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| 1 | Prognostic Value of Serum LP-PLA2 and hs-CRP in Unstable Atherosclerotic Plaques显示文摘 | Yimeng Du Fengtao Wei Zhaoqiang Dong Junni Liu Weidong Jiang Qinghua Lu | 2011 | Clinical and Experimental Hypertension2011，，2： | 3 |
| 2 | Enhancement of toxic effects of phenanthrene to Daphnia magna due to the presence of suspended sediment显示文摘 | Xiaotian Zhang Xinghui Xia Jianwei Dong Yimeng Bao Husheng Li | 2013 | Chemosphere2013，，： | 1 |
| 3 | The First High-quality Reference Genome of Sika Deer Provides Insights into High-tannin Adaptation显示文摘Sika deer are known to prefer oak leaves,which are rich in tannins and toxic to most mammals;however,the genetic mechanisms underlying their unique ability to adapt to living in the jungle are still unclear.In identifying the mechanism responsible for the tolerance of a highly toxic diet,we have made a major advancement by explaining the genome of sika deer.We generated the first high-quality,chromosome-level genome assembly of sika deer and measured the correlation between tannin intake and RNA expression in 15 tissues through 180 experiments.Comparative genome analyses showed that the UGT and CYP gene families are functionally involved in the adaptation of sika deer to high-tannin food,especially the expansion of the UGT family 2 subfamily B of UGT genes.The first chromosome-level assembly and genetic characterization of the tolerance to a highly toxic diet suggest that the sika deer genome may serve as an essential resource for understanding evolutionary events and tannin adaptation.Our study provides a paradigm of comparative expressive genomics that can be applied to the study of unique biological features in non-model animals. | Xiumei Xing Cheng Ai Tianjiao Wang Yang Li Huitao Liu Pengfei Hu Guiwu Wang Huamiao Liu Hongliang Wang Ranran Zhang Junjun Zheng Xiaobo Wang Lei Wang Yuxiao Chang Qian Qian Jinghua Yu Lixin Tang Shigang Wu Xiujuan Shao Alun Li Peng Cui Wei Zhan Sheng Zhao Zhichao Wu Xiqun Shao Yimeng Dong Min Rong Yihong Tan Xuezhe Cui Shuzhuo Chang Xingchao Song Tongao Yang Limin Sun Yan Ju Pei Zhao Huanhuan Fan Ying Liu Xinhui Wang Wanyun Yang Min Yang Tao Wei Shanshan Song Jiaping Xu Zhigang Yue Qiqi Liang Chunyi Li Jue Ruan Fuhe Yang | 2023 | Genomics, Proteomics & Bioinformatics2023，21，1： | 1 |
| 4 | Preparation of slow-release regulated Rs-198 bilayer microcapsules and application of its lyophilized bacterial inoculant on Capsicum annuum L.under salt stress显示文摘The survival adaptation of bacteria in saline soil is poor.The bilayer microcapsules were prepared by secondary embedding of monolayer sodium alginate(NaAlg)-bentonite(Bent)-sodium carboxy-methylcellulose(CMC)microcapsules wrapped with plant growth promoting rhizobacteria(PGPR)Pseudomonas putida Rs-198 by chitosan solution to promote the synergistic effect of bilayer microen-capsulation and PGPR.The characterization of the Rs-198 bilayer microcapsules showed that the amino and carboxyl groups were cross-linked and a thin layer of chitosan was formed on the outside of the microcapsule.The bilayer microcapsule(Ch-d)with a chitosan concentration of 0.8 wt%and pH 6 showed a slow release of bacteria with a maximum release of 6.06 × 10^(9) cfu/g on the 7th day.The viable bacteria of Ch-d increased by 4.42%after 60 days of storage compared with monolayer microcapsules.The 0.9 wt%L-cysteine,10 wt%glycerinum,10 wt%trehalose and 12 wt%soluble starch were added as bacterial protective agents during the process of preparing the Ch-d lyophilized bacterial inoculant(Ch-d LBI).Pot experiments showed that Ch-d LBI exhibited better growth promotion of Capsicum annuum L.under salt stress.Therefore,the bilayer microcapsule as slow-release bacterial inoculant is a potential alternative for sustainable agriculture. | Shuangxi Zhu Yanhui He Jiawei Dong Yujia Dong Chun Li Zhansheng Wu Yimeng Lu | 2023 | Particuology2023，，8： | 1 |
| 5 | Facile fabrication of self-healing silicone-based poly(urea-thiourea)/tannic acid composite for anti-biofouling显示文摘A novel silicone-based poly(urea-thiourea)/tannic acid composite(PDMS-P(Ua-TUa)-TA)with excellent mechanical,self-healing and antifouling properties is developed.The multiple dynamic hydrogen bonds formed by thiourea groups,urea groups,and tannic acid(TA)molecules ensured a tough elastomer(ultimate strength:2.47 MPa)with high stretchability(~1000%).TA molecules as partial hydrogen bonding cross-linking sites interacted rapidly with urea and thiourea groups before the migration of polymer chains,resulting in fast and efficient self-healing.Scratches on the film completely disappeared within12 min,and the repair efficiency of strength was up to 98.4%within 3 h under ambient condition.Selfhealing behavior was also evaluated in artificial seawater and the healing efficiency(HE)was 95.1%.Furthermore,TA uniformly dispersed in the polymer matrix provides good antibacterial and anti-diatom properties,as well as strong adhesion to the substrate(~2.2 MPa).Laboratory bioassays against marine bacteria adhesion(~96%,~95%and~93%reduction for P.sp.,E.coli,and S.aureus,respectively)and diatom attachment(~84%reduction)demonstrated an outstanding antifouling property of the PDMSP(Ua-TUa)-TA.This work provides a promising pathway towards the development of high-performance silicone-based coatings for marine anti-biofouling. | Jiawen Sun Chao Liu Jizhou Duan Jie Liu Xucheng Dong Yimeng Zhang Ning Wang Jing Wang Baorong Hou | 2022 | Journal of Materials Science & Technology2022，，29： | 1 |
| 6 | In vivo and in situ real-time fluorescence imaging of peripheral nerves in the NIR-II window显示文摘The peripheral nervous system(PNS)is essential for performing and maintaining various motor and sensory functions.Abnormalities can lead to a series of peripheral neurological conditions,such as paraesthesia,pain,or spasms,which are debilitating and lowering the quality of life.Thecurrent guidelines for diagnosis rely predominantly on clinical symptoms resulting from PNS dysfunction,which occur already at an advancedstage.There are currently no effective methods that visually reflect the extent of peripheral neuropathy.In our study,we present a novel in vivoand in situ real-time imaging of peripheral nerves based on the second near-infrared window(NIR-II)fluoresce nee.In NIR-II system,lead sulfidequa ntum dots(PbS Qds)with NIR-II fluoresce nee specifically bound to motor neuro rvspecific protein agrin,acting as image con trast.In micemodel,peripheral nerves were visible as soon as after 2 h post injection.We provide evidenee for the efficacy of this approach,which allows todirectly dem on strate peripheral nerves,their structure,and pote ntial damagesites and degree.Furthermore,our products were of goodbiocompatibility,while the n eural fluoresce nee signal was solid,bright and stable for 4 h in vivo.Thus,overall,our results suggest that NIR-II isan effective new method for direct imaging of peripheral nerves in vivo,opening new horizons on early,improved and more precise,targeteddiag no sis.A resulti ng more rapid installatio n of perso nalized therapy facilitates a better prognosis of clinical peripheral neuropathy. | Zhujun Feng Yimeng Yang Jian Zhang Kan Wang Yunxia Li Heng Xu Zhen Wang Ewelina Biskup Shixian Dong Xing Yang Yuefeng Hao Jun Chen Yan Wo | 2019 | Nano Research2019，12，12： | 1 |
| 7 | Inhibition of aryl hydrocarbon receptor signaling promotes the terminal differentiation of human erythroblasts显示文摘The aryl hydrocarbon receptor(AHR)plays an important role during mammalian embryo development.Inhibition of AHR signaling promotes the development of hematopoietic stem/progenitor cells.AHR also regulates the functional maturation of blood cells,such as T cells and megakaryocytes.However,little is known about the role of AHR modulation during the development of erythroid cells.In this study,we used the AHR antagonist StemRegenin 1(SR1)and the AHR agonist 2,3,7,8-tetrachlorodibenzo-p-dioxin during different stages of human erythropoiesis to elucidate the function of AHR.We found that antagonizing AHR signaling improved the production of human embryonic stem cell derived erythrocytes and enhanced erythroid terminal differentiation.RNA sequencing showed that SR1 treatment of proerythroblasts upregulated the expression of erythrocyte differentiation-related genes and downregulated actin organization-associated genes.We found that SR1 accelerated F-actin remodeling in terminally differentiated erythrocytes,favoring their maturation of the cytoskeleton and enucleation.We demonstrated that the effects of AHR inhibition on erythroid maturation were associated with F-actin remodeling.Our findings help uncover the mechanism for AHRmediated human erythroid cell differentiation.We also provide a new approach toward the large-scale production of functionally mature human pluripotent stem cell-derived erythrocytes for use in translational applications. | Yijin Chen Yong Dong Xulin Lu Wanjing Li Yimeng Zhang Bin Mao Xu Pan Xiaohong Li Ya Zhou Quanming An Fangxin Xie Shihui Wang Yuan Xue Xinping Cai Mowen Lai Qiongxiu Zhou Yan Yan Ruohan Fu Hong Wang Tatsutoshi Nakahata Xiuli An Lihong Shi Yonggang Zhang Feng Ma | 2022 | Journal of Molecular Cell Biology2022，14，2： | 0 |
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