global ocean from TOPEX/Poseidon and JASON-1 altimetry显示文摘The global distributions of eight principal tidal constituents, M_2 , S_2 , K_1 , O_1 , N_2 , K_2 , P_1 , and Q_1 , are derived using TOPEX/Poseidon and JASON-1(T/P-J) satellite altimeter data for 16 a. The intercomparison of the derived harmonics at 7000 subsatellite track crossover points shows that the root mean square (RMS) values of the tidal height differences of the above eight constituents range from 1.19 cm to 2.67 cm, with an average of about 2 cm. The RMS values of the tidal height differences between T/P-J solutions and the harmonics from ground measurements at 152 tidal gauge stations for the above constituents range from 0.34 cm to 1.08 cm, and the relative deviations range from 0.031 to 0.211. The root sum square of the RMS differences of these eight constituents is 2.12 cm, showing the improvement of the present model over the existing global ocean tidal models. Based on the obtained tidal model the global ocean tidal energetics is studied and the global distribution of the tidal power input density by tide-generating force of each constituent is calculated, showing that the power input source regions of semidiurnal tides are mainly concentrated in the tropical belt between 30 S and 30 N, while the power input source regions of diurnal tides are mainly concentrated off the tropic oceans. The global energy dissipation rates of the M_2 , S_2 , K_1 , O_1 , N_2 , P_1 , K_2 and Q_1 tides are 2.424, 0.401, 0.334, 0.160, 0.113, 0.035, 0.030 and 0.006 TW, respectively. The total global tidal dissipation rate of these eight constituents amounts to 3.5 TW. | WANG Yihang FANG Guohong WEI Zexun WANG Yonggang WANG Xinyi XU Xiaoqing | 2012 | Acta Oceanologica Sinica2012，31，4： | 5 |
| 11 | Coupling Effect of Morphology and Mechanical Properties Contributes to the Tribological Behaviors of Snake Scales显示文摘 | Long Zheng Yinghui Zhong Yihang Gao Jiayi Li Zhihui Zhang Zhenning Liu Luquan Ren | 2018 | Journal of Bionic Engineering2018，15，3： | 4 |
| 12 | Signaling pathways and therapeutic interventions in gastric cancer显示文摘Gastric cancer(GC)ranks fifth in global cancer diagnosis and fourth in cancer-related death.Despite tremendous progress in diagnosis and therapeutic strategies and significant improvements in patient survival,the low malignancy stage is relatively asymptomatic and many GC cases are diagnosed at advanced stages,which leads to unsatisfactory prognosis and high recurrence rates.With the recent advances in genome analysis,biomarkers have been identified that have clinical importance for GC diagnosis,treatment,and prognosis.Modern molecular classifications have uncovered the vital roles that signaling pathways,including EGFR/HER2,p53,PI3K,immune checkpoint pathways,and cell adhesion signaling molecules,play in GC tumorigenesis,progression,metastasis,and therapeutic responsiveness.These biomarkers and molecular classifications open the way for more precise diagnoses and treatments for GC patients.Nevertheless,the relative significance,temporal activation,interaction with GC risk factors,and crosstalk between these signaling pathways in GC are not well understood.Here,we review the regulatory roles of signaling pathways in GC potential biomarkers,and therapeutic targets with an emphasis on recent discoveries.Current therapies,including signaling-based and immunotherapies exploited in the past decade,and the development of treatment for GC,particularly the challenges in developing precision medications,are discussed.These advances provide a direction for the integration of clinical,molecular,and genomic profiles to improve GC diagnosis and treatments. | Zi-Ning Lei Qiu-Xu Teng Qin Tian Wei Chen Yuhao Xie Kaiming Wu Qianlin Zeng Leli Zeng Yihang Pan Zhe-Sheng Chen Yulong He | 2022 | Signal Transduction and Targeted Therapy2022，7，11： | 4 |
| 13 | Supermolecular layered double hydroxides显示文摘Research progresses in the layered double hydroxides [M2+(1-x)M3+x(OH)2]x+An-x/n.mH2O intercalatedwith metal coordinate ions or oxometalates in the last ten years are reviewed. These layered double hydroxides are mainly intercalated with polyoxometalate (POM) ions, a LiAl-LDH photochemical assembly containing TiO2 and CH3(CH2)12COO- anions, together with Zn(TPPC) (porphy-rin derivate) and macrocyclic ligand-containing porphyrin derivate anions. Emphasis is put on the synthesis methods for intercalation of the anions into the interlayer regions, the characterization techniques and structures for the layeredcompounds and the newest research progress in the fields such as catalysis. The review also forecasts the prospects of the field. | Hu Changwen Li Danfeng Guo Yihang Wang Enbo | 2001 | Chinese Science Bulletin2001，46，13： | 3 |
| 14 | Laser produced electromagnetic pulses: generation, detection and mitigation显示文摘This paper provides an up-to-date review of the problems related to the generation,detection and mitigation of strong electromagnetic pulses created in the interaction of high-power,high-energy laser pulses with different types of solid targets.It includes new experimental data obtained independently at several international laboratories.The mechanisms of electromagnetic field generation are analyzed and considered as a function of the intensity and the spectral range of emissions they produce.The major emphasis is put on the GHz frequency domain,which is the most damaging for electronics and may have important applications.The physics of electromagnetic emissions in other spectral domains,in particular THz and MHz,is also discussed.The theoretical models and numerical simulations are compared with the results of experimental measurements,with special attention to the methodology of measurements and complementary diagnostics.Understanding the underlying physical processes is the basis for developing techniques to mitigate the electromagnetic threat and to harness electromagnetic emissions,which may have promising applications. | Fabrizio Consoli Vladimir TTikhonchuk Matthieu Bardon Philip Bradford David CCarroll Jakub Cikhardt Mattia Cipriani Robert JClarke Thomas ECowan Colin NDanson Riccardo De Angelis Massimo De Marco Jean-Luc Dubois Bertr Etchessahar Alejro Laso Garcia David IHillier Ales Honsa Weiman Jiang Viliam Kmetik Josef Krása Yutong Li FredériéLubrano Paul McKenna Josefine Metzkes-Ng Alexre Poyé Irene Prencipe Piotr Ra¸czka Rol ASmith Roman Vrana Nigel CWoolsey Egle Zemaityte Yihang Zhang Zhe Zhang Bernhard Zielbauer David Neely | 2020 | High Power Laser Science and Engineering2020，8，2： | 3 |
| 15 | Buildup dynamics of multiple solitons in spatiotemporal mode-locked fiber lasers显示文摘Spatiotemporal mode locking is a nonlinear process of multimode soliton self-organization.Here the real-time buildup dynamics of the multiple solitons in a spatiotemporal mode-locked multimode fiber laser are investigated,assisted by the time-stretch technique.We find that the buildup processes are transverse mode dependent,especially during the stages of relaxation oscillation and Q-switching prior to multiple soliton formation.Furthermore,we observe that the transverse modal composition of these generated pulses among the multiple solitons can be different from each other,indicating the spatiotemporal structure of the multiple soliton.A simplified theoretical model based on pulse energy evolution is put forward to interpret the role of 3D saturable absorber on spatiotemporal structures of spatiotemporal mode-locking multiple solitons.Our work has presented the spatiotemporal nonlinear dynamics in multimode fiber lasers,which are novel to those inside the single transverse mode fiber lasers. | KEWEI LIU XIAOSHENG XIAO YIHANG DING HONGYAN PENG DONGDONG LV CHANGXI YANG | 2021 | Photonics Research2021，9，10： | 3 |
| 16 | Single-step flash-heat synthesis of red phosphorus/ graphene flame-retardant composite as flexible anodes for sodium-ion batteries显示文摘红磷(RP ) 为高效的 Na 离子电池作为阳极吸引了可观的注意,由于它的低费用和 2,600 mAh/g 的高理论特定的能力。在这研究,一个灵巧的单个步的闪光热处理被开发完成 graphene 氧化物的减小(去) 并且 RP 的同时的免职到减少的 graphene 氧化物(rGO ) 上表。产生 RP/rGO 合成被显示是克服在骑车期间与差的电子传导性和 RP 的大体积变化联系的期的一个有希望的候选人。RP/rGO 灵活电影阳极在 1 A/g 的控告 / 解除电流密度在 200 个周期期间交付了 1,625 mAh/g 的一个平均能力。在 1, 2, 4,和 6 A/g 当前的密度的 1,786, 1,597, 1,324,和 679 mAh/g 的平均电荷能力在率能力测试被获得。而且由于 RP 部件, RP/rGO 电影与一部 rGO 电影相比介绍了优异火焰 retardancy。这个工作因此介绍一个高度可存取的合成方法向 Na 离子存储与优异电气化学的性能准备灵活、安全的 RP 阳极。 | Yihang Liu Anyi Zhang Chenfei Shen Qingzhou Liu Jiansong Cai Xuan Cao Chongwu Zhou | 2018 | Nano Research2018，11，7： | 3 |
| 17 | Mapping QTL underlying tuber starch content and plant maturity in tetraploid potato显示文摘Tuber starch content and plant maturity are two important agronomic traits of potato. To investigate the complex genetic basis of these traits in the cultivated potato, as well as the relationship between them, we developed a linkage map in a tetraploid population of 192 clones derived from the cross Longshu 8 × Zaodabai and mapped quantitative trait loci(QTL) for tuber starch content and plant maturity using data collected in three diverse environments over two years. We detected eleven QTL for tuber starch content distributed on seven chromosomes, of which four, on chromosomes I, II, and VIII, were expressed in at least three environments. For plant maturity, we identified six QTL on chromosomes II, IV,V, VII, and XI, one of which, on chromosome V, showed LOD peaks ranging from 45.2 to 62.5 cM and explained 21.6%–26.6% of phenotypic variation was expressed in five of the six environments. Because the reproducible QTL for plant maturity and tuber starch content mapped to different chromosomes and neither overlapping QTL, nor any genetic interaction between QTL were detected, we infer that tuber starch content and plant maturity are controlled by independent genetic loci. This inference supports the prospect of breeding potato for both early maturity and high starch content. | Jianwu Li Yihang Wang Guohong Wen Gaofeng Li Zhang Li Rong Zhang Sheng Ma Jun Zhou Conghua Xie | 2019 | The Crop Journal2019，7，2： | 3 |
| 18 | Acute toxicity study of Aspidopterys obcordata aqueous extract in Sprague-Dawley rats显示文摘OBJECTIVE: To examine the acute toxicity of an aqueous extract of Aspidopterys obcordata(A. obcordata) in Sprague Dawley rats.METHODS: The rats were orally administered a dose of 5000 mg/kg body weight and observed continuously for 6 h and then daily for 14 days. Control rats were administered distilled water. The effect of the extract on general behavior, body weight, and food and water intake were measured.After 14 days, the rats were sacrificed and their organs(liver, heart, spleen, lungs, kidney, adrenal glands, ovaries, and testes) were removed for macroscopic examination. The body and organ weights in addition to hematology(e.g., hemoglobin and white blood cell counts) and clinical blood biochemistry(e.g., albumin and bilirubin) were also examined.RESULTS: There were no deaths recorded, and the rats treated with A. obcordata showed no signs of toxicity. All measured parameters in rats treated with A. obcordata were unaffected when compared with those in control rats. The acute toxicity(LD_(50))was estimated to be > 5000 mg/kg body weight.CONCLUSION: Our results demonstrate the safety of an acute oral administration of an aqueous extract of A. obcordata in rats and indicate that future subacute and long-term toxicity testing of A. obcordata is warranted. | Li Yihang Li Guang Song Meifang Li Xuelan Zhan Xia Lu Juan Chen Xi | 2016 | Journal of Traditional Chinese Medicine2016，36，3： | 3 |
| 19 | Experiment and simulation study of emergency evacuation during violent attack in classrooms显示文摘In recent years,as a disaster,terrorist attacks have occurred throughout the world.However,emergency evac-uation behaviors during these incidents were not clear,and the traditional emergency plans were not suitable for such incidents.In this paper,evacuation behaviors under armed assault attack in a classroom were studied based on evacuation experiments.A total of 103 participants took part in three experiments.In each experiment,the attacker’s attacking route was set differently to study the impact of the attacking route on evacuation be-haviors.Pre-evacuation delay,panic of the evacuees,exit choices,evacuation time,and evacuees’trajectories in the experiments were all analyzed.The results of the experiments showed that when a terrorist attack occurs,there is a long delay before evacuation,and most of the evacuees were in the state of“observation”before they moved.When one of the participants started to evacuate or shout,other participants would begin to recognize the danger and escape quickly.These three experiments showed that the route of the attacker had a significant impact on the routes and exit choices of the evacuees.Rather than searching for the nearest exit,the primary purpose of evacuees was to keep a safe distance from the attacker.The average speed of the evacuees in these three experiments was 1.07 m/s,0.81 m/s,and 0.84 m/s,respectively.The density distribution during the crowd evacuation process was uneven,with the highest density occurring at the area from the seats to the aisles.The research can provide data support for the design of emergency plans and the computer simulation of the armed assault attack. | Ning Ding Yihang Ma Dapeng Dong Yadi Wang | 2021 | Journal of Safety Science and Resilience2021，2，4： | 2 |
| 20 | Nicotinamide mononucleotide supplementation improves the quality of porcine oocytes under heat stress显示文摘Background:Elevated ambient temperature-caused heat stress is a major concern for livestock production due to its negative impact on animal feed intake,growth,reproduction,and health.Particularly,the germ cells are extremely sensitive to the heat stress.However,the effective approach and strategy regarding how to protect mammalian oocytes from heat stress-induced defects have not been determined.Methods:Germinal vesicle(GV)porcine oocytes were cultured at 41.5℃ for 24 h to induce heat stress,and then cultured at 38.5℃ to the specific developmental stage for subsequent analysis.Nicotinamide mononucleotide(NMN)was dissolved in water to 1 mol/L for a stock solution and further diluted with the maturation medium to the final concentrations of 10μmol/L,20μmol/L,50μmol/L or 100μmol/L,respectively,during heat stress.Immunostaining and fluorescence intensity quantification were applied to assess the effects of heat stress and NMN supplementation on the key processes during the oocyte meiotic maturation.Results:Here,we report that NMN supplementation improves the quality of porcine oocytes under heat stress.Specifically,we found that heat stress resulted in oocyte maturation failure by disturbing the dynamics of meiotic organelles,including the cytoskeleton assembly,cortical granule distribution and mitochondrial function.In addition,heat stress induced the production of excessive reactive oxygen species(ROS)and DNA damage,leading to the occurrence of apoptosis in oocytes and subsequent embryonic development arrest.More importantly,we validated that supplementation of NMN during heat stress restored the meiotic defects during porcine oocyte maturation.Conclusions:Taken together,our study documents that NMN supplementation is an effective approach to improve the quality of oocytes under heat stress by promoting both nuclear and cytoplasmic maturation. | Meijie Song Yu Li Yihang Zhou Jiner Yan Xiaohua Zhou Qian Gao Yilong Miao Bo Xiong | 2022 | Journal of Animal Science and Biotechnology2022，13，5： | 2 |
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