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| 1 | Protective effects of asiatic acid against D-galactosamine/lipopolysaccharide-induced hepatotoxicity in hepatocytes and kupffer cells co-cultured system via redox-regulated leukotriene C 4 synthase expression pathway显示文摘 | Kuifen Ma Yuyu Zhang Danyan Zhu Yijia Lou | 2008 | European Journal of Pharmacology2008，，1： | 1 |
| 2 | Prudently conduct the engineering and synthesis of the SARS-CoV-2 virus显示文摘In response to the outbreak of COVID-19 that has been sweeping the world,scientists reconstructed the SARSCoV-2 rapidly using a synthetic genomics platform,in order to accelerate therapeutics and vaccine development.However,given the dual-use nature of this technology,there exists a high biosecurity risk.This paper points out the potential risks of the engineering SARS-CoV-2 virus and puts forward 6 questions to this work.The authors emphasize that the two basic values of safety/security and intellectual freedom of research must be considered evenly.From the perspective of responsible development of biotechnology,this paper calls for a careful assessment to the risks of the technology,replacing risky technologies with safe ones.The risks of publication also need to be strictly assessed.The authors believe,in addition to enhancing the“self-government”and self-discipline of scientists and scientific communities,government supervision must be reinforced,laws and regulations should be improved,and global regulation framework ought to be constructed. | Peng Gao Shiwen Ma Daru Lu Carl Mitcham Yijia Jing Guoyu Wang | 2020 | Synthetic and Systems Biotechnology2020，5，2： | 0 |
| 3 | An endolysin gene from Candidatus Liberibacter asiaticus confers dual resistance to huanglongbing and citrus canker显示文摘The most damaging citrus diseases are Huanglongbing(HLB)and citrus canker,which are caused by Candidatus Liberibacter asiaticus(CaLas)and Xanthomonas citri pv.citri(Xcc),respectively.Endolysins from bacteriophages are a possible option for disease resistance in plant breeding.Here,we report improvement of citrus resistance to HLB and citrus canker using the LasLYS1 and LasLYS2 endolysins from CaLas.LasLYS2 demonstrated bactericidal efficacy against several Rhizobiaceae bacteria and Xcc,according to inhibition zone analyses.The two genes,driven by a strong promoter from Cauliflower mosaic virus,35S,were integrated into Carrizo citrange via Agrobacterium-mediated transformation.More than 2 years of greenhouse testing indicated that LasLYS2 provided substantial and long-lasting resistance to HLB,allowing transgenic plants to retain low CaLas titers and no obvious symptoms while also clearing CaLas from infected plants in the long term.LasLYS2 transgenic plants with improved HLB resistance also showed resistance to Xcc,indicating that LasLYS2 had dual resistance to HLB and citrus canker.A microbiome study of transgenic plants revealed that the endolysins repressed Xanthomonadaceae and Rhizobiaceae populations in roots while increasing Burkholderiaceae and Rhodanobacteraceae populations,which might boost the citrus defense response,according to transcriptome analysis.We also found that Lyz domain 2 is the key bactericidal motif of LasLYS1 and LasLYS2.Four endolysins with potential resistance to HLB and citrus canker were found based on the structures of LasLYS1 and LasLYS2.Overall,the work shed light on the mechanisms of resistance of CaLas-derived endolysins,providing insights for designing endolysins to develop broad-spectrum disease resistance in citrus. | Lanzhen Xu Kaiqing Mo Danlu Ran Juanjuan Ma Lehuan Zhang Yijia Sun Qin Long Guojin Jiang Xiaochun Zhao Xiuping Zou | 2023 | Horticulture Research2023，10，9： | 0 |
| 4 | EZCalm:A User Emotion Regulation System by Immersive Music Based on Plutchik's Wheel of Emotions显示文摘Nowadays,many companies hire professional trainers to keep their employees emotionally positive.In addition,more and more people are visiting psychological doctors to adjust their emotion,in order to treat mental illness or gain sense of happiness.All kinds of people mentioned above want to adjust emotions in an effective way.Therefore,a simple and effective household pattern of emotion adjustment is particularly important for people to use in common days.For such a pattern,an emotion regulation pattern combined with Plutchiks' wheel of emotions is proposed for emotion adjustment.In order to enhance the effectiveness of emotion adjustment from both the vision channel and the hearing channel,we adjust the user's emotion by visualizing music on a Helmet mounted display(HMD)device.Findings demonstrate that the proposed system can calm down participants e'motions effectively. | Yajie Xu Lu Wang Yulin Wang Jiyue Hu Peng Shao Yijia Ma Xiangxu Meng | 2019 | Journal of Beijing Institute of Technology2019，28，1： | 0 |
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