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| 1 | Synthesis of Fe_3O_4@SiO_2@polymer nanoparticles for controlled drug release显示文摘Novel multifunctional nanoparticles containing a magnetic Fe3O4@SiO2 sphere and a biocompatible block copolymer poly(ethylene glycol)-b-poly(aspartate)(PEG-b-PAsp) were prepared.The silica coated on the superparamagnetic core was able to achieve a magnetic dispersivity,as well as to protect Fe3O4 against oxidation and acid corrosion.The PAsp block was grafted to the surface of Fe3O4@SiO2 nanoparticles by amido bonds,and the PEG block formed the outermost shell.The anticancer agent doxorubicin(DOX) was loaded into the hybrid nanoparticles via an electrostatic interaction between DOX and PAsp.The release rate of DOX could be adjusted by the pH value. | WU ChengLin,HE Huan,GAO HongJun,LIU Gan,MA RuJiang,AN YingLi & SHI LinQi Key Laboratory of Functional Polymer Materials,Ministry of Education Institute of Polymer Chemistry,Nankai University,Tianjin 300071,China | 2010 | Science China Chemistry2010，53，3： | 9 |
| 2 | Injectable dual glucose-responsive hydrogel-micelle composite for mimicking physiological basal and prandial insulin delivery显示文摘For type 1 and advanced type 2 diabetic patients, insulin replacement therapy with simulating on-demand prandial and basal insulin secretion is the best option for optimal glycemic control. However, there is no insulin delivery system yet could mimic both controlled basal insulin release and rapid prandial insulin release in response to real-time blood glucose changes. Here we reported an artificial insulin delivery system, mimicking physiological basal and prandial insulin secretion, to achieve real-time glycemic control and reduce risk of hypoglycemia. A phenylboronic acid(PBA)/galactosyl-based glucose-responsive insulin delivery system was prepared with insulin-loaded micelles embedded in hydrogel matrix. At the hyperglycemic state, both the hydrogel and micelles could swell and achieve rapid glucose-responsive release of insulin, mimicking prandial insulin secretion.When the glucose level returned to the normal state, only the micelles partially responded to glucose and still released insulin gradually. The hydrogel with increased crosslinking density could slow down the diffusion speed of insulin inside, resulting in controlled release of insulin and simulating physiological basal insulin secretion. This hydrogel-micelle composite insulin delivery system could quickly reduce the blood glucose level in a mouse model of type 1 diabetes, and maintain normal blood glucose level without hypoglycemia for about 24 h. This kind of glucose-responsive hydrogel-micelle composite may be a promising candidate for delivery of insulin in the treatment of diabetes. | Juan Lv Gang Wu Ying Liu Chang Li Fan Huang Yumin Zhang Jinjian Liu Yingli An Rujiang Ma Linqi Shi | 2019 | Science China Chemistry2019，62，5： | 5 |
| 3 | Optic and catalytic properties of gold nanoparticles tuned by homopolymers显示文摘Gold nanoparticles (GNs) are prepared through in situ reduction using NaBH4 in the presence of homopolymer PDMAEMA. The sizes of the GNs can be adjusted by alternating the molar ratio of gold to DMAEMA. Pure PDMAEMA aqueous solution shows a phase-transition at 50℃ at pH 10 and 25℃ at pH 14, while PDMAEMA-supported GNs aqueous solution shows a phase-transition at 47℃ at pH 10 because of the increasing hydrophobic property resulting from GNs. Due to the pH and tempera-ture-responsible characteristics of PDMAEMA, the resulting PDMAEMA-supported GNs exhibit pH adjustable temperature-responsive characteristics in optic and catalytic aspects. Under an acidic condi-tion (pH 2), the GNs show unchanged surface Plasmon absorbance with a peak of 518 nm in a tem-perature range from 20 to 65℃. Under a basic condition (pH 10), the GNs first show the same absorb-ance with a peak at 518 nm in a temperature range from 20 to 40℃, and then the absorbance red shifts from 518 to 545 nm as temperature increases from 40 to 65℃. When the GNs are used as catalysts to catalyze the reduction of p-nitrophenol, the catalytic activity can be adjusted by changing the permeation of reactants in the PDMAEMA layer at low and high temperatures, respectively. | CHEN Xi ZHAO DongYun ZHAO LiZhi AN YingLi MA RuJiang SHI LinQi HE QiJun CHEN Li | 2009 | Science China Chemistry2009，52，9： | 3 |
| 4 | Formation of spindlelike aggregates and flowerlike arrays of polystyrene-b-poly (acrylic acid) mieelles显示文摘 | Lichao Gao Linqi Shi Yingli An | 2004 | Langmuir2004，20，47： | 1 |
| 5 | Preparation and morphology studies of core-shell type waterborne polyacrylate-polyurethane microspheres显示文摘 | Anjie Dong Yingli An Shiyou Feng | 1999 | Journal of Colloid and Interface Science1999，214，： | 1 |
| 6 | Preparation and morphology studies of core-shell type waterborne polyacrylatepolyurethane microspheres显示文摘 | Dong Anjie An Yingli Feng Shiyou | 1999 | Journal of Colloid and Interface Science1999，214，： | 1 |
| 7 | Double-responsive core-shell-corona mieelles from self-assembly of diblock eopolymer of poly(t-butyl acrylate-co-acrylic)-b-poly(N-isopropylacrylamide)显示文摘 | Li Guiying Shi Linqi An Yingli | 2006 | Polymer2006，47，13： | 1 |
| 8 | Mieelles formed from the complexation of PNIPAM-b-P4VP block-copolymer and PS-b-PAA core-shell micelles显示文摘 | De'an Xiong Zhenping He Yingli An | 2008 | Polymer2008，49，： | 1 |
| 9 | Preparation and morphology studies of core-shell type waterborne polyacrylate-polyurethane micropheres显示文摘 | Dong Anjie An Yingli Feng Shiyou | 1999 | Jounral of Colloid and Interface Science1999，21，4： | 1 |
| 10 | Preparation and morphology studies of core-shell type waterborne polyacrylate-polyurethane microspheres显示文摘 | Dong Anjie An Yingli Feng Shiyou | 1999 | Journal of Colloid and Interface Science1999，214，： | 1 |
| 11 | Reverse micelles of star - block copolymer as nanoreactors for preparation of gold nanoparticles显示文摘 | Li Junbo Shi Linqi An Yingli | 2006 | Polymer2006，47，： | 1 |
| 12 | Preparation and morphology studies of core-shell type waterborne polyacrylate-polyurethane microspheres 显示文摘 | Dong Anjie An Yingli Feng Shiyou | 1999 | Journal of Colloid and Interface Science1999，214，1： | 1 |
| 13 | Preparation and Morphology studies of core-shell type waterborne polyacrylate-polyurethane microspheres显示文摘 | Dong A Yingli An Shiyou Feng | 1999 | Journal of Colloid and Interface Science1999，214，1： | 1 |
| 14 | Catalytic properties of gold nanoparticles immobilized on the surfaces of nanocarriers显示文摘 | Chen Xi Zhao Dongyun An Yingli | 2010 | Journal of Nanoparticle Research2010，12，5： | 1 |
| 15 | Evaporation-induced aggregation of polystyrene-block-poly(acrylic acid) micelles to microcubic particles显示文摘 | Zhang Wangqing Shi Linqi An Yingli | 2003 | Langmuir2003，19，15： | 1 |
| 16 | Preparation and Morphology Studies of Core-Shell Type Waterborne Polyacrylate–Polyurethane Microspheres显示文摘 | Anjie Dong Yingli An Shiyou Feng Duoxian Sun | 1999 | Journal of Colloid And Interface Science1999，，1： | 1 |
| 17 | Reverse micelles of star-block copolymer as nanoreactors for preparation of gold nanoparticles显示文摘 | Li Junbo Shi Linqi An Yingli | 2006 | Polymer2006，478，： | 1 |
| 18 | In-biofilm generation of nitric oxide using a magnetically-targetable cascade-reaction container for eradication of infectious biofilms显示文摘Cascade-reaction chemistry can generate reactive-oxygen-species that can be used for the eradication of infectious biofilms.However,suitable and sufficient oxygen sources are not always available near an infection site,while the reactive-oxygen-species generated are short-lived.Therefore,we developed a magnetic cascade-reaction container composed of mesoporous Fe_(3)O_(4)@SiO_(2) nanoparticles containing glucose-oxidase and L-arginine for generation of reactive-oxygen-species.Glucose-oxidase was conjugated with APTES facilitating coupling to Fe_(3)O_(4)@SiO_(2) nanoparticles and generation of H_(2)O_(2) from glucose.L-arginine was loaded into the nanoparticles to generate NO from the H_(2)O_(2) generated.Using an externally-applied magnetic field,cascade-reaction containers could be homogeneously distributed across the depth of an infectious biofilm.Cascade-reaction containers with coupled glucose-oxidase were effective in killing planktonic,Gram-positive and Gram-negative bacteria.Additional efficacy of the L-arginine based second cascade-reaction was only observed when H_(2)O_(2) as well as NO were generated in-biofilm.In vivo accumulation of cascade-reaction containers inside abdominal Staphylococcus aureus biofilms upon magnetic targeting was observed real-time in living mice through an implanted,intra-vital window.Moreover,vancomycin-resistant,abdominal S.aureus biofilms could be eradicated consuming solely endogenous glucose,without any glucose addition.Herewith,a new,non-antibiotic-based infection-control strategy has been provided,constituting a welcome addendum to the shrinking clinical armamentarium to control antibiotic-resistant bacterial infections. | Guang Yang Da-Yuan Wang Yong Liu Fan Huang Shuang Tian Yijin Ren Jianfeng Liu Yingli An Henny C.van der Mei Henk J.Busscher Linqi Shi | 2022 | Bioactive Materials2022，7，8： | 0 |
| 19 | 诱导性多能干细胞的低基因组稳定性使非同源末端连接增加显示文摘背景与目的诱导性多能干细胞(induced pluripotent stem cells,iPSCs)和胚胎干细胞(embryonic stem cells,ESCs)具有许多共同特征,包括相似的形态、基因表达和体外分化谱。然而,iPSCs的基因组稳定性远低于ESCs。在本研究中,我们研究了iPSCs中DNA损伤修复的改变是否为其具有更大诱变倾向的原因。方法将小鼠iPSCs、ESCs和胚胎成纤维细胞暴露于电离辐射(4 Gy),导致双链DNA断裂。照射4 h后使用全基因组重测序评估DNA损伤修复的保真度。我们还分析了分别源自iPSCs或ESCs的小鼠的基因组稳定性。结果照射后,与胚胎干细胞和胚胎成纤维细胞相比,iPSCs具有较低的DNA损伤修复能力,有更多的体细胞突变和短片段插入缺失。iPSCs有更多的非同源末端连接DNA修复和更少的同源重组DNA修复。源自iPSCs的小鼠比ESCs小鼠以及C57对照小鼠的DNA损伤修复能力更低。结论本研究结果部分表明,iPSCs的低基因组稳定性及其在体内的高致瘤性是由DNA损伤修复的低保真度所致。 | Minjie Zhang Liu Wang Ke An Jun Cai Guochao Li Caiyun Yang Huixian Liu Fengxia Du Xiao Han Zilong Zhang Zitong Zhao Duanqing Pei Yuan Long Xin Xie Qi Zhou Yingli Sun | 2019 | 癌症2019，38，8： | 0 |
| 20 | Complex micelles with the bioactive function of reversible oxygen transfer显示文摘复杂 micelle 作为血红素,有可逆的氧转移的 biaoactive 函数的功能的模型 poly 通过 diblock 共聚物的层次汇编被构造了(乙烯乙二醇)-blockpoly(4-vinylpyridine-co-N-heptyl-4-vinylpyridine)( PEG-b-P ( 4VP-co-4VPHep )), tetrakis ( 4-sulfonatophenyl ) porphinato 铁( II )( Fe ( II ) TPPS )和 -cyclodextrin (-CD)。含氧 Fe (II ) TPPS 更暗淡因为 Fe (II ) TPPS 通过主人客人被包括进 CD 的洞,成功地被禁止相互作用。与 pyridine 组一起协调的 Fe (II ) TPPS 作为活跃地点工作 reversibly 绑 dioxygen。在 adition,主人客人包括(-CD/Fe(II)TPPS) 在复杂 micelle 的恐水病的核心被包含并且紧由 P4VP 链修理了。在水的答案拉长组成稳定复杂 micelle 的结构象一样的壳的吸水的木钉块赋予复杂 micelle 以足够的血发行量时间。Dioxygen 能被绑在位于限制空间和 dioxygen 的有约束力版本的过程的优秀可逆性的 Fe (II ) TPPS 能被完成。第四级的胺 N-heptyl-4-vinylpyridine 能强制丰富的 S < 潜水艇 class= “ a-plus-plus ” > 2 O < 潜水艇 class= “ a-plus-plus ” > 4 < 啜 class= “ a-plus-plus ” > 进复杂 micelle 的核心的 2 个 离子处理便于自我减小。Dioxygen 使内收(Fe (II ) TPPS (O < 潜水艇 class= “ a-plus-plus ” > 2 )) 被由 cyclodextrin 和提高能力抵抗亲核的分子的复杂 micelle 的核心的洞构造的双恐水病的障碍有效地保护。因此,讲道理地设计的 amphiphilic 结构能作为有希望的人工的 O 工作 < 潜水艇 class= “ a-plus-plus ” > 2 搬运人。潜在地,复杂 micelle 能被期望改进与组织缺氧连接的疾病的治疗。 | Liangliang Shen Lizhi Zhao Rui Qu Fan Huang Hongjun Gao Yingli An Linqi Shi | 2015 | Nano Research2015，8，2： | 0 |
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