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| 1 | Solid-state additive manufacturing and repairing by cold spraying:A review显示文摘High-performance metal additive manufacturing(AM) has been extensively investigated in recent year because of its unique advantages over traditional manufacturing processes. AM has been applied to form complex components of Ti, Fe or Ni alloys. However, for other nonferrous alloys such as Al alloys, Mg alloys and Cu alloys, AM may not be appropriate because of its melting nature during processing by laser electron beam, and/or arc. Cold spraying(CS) has been widely accepted as a promising solid-state coating technique in last decade for its mass production of high-quality metals and alloys, and/or metal matrix composites coatings. It is now recognized as a useful and powerful tool for AM, but the related research work has just started. This review summarized the literature on the state-of-the-art and problems for C as an AM and repairing technique. | Wenya Li Kang Yang Shuo Yin Xiawei Yang Yaxin Xu Rocco Lupoi | 2018 | Journal of Materials Science & Technology2018，34，3： | 35 |
| 2 | PTEN-L is a novel protein phosphatase for ubiquitin dephosphorylation to inhibit PINK1-Parkin-mediated mitophagy显示文摘Mitophagy 是为损坏线粒体的特定的消除的选择 autophagy 的一种重要类型。(PINK1 )导致 PTEN 的通常认为的 kinase 蛋白质 1 催化 ubiquitin (Ub ) 的 phosphorylation 在 PINK1-Parkin-mediated mitophagy 的发作起一个关键作用。(PTEN-L ) 磷酸酶和 tensin 相当或相同的事物(PTEN ) 长是 PTEN 的最新识别的 isoform,与到它的 N 终点的 173 氨基酸的增加。这里,我们报导 PTEN-L 是经由它对 phosphorylated ubiquitin 的蛋白质磷酸酶活动的 mitophagy 的一个新奇否定管理者。我们发现 PTEN-L 在外部 mitochondrial 膜(OMM ) 本地化,而 PTEN-L 的删除支持, PTEN-L 的 overexpression 禁止, mitophagy 由各种各样的损坏线粒体的代理人导致了。机械学地, PTEN-L 能够有效地阻止 Parkin mitochondrial translocation,减少 Parkin phosphorylation,维持它的关上的不活跃的符合构造,并且禁止它的 E3 ligase 活动。更重要地, PTEN-L 在 vivo 减少 phosphorylated ubiquitin (pSer65-Ub ) 的水平,并且在 vitro,磷酸酶试金经由它的蛋白质磷酸酶活动证实那 PTEN-L dephosphorylates pSer65-Ub,独立于它的类脂化合物磷酸酶功能。一起拿,我们的调查结果为 ubiquitin 作为蛋白质磷酸酶表明 PTEN-L 的新奇功能,它抵抗在 mitophagy 正式就职和 mitophagy 的最终的抑制导致前馈控制机制的阻塞的调停 PINK1 的 ubiquitin phosphorylation。因此,理解 PTEN-L 的这新奇功能在控制 mitophagy 的分子的难题提供一关键错过片,在包括象 Parkinsons 那样的 neurodegenerative 混乱的许多重要人的疾病的一个批评过程疾病。 | Liming Wang Yik-Lam Cho Yancheng Tang Jigang Wang Jung-Eun Park Yajun Wu Chunxin Wang Yan Tong Ritu Chawla Jianbin Zhang Yin Shi Shuo Deng Guang Lu Yihua Wu Hayden Weng-Siong Tan Pornteera Pawijit Grace Gui-Yin Lim Hui-Ying Chan Jingzi Zhang Lei Fang Hanry Yu Yih-Cherng Liou Mallilankaraman Karthik Boon-Huat Bay Kah-Leong Lim Siu-Kwan Sze Celestial T. Yap Han-Ming Shen | 2018 | Cell Research2018，28，8： | 25 |
| 3 | Tumor-associated macrophage-derived CCL20 enhances the growth and metastasis of pancreatic cancer显示文摘胰腺的癌症是有导致世界范围的高死亡率的一个高变形的潜力的好攻击的恶意。尽管巨噬细胞有潜力杀死肿瘤房间并且对肿瘤得到有免疫力的回答,有证据,联系肿瘤的巨噬细胞(TAM ) 支持肿瘤前进并且压制 T 房间回答。CC-chemokine ligand 20 (CCL20 ) 并且它的唯一的受体 CC-chemokine 受体(CCR6 ) 6 被癌症房间为移植和转移利用并且在癌症的发展和前进起重要作用。最近的研究证明了 CCL20 的表示是在胰腺的癌症的 upregulated;然而, CCL20 的行动的机制尚待充分被阐明。在这研究,包括变形胰腺的癌症织物,在胰腺的癌症织物的 TAM 的 CCL20 的异常表示被检测。CCL20 表示比在胰腺的癌症房间排队的在巨噬细胞是更加更高的,特别地在 interleukin-4-treated (M2 ) 巨噬细胞。用胰腺的癌症房间的 Boyden 房间试金,我们发现 M2 巨噬细胞分泌的 CCL20 支持了胰腺的癌症房间的迁居,上皮间充质的转变,和侵略。RNA 干扰结果证明 CCR6 是为在胰腺的癌症房间的 CCL20 的受体,调停这些房间的增加的侵略性质由 CCL20 支持了。用一个老鼠模型,我们在在 vivo 支持胰腺的癌症生长和肝转移证实了 CCR6/CCL20 的角色。我们的调查结果在胰腺的癌症提供卓见进藏匿巨噬细胞的 CCL20 的重要角色并且含有 CCR6/CCL20 同样潜在的治疗学的目标。 | Bingyan Liu Yiping Jia Jun Ma Shaoqiu Wu Haosheng Jiang Yan Cao Xianjun Sun Xiang Yin Shuo Yan Mingyi Shang Aiwu Mao | 2016 | Acta Biochimica et Biophysica Sinica2016，48，12： | 13 |
| 4 | Deposition of FeCoNiCrMn high entropy alloy(HEA) coating via cold spraying显示文摘High entropy alloys(HEAs) are of great interest in the community of materials science and engineering due to their unique phase structure. They are constructed with five or more principal alloying elements in equimolar or near-equimolar ratio. Therefore, HEAs can derive their performance from multiple principal elements rather than a single element. In this work, solid-state cold spraying(CS) was applied for the first time to produce FeCoNiCrMn HEA coating. The experimental results confirm that CS can be used to produce a thick HEA coating with low porosity. As a low-temperature deposition process, CS completely retained the HEA phase structure in the coating without any phase transformation. The characterization also reveals that the grains in the CSed HEA coating had experienced significant refinement as compared to those in the as-received HEA powder due the occurrence of dynamic recrystallization at the highly deformed interparticle region. Due to the increased dislocation density and grain boundaries,CSed HEA coating was much harder than the as-received powder. The tribological study shows that the CSed FeCoNiCrMn HEA coating resulted in lower wear rate than laser cladded HEA coatings. | Shuo Yin Wenya Li Bo Song Xingchen Yan Min Kuang Yaxin Xu Kui Wen Rocco Lupoi | 2019 | Journal of Materials Science & Technology2019，35，6： | 13 |
| 5 | Effect of Chinese Medicine on No or Slow Reflow after Percutaneous Coronary Intervention in Myocardial Infarction Patients: A Systematic Review and Meta-Analysis显示文摘Objective:To systematic review the effect of Chinese medicine(CM)on no or slow reflow after percutaneous coronary intervention(PCI)in myocardial infarction(MI)patients.Methods:The Pub Med,EMBASE databases,Cochrane Central Register of Controlled Trials(CENTRAL),Web of Science,China National Knowledge Infrastructure(CNKI),Chinese BioMedical Literature Database(CBM),Wanfang Knowledge Service Platform(Wanfang Database)and Chinese Scientific Journal Database(VIP)were searched up to December 2017.Randomized controlled trials(RCTs)which evaluated the effect of CM therapies on no or slow reflow after PCI in MI patients were included.The primary outcome was the effect of reperfusion.Secondary outcomes were left ventricular ejection fraction,incidence of major adverse cardiovascular events and adverse effect.Results:Ten RCTs covering 814 patients were included.Two studies revealed that the incidence of no or slow reflow was less in Shenmai Injection(参麦注射液)group than in the control group measured by thrombolysis in myocardial infarction(TIMI)2(risk ratio=0.55,95%confidence interval 0.38 to 0.81,P=0.003,I^2=37%).Two studies indicated that Salvianolate Injection showed no additional benefit on no or slow reflow measured by corrected TIMI frame count compared with the conventional treatment(mean difference–4.24,95% confidence interval–13.03 to 4.54,P=0.34,I^2=86%).In addition,Tongxinluo Capsules(通心络胶囊),Danhong Injection(丹红注射液)and Xuesaitong Injection(血塞通注射液)may have the potential to reduce no or slow reflow measured during or after PCI in individual studies.Conclusions:Current evidence from RCTs are not sufficient to evaluate the effect of CM adjuvant therapies on no or slow reflow after PCI for MI patients.The included studies are limited by small sample size and unclear baseline conditions.Further rigorously designed researches and verification studies with sufficient number of patients are warranted. | ZHANG Xiao-yu SUN Yang YANG Xin-yu HU Jia-yuan ZHENG Rui CHEN Shi-qi LI Min LI Cheng-yu JIANG Yin LIU Shuo ZHAO Chen XING Yan-wei SHANG Hong-cai | 2020 | Chinese Journal of Integrative Medicine2020，26，3： | 11 |
| 6 | Al matrix composites fabricated by solid-state cold spray deposition:A critical review显示文摘Cold spraying(CS),or cold gas dynamic spray(CGDS),is an emerging solid-state powder deposition process,allowing fast and mass production and restoration of metallic components.CS of metal matrix composites(MMCs)has attracted increasing attention from academia and industry over the last decades,especially in the area of Al matrix composites(AMCs),which have demonstrated a high potential for applications in aerospace,automotive,and electronics industries.This article aims to summarize the recent development of CS-processed AMCs in terms of composite powder preparation,deposition processing,microstructure evolution,mechanical and corrosion properties.Furthermore,this review also reports the relevant research progress with the focus on post-treatments of the AMCs for CS additive manufacturing applications including heat treatment,hot rolling,and friction stir processing.Finally,the challenges and perspectives on the fabrication of advanced AMCs by CS are addressed. | Xinliang Xie Shuo Yin Rija-nirina Raoelison Chaoyue Chen Christophe Verdy Wenya Li Gang ji Zhongming Ren Hanlin Liao | 2021 | Journal of Materials Science & Technology2021，，27： | 8 |
| 7 | The prevalence rates of major chronic diseases in retired and in-service Chinese military officers(2000-2016): a meta-analysis显示文摘Background:Chronic diseases cause a tremendous burden to the military medical system.However,the prevalence rates of major chronic diseases among military officers remain unclear in China.Methods:China National Knowledge Infrastructure(CNKI),Wanfang Database,VIP Database for Chinese Technical Periodicals(VIP),Pub Med and Web of Science were searched for studies(from 2000 to 2016)concerning 6 major chronic diseases:hypertension,hyperlipidemia,diabetes mellitus,heart diseases,cerebrovascular diseases,and chronic obstructive pulmonary diseases(COPD)in Chinese military officers following strict inclusion and exclusion criteria.Three researchers independently extracted data from the included studies,and a fourth researcher reviewed and solved every disagreement.Statistical analysis was performed with STATA 14.0 and R 3.3.2.Heterogeneity was evaluated by the I^2 value.A random effect model was performed to combine the heterogeneous data.The Egger test was performed to test the publication bias.Results:A total of 90,758 military officers derived from 75 articles were pooled together.Publication bias was only observed in 37 studies reporting heart disease(P_(Egger test)=0.01).The overall prevalence rates of hypertension,hyperlipidemia,diabetes mellitus,heart diseases,cerebrovascular diseases,and COPD were 46.6%(95%CI 41.8%–51.5%),30.9%(26.4%–35.7%),20.7%(16.5%–25.7%),48.2%(41.7%–54.9%),20.2%(14.8%–26.9%)and 16.6%(12.9%–21.0%),respectively.The prevalence rates of hypertension,diabetes,heart disease,cerebrovascular disease,and COPD,rather than hyperlipidemia,increased with age in Chinese military officers.Heart diseases(P_(Q-test)<0.001)and hypertension(P_(Q-test)<0.001)increased sharply in retired officers compared with officers in service.Cerebrovascular disease was more frequent in Northern Theater Command than in any other theater command(P_(Q-test)<0.001).Conclusion:Major chronic diseases heavily affect Chinese military officers,especially retirees.Medical intervention should be enforced on the prevention of cerebrovascular diseases in those working in cold areas in the north,as well as hypertension and heart diseases in retirees. | Thermite Mara Long-Teng Ma Shuo Wang Ling Wang Fan Yang Jia-Hui Song Yi-Chun Cao Jian-Hua Yin Guang-Wen Cao | 2018 | Military Medical Research2018，5，3： | 6 |
| 8 | Extraction(DSX) from Erigeron breviscapus modulates outward potassium currents in rat retinal ganglion cells显示文摘AIM: To investigate the effect of DSX, an active component extracted from Erigeron breviscapus, on the voltage-gated outward K+channel currents in rat retinal ganglion cells(RGCs) by using electrophysiological method, and to explore the possible mechanisms of DSX on optic nerve protection.· METHODS: Outward K + currents were recorded by using whole-cell patch-clamp techniques on acutely isolated rat RGCs. Outward K+currents were induced by a series of depolarizing voltage pulses from a holding potential of-70 m V to +20 m V in an increment of 10 m V.·RESULTS: Extracellular application of DSX voltage-dependently suppressed both the steady-state and peak current amplitudes of outward K+currents in rat RGCs.Furthermore, DSX reversibly and dose-dependently inhibited the amplitudes of outward K+currents of the cells. At +20 m V membrane potential DSX at the concentrations of 0.02 g/L and 0.05 g/L showed no significant effects on the currents. In contrast, DSX at higher concentrations(0.1 g/L, 0.2 g/L and 0.5 g/L)significantly suppressed the current amplitudes.· CONCLUSION: These results suggest that DSX reversibly and dose-dependently suppress outward K+channel currents in rat RGCs, which may be one of the possible mechanisms underlying Erigeron breviscapus prevents vision loss and RGC damage caused by glaucoma. | Shuo Yin Zhong-Feng Wang Jun-Guo Duan Lu Ji Xue-Jing Lu | 2015 | International Journal of Ophthalmology(English edition)2015，8，6： | 6 |
| 9 | Antigens synthesis and antibodies preparation for furazolidone and its metabolite 3-amino-2-oxazolidinone显示文摘3- 的二 haptens [(5-amino-furan-2-ylmethylene ) 氨基] oxazolidin-5-one (FZ-NH2 ) 和 3-{[(4-carboxyphenyl ) 甲又]-amino}-2-oxazolidinone (CPAOZ ) 被综合。为 FZ-NH2, immunogens 被 glutaraldehyde 和重氮基的盐方法准备。为 CPAOZ, immunogens 被活跃酉旨的方法连接并且混合了酸酐。与联合相比,间接竞争连接酶的 immunosorbent 试金(ic-ELISA ) 经由活跃酉旨方法经由 glutaraldehyde 方法和 CPAOZ-KLH 的 immunogen 与 FZ-NH2-OVA 的涂层抗原被开发。为 furazolidone 和它的代谢物 AOZ (是的 NPAOZ 衍生物) ,敏感(IC50 ) 是 2.0 渭 g /L 和 2.5 渭 g /L,察觉(IC15 ) 的限制是 0.09 渭 g /L 和 0.25 渭 g /L 分别地。一个敏感方法为 furazolidone 的同时的决心被开发在喂并且它在织物的代谢物 AOZ。 | Hua Ping Zhu Ting Ting Liu Bing Liu Hui Ling Yin Xiao Long Li Li Wang Shuo Wang | 2010 | Chinese Chemical Letters2010，21，9： | 6 |
| 10 | Physical sensors for skin-inspired electronics显示文摘Skin,the largest organ in the human body,is sensitive to external stimuli.In recent years,an increasing number of skin-inspired electronics,including wearable electronics,implantable electronics,and electronic skin,have been developed because of their broad applications in healthcare and robotics.Physical sensors are one of the key building blocks of skin-inspired electronics.Typical physical sensors include mechanical sensors,temperature sensors,humidity sensors,electrophysiological sensors,and so on.In this review,we systematically review the latest advances of skin-inspired mechanical sensors,temperature sensors,and humidity sensors.The working mechanisms,key materials,device structures,and performance of various physical sensors are summarized and discussed in detail.Their applications in health monitoring,human disease diagnosis and treatment,and intelligent robots are reviewed.In addition,several novel properties of skin-inspired physical sensors such as versatility,self-healability,and implantability are introduced.Finally,the existing challenges and future perspectives of physical sensors for practical applications are discussed and proposed. | Shuo Li Yong Zhang Yiliang Wang Kailun Xia Zhe Yin Huimin Wang Mingchao Zhang Xiaoping Liang Haojie Lu Mengjia Zhu Haomin Wang Xinyi Shen Yingying Zhang | 2020 | InfoMat2020，2，1： | 5 |
| 11 | Bystin-like protein is upregulated in hepatocellular carcinoma and required for nucleologenesis in cancer cell proliferation显示文摘象 bystin 一样(BYSL ) 基因以前被描绘为参予早胚胎培植的房间粘附编码附件蛋白质。它也涉及 40S ribosomal 子单元生物的续生说并且被发现在很快种胚胎和癌症房间线被表示。以便在癌症房间增长和生长探索 BYSL 的角色,我们把 hepatocellular 癌(HCC ) 用作一个模型。这里,我们报导 BYSL 在 vitro 并且在 vivo 为 HCC 房间生长是关键的。在人的 HCC 标本的 BYSL mRNA 和蛋白质的表示层次显著地与在邻近的非癌的织物看见的那些相比被增加。在 vitro,由短发卡 RNA 的 BYSL 的抑制减少了 HCC 房间增长,导致了 apoptosis 并且部分在 G2/M 阶段逮捕了房间周期。在 vivo,与 BYSL siRNA 对待的 HCC 房间没能在下的培植以后在裸体老鼠形成肿瘤。为了为 BYSL 导致 RNAi 的细胞生长决定细胞的基础,逮捕, BYSL subcellular 本地化在有丝分裂并且分裂期间 HepG2 细胞被检验。BYSL 在 nucleologenesis 期间在多重阶段是在场的,在导出核的 foci (NDF ) 包括, perichromosomal 区域和 prenucleolar 身体(PNB ) 在有丝分裂期间。BYSL 弄空显著地压制了 NDF 和 PNB 形成,并且在有丝分裂以后破坏了 nucleoli 汇编,导致增加的 apoptosis 和到浆液饥饿的 HCC 房间的减少的忍耐。一起拿,我们的研究显示那 upregulated BYSL 表情在 hepatocarcinogenesis 起一个作用。 | Hanzhi Wang Wei Xiao Qinbo Zhou Yun Chen Shuo Yang Jiansong Sheng Yanqing Yin Jia Fan Jiawei Zhou | 2009 | Cell Research2009，19，10： | 5 |
| 12 | Temporal regulation of prenatal embryonic development by paternal imprinted loci显示文摘Paternal imprinted genes(H19 and Gtl2)are pivotal for prenatal embryonic development in mice.Nongrowing oocytes and sperm-or oocyte-originated haploid embryonic stem cells(ha ESCs)carrying both H19-DMR(differentially DNA-methylated region)and IG(intergenic)-DMR deletions that partially mimic paternal imprinting of H19-Igf2 and Dlk1-Dio3 can be employed as sperm replacement to efficiently support full-term embryonic development.However,how H19-DMR and IG-DMR act together to regulate embryonic development is still largely unknown.Here,using androgenetic ha ESC(AG-ha ESC)-mediated semi-cloned(SC)technology,we showed that paternal H19-DMR and IG-DMR are not essential for pre-implantation development of SC embryos generated through injection of AG-ha ESCs into oocytes.H19-DMR plays critical roles before 12.5 days of gestation while IG-DMR is essential for late-gestation of SC embryos.Interestingly,we found that combined deletions of H19 and H19-DMR can further improve the efficiency of normal development of SC embryos at mid-gestation compared to DKO SC embryos.Transcriptome and histology analyses revealed that H19 and H19-DMR combined deletions rescue the placental defects.Furthermore,we showed that H19,H19-DMR and IG-DMR deletions(TKO)give rise to better prenatal and postnatal embryonic development of SC embryos compared to DKO.Together,our results indicate the temporal regulation of paternal imprinted loci during embryonic development. | Qing Li Yuanyuan Li Qi Yin Shuo Huang Kai Wang Liangchai Zhuo Wei Li Boran Chang Jinsong Li | 2020 | Science China(Life Sciences)2020，63，1： | 4 |
| 13 | The Effect of Bioturbation Activity of the Ark Clam Scapharca subcrenata on the Fluxes of Nutrient Exchange at the Sediment–Water Interface显示文摘Filter-feeding shellfish are common benthos and significantly affect the biogeochemical cycle in the shallow coastal ecosystems.Ark clam Scapharca subcrenata is one of the widely cultured bivalve species in many coastal areas owing to its tremendous economic value.However,there is little information regarding the effects of the bioturbation of S.subcrenata on the fluxes of nutrient exchange in the sediment-water interface(SWI).In this regard,S.subcrenata was sampled during October 2016 to determine the effects of its bioturbation activity on the nutrient exchange flux of the SWI.The results showed that the biological activity of S.subcrenata could increase the diffusion depth and the rate of the nutrients exchange in the sediments.The bioturbation of S.subcrenata could allow the nutrients to permeate into the surface sediments at 6-10cm and increase the release rate of nutrients at the SWI.The releasing fluxes of DIN and PO43−-P in the culture area were found to be around three times higher than that in the non-cultured region.The culture of S.subcrenata has been proved to be an important contributor to nutrient exchange across the SWI in the farming area of Haizhou Bay.Nutrients exchange in the SWI contributes a part of 86%DIN,71%PO43−-P and 18%SiO32−-Si for the aquaculture farm. | ZHANG Shuo FANG Xin ZHANG Junbo YIN Fang ZHANG Hu WU Lizhen KITAZAWA Daisuke | 2020 | Journal of Ocean University of China2020，19，1： | 4 |
| 14 | A SNX10/V-ATPase pathway regulates ciliogenesis in vitro and in vivo显示文摘排序 nexins (SNX )phosphoinositide 有约束力的蛋白质在在 vitro 排序各种各样的膜蛋白质被含有,但是在里面他们的 vivo 功能仍然保持大部分未知。我们以前报导 SNX10 是 SNX 家庭基因的一个独特成员因为它在房间举办 vacuolation 活动。我们在这研究由 loss-of-function 试金调查 SNX10 的生物功能并且证明 SNX10 在有教养的房间为主要的睫的形成被要求。在 zebrafish, SNX10 为内脏的机关的左右的 patterning 在 Kupffer 的泡和必需品涉及 ciliogenesis。机械学地, SNX10 与复杂的 V-ATPase 交往并且指向它到 ciliogenesis 被开始的中心体。象 SNX10 一样, V-ATPase 在 vitro 并且在 vivo 调整 ciliogenesis 并且对 SNX10 那么 synergistically 做。我们进一步发现 SNX10 和 V-ATPase 调整 Rab8a 的睫的 trafficking,它是睫的膜扩展的一个批评管理者。这些结果识别为 ciliogenesis 是关键的一条 SNX10/V-ATPase-regulated 小囊的 trafficking 小径,并且表明通过在各种各样的机关的睫形成的规定, SNX10/V-ATPase 在早胚胎的开发期间起一个必要作用。 | Yanqun Chen Bin Wu Liangliang Xu Huapeng Li Jianhong Xia Wenguang Yin Zhuo Li Dawei Shi Song Li Shuo Lin Xiaodong Shu Duanqing Pei | 2012 | Cell Research2012，22，2： | 4 |
| 15 | Modifed Multifdelity Surrogate Model Based on Radial Basis Function with Adaptive Scale Factor显示文摘Multifdelity surrogates(MFSs)replace computationally intensive models by synergistically combining information from diferent fdelity data with a signifcant improvement in modeling efciency.In this paper,a modifed MFS(MMFS)model based on a radial basis function(RBF)is proposed,in which two fdelities of information can be analyzed by adaptively obtaining the scale factor.In the MMFS,an RBF was employed to establish the low-fdelity model.The correlation matrix of the high-fdelity samples and corresponding low-fdelity responses were integrated into an expansion matrix to determine the scaling function parameters.The shape parameters of the basis function were optimized by minimizing the leave-one-out cross-validation error of the high-fdelity sample points.The performance of the MMFS was compared with those of other MFS models(MFS-RBF and cooperative RBF)and single-fdelity RBF using four benchmark test functions,by which the impacts of diferent high-fdelity sample sizes on the prediction accuracy were also analyzed.The sensitivity of the MMFS model to the randomness of the design of experiments(DoE)was investigated by repeating sampling plans with 20 diferent DoEs.Stress analysis of the steel plate is presented to highlight the prediction ability of the proposed MMFS model.This research proposes a new multifdelity modeling method that can fully use two fdelity sample sets,rapidly calculate model parameters,and exhibit good prediction accuracy and robustness. | Yin Liu Shuo Wang Qi Zhou Liye Lv Wei Sun Xueguan Song | 2022 | Chinese Journal of Mechanical Engineering2022，35，4： | 3 |
| 16 | Plant buffering against the high-light stress- induced accumulation of CsGA2ox8 transcripts via alter native splici ng to fi n ely tune gibberelli n levels and maintain hypocotyl elongation显示文摘In plants,alternative splicing(AS)is markedly induced in response to environmental stresses,but it is unclear why plants generate multiple transcripts under stress conditions.In this study,RNA-seq was performed to identify AS events in cucumber seedlings grown under different light intensities.We identi fi ed a novel transcript of the gibberellin(GA)-deactivating enzyme Gibberellin 2-beta-dioxygenase 8(CsGA2ox8).Compared with canonical CsGA2ox8.1,the CsGA2ox8.2 isoform presented intron retention between the second and third exons.Functional analysis proved that the transcript of CsGA2ox8.1 but not CsGA2ox8.2 played a role in the deactivation of bioactive GAs.Moreover,expression analysis demonstrated that both transcripts were upregulated by increased light intensity,but the expression level of CsGA2ox8.1 increased slowly when the light intensity was>400μmol-m-2-s-1 PPFD(photosynthetic photon fl ux density),while the CsGA2ox8.2 transcript levels increased rapidly when the light intensity was>200 pmol-m-2-s-1 PPFD.Our fi ndings provide evidence that plants might fi nely tune their GA levels by buffering against the normal transcripts of CsGA2ox8 through AS. | Bin Liu Shuo Zhao Pengli Li Yilu Yin Qingliang Niu Jinqiang Yan Danfeng Huang | 2021 | Horticulture Research2021，8，1： | 2 |
| 17 | Strengthening behavior of AlCoCrFeNi(TiN)_(x) high-entropy alloy coatings fabricated by plasma spraying and laser remelting显示文摘High-entropy alloy(HEA)coatings are of great importance in the fabrication of wear resistance materials.HEA coatings containing ceramic particles as reinforcement phase usually have better wear performance.In this study,AlCoCrFe Ni(TiN)_(x)(x:molar ratio;x=0,0.2,0.4,0.6,0.8,1.0)HEA coatings were fabricated on Q235 steel by plasma spray first and then subjected to laser remelting.The experimental results confirm that plasma spray together with post laser remelting could result in the in-situ formation of TiN-Al_(2)O_(3) ceramic particles and cuboidal B2 phase in the AlCoCrFeNi(TiN)_(x) HEA coatings.The in-situ TiN-Al_(2)O_(3) and nano-cuboidal B2 precipitation phase strengthened the coatings and improved their wearresistance properties.Due to the dispersion of hard phase and nano-particles resulting from second heating,the microhardness of the Al Co Cr Fe Ni(Ti N)coatings significantly increased from 493 to 851 HV after laser remelting.For the same reasons,the wear-resistance performance was also significantly promoted after laser remelting. | Bingqian Jin Nannan Zhang Shuo Yin | 2022 | Journal of Materials Science & Technology2022，，26： | 2 |
| 18 | Biodegradation Behavior of Coated As-Extruded Mg–Sr Alloy in Simulated Body Fluid显示文摘As-extruded Mg-Sr alloy, a kind of promising biodegradable biomedical material, was coated using micro-arc oxidation and also using a phosphate conversion coating. The corrosion behaviors were investigated using Hanks' solution. The corrosion of the as-extruded Mg-Sr alloy became more serious with increasing immersion time;that is, the corrosion pits became more numerous, larger and deeper, The micro-arc oxidation coating and the phosphate conversion coating were effective in improving the corrosion resistance of the as-extruded Mg-Sr alloy. The micro-arc oxidation coating was much more effective. Moreover, the as-extruded Mg-Sr alloy and the coated as-extruded Mg-Sr alloy exhibited lower corrosion rates than the as-cast Mg-Sr alloy and the corresponding coated as-cast Mg-Sr alloy, indicating that the corrosion properties of the coated samples are dependent on their substrates. The finer microstructure of the substrate of the as-extruded condition corroded much slower. The corrosion resistance of the coated Mg-Sr alloy depended on the coating itself and on the microstructure of the substrate. | Ming-Chun Zhao Ying-Chao Zhao Deng-Feng Yin Shuo Wang Yong-Ming Shangguan Chao Liu Li-Li Tan Ci-Jun Shuai Ke Yang Andrej Atrens | 2019 | Acta Metallurgica Sinica(English Letters)2019，32，10： | 2 |
| 19 | Complement C3 Aggravates Post-epileptic Neuronal Injury Via Activation of TRPV1显示文摘Epilepsy is a brain condition characterized by the recurrence of unprovoked seizures.Recent studies have shown that complement component 3(C3)aggravate the neuronal injury in epilepsy.And our previous studies revealed that TRPV1(transient receptor potential vanilloid type 1)is involved in epilepsy.Whether complement C3 regulation of neuronal injury is related to the activation of TRPV1 during epilepsy is not fully understood.We found that in a mouse model of status epilepticus(SE),complement C3 derived from astrocytes was increased and aggravated neuronal injury,and that TRPV 1-knockout rescued neurons from the injury induced by complement C3.Circular RNAs are abundant in the brain,and the reduction of circRad52 caused by complement C3 promoted the expression of TRPV 1 and exacerbated neuronal injury.Mechanistically,disorders of neuron-glia interaction mediated by the C3-TRPV1 signaling pathway may be important for the induction of neuronal injury.This study provides support for the hypothesis that the C3-TRFV1 pathway is involved in the prevention and treatment of neuronal injury and cognitive disorders. | Guang-Tong Jiang Lin Shao Shuo Kong Meng-Liu Zeng Jing-Jing Cheng Tao-Xiang Chen Song Han Jun Yin Wan-Hong Liu Xiao-Hua He Yu-Min Liu Lanzi Gongga Bi-Wen Peng | 2021 | Neuroscience Bulletin2021，37，10： | 2 |
| 20 | Geochemistry and zircon U-Pb chronology of quartz porphyry in Yuejinshan Fe-polymetallic deposit of Heilongjiang显示文摘Quartz porphyry in Yuejinshan Fe-polymetallic deposit is one of the rock masses, which formed the granite belt relating to the late Yanshanian skarn-type Fe-polymetallic deposits in the eastern Heilongjiang, and is also closely related to the metallogenic space of the Fe-polymetallic deposits. Quartz porphyry has the zircon U-Pb concordia age of 125.0±1.1 Ma, overall showing high Si(SiO_2=74.48%--75.00%), rich alkaline(Na_2O+K_2O=7.93%--8.17%, K_2O/Na_2O=1.39--1.46), and poor Mg(MgO=0.27%--0.31%), with the A/CNK value being 0.95--0.99, having the characteristics of obvious enrichment of LREE and medium Eu negative anomaly(0.69--0.74), indicating that the rock belongs to quasi-aluminous high potassium calc-alkaline series and has the same characteristics as those of the I-type granite. The rock is also characterized by the enrichment of LILE and active incompatible elements, and depletion of HFSE such as Nb, Ta, P and Ti, with the Mg~# value being 32--37, indicating that the rock originated from partial melting of crustal materials. It can be concluded from the above characteristics or data and from the distribution of contemporary magmatic rocks in the area, that quartz porphyry in Yuejinshan Fe-polymetallic deposit was formed in a tectonic background of the subduction of the paleo-Pacific plate in late Yanshanian. | JIN Ye CUI Bo WANG Li YANG Baihui YIN Yue LI Qing WANG Shuo CHEN Xiaohang LIU Xiang | 2019 | Global Geology2019，22，2： | 2 |
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