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| 1 | p53 upregulated by HIF-la promotes hypoxiainduced G2/M arrest and renal fibrosis in vitro and in vivo显示文摘Hypoxia plays an important role in the genesis and progression of renal fibrosis.The underlying mechanisms, however, have not been sufficiently elucidated. We examined the role of p53 in hypoxia-induced renal fibrosis in cell culture (human and rat renal tubular epithelial cells) and a mouse unilateral ureteral obstruction (UUO) model. Cell cycle of tubular cells was determined by flow cytometry, and the expression of profibrogenic factors was determined by RT-PCR, immunohistochemistry, and western blotting. Chromatin immunoprecipitation and luciferase reporter experiments were performed to explore the effect of HIF-lα on p53 expression. We showed that, in hypoxic tubular cells, p53 upregulation suppressed the expression of CDK1 and cyclins Bl and DI, leading to cell cycle (G2/M) arrest (or delay) and higher expression of TGF-β, CTGF, collagens, and fibronectin. p53 suppression by siRNA or by a specific p53 inhibitor (PIF-α) triggered opposite effects preventing the G2/M arrest and profibrotic changes. In vivo experiments in the UUO model revealed similar antifibrotic results following intraperitoneal administration of PIF-α(2.2 mg/kg). Using gain-of-function, loss-of-function, and luciferase assays, we further identified an HRE3 region on the p53 promoter as the HIF-lα-binding site. The HIF-la-HRE3 binding resulted in a sharp transcriptional activation of p53. Collectively, we show the presence of a hypoxia-activated, p53-responsive profibrogenic pathway in the kidney. During hypoxia, p53 upregulation induced by HIF-la suppresses cell cycle progression, leading to the accumulation of G2/M cells, and activates profibrotic TGF-β and CTGF-mediated signaling pathways, causing extracellular matrix production and renal fibrosis. | Limin Liu Peng Zhang Ming Bai Lijie He Lei Zhang Ting Liu Zhen Yang Menglu Duan Minna Liu Baojian Liu Rui Du Qi Qian Shiren Sun | 2019 | Journal of Molecular Cell Biology2019，11，5： | 18 |
| 2 | Ultrasensitive skin‐like wearable optical sensors based on glass micro/nanofibers显示文摘Electronic skin,a class of wearable electronic sensors that mimic the functionalities of human skin,has made remarkable success in applications including health monitoring,human-machine interaction and electronic-biological interfaces.While electronic skin continues to achieve higher sensitivity and faster response,its ultimate performance is fundamentally limited by the nature of low-frequency AC currents.Herein,highly sensitive skin-like wearable optical sensors are demonstrated by embedding glass micro/nanofibers(MNFs)in thin layers of polydimethylsiloxane(PDMS).Enabled by the transition from guided modes into radiation modes of the waveguiding MNFs upon external stimuli,the skin-like optical sensors show ultrahigh sensitivity(1870 k·Pa^-1),low detection limit(7 mPa)and fast response(10μs)for pressure sensing,significantly exceeding the performance metrics of state-of-the-art electronic skins.Electromagnetic interference(EMI)-free detection of high-frequency vibrations,wrist pulse and human voice are realized.Moreover,a five-sensor optical data glove and a 2×2-MNF tactile sensor are demonstrated.These initial results pave the way toward a new category of optical devices ranging from ultrasensitive wearable sensors to optical skins. | Lei Zhang Jing Pan Zhang Zhang Hao Wu Ni Yao Dawei Cai Yingxin Xu Jin Zhang Guofei Sun Liqiang Wang Weidong Geng Wenguang Jin Wei Fang Dawei Di Limin Tong | 2020 | Opto-Electronic Advances2020，3，3： | 12 |
| 3 | H5N1 influenza virus-specific miRNA-like small RNA increases cytokine production and mouse mortality via targeting poly(rC)-binding protein 2显示文摘H5N1 流行性感冒病毒的感染在所有流行性感冒病毒之中引起最高的死亡。位于如此的高病毒的致病力下面的机制不完全地被理解。这里,我们报导 H5N1 流行性感冒病毒编码象 microRNA 一样小 RNA, miR-HA-3p,它从茎被处理由 Argonaute 2 的包含环的病毒的 RNA 先锋,和戏在在 H5N1 感染期间提高 cytokine 生产的一个角色。miR-HA-3p poly 指向的机械学的学习表演(rC ) 有约束力的蛋白质 2 (PCBP2 ) 并且压制它的表达式。与 PCBP2 being 一致 RIG-I/MAVS-mediated 抗病毒的天生的免疫的一个重要否定管理者,由 miR-HA-3p 的 PCBP2 表示的抑制在感染 H5N1 的人的巨噬细胞和老鼠支持 cytokine 生产病毒。我们断定 miR-HA-3p 是首先识别的流行性感冒编码病毒的象 microRNA 一样功能的 RNA 碎片和贡献导致 H5N1 的 cytokine 暴风雨和死亡的一个新奇毒力因素。 | Xihan Li Zheng Fu Hongwei Liang Yanbo Wang Xian Qi Meng Ding Xinlei Sun Zhen Zhou Ying Huang Hongwei Gu Limin Li Xi Chen Donghai Li Quan Zhao Fenyong Li Hua Wang Jin Wang Ke Zen Chen-Yu Zhang | 2018 | Cell Research2018，28，2： | 12 |
| 4 | Cervical Cancer Screening Coverage — China, 2018–2019显示文摘What is already known about this topic?The World Health Organization set a 2030 target of 70%cervical cancer screening coverage for women aged 35–45 years.Coverage stood at 37%in China in 2015.What is added by this report?In 2018–2019,China’s cervical cancer screening coverage reached 43.4%in women aged 35–44 years and 36.8%in women aged 35–64 years.Screening coverage was still lower in rural areas as well as central and western regions;large variations existed across provincial-level administrative divisions.What are the implications for public health practice?National and local policy and financial support should be maintained for cervical cancer screening,along with more targeted health education and outreach efforts and strengthened accessibility of health services in the rural areas and central and western regions. | Mei Zhang Yijing Zhong Limin Wang Heling Bao Zhengjing Huang Zhenping Zhao Xiao Zhang Chun Li Kelly Liang Sun Jing Wu Xiaoying Zheng Linhong Wang | 2022 | China CDC weekly2022，4，48： | 11 |
| 5 | Characteristics and formation mechanism of regional haze episodes in the Pearl River Delta of China显示文摘To investigate the characteristics and the specific mechanism of continuous haze,comprehensive measurements were conducted from 15 October to 19 November in the Atmospheric Environment Monitoring Super-Station in Heshan of Guangdong province.Five haze episodes occurred in October and November 2014 in the Pearl River Delta(PRD)region. The meteorological parameters, gas data, chemical compositions, and optical parameters of the aerosols were obtained. Among these events, the second haze episode,with the highest concentration of PM2.5 of 187.51 μg/m^3, was the most severe. NO^3-was always higher than SO_4^(2-), which indicated that motor vehicles played an important role in the haze, even though the oxidation rate from SO_2 to SO_4^(2-)was faster than that of NOXto NO_3^-. The difference between the hourly averages of Na+and K+during the haze episode and clean days was small, implying that straw combustion and sea salt had no significant effect on the occurrence of haze, and the backward trajectories of the air masses also conformed with this result. The air pollutants were difficult to disperse because of the significant decrease in the planetary boundary layer(PBL) height. Relative humidity played a crucial role in the formation of haze by leading to hygroscopic growth of the diameter of aerosols. | Wenguang Li Xingang Liu Yuanhang Zhang Kang Sun Yusheng Wu Rui Xue Limin Zeng Yu Qu Junling An | 2018 | Journal of Environmental Sciences2018，30，1： | 11 |
| 6 | Enhancement of High Energy Electron Fluxes and Variation of Atmospheric Electric Field in the Antarctic Region显示文摘High-energy electron precipitation in the high latitude regions enhances the ionization of the atmosphere,and subsequently increases the atmospheric conductivities and the vertical electric field of the atmosphere near the ground as well.The High-Energy Electron Flux(HEEF) data measured by the Fengyun-3 meteorological satellite are analyzed together with the data of nearsurface atmospheric vertical electric field measured at the Russian Vostok Station.Three HEEF enhancements are identified and it is shown that when the HEEF increases to a certain level,the local atmospheric vertical electric field near the ground can increase substantially than usual.The response time of the electric field to HEEF enhancement is about 3.7 to 4 days. | LI Renkang CHEN Tao LUO Jing ZHOU Limin HE Zhaohai WANG Chunqin SUN Yueqiang | 2016 | 空间科学学报2016，36，1： | 8 |
| 7 | Validation of dynamic cavitation model for unsteady cavitating flow on NACA66显示文摘Unsteady cavitating flow is extremely complicated and brings more serious damages and unignorable problems compared with steady cavitating flow.CFD has become a practical way to model cavitation;however,the popularly used full cavitation model cannot reflect the pressure-change that the bubble experiences during its life path in the highly unsteady flow like cloud cavitating.Thus a dynamic cavitation model(DCM)is proposed and it has been considered to have not only the first-order pressure effects but also zero-order effect and can provide greater insight into the physical process of bubble producing,developing and collapsing compared to the traditional cavitation model.DCM has already been validated for steady cavitating flow,and the results were reported.Furthermore,DCM is designed and supposed to be more accurate and efficient in modeling unsteady cavitating flow,which is also the purpose of this paper.The basic characteristic of the unsteady cavitating flow,such as the vapor volume fraction distribution and the evolution of pressure amplitude and frequency at different locations of the hydrofoil,are carefully studied to validate DCM.It is found that not only these characteristics mentioned above accord well with the experimental results,but also some detailed transient flow information is depicted,including the re-entrant jet flow that caused the shedding of the cavity,and the phenomenon of two-peak pressure fluctuation in the vicinity of the cavity closure in a cycle.The numerical results validate the capability of DCM for the application of modeling the complicated unsteady cavitating flow. | ZHANG XiaoBin ZHANG Wei CHEN JianYe QIU LiMin SUN DaMing | 2014 | Science China(Technological Sciences)2014，57，4： | 8 |
| 8 | Efficacy and safety of low-dose interleukin-2 in combination with methotrexate in patients with active rheumatoid arthritis:a randomized,double-blind,placebo-controlled phase 2 trial显示文摘Rheumatoid arthritis(RA)is an aggressive autoimmune arthritis,and current therapies remain unsatisfactory due to low remission rate and substantially adverse effects.Low-dose interleukin-2(Ld-IL2)is potentially a therapeutic approach to further improve the disease.This randomized,double-blind,placebo-controlled trial was undertaken to evaluate the efficacy and safety of Ld-IL2 in patients with active RA.Patients were randomly assigned(1:1)to receive Ld-IL2,defined as a dose of 1 million IU,or placebo in a 12-week trial with a 12-week follow-up.Three cycles of Ld-IL2 or placebo were administered subcutaneously every other day for 2 weeks(a total of 7 doses),followed by a 2-week break.All patients received a stable dose of methotrexate(MTX).The primary outcomes were the proportion of patients achieving the ACR20,DAS28-ESR<2.6,and the change from baseline in CDAI or SDAI at week 24.Secondary endpoints included other clinical responses and safety.The primary outcomes were achieved in the perprotocol population.The improvements from baseline in CDAI and SDAI were significantly greater across time points for the LdIL2+MTX group(n=17)than for the placebo+MTX group(n=23)(P=0.018 and P=0.015,respectively).More patients achieved ACR20 response in the Ld-IL2+MTX group than those in the placebo+MTX group at week 12(70.6%vs 43.5%)and at week 24(76.5%vs 56.5%)(P=0.014).In addition,low Treg and high IL-21 were associated with good responses to Ld-IL2.Ld-IL-2 treatment was well-tolerated in this study.These results suggested that Ld-IL2 was effective and safe in RA.ClinicalTrials.gov number:NCT 02467504. | Xiaoying Zhang Miao Miao Ruijun Zhang Xu Liu Xiaozhen Zhao Miao Shao Tian Liu Yuebo Jin Jiali Chen Huixin Liu Xia Zhang Yun Li Yunshan Zhou Yue Yang Ru Li Haihong Yao Yanying Liu Chun Li Yuhui Li Limin Ren Yin Su Xiaolin Sun Jing He Zhanguo Li | 2022 | Signal Transduction and Targeted Therapy2022，7，4： | 7 |
| 9 | Investigation on regenerator temperature inhomogeneity in Stirling-type pulse tube cooler显示文摘Regenerator is one of the most crucial components to pulse tube cooler (PTC) and thermoacoustic engine. As such regenerator is scaled up to high-power, the thermal and hydrodynamic communication transverse to the acoustic axis gets weaker and weaker. Under this condition, any unsymmetric factor could cause serious instability to the cooler or engine, which degrades their performance. Investigation has been carried out on a high-power two-stage thermal-coupled U-shape Stirling-type PTC. By detailed circumferential temperature measurements along the middle heat exchanger and second stage regen-erator, a kind of temperature inhomogeneity caused by unsymmetric pre-cooling effect of inter-stage thermal bridge was found in the lower part of the regenerator of the PTC. The temperature inhomoge-neity originating from the middle heat exchanger of the second stage regenerator amplified itself in the lower part of the regenerator and then internal streaming formed. The maximal radial temperature dif-ference could reach 30―40 K. Experimental results show that the temperature inhomogeneity intensi-fies with increased pre-cooling power and its direction can be reversed by changing the pre-cooling effect of the first stage PTC to heating effect by using external thermal load. This research shows that it is important to maintain the heating or cooling effects of heat exchangers uniform in high-power re-generative coolers and engines. | SUN DaMing MARC Dietrich GUENTER Thummes Qiu LiMin | 2009 | Chinese Science Bulletin2009，54，6： | 7 |
| 10 | Overactive bladder symptom score to evaluate efficacy of solifenacin for the treatment of overactive bladder symptoms显示文摘 | Liu Ming Wang Jianye Yang Yong An Ruihua Wen Jianguo Guan Zhichen Zheng Shaobin Wang Dongwen Song Bo Liao Limin Guo Hongqian Xiao Jiaquan Sun Yinghao Shen Zhoujun Kong Chuize He Dalin Huang Yiran Wang Xiaofeng Zhang Xu Li Hanzhong Huang Jian Zhao Xiaokun Zeng Puqing Song Xishuang Ye Zhangqun | 2014 | Chinese Medical Journal2014，，2： | 7 |
| 11 | A Multicenter Study of Viral Aetiology of Community-Acquired Pneumonia in Hospitalized Children in Chinese Mainland显示文摘Community-acquired pneumonia(CAP) is one of the leading causes of morbidity and mortality in children worldwide.In this study,we aimed to describe the aetiology of viral infection of pediatric CAP in Chinese mainland.During November2014 to June 2016,the prospective study was conducted in 13 hospitals.The hospitalized children under 18 years old who met the criteria for CAP were enrolled.The throat swabs or nasopharyngeal aspirates(NPAs) were collected which were then screened 18 respiratory viruses using multiplex PCR assay.Viral pathogens were present in 56.6%(1539/2721) of the enrolled cases,with the detection rate of single virus in 39.8% of the cases and multiple viruses in 16.8% of the cases.The most frequently detected virus was respiratory syncytial virus(RSV)(15.2%,414/2721).The highest detection rate of virus was in <6-month-age group(70.7%,292/413).RSV,human metapneumovirus(HMPV),human parainfluenza viruses(HPIVs) and influenza B virus(Flu B) showed the similar prevalence patterns both in north and south China,but HPIVs,Flu A,human bocavirus(HBoV),human adenovirus(HAdV) and human coronaviruses(HCoVs) showed the distinct circulating patterns in north and south China.Human enterovirus/human rhinovirus(HEV/HRV)(27.6%,27/98),HBoV(18.4%,18/98),RSV(16.3%,16/98) and HMPV(14.3%,14/98) were the most commonly detected viruses in severe pneumonia cases with single virus infection.In conclusion,viral pathogens are frequently detected in pediatric CAP cases and may therefore play a vital role in the aetiology of CAP.RSV was the most important virus in hospitalized children with CAP in Chinese mainland. | Yun Zhu Baoping Xu Changchong Li Zhimin Chen Ling Cao Zhou Fu Yunxiao Shang Aihuan Chen Li Deng Yixiao Bao Yun Sun Limin Ning Shuilian Yu Fang Gu Chunyan Liu Ju Yin Adong Shen Zhengde Xie Kunling Shen | 2021 | Virologica Sinica2021，36，6： | 7 |
| 12 | Generation and analysis of expressed sequence tags from the salt-tolerant eelgrass species, Zostera marina显示文摘Zostera marina, a monocotyledonous angiosperm, is one of the most important seagrass species. To investigate the salt-tolerance mechanism and discover salt-tolerant genes in Z. marina, a cDNA library was constructed. Single-pass sequencing of the 5'ends of 4 081 clones yielded 4 002 high quality expressed sequence tags (ESTs), which were assembled into 241 contigs and 1 673 singletons, representing 1 914 unigenes. The average length of the ESTs was 582 bp, with sizes ranging from 100-1 500 bp. Basic Local Alignment Search Tool (BLASTX) analysis revealed that 1 664 unigenes had significant homology to known genes in the National Center for Biotechnology Information (NCBI) non-redundant (nr) database (E-value 5-10). Among them, the two most abundant genes encoded metallothionein (157 ESTs) and chlorophyll a/b-binding protein (38 ESTs), accounting for 7.1% and 1.7% of the total ESTs, respectively. Using Kyoto Encyclopedia of Genes and Genomes (KEGG), 1 462 unigenes were assigned to 1 161 pathways (E-value 5-10). A total of 938 unigenes were assigned Gene Ontology (GO) terms based on the GO hierarchy analysis, and InterProScan searches recognized 1 003 InterPro families. Three genes for metallothionein in Z. marina that belonged to Class II was identified. Results of this study will improve understanding of the molecular mechanisms of saline tolerance in Z. marina. | KONG Fanna ZHOU Yang SUN Peipei LIU Limin MAO Yunxiang | 2013 | Acta Oceanologica Sinica2013，32，8： | 5 |
| 13 | Structural effects of three-dimensional angle-interlock woven composite undergoing bending cyclic loading显示文摘This paper reports the structural effects of three-dimensional(3-D)angle-interlock woven composite(3DAWC)undergoing three-point bending cyclic loading from experimental and finite element analysis(FEA)approaches.In experiment,the fatigue tests were conducted to measure the bending deflection and to observe the damage morphologies.By the FEA approach,a micro-structural unit-cell model of the 3DAWC was established at the yarn level to simulate the fatigue damage.The stress degradation at the loading condition of constant deformation amplitude was calculated to show the degradation of mechanical properties.In addition,the stress distribution,fatigue damage evolution and critical damage regions were also obtained to qualitatively reveal the structural effects and damage mechanisms of the 3DAWC subjected to three-point bending cyclic loading. | JIN LiMin YAO Yao YU YiMin ROTICH Gideon SUN BaoZhong GU BoHong | 2014 | Science China(Physics,Mechanics & Astronomy)2014，57，3： | 5 |
| 14 | Stabilizing effects of atomic Ti doping on high-voltage high-nickel layered oxide cathode for lithium-ion rechargeable batteries显示文摘High-voltage high-nickel lithium layered oxide cathodes show great application prospects to meet the ever-increasing demand for further improvement of the energy density of rechargeable lithium-ion batteries(LIBs)mainly due to their high output capacity.However,severe bulk structural degradation and undesired electrode-electrolyte interface reactions seriously endanger the cycle life and safety of the battery.Here,2 mol%Ti atom is used as modified material doping into LiNi_(0.8)Co_(0.2)Mn_(0.2O2)(NCM)to reform LiNi_(0.6)Co_(0.2)Mn_(0.18)Ti_(0.02)O_(2)(NCM-Ti)and address the long-standing inherent problem.At a high cut-off voltage of 4.5 V,NCM-Ti delivers a higher capacity retention ratio(91.8%vs.82.9%)after 150 cycles and a superior rate capacity(118 vs.105 mAh·g^(-1))at the high current density of 10 C than the pristine NCM.The designed high-voltage full battery with graphite as anode and NCM-Ti as cathode also exhibits high energy density(240 Wh·kg^(-1))and excellent electrochemical performance.The superior electrochemical behavior can be attributed to the improved stability of the bulk structure and the electrode-electrolyte interface owing to the strong Ti-O bond and no unpaired electrons.The in-situ X-ray diffraction analysis demonstrates that Ti-doping inhibits the undesired H2-H3 phase transition,minimizing the mechanical degradation.The ex-situ TEM and X-ray photoelectron spectroscopy reveal that Ti-doping suppresses the release of interfacial oxygen,reducing undesired interfacial reactions.This work provides a valuable strategic guideline for the application of high-voltage high-nickel cathodes in LIBs. | Yong Cheng Yan Sun Changting Chu Limin Chang Zhaomin Wang Dongyu Zhang Wanqiang Liu Zechao Zhuang Limin Wang | 2022 | Nano Research2022，15，5： | 5 |
| 15 | Social engineering in cybersecurity:a domain ontology and knowledge graph application examples显示文摘Social engineering has posed a serious threat to cyberspace security.To protect against social engineering attacks,a fundamental work is to know what constitutes social engineering.This paper first develops a domain ontology of social engineering in cybersecurity and conducts ontology evaluation by its knowledge graph application.The domain ontology defines 11 concepts of core entities that significantly constitute or affect social engineering domain,together with 22 kinds of relations describing how these entities related to each other.It provides a formal and explicit knowledge schema to understand,analyze,reuse and share domain knowledge of social engineering.Furthermore,this paper builds a knowledge graph based on 15 social engineering attack incidents and scenarios.7 knowledge graph application examples(in 6 analysis patterns)demonstrate that the ontology together with knowledge graph is useful to 1)understand and analyze social engineering attack scenario and incident,2)find the top ranked social engineering threat elements(e.g.the most exploited human vulnerabilities and most used attack mediums),3)find potential social engineering threats to victims,4)find potential targets for social engineering attackers,5)find potential attack paths from specific attacker to specific target,and 6)analyze the same origin attacks. | Zuoguang Wang Hongsong Zhu Peipei Liu Limin Sun | 2021 | Cybersecurity2021，4，1： | 4 |
| 16 | Perturbative countersurveillance metaoptics with compound nanosieves显示文摘The progress of metaoptics relies on identifying photonic materials and geometries,the combination of which represents a promising approach to complex and desired optical functionalities.Material candidate options are primarily limited by natural availability.Thus,the search for meta-atom geometries,by either forward or inverse means,plays a pivotal role in achieving more sophisticated phenomena.Past efforts mainly focused on building the geometric library of individual meta-atoms and synthesizing various ones into a design.However,those efforts neglected the powerfulness of perturbative metaoptics due to the perception that perturbations are usually regarded as adverse and in need of being suppressed.Here,we report a perturbation-induced countersurveillance strategy using compound nanosieves mediated by structural and thermal perturbations.Private information can be almost perfectly concealed and camouflaged by the induced thermal-spectral drifts,enabling information storage and exchange in a covert way.This perturbative metaoptics can self-indicate whether the hidden information has been attacked during delivery.Our results establish a perturbative paradigm of securing a safer world of information and internet of things. | Jiancai Xue Zhang-Kai Zhou Limin Lin Chao Guo Shang Sun Dangyuan Lei Cheng-Wei Qiu Xue-Hua Wang | 2019 | Light(Science & Applications)2019，8，1： | 4 |
| 17 | UV/H2O2 oxidation of tri(2-chloroethyl) phosphate: Intermediate products, degradation pathway and toxicity evaluation显示文摘Tri(2-chloroethyl) phosphate(TCEP) with the initial concentration of 5 mg/L was degraded by UV/H2O2 oxidation process. The removal rate of TCEP in the UV/H2O2 system was 89.1% with the production of Cl-and PO4^3- of 0.23 and 0.64 mg/L. The removal rate of total organic carbon of the reaction was 48.8% and the pH reached 3.3 after the reaction. The oxidative degradation process of TCEP in the UV/H2O2 system obeyed the first order kinetic reaction with the apparent rate constant of 0.0025 min^-1( R^2 = 0.9788). The intermediate products were isolated and identified by gas chromatography-mass spectrometer. The addition reaction of HO · and H2O and the oxidation reaction with H2O2 were found during the degradation pathway of 5 mg/L TCEP in the UV/H2O2 system. For the first time, environment risk was estimated via the 'ecological structure activity relationships' program and acute and chronic toxicity changes of intermediate products were pointed out. The luminescence inhibition rate of photobacterium was used to evaluate the acute toxicity of intermediate products. The results showed that the toxicity of the intermediate products increased with the increase of reaction time, which may be due to the production of chlorine compounds. Some measures should be introduced to the UV/H2O2 system to remove the highly toxic Cl-containing compounds, such as a nanofiltration or reverse osmosis unit. | Qiuyi Ji Huan He Zhanqi Gao Xiaohan Wang Shaogui Yang Cheng Sun Shiyin Li Yong Wang Limin Zhang | 2020 | Journal of Environmental Sciences2020，32，12： | 4 |
| 18 | Effects on Growth Performance and Feed Digestibility of Hainan Black Pigs by Adding Lysine in Low Protein Diet显示文摘[Objective] The paper was to study the effects on growth performance and feed digestibility of Hainan black pigs by adding lysine in low protein diet.[Method] A total of 36 Hainan black pigs with the body weight of(46.34 ±3.06) kg were randomly divided into three groups:control group(protein level 15%,lysine level 0.83%),experimental group I(protein level 13%,0.83%),and experimental group II(protein level 13%,lysine level 1.03),each group had three replicates of four pigs.The trial lasted 35 d.[Result] The growth performance of Hainan black pig in group II had no significant difference with that in control group(P>0.05).The apparent digestibility of crude protein and phosphorus of Hainan black pigs in Group II increased significantly(P<0.05),which were increased by 10.08% and 11.85% respectively compared to the control group;the apparent digestibility of calcium was increased,but the difference was not significant(P>0.05).[Conclusion] It will not reduce the growth performance of Hainan black pig when the protein level of diet is reduced by 2% and the lysine level is increased to 1.03%.It is recommended that the diet can be used in the production of Hainan black pig. | Wei Limin Liu Quanwei Sun Ruiping Zheng Xinli Wang Feng Tan Shuyi Huang Lili Xing Manping | 2018 | Animal Husbandry and Feed Science2018，10，2： | 4 |
| 19 | Effect of Pelleted Total Mixed Ration on Production Performance and Serum Biochemical Index of Growing Hainan Black Goats显示文摘[Objective] The paper was to investigate effects of pelleted total mixed ration on production performance and serum biochemical index of growing Hainan black goats.[Method] Twenty-four growing Hainan black goats with the same genetic backgrounds and similar initial weight of(10.05±0.049) kg were randomly assigned into two treatments, and supplied with Juncao + concentrate(control group), pelleted total mixed ration(experimental group), respectively. The trial lasted 50 d.[Result] The final weight, daily gain and feed intake of experimental group were significantly higher than those of control group(P<0.05), but the feed/gain ratio of experimental group was markedly lower than that of control group(P<0.05). Compared with the control group, the gross profit of experimental group significantly increased( P <0.05).[Conclusion] Pelleted total mixed ration led to better production performance of growing Hainan black goat. | Liu Quanwei Wang Feng Wei Limin Huang Lili Sun Ruiping Xing Manping Zheng Xinli | 2019 | Animal Husbandry and Feed Science2019，11，1： | 4 |
| 20 | Effects of gravity on the microstructure of Zr_(41)Ti_(14)-Cu_(12.5)Ni_(10)Be_(22.5) bulk glass forming alloy显示文摘The ZrTiCuNiBe alloy is melt and solidified by Bridgman unidirectional solidification on two gravity field orientations (the gravity field orientation is parallel and opposite to solidification direction). Effects of gravity on morphology and microstructure are investigated by scanning electron microscope (SEM) and X-ray diffraction (XRD). When gravity field orientation is parallel to solidificationdirection, less needle-like primary phase is embedded in a matrix eutectic; when gravity field orientation is opposite to solidification direction, a large amount of coarser needle-like primary phases were observed. | LI Gong, ZHAN Zaiji, WANG Limin, CAO Limin, SUN Liling, DAI Daoyang, ZHANG Jun & WANG WenkuiInstitute of Physics, Center for Condensed Matter Physics, Chinese Academy of Sciences, Beijing 100080, China Department of Materials Science and Engineering, Yanshan University, Qinhuangdao 066004, China | 2001 | Chinese Science Bulletin2001，46，11： | 3 |
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