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| 1 | Fegeneration of functional alveoli by adult human SOX9^+ airway basal cell transplantation显示文摘 | Qiwang Ma Yu Ma Xiaotian Dai Tao Ren Yingjie Fu Wenbin Liu Yufei Han Yingchuan Wu Yu Cheng Ting Zhang Wei Zuo | 2018 | Protein & Cell2018，9，3： | 20 |
| 2 | Expert consensus on the glycemic management of critically ill patients显示文摘Introduction The incidence of hyperglycemia is 40-60%in critically ill patients and is up to 60-80%in those who have undergone car-diac surgery.[1]The results of an epidemiological study in the United States showed that 28.6%of diabetic patients and 9.3%of non-diabetic patients had elevated mean daily glucose on the day of ICU admission.[2]In critically ill patients,elevated blood glucose is primarily the result of stress,and stress-induced hy-perglycemia is an independent risk factor associated with prog-nosis,regardless of a previous diagnosis of diabetes.Nutritional therapy has become an integral treatment option for patients in the ICU,[3,4]though nearly 30%of patients with enteral nu-trition and 44-50%with parenteral nutrition(PN)experience elevated glucose.[5,6]Intensive insulin therapy(IIT)is an impor-tant treatment for controlling hyperglycemia in critically ill pa-tients,but it also carries a corresponding risk of hypoglycemia. | Zhixiong Wu Jiao Liu Dong Zhang Kai Kang Xiangrong Zuo Qianghong Xu Aijun Pan Wei Fang Fen Liu You Shang Haiyan Yin Juntao Hu Jinglun Liu Jiangquan Fu Wei Zhang Yuan Zong Min Shao Feng Zhao Mei Meng Yanfei Mao Yingchuan Li Dechang Chen | 2022 | Journal of Intensive Medicine2022，2，3： | 9 |
| 3 | Changes in the Prevalence of Visual Impairment Due to Blinding Trachoma in Sichuan Province, China: A Comparative Study Between 1987 and 2006显示文摘 | Hui Chen Xiaoyun Wu Min Wei June E. Eichner Yingchuan Fan Zuoming Zhang Chuntao Lei Donald U. Stone Jingyun Yang | 2012 | Ophthalmic Epidemiology2012，，1： | 1 |
| 4 | Transfer learning: A new aerodynamic force identification network based on adaptive EMD and soft thresholding in hypersonic wind tunnel显示文摘The aerodynamic test in the pulse combustion wind tunnel is very important for the design, evaluation and optimization of aerodynamic characteristics of the hypersonic aircraft.The test accuracy even affects the success or failure of hypersonic aircraft development. In the aerodynamic test of pulse combustion wind tunnel, the aerodynamic signal is disturbed by the inertial force signal, which seriously affects the test accuracy of aerodynamic force. Aiming at the above problems, this paper innovatively proposes an aerodynamic intelligent identification method, that is the transfer learning network based on adaptive Empirical Modal Decomposition(EMD) and Soft Thresholding(TLN-AE&ST). Compared with the existing aerodynamic intelligent identification model based on deep learning technology, this study introduces the transfer learning idea into the aerodynamic intelligent identification model for the first time. The TLN-AE&ST effectively alleviates the problem of scarcity of training samples for intelligent models due to the high cost of wind tunnel tests, and provides a new idea for further implementation of deep learning technology in the field of wind tunnel aerodynamic testing. And this study designed residual attention block with soft threshold and dense block with adaptive EMD in TLN-AE&ST model. Residual attention block with soft threshold module can more effectively suppress the influence of instrument noise signal on model training effect. Dense block with adaptive EMD makes the deep learning model no longer a black box to a certain extent, and has certain physical significance. Finally, a series of wind tunnel tests were carried out in the Φ = 2.4 m pulse combustion wind tunnel of China Aerodynamic Research and Development Center to verify the effectiveness of TLN-AE&ST. | Yi SUN Shichao LI Hongli GAO Xiaoqing ZHANG Jinzhou LV Weixiong LIU Yingchuan WU | 2023 | Chinese Journal of Aeronautics2023，36，8： | 0 |
| 5 | Single-cell analysis defines the lineage plasticity of stem cells in cervix epithelium显示文摘Information about the dynamic change and post-injury regeneration of cervical epithelium is relatively rare,even though it is tightly related to gynecologic malignancy.Here,using a feeder cell-based culturing system,we stably cloned mouse and human P63 and KRT5 expressing cells from the adult cervix as putative cervical stem/progenitor cells(CVSCs).When subjected to differentiation,the cultured cells gave rise to mature cervical epithelium by differentiating into squamous or glandular cells.The ability of endogenous mouse CVSCs to reconstitute cervical epithelium after injury was also evident from the genetic lineage tracing experiments.Single-cell transcriptomic analysis further classified the CVSCs into three subtypes and delineated their bi-lineage differentiation roadmap by pseudo-time analysis.We also tracked the real-time differentiation routes of two representing single CVSC lines in vitro and found that they recapitulated the predicted roadmap in pseudo-time analysis.Signaling pathways including Wnt,TGF-beta,Notch and EGFR were found to regulate the cervical epithelial hierarchy and implicated the different roles of distinct types of cells in tissue homeostasis and tumorigenesis.Collectively,the above data provide a cloning system to achieve stable in vitro culture of a bi-lineage stem/progenitor cell population in the cervix,which has profound implications for our understanding of the cervix stem/progenitor cell function in homeostasis,regeneration,and disease and could be helpful for developing stem cell-based therapies in future. | Zixian Zhao Yujia Wang Yingchuan Wu Dandan Li Ting Zhang Yu Ma Xiaoming Teng Wei Zuo | 2021 | Cell Regeneration2021，10，1： | 0 |
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