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| 1 | Family history influences the early onset of hepatocellular carcinoma显示文摘AIM: To evaluate the relationship between a positive family history of primary liver cancer and hepatocellular carcinoma (HCC) development in Korean HCC patients. METHODS: We studied a total of 2242 patients diagnosed with HCC between January 1990 and July 2008, whose family history of primary liver cancer was clearly described in the medical records.positive family history of HCC and 2077 (92.6%) did not. The male to female ratio was 3.6:1, and the major causes of HCC were chronic hepatitis B virus (HBV) infection in 75.1%, chronic hepatitis C virus infection in 13.2% and alcohol in 3.1%. The median ages at diag- nosis in the positiveand negative-history groups were 52 years (range: 29-79 years) and 57 years (range: 18-89 years), respectively (P < 0.0001). Furthermore, among 1713 HCC patients with HBV infection, the number of patients under 45 years of age out of 136 patients with positive family history was 26 (19.1%), whereas those out of 1577 patients with negative family history was 197 (12.5%), suggesting that a positive family history may be associated with earlier development of HCC in the Korean population (P = 0.0028). CONCLUSION: More intensive surveillance maybe recommended to those with a positive family history of HCC for earlier diagnosis and proper management especially when HBV infection is present. | Chung-Hwa Park Seung-Hee Jeong Hyeon-Woo Yim Jin Dong Kim Si Hyun Bae Jong Young Choi Seung Kew Yoon | 2012 | World Journal of Gastroenterology2012，18，21： | 9 |
| 2 | Assessment of scoring systems for acute-on-chronic liver failure at predicting short-term mortality in patients with alcoholic hepatitis显示文摘AIM To assess the performance of proposed scores specific for acute-on-chronic liver failure in predicting shortterm mortality among patients with alcoholic hepatitis.METHODS We retrospectively collected data from 264 patients with clinically diagnosed alcoholic hepatitis from January to December 2013 at 21 academic hospitals in Korea. The performance for predicting short-term mortality was calculated for Chronic Liver FailureSequential Organ Failure Assessment(CLIF-SOFA), CLIF Consortium Organ Failure score(CLIF-C OFs), Maddrey'sdiscriminant function(DF), age, bilirubin, international normalized ratio and creatinine score(ABIC), Glasgow Alcoholic Hepatitis Score(GAHS), model for end-stage liver disease(MELD), and MELD-Na.RESULTS Of 264 patients, 32(12%) patients died within 28 d. The area under receiver operating characteristic curve of CLIF-SOFA, CLIF-C OFs, DF, ABIC, GAHS, MELD, and MELD-Na was 0.86(0.81-0.90), 0.89(0.84-0.92), 0.79(0.74-0.84), 0.78(0.72-0.83), 0.81(0.76-0.86), 0.83(0.78-0.88), and 0.83(0.78-0.88), respectively, for 28-d mortality. The performance of CLIF-SOFA had no statistically significant differences for 28-d mortality. The performance of CLIF-C OFs was superior to that of DF, ABIC, and GAHS, while comparable to that of MELD and MELD-Na in predicting 28-d mortality. A CLIF-SOFA score of 8 had 78.1% sensitivity and 79.7% specificity, and CLIF-C OFs of 10 had 68.8% sensitivity and 91.4% specificity for predicting 28-d mortality.CONCLUSION CLIF-SOFA and CLIF-C OF scores performed well, with comparable predictive ability for short-term mortality compared to the commonly used scoring systems in patients with alcoholic hepatitis. | Hee Yeon Kim Chang Wook Kim Tae Yeob Kim Do Seon Song Dong Hyun Sinn Eileen L Yoon Young Kul Jung Ki Tae Suk Sang Soo Lee Chang Hyeong Lee Tae Hun Kim Jeong Han Kim Hyung Joon Yim Sung Eun Kim Soon Koo Baik Byung Seok Lee Jae Young Jang Young Seok Kim Sang Gyune Kim Jin Mo Yang Joo Hyun Sohn Heon Ju Lee Seung Ha Park Eun Hee Choi Dong Joon Kim Korean Acute-on-Chronic Liver Failure Study Group | 2016 | World Journal of Gastroenterology2016，22，41： | 5 |
| 3 | Diagnostic delay in inflammatory bowel disease increases the risk of intestinal surgery显示文摘AIM To investigate the factors affecting diagnostic delay and outcomes of diagnostic delay in inflammatory bowel disease(IBD) METHODS We retrospectively studied 165 patients with Crohn's disease(CD) and 130 patients with ulcerative colitis(UC) who were diagnosed and had follow up durations > 6 mo at Korea University Ansan Hospital from January 2000 to December 2015. A diagnostic delay was defined as the time interval between the first symptom onset and IBD diagnosis in which the 76^(th) to 100^(th) percentiles of patients were diagnosed.RESULTS The median diagnostic time interval was 6.2 and 2.4 mo in the patients with CD and UC, respectively. Among the initial symptoms, perianal discomfort before diagnosis(OR = 10.2, 95%CI: 1.93-54.3, P = 0.006) was associated with diagnostic delays in patients with CD; however, no clinical factor was associated with diagnostic delays in patients with UC. Diagnostic delays, stricturing type, and penetrating type were associated with increased intestinal surgery risks in CD(OR = 2.54, 95%CI: 1.06-6.09; OR = 4.44, 95%CI: 1.67-11.8; OR = 3.79, 95%CI: 1.14-12.6, respectively). In UC, a diagnostic delay was the only factor associated increased intestinal surgery risks(OR = 6.81, 95%CI: 1.12-41.4).CONCLUSION A diagnostic delay was associated with poor outcomes, such as increased intestinal surgery risks in patients with CD and UC. | Dong-won Lee Ja Seol Koo Jung Wan Choe Sang Jun Suh Seung Young Kim Jong Jin Hyun Sung Woo Jung Young Kul Jung Hyung Joon Yim Sang Woo Lee | 2017 | World Journal of Gastroenterology2017，23，35： | 3 |
| 4 | Adding adefovir vs. switching to entecavir for lamivudine‐resistant chronic hepatitis B ( ACE study): a 2‐year follow‐up randomized controlled trial显示文摘 | Hyung Joon Yim Yeon Seok Seo Eileen L. Yoon Chang Wook Kim Chang Don Lee Sang Hoon Park Myung Seok Lee Choong Kee Park Hee Bok Chae Moon Young Kim Soon Koo Baik Yun Soo Kim Ju Hyun Kim Jung Il Lee Jin Woo Lee Sun Pyo Hong Soon Ho Um | 2013 | Liver Int2013，，2： | 2 |
| 5 | Comparative Study of Helicobacter pylori Eradication Rates With 5-day Quadruple “Concomitant” Therapy and 7-day Standard Triple Therapy显示文摘 | Seung Young Kim Sang Woo Lee Jong Jin Hyun Sung Woo Jung Ja Seol Koo Hyung Joon Yim Jong Jae Park Hoon Jai Chun Jai Hyun Choi | 2013 | Journal of Clinical Gastroenterology2013，，1： | 2 |
| 6 | Adefovir and Lamivudine Combination Therapy in Patients with Entecavir-Resistant Chronic Hepatitis B: Antiviral Responses and Evolution of Mutations显示文摘 | Yim Hyung Joon Lee Hyun Jung Suh Sang Jun Seo Yeon Seok Kim Chang Wook Lee Chang Don Park Sang Hoon Lee Myung Seok Park Choong Kee Chae Hee Bok Kim Moon Young Baik Soon Koo Kim Yun Soo Kim Ju Hyun Lee Jung Il Lee Jin Woo Hong Sun Pyo Um | 2014 | Intervirology2014，，5： | 1 |
| 7 | ‘Hot liver’ on 18F-FDG PET/CT imaging in a patient with hepatosplenic tuberculosis显示文摘 | Young Jin Jeong Myung-Hee Sohn Seok Tae Lim Dong Wook Kim Hwan-Jeong Jeong Myoung-Ja Chung Chang-Seob Lee Chang-Yeol Yim | 2010 | European Journal of Nuclear Medicine and Molecular Imaging2010，，8： | 1 |
| 8 | Performance of horizontal axis tidal current turbine by blade configuration 显示文摘 | JO Chul hee YIM Jin young LEE Kang hee | 2012 | Renewable Energy2012，42，： | 1 |
| 9 | Psychometric Hepatic Encephalopathy Score for the detection of minimal hepatic encephalopathy in Korean patients with liver cirrhosis显示文摘 | Yeon Seok Seo Sun Young Yim Jin Yong Jung Chang Ha Kim Jin Dong Kim Bora Keum Hyonggin An Hyung Joon Yim Hong Sik Lee Chang Duck Kim Ho Sang Ryu Soon Ho Um | 2012 | Journal of Gastroenterology and Hepatology2012，，11： | 1 |
| 10 | Performance of horizontal axis tidal current turbine by blade configuration 显示文摘 | Jo Chul bee Yim Jin young Lee Kang hee | 2012 | Renewable Energy2012，42，： | 1 |
| 11 | The Usefulness of Tc-99m HMPAO Labeled WBC SPECT in Eosinophilic Gastroenteritis显示文摘 | KWANG JAE LEE KI BAIK HAHM YOUNG SOO KIM JIN HONG KIM SUNG WON CHO HOON JIE CHAN HEE PARK HYUNEE YIM | 1997 | CLINICAL NUCLEAR MEDICINE1997，，8： | 1 |
| 12 | Clinical implication of protease-activated receptor-2 in idiopathic pulmonary fibrosis显示文摘 | Young Sik Park Chang Min Park Hyun Ju Lee Jin Mo Goo Doo Hyun Chung Sang-Min Lee Jae-Joon Yim Young Whan Kim Sung Koo Han Chul-Gyu Yoo | 2012 | Respiratory Medicine2012，，： | 1 |
| 13 | Combination of vitamin c and rutin on neuropathy and lung damage of diabetes mellitus rats显示文摘 | Hyun Dong Je Chang Yell Shin Sun Young Park Sung Hyuk Yim Chan Kum In Hoi Huh Jin Hak Kim Uy Dong Sohn | 2002 | Archives of Pharmacal Research2002，，2： | 1 |
| 14 | Clinical Significance of Hepatitis B Virus Precore and Core Promoter Variants in Korean Patients With Chronic Hepatitis B显示文摘 | Sun Young Yim Soon Ho Um Jin Young Jung Tae Hyung Kim Jin Dong Kim Bora Keum Yeon Seok Seo Hyung Joon Yim Yoon Tae Jeen Hong Sik Lee Hoon Jai Chun Chang Duck Kim Ho Sang Ryu | 2015 | Journal of Clinical Gastroenterology2015，，1： | 1 |
| 15 | A nationwide seroepidemiology of hepatitis C virus infection in South Korea显示文摘 | Do Young Kim In Hee Kim Sook‐Hyang Jeong Yong Kyun Cho Joon Hyoek Lee Young‐Joo Jin Don Lee Dong Jin Suh Kwang‐Hyub Han Neung Hwa Park Ha Yan Kang Young Kul Jung Young Seok Kim Kyung‐Ah Kim Youn Jae Lee Byung Seok Lee Hyung Joon Yim Heon Ju Lee Soon Koo B | 2013 | Liver Int2013，，4： | 1 |
| 16 | Physical activity and other lifestyle factors in relation to the prevalence of colorectal adenoma: a colonoscopy-based study in asymptomatic Koreans显示文摘 | Ji Hyun Song Young Sun Kim Sun Young Yang Su Jin Chung Min Jung Park Seon Hee Lim Jeong Yoon Yim Joo Sung Kim Hyun Chae Jung | 2013 | Cancer Causes & Control2013，，9： | 1 |
| 17 | Determination of mesopore size of aerogels from thermal conductivity measurements显示文摘 | Ok-Joo Lee Kun-Hong Lee Tae Jin Yim Sun Young Kim Ki-Pung Yoo | 2002 | Journal of Non-Crystalline Solids2002，，2： | 1 |
| 18 | Two distinct stem cell-like subtypes of hepatocellular carcinoma with clinical significance and their therapeutic potentials显示文摘Dear Editor Hepatocellular carcinoma(HCC)is among the most com-mon cancers worldwide,causing about 600,000 deaths annully[1].In HCC,stem cell-like characteristics,which drive early recurrence and therapy resistance,are major contributors to poor prognosis[2].In this current study,we integrated and analyzed gene expression data from human fetal liver cells and primary HCC tumors(n=1231)and.uncovered two clinically and biologically distinct hepatic stem cell(HS)subtypes,potential biomarkers associated with these subtypes,and a potential new therapeutic inter-vention for these subtypes. | Sung Hwan Lee Yun Seong Jeong Sunyoung Lee Bo Hwa Sohn Ho Kyoung Hwang Gi Hong Choi Chang Moo Kang Jin Sub Choi Woo Jung Lee Jae-Ho Cheong Hee Jin Jang Ahmed Kaseb Lewis Roberts Sun Young Yim Yun Shin Chun Ju-Seog Lee | 2022 | Cancer Communications2022，42，2： | 0 |
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