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| 1 | Expert consensus on the glycemic management of critically ill patients显示文摘Introduction The incidence of hyperglycemia is 40-60%in critically ill patients and is up to 60-80%in those who have undergone car-diac surgery.[1]The results of an epidemiological study in the United States showed that 28.6%of diabetic patients and 9.3%of non-diabetic patients had elevated mean daily glucose on the day of ICU admission.[2]In critically ill patients,elevated blood glucose is primarily the result of stress,and stress-induced hy-perglycemia is an independent risk factor associated with prog-nosis,regardless of a previous diagnosis of diabetes.Nutritional therapy has become an integral treatment option for patients in the ICU,[3,4]though nearly 30%of patients with enteral nu-trition and 44-50%with parenteral nutrition(PN)experience elevated glucose.[5,6]Intensive insulin therapy(IIT)is an impor-tant treatment for controlling hyperglycemia in critically ill pa-tients,but it also carries a corresponding risk of hypoglycemia. | Zhixiong Wu Jiao Liu Dong Zhang Kai Kang Xiangrong Zuo Qianghong Xu Aijun Pan Wei Fang Fen Liu You Shang Haiyan Yin Juntao Hu Jinglun Liu Jiangquan Fu Wei Zhang Yuan Zong Min Shao Feng Zhao Mei Meng Yanfei Mao Yingchuan Li Dechang Chen | 2022 | Journal of Intensive Medicine2022，2，3： | 9 |
| 2 | Effect of UTRs from TMV-RNA on the expression of foreign gene in transgenic plants显示文摘To investigate the effects of 5’and 3’ untranslated region (UTR) from tobacco mosaicvirus (TMV) on expression of foreign genes, four plant-expression vectors pBG437, pBG438, pBG440 and pBG440ANOS containing expression cassettes of GUS-NOS; Ω-GUS-NOS, Ω-GUS-3’ UTR-NOS and Ω-GUS-3’ UTR downstream of CaMV 35S promoter with double enhancer sequences respectively have been constructed. Results from a large number of transgenic tobacco plants show that the GUS activity of pBG440 transformed plants is the highest, being 5-fold that of pBG437 and 1.6-fold that of pBG438. Similar results have been obtained in transient expression by injection of Agrobacterium tumefaciens harbouring these constructs into N. benthamiana leaves. These results obtained at the whole plant level confirm the conclusion drawn from the transient expression studies in protoplast system that TMV- Ω fragment can be a translation enhancer and the 3’ UTR has a coordinate effect with ft fragment to enhance foreign gene expression, but | Hongmin Qin Hongnian Guo Yantao Jia Lihong Li Yingchuan Tian | 2000 | Chinese Science Bulletin2000，45，18： | 2 |
| 3 | Theory and ex- periment research on the liquid continuous removal of horizontal gas well显示文摘 | Xiao Gaomian Li Yingchuan Yu Xin | 2010 | Journal of Southwest Petroleum University: Science & Technology Edition2010，32，3： | 1 |
| 4 | Construction of a new plant expression vector containing two insect resistant genes and its expression in transgenic tobacco plants显示文摘A new plant expression vector (pBS29K-BA) containing two insect resistant genes, a synthetic chimeric gene BtS29K encoding the activated insecticidal protein Cry1Ac and a gene API-BA encoding the arrowhead (Sagittaria sagittifolia L.) proteinase inhibitor (API) A and B, is constructed. Transgenic tobacco plants expressing these two genes are obtained through Agrobacterium-mediated transformation of tobacco leaf discs. The average expression levels of Cry1Ac and API-BA proteins in transgenic plants are of 3.2 μg and 4.9 μg per gram fresh leaf respectively. The results of insecticidal assay of transgenic plants indicate that the pBS29K-BA transformed plants are more resistant to insect damage than the plants expressing the Cry1Ac gene or API-BA gene alone. | GUO Hongnian, QIN Hongmin, CHEN Xiaoying, LI Changqing, LU Rui and TIAN Yingchuan(Institute of Microbiology, Chinese Academy of Sciences, Beijing 100080, China) | 2002 | Progress in Natural Science:Materials International2002，12，5： | 1 |
| 5 | Transfer learning: A new aerodynamic force identification network based on adaptive EMD and soft thresholding in hypersonic wind tunnel显示文摘The aerodynamic test in the pulse combustion wind tunnel is very important for the design, evaluation and optimization of aerodynamic characteristics of the hypersonic aircraft.The test accuracy even affects the success or failure of hypersonic aircraft development. In the aerodynamic test of pulse combustion wind tunnel, the aerodynamic signal is disturbed by the inertial force signal, which seriously affects the test accuracy of aerodynamic force. Aiming at the above problems, this paper innovatively proposes an aerodynamic intelligent identification method, that is the transfer learning network based on adaptive Empirical Modal Decomposition(EMD) and Soft Thresholding(TLN-AE&ST). Compared with the existing aerodynamic intelligent identification model based on deep learning technology, this study introduces the transfer learning idea into the aerodynamic intelligent identification model for the first time. The TLN-AE&ST effectively alleviates the problem of scarcity of training samples for intelligent models due to the high cost of wind tunnel tests, and provides a new idea for further implementation of deep learning technology in the field of wind tunnel aerodynamic testing. And this study designed residual attention block with soft threshold and dense block with adaptive EMD in TLN-AE&ST model. Residual attention block with soft threshold module can more effectively suppress the influence of instrument noise signal on model training effect. Dense block with adaptive EMD makes the deep learning model no longer a black box to a certain extent, and has certain physical significance. Finally, a series of wind tunnel tests were carried out in the Φ = 2.4 m pulse combustion wind tunnel of China Aerodynamic Research and Development Center to verify the effectiveness of TLN-AE&ST. | Yi SUN Shichao LI Hongli GAO Xiaoqing ZHANG Jinzhou LV Weixiong LIU Yingchuan WU | 2023 | Chinese Journal of Aeronautics2023，36，8： | 0 |
| 6 | Human-centered Design for Green Landscape of Urban Streets显示文摘This paper first introduces the development process of urban street green landscape in China and the human-centered thinking of the design of urban street green landscape.On the basis of detailed elaboration of the basic theories of urban street green landscape,it analyzes the existing problems and causes for urban street green landscape.Then,from the perspective of human-centered thought,it comes up with several measures for optimizing the green landscape design of urban streets,to provide much more human-centered experience of urban street green landscape. | Yingchuan ZHAO Zhi LI | 2020 | Asian Agricultural Research2020，12，11： | 0 |
| 7 | YBa_(2)Cu_(3)O_(7-x) Superconducting Thin Films Grown on CaNdA1O_(4)(100) Substrates显示文摘We report the fabrication of high temperature superconducting YBa_(2)Cu_(3)O_(7-x) thin films on CaNdA1O_(4)(100) substrate by pulsed laser deposition.Films have excellent features.X-ray diffraction patterns show that thin films are epitaxial with c-axis orientation normal to the surface of su bstrate.The four-terminal measurements indicate the zero resistance temperature of 92.1 K,and transition width of 0.7K,the critical current density of 3×10^(6)A/cm^(2)at 77K and under zero magnetic field. | XU Shifa ZHOU Yueliang LÜHuibin CUI Dafu CHEN Zhenghao YANG Guozhen TIAN Yongjun LIU Junzheng LI Lin CHANG Yingchuan HOU Desen FAN Hui ZHANG Zuren | 1994 | Chinese Physics Letters1994，11，5： | 0 |
| 8 | Single-cell analysis defines the lineage plasticity of stem cells in cervix epithelium显示文摘Information about the dynamic change and post-injury regeneration of cervical epithelium is relatively rare,even though it is tightly related to gynecologic malignancy.Here,using a feeder cell-based culturing system,we stably cloned mouse and human P63 and KRT5 expressing cells from the adult cervix as putative cervical stem/progenitor cells(CVSCs).When subjected to differentiation,the cultured cells gave rise to mature cervical epithelium by differentiating into squamous or glandular cells.The ability of endogenous mouse CVSCs to reconstitute cervical epithelium after injury was also evident from the genetic lineage tracing experiments.Single-cell transcriptomic analysis further classified the CVSCs into three subtypes and delineated their bi-lineage differentiation roadmap by pseudo-time analysis.We also tracked the real-time differentiation routes of two representing single CVSC lines in vitro and found that they recapitulated the predicted roadmap in pseudo-time analysis.Signaling pathways including Wnt,TGF-beta,Notch and EGFR were found to regulate the cervical epithelial hierarchy and implicated the different roles of distinct types of cells in tissue homeostasis and tumorigenesis.Collectively,the above data provide a cloning system to achieve stable in vitro culture of a bi-lineage stem/progenitor cell population in the cervix,which has profound implications for our understanding of the cervix stem/progenitor cell function in homeostasis,regeneration,and disease and could be helpful for developing stem cell-based therapies in future. | Zixian Zhao Yujia Wang Yingchuan Wu Dandan Li Ting Zhang Yu Ma Xiaoming Teng Wei Zuo | 2021 | Cell Regeneration2021，10，1： | 0 |
| 9 | Potential benefit of high-dose intravenous vitamin C for coronavirus disease 2019 pneumonia显示文摘The coronavirus disease 2019(COVID-19)has been declared as a pandemic by the World Health Organization.[1]Most COVID-19 patients exhibit mild to moderate symptoms,while approximately 15%progress rapidly to severe pneumonia,and about 5%eventually develop acute respiratory distress syndrome(ARDS),[2]which requires mechanical ventilation(MV)and even extracorporeal membrane oxygenation.The mortality of COVID-19 patients who received MV was reported to be as high as 66%.[3]Therefore,the treatments aiming to improve mortality should focus on two aspects:first,prevention of the aggravation of the disease in mild and moderate COVID-19 patients;second,the rescue therapy for patients in serious conditions.We have been applying high-dose intravenous vitamin C(HDIVC)in the treatment of critical illnesses for almost 10 years in our center.Our previous in vivo research showed that HDIVC protected hemorrhagic shock-related multiple organ failure(MOF)by inhibiting inflammatory cytokines and oxidative indicators through activating Sirtuin1 pathway. | Bing Zhao Mengjiao Li Yun Ling Yibing Peng Jun Huang Hongping Qu Yuan Gao Yingchuan Li Bijie Hu Shuihua Lu Hongzhou Lu Wenhong Zhang Enqiang Mao | 2022 | Chinese Medical Journal2022，，1： | 0 |
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