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| 1 | PTEN-L is a novel protein phosphatase for ubiquitin dephosphorylation to inhibit PINK1-Parkin-mediated mitophagy显示文摘Mitophagy 是为损坏线粒体的特定的消除的选择 autophagy 的一种重要类型。(PINK1 )导致 PTEN 的通常认为的 kinase 蛋白质 1 催化 ubiquitin (Ub ) 的 phosphorylation 在 PINK1-Parkin-mediated mitophagy 的发作起一个关键作用。(PTEN-L ) 磷酸酶和 tensin 相当或相同的事物(PTEN ) 长是 PTEN 的最新识别的 isoform,与到它的 N 终点的 173 氨基酸的增加。这里,我们报导 PTEN-L 是经由它对 phosphorylated ubiquitin 的蛋白质磷酸酶活动的 mitophagy 的一个新奇否定管理者。我们发现 PTEN-L 在外部 mitochondrial 膜(OMM ) 本地化,而 PTEN-L 的删除支持, PTEN-L 的 overexpression 禁止, mitophagy 由各种各样的损坏线粒体的代理人导致了。机械学地, PTEN-L 能够有效地阻止 Parkin mitochondrial translocation,减少 Parkin phosphorylation,维持它的关上的不活跃的符合构造,并且禁止它的 E3 ligase 活动。更重要地, PTEN-L 在 vivo 减少 phosphorylated ubiquitin (pSer65-Ub ) 的水平,并且在 vitro,磷酸酶试金经由它的蛋白质磷酸酶活动证实那 PTEN-L dephosphorylates pSer65-Ub,独立于它的类脂化合物磷酸酶功能。一起拿,我们的调查结果为 ubiquitin 作为蛋白质磷酸酶表明 PTEN-L 的新奇功能,它抵抗在 mitophagy 正式就职和 mitophagy 的最终的抑制导致前馈控制机制的阻塞的调停 PINK1 的 ubiquitin phosphorylation。因此,理解 PTEN-L 的这新奇功能在控制 mitophagy 的分子的难题提供一关键错过片,在包括象 Parkinsons 那样的 neurodegenerative 混乱的许多重要人的疾病的一个批评过程疾病。 | Liming Wang Yik-Lam Cho Yancheng Tang Jigang Wang Jung-Eun Park Yajun Wu Chunxin Wang Yan Tong Ritu Chawla Jianbin Zhang Yin Shi Shuo Deng Guang Lu Yihua Wu Hayden Weng-Siong Tan Pornteera Pawijit Grace Gui-Yin Lim Hui-Ying Chan Jingzi Zhang Lei Fang Hanry Yu Yih-Cherng Liou Mallilankaraman Karthik Boon-Huat Bay Kah-Leong Lim Siu-Kwan Sze Celestial T. Yap Han-Ming Shen | 2018 | Cell Research2018，28，8： | 25 |
| 2 | Impact of dissolved organic matter on the photolysis of the ionizable antibiotic norfloxacin显示文摘Norfloxacin(NOR), an ionizable antibiotic frequently used in the aquaculture industry, has aroused public concern due to its persistence, bacterial resistance, and environmental ubiquity.Therefore, we investigated the photolysis of different species of NOR and the impact of a ubiquitous component of natural water — dissolved organic matter(DOM), which has a special photochemical activity and normally acts as a sensitizer or inhibiter in the photolysis of diverse organics; furthermore, scavenging experiments combined with electron paramagnetic resonance(EPR) were performed to evaluate the transformation of NOR in water. The results demonstated that NOR underwent direct photolysis and self-sensitized photolysis via hydroxyl radical(U OH) and singlet oxygen(1O2) based on the scavenging experiments. In addition, DOM was found to influence the photolysis of different NOR species, and its impact was related to the concentration of DOM and type of NOR species. Photolysis of cationic NOR was photosensitized by DOM at low concentration, while zwitterionic and anionic NOR were photoinhibited by DOM, where quenching of U OH predominated according to EPR experiments, accompanied by possible participation of excited triplet-state NOR and1O2. Photo-intermediate identification of different NOR species in solutions with/without DOM indicated that NOR underwent different photodegradation pathways including dechlorination, cleavage of the piperazine side chain and photooxidation, and DOM had little impact on the distribution but influenced the concentration evolution of photolysis intermediates. The results implied that for accurate ecological risk assessment of emerging ionizable pollutants, the impact of DOM on the environmental photochemical behavior of all dissociated species should not be ignored. | Chen Liang Huimin Zhao Minjie Deng Xie Quan Shuo Chen Hua Wang | 2015 | Journal of Environmental Sciences2015，27，1： | 11 |
| 3 | Structural insights into a novel histone demethylase PHF8显示文摘histone methylation/demethylation 的动态规定在开发期间起一个重要作用。在人的植物 homeodomain (哲学博士) 的变化和截断摸蛋白质 8 (PHF8 ) 与 X 连接智力迟钝和面部异例被联系,例如一张长脸,宽广鼻音尖端,劈开 lip/cleft 腭和大手,然而,它的分子的功能和结构的基础仍然保持不清楚。这里,我们在高分辨率报导 PHF8 的催化核心的水晶结构与或没有伪 - ketoglutarate (伪 - KG ) 。生物化学、结构的研究表明 PHF8 是为甲醇化物 di 、单音甲醇化物的 histone H3 离氨酸 9,然而并非为 H3K9me3 特定的新奇 histone demethylase (H3K9me2/1 ) 。我们的分析也揭示人的 PHF8 怎么在 methylation 状态之间区别并且为 methylated H3K9 完成顺序特性。在里面 vitro demethylation 试金也证明在临床的病人观察的 F279S 异种不拥有 demethylation 活动,建议酶的活动的那损失为 PHF8 病人的致病是关键的。一起拿,这些结果将使位于联系 PHF8 的发展、神经病学的疾病下面的分子的机制清楚些。 | Lin Yu Yang wang Shuo Huang Jianjun Wang Zengqin Deng Qi Zhang Wei Wu Xingliang Zhang Zhao Liu Weimin Gong Zhongzhou Chen | 2010 | Cell Research2010，20，2： | 11 |
| 4 | SARS-CoV-2 infects human neural progenitor cells and brain organoids显示文摘Dear Editor,Coronavirus disease 2019(COVID-19)caused by the novel severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)1 has resulted in over 13 million confirmed cases and more than 580,045 deaths across 218 countries and geographical regions as of July 16,2020.This novel coronavirus primarily causes respiratory illness with clinical manifestations largely resembling those of SARS.However,neurological symptoms including headache,anosmia,ageusia,confusion,seizure,and encephalopathy have also been frequently reported in COVID-19 patients. | Bao-Zhong Zhang Hin Chu Shuo Han Huiping Shuai Jian Deng Ye-fan Hu Hua-rui Gong Andrew Chak-Yiu Lee Zijiao Zou Thomas Yau Wutian Wu Ivan Fan-Ngai Hung Jasper Fuk-Woo Chan Kwok-Yung Yuen Jian-Dong Huang | 2020 | Cell Research2020，30，10： | 8 |
| 5 | Extent of Lung Involvement and Serum Cryptococcal Antigen Test in Non-Human Immunodeficiency Virus Adult Patients with Pulmonary Cryptococcosis显示文摘 | Tao Zhu Wan-Ting Luo Gui-Hua Chen Yue-Sheng Tu Shuo Tang Huo-Jin Deng Wei Xu Wei Zhang Di Qi Dao-Xin Wang Chang-Yi Li He Li Yan-Qiao Wu Shen-Jin Li | 2018 | Chinese Medical Journal2018，，18： | 7 |
| 6 | Unilateral moyamoya disease associated with cerebellar arteriovenous malformation: one case report显示文摘 | DENG Zheng-hai WANG Shuo LI Zhong ZHAO Ji-zong | 2008 | Chinese Medical Journal2008，，12： | 6 |
| 7 | Twistor-based synchronous sliding mode control of spacecraft attitude and position显示文摘A synchronous control of relative attitude and position is required in separated ultraquiet spacecraft, such as drag-free, disturbance-free, and distributed spacecraft. Thus, a twistorbased synchronous sliding mode control is investigated in this paper to solve the control problem of relative attitude and position among separated spacecraft modules. The twistor-based control design and the stability proof are implemented using the Modified Rodrigues Parameter(MRP).To evaluate the effectiveness of the proposed control method, this paper presents a case study of separated spacecraft flying control considering the mass uncertainty and external disturbances. In addition, a simulation study of the Proportional-Derivative(PD) control is also presented for comparison. The results indicate that the twistor-based sliding mode controller can ensure global asymptotic stability. The states converge fast with ultra-precision and ultra-stability in both the attitude and position. Moreover, the proposed twistor-based sliding mode control system is robust to the mass uncertainty and external disturbances. | Qing LI Lei LIU Yifan DENG Shuo TANG Yanbin ZHAO | 2018 | Chinese Journal of Aeronautics2018，31，5： | 5 |
| 8 | A potential red-emitting phosphor Ca_(2)YTaO_(6):Eu^(3+):Luminescence properties,thermal stability and applications for white LEDs显示文摘A novel red-emitting phosphor tantalate Ca_(2)YTaO_(6):Eu^(3+)was synthesized by a solid-state reaction.The purity and surface morphology of the phosphors were characterized.The Ca_(2)YTaO_(6):Eu^(3+)phosphors show a sharp emission peak at 612 nm under near-ultraviolet(n-UV) at 395 nm because of the ^(5)D0→^(7)F_(2) transition of Eu^(3+).The optimal Eu^(3+)doping concentration in Ca_(2)YTaO_(6) is 40 mol% and the critical energy-transfer distance of Eu^(3+)ions was calculated to be 0.9 nm.The emission spectra of Ca_(2)YTaO_(6):Eu_(3+)from 300 to 480 K were investigated.The thermal-quenching temperature(T_(0.5)) of Ca_(2)YTaO_(6):Eu^(3+)is above 480 K.The color purity of Ca_(2)YTaO_(6):40 mol%Eu^(3+)is as high as 99.8%.The luminescence lifetime of Ca_(2)YTaO_(6):40 mol%Eu^(3+)was also discussed.The high color purity and high thermal stability of Eu^(3+)-doped Ca_(2)YTaO_(6) phosphors contribute to its application value in white lightemitting diodes(w-LEDs). | Ka Ding Siru A Shuo Pang Leyan Shan Yaqi Zhang Pengfei Sun Bin Deng Ruijin Yu | 2021 | Journal of Rare Earths2021，39，7： | 4 |
| 9 | Cancer-associated adipocyte-derived G-CSF promotes breast cancer malignancy via Stat3 signaling显示文摘Adipocyte is the most predominant cell type in the tumor microenvironment of breast cancer and plays a pivotal role in cancer progression,yet the underlying mechanisms and functional mediators remain elusive.We isolated primary preadipocytes from mammary fat pads of human breast cancer patients and generated mature adipocytes and cancer-associated adipocytes(CAAs)in vitro.The CAAs exhibited significantly different gene expression profiles as assessed by transcriptome sequencing.One of the highly expressed genes in CAAs is granulocyte colony-stimulating factor(G-CSF).Treatment with recombinant human G-CSF protein or stable expression of human G-CSF in triple-negative breast cancer(TNBC)cell lines enhanced epithelial–mesenchymal transition,migration,and invasion of cancer cells,by activating Stat3.Accordantly,targeting G-CSF/Stat3 signaling with G-CSF-neutralizing antibody,a chemical inhibitor,or siRNAs for Stat3 could all abrogate CAA-or G-CSF-induced migration and invasion of breast cancer cells.The pro-invasive genes MMP2 and MMP9 were identified as target genes of G-CSF in TNBC cells.Furthermore,in human breast cancer tissues,elevated G-CSF expression in adipocytes is well correlated with activated Stat3 signal in cancer cells.Together,our results suggest a novel strategy to intervene with invasive breast cancers by targeting CAA-derived G-CSF. | Li Liu Yudong Wu Cheng Zhang Chong Zhou Yining Li Yi Zeng Chunbo Zhang Rong Li Daya Luo Lieliang Wang Long Zhang Shuo Tu Huan Deng Shiwen Luo Ye-Guang Chen Xiangyang Xiong Xiaohua Yan | 2020 | Journal of Molecular Cell Biology2020，12，9： | 4 |
| 10 | Two competitive nucleation mechanisms of calcium carbonate biomineralization in response to surface functionality in low calcium ion concentration solution显示文摘Four self-assembled monolayer surfaces terminated with–COOH,–OH,–NH_(2)and–CH_(3)functional groups are used to direct the biomineralization processes of calcium carbonate(CaCO_(3))in low Ca^(2+)concentration,and the mechanism of nucleation and initial crystallization within 12 h was further explored.On-COOH surface,nucleation occurs mainly via ion aggregation mechanism while prenucleation ions clusters may be also involved.On-OH and-NH_(2)surfaces,however,nucleation forms via calcium carbonate clusters,which aggregate in solution and then are adsorbed onto surfaces following with nucleation of amorphous calcium carbonate(ACC).Furthermore,strongly negative-charged-COOH surface facilitates the direct formation of calcites,and the-OH and-NH_(2)surfaces determine the formation of vaterites with preferred crystalline orientations.Neither ACC nor crystalline CaCO_(3)is observed on-CH_(3)surface.Our findings present a valuable model to understand the CaCO_(3)biomineralization pathway in natural system where functional groups composition plays a determining role during calcium carbonate crystallization. | Hua Deng Shuo Wang Xiumei Wang Chang Du Xingcan Shen Yingjun Wang Fuzhai Cui | 2015 | Regenerative Biomaterials2015，2，3： | 3 |
| 11 | Ten‐Day Quadruple Therapy Comprising Proton‐Pump Inhibitor, Bismuth, Tetracycline, and Levofloxacin Achieves a High Eradication Rate for H elicobacter pylori Infection after Failure of Sequential Therapy显示文摘 | Ping‐I Hsu Wen‐Chi Chen Feng‐Woei Tsay Chih‐An Shih Sung‐Shuo Kao Huay‐Min Wang Hsien‐Chung Yu Kwok‐Hung Lai Hui‐Hwa Tseng Nan‐Jing Peng Angela Chen Chao‐Hung Kuo Deng‐Chyang Wu | 2014 | Helicobacter2014，，1： | 3 |
| 12 | Probabilistic outlier detection for sparse multivariate geotechnical site investigation data using Bayesian learning显示文摘Various uncertainties arising during acquisition process of geoscience data may result in anomalous data instances(i.e.,outliers)that do not conform with the expected pattern of regular data instances.With sparse multivariate data obtained from geotechnical site investigation,it is impossible to identify outliers with certainty due to the distortion of statistics of geotechnical parameters caused by outliers and their associated statistical uncertainty resulted from data sparsity.This paper develops a probabilistic outlier detection method for sparse multivariate data obtained from geotechnical site investigation.The proposed approach quantifies the outlying probability of each data instance based on Mahalanobis distance and determines outliers as those data instances with outlying probabilities greater than 0.5.It tackles the distortion issue of statistics estimated from the dataset with outliers by a re-sampling technique and accounts,rationally,for the statistical uncertainty by Bayesian machine learning.Moreover,the proposed approach also suggests an exclusive method to determine outlying components of each outlier.The proposed approach is illustrated and verified using simulated and real-life dataset.It showed that the proposed approach properly identifies outliers among sparse multivariate data and their corresponding outlying components in a probabilistic manner.It can significantly reduce the masking effect(i.e.,missing some actual outliers due to the distortion of statistics by the outliers and statistical uncertainty).It also found that outliers among sparse multivariate data instances affect significantly the construction of multivariate distribution of geotechnical parameters for uncertainty quantification.This emphasizes the necessity of data cleaning process(e.g.,outlier detection)for uncertainty quantification based on geoscience data. | Shuo Zheng Yu-Xin Zhu Dian-Qing Li Zi-Jun Cao Qin-Xuan Deng Kok-Kwang Phoon | 2021 | Geoscience Frontiers2021，12，1： | 2 |
| 13 | Thrombin induces ACSL4-dependent ferroptosis during cerebral ischemia/reperfusion显示文摘Ischemic stroke represents a significant danger to human beings,especially the elderly.Interventions are only available to remove the clot,and the mechanism of neuronal death during ischemic stroke is still in debate.Ferroptosis is increasingly appreciated as a mechanism of cell death after ischemia in various organs. | Qing-zhang Tuo Yu Liu Zheng Xiang Hong-Fa Yan Ting Zou Yang Shu Xu-long Ding Jin-jun Zou Shuo Xu Fei Tang Yan-qiu Gong Xiao-lan Li Yu-jie Guo Zhao-yue Zheng Ai-ping Deng Zhang-zhong Yang Wen-jing Li Shu-ting Zhang Scott Ayton Ashley I.Bush Heng Xu Lunzhi Dai Biao Dong Peng Lei | 2022 | Signal Transduction and Targeted Therapy2022，7，3： | 2 |
| 14 | Evolution behavior of γ″ phase of IN718 superalloy in temperature/stress coupled field显示文摘The evolution behavior of theγ″phase of IN718 superalloy in a temperature/stress coupled field was investigated.Results showed that the coarsening rate of theγ″phase was significantly accelerated in the temperature/stress coupled field.Based on the detail microstructural and crystal defect analysis,it was found that the coarsening rate of theγ″phase with applied stress was significantly higher than that without stress.The main reasons for the increase in the coarsening rate of theγ″phase are as follows:the vacancy formation energy is decreased by the applied stress,which leads to an increase in the vacancy concentration;in the temperature/stress coupled field,the Nb atoms easily combine with vacancies to form complexes and diffuse with the complexes,resulting in a significant increase in the Nb atom diffusion coefficient;Nb atom diffusion is the key control factor for the coarsening of theγ″phase. | Han-zhong Deng Lei Wang Yang Liu Xiu Song Fan-qiang Meng Shuo Huang | 2021 | International Journal of Minerals,Metallurgy and Materials2021，28，12： | 2 |
| 15 | Transfer of convalescent serum to pregnant mice prevents Zika virus infection and microcephaly in offspring显示文摘 | Shuo Wang Shuai Hong Yong-Qiang Deng Qing Ye Ling-Zhai Zhao Fu-Chun Zhang Cheng-Feng Qin Zhiheng Xu | 2017 | Cell Research2017，27，1： | 2 |
| 16 | China's battery electric vehicles lead the world:achievements in technology system architecture and technological breakthroughs显示文摘Developing new energy vehicles has been a worldwide consensus,and developing new energy vehicles characterized by pure electric drive has been China's national strategy.After more than 20 years of high-quality development of China's electric vehicles(EVs),a technological R&D layout of“Three Verticals and Three Horizontals”has been created,and technological advantages have been accumulated.As a result,China's new energy vehicle market has ranked first in the world since 2015.To systematically solve the key problems of battery electric vehicles(BEVs)such as“driving range anxiety,long battery charging time,and driving safety hazards”,China took the lead in putting forward a“system engineering-based technology system architecture for BEVs”and clarifying its connotation.This paper analyzes the research status and progress of the three core components of this architecture,namely,“BEV platform,charging/swapping station,and real-time operation monitoring platform”,and their key technological points.The three major demonstration projects of the 2008 Beijing Olympic Games,the 2022 Beijing Winter Olympics,and the intelligent and connected autonomous battery electric bus project are discussed to specify the applications of BEVs in China.The key research directions for upgrading BEV technologies remain to be further improving the vehicle-level all-climate environmental adaptability and all-day safety of BEVs,systematically solving the charging problem of BEVs and improving their application convenience,and safeguarding safety with early warning and implementing active/passive safety protection for the whole life cycle of power batteries on the basis of BEVs'operation big data.BEVs have acquired new technological features such as intelligent and networked technology empowerment,extensive integration of control-by-wire systems,a platform of chassis hardware,and modularization of functional software. | Hongwen He Fengchun Sun Zhenpo Wang Cheng Lin Chengning Zhang Rui Xiong Junjun Deng Xiaoqing Zhu Peng Xie Shuo Zhang Zhongbao Wei Wanke Cao Li Zhai | 2022 | Green Energy and Intelligent Transportation2022，1，1： | 2 |
| 17 | RID1 sets rice heading date by balancing its binding with SLR1 and SDG722显示文摘Rice(Oryza sativa) is a major crop that feeds billions of people, and its yield is strongly influenced by flowering time(heading date). Loss of RICE INDETERMINATE1(RID1) function causes plants not to flower;thus, RID1 is considered a master switch among flowering-related genes. However, it remains unclear whether other proteins function together with RID1 to regulate rice floral transition.Here, we revealed that the chromatin accessibilityand H3 K9 ac, H3 K4 me3, and H3 K36 me3 levels at Heading date 3 a(Hd3 a) and RICE FLOWERING LOCUS T1(RFT1) loci were significantly reduced in rid1 mutants. Notably, RID1 interacted with SET DOMAIN GROUP PROTEIN 722(SDG722), a methyltransferase. We determined that SDG722 affects the global level of H3 K4 me2/3 and H3 K36 me2/3, and promotes flowering primarily through the Early heading date1-Hd3 a/RFT1 pathway. We further established that rice DELLA protein SLENDER RICE1(SLR1) interacted with RID1 to inhibit its transactivation activity, that SLR1 suppresses rice flowering, and that messenger RNA and protein levels of SLR1 gradually decrease with plant growth. Furthermore, SLR1 competed with SDG722 for interaction with RID1. Overall, our results establish that interplay between RID1, SLR1, and SDG722 feeds into rice flowering-time control. | Shuo Zhang Li Deng Rui Cheng Jie Hu Chang-Yin Wu | 2022 | Journal of Integrative Plant Biology2022，64，1： | 2 |
| 18 | KLF2 inhibits TGF-β-mediated cancer cell motility in hepatocellular carcinoma显示文摘Feedback regulation plays a pivotal role in determining the intensity and duration of TGF-p signaling and subsequently affecting the pathophysiological roles of TGF-p,including those in liver malignancy.KLF2,a member of the Kruppel-like factor(KLF)fam ily transcription factors,has been implicated in impeding hepatocellular carcinoma(HCC)development.However,the underlying molecular mechanisms are not fully understood.In the present study,we found that TGF-p stimulates the expression of KLF2 gene in several HCC cell lines.KLF2 protein is able to inhibit TGF-p/Smad signaling in HCC cells as assessed by luciferase reporter assay.Further studies indicated that KLF2 inhibits the transcriptional activity of Smad2/3 and Smad4 and ameliorates TGF-p-induced target gene expression,therefore creating a novel negative feedback loop in TGFp signaling.Functionally,stably expression of KLF2 in HCCLM3 cells attenuated TGF-卜induced cancer cell motility in wound-healing and transwell assays by interfering with TGF-p-mediated upregulation of MMP2.Together,our results revealed that KLF2 protein has a tumor-suppressive function in HCC through a negative feedback loop over TGF-p signaling. | Yining Li Shuo Tu Yi Zeng Cheng Zhang Tian Deng Weicheng Luo Lingyan Lian Ling Chen Xiangyang Xiong Xiaohua Yan | 2020 | Acta Biochimica et Biophysica Sinica2020，52，5： | 2 |
| 19 | Associations of early-life factors and indoor environmental exposure with asthma among children:a case-control study in Chongqing,China显示文摘Background Childhood asthma has substantial effects on children’s health.It is important to identify influencing factors in early life in the development of childhood asthma.We aim to evaluate the effects of early-life factors and indoor environmental exposure on childhood asthma in Chongqing,China.Method We designed a case-control study to enrol children with asthma aged 3 to<14 years old and controls in Chongqing,China.The“Children’s Early Life and Indoor Environment Survey”was used to collect the early-life factors and indoor environmental exposure of foetuses in utero and of infants during the first 3 years of life.A multivariate logistic regression model was used to evaluate the association between independent variables and childhood asthma and the interaction of early-life factors and environmental exposure.Results A total of 160 asthma cases and 247 controls were included in this study.The mean ages of the cases and controls were 5.53±1.88 and 5.72±2.34 years,respectively(P=0.192).Early-life factors and indoor environmental exposure were independently associated with childhood asthma.Infectious diseases of the respiratory system in children under 3 years old[adjusted odds ratio(OR)=5.76,95%confidence interval(CI)2.49-13.30],bedroom air conditioner use(adjusted OR=4.61,95%CI 1.45-14.64),and bedroom dampness/mould(adjusted OR=2.98,95%CI 1.54-5.75)ranked as the three most significant exposures associated with the risk of childhood asthma.Other factors associated with an increased risk of childhood asthma included second-hand smoke exposure in early life(adjusted OR=1.93,95%CI 1.24-3.00),neonatal pneumonia(adjusted OR=1.90,95%CI 1.05-3.42)and maternal allergic diseases during pregnancy(adjusted OR=2.13,95%CI 1.10-4.10).The interaction effects of child second-hand smoke exposure with other covariates were not found to be statistically significant.Conclusions Early-life factors and indoor environmental exposure are closely related to childhood asthma in Chongqing,China.Further interventions and management in the early life of children should be considered to prevent and control childhood asthma in Chongqing and similar cities. | Yun-Tian Deng Xue-Mei Li En-Mei Liu Wen-Kui Xiong Shuo Wang Rui Zhu Yu-Bin Ding Zhao-Hui Zhong | 2022 | World Journal of Pediatrics2022，18，3： | 2 |
| 20 | Molecular diagnosis and treatment of meningiomas:an expert consensus(2022)显示文摘Meningiomas are the most common primary intracranial neoplasm with diverse pathological types and complicated clinical manifestations.The fifth edition of the WHO Classification of Tumors of the Central Nervous System(WHO CNS5),published in 2021,introduces major changes that advance the role of molecular diagnostics in meningiomas.To follow the revision of WHO CNS5,this expert consensus statement was formed jointly by the Group of Neuro-Oncology,Society of Neurosurgery,Chinese Medical Association together with neuropathologists and evidence-based experts.The consensus provides reference points to integrate key biomarkers into stratification and clinical decision making for meningioma patients. | Jiaojao Deng Lingyang Hua Liuguan Bian Hong Chen Ligang Chen Hongwei Cheng Changwu Dou Dangmurenjiapu Geng Tao Hong Hongming Ji Yugang Jiang Qing Lan Gang Li Zhixiong Liu Songtao Qi Yan Qu Songsheng Shi Xiaochuan Sun Hajun Wang Yongping You Hualin Yu Shuyuan Yue Jianming Zhang Xiaohua Zhang Shuo Wang Ying Mao Ping Zhong Ye Gong Group of Neuro-Oncology Society of Neurosurgery Chinese Medical Association | 2022 | Chinese Medical Journal2022，135，16： | 1 |
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