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| 1 | Effect of pulsatile perfusion during cardiopulmonary bypass in terms of radial artery sphygmogram显示文摘OBJECTIVE: To investigate a quantitative method for using radial artery pulse waveforms to assess the effect of pulsatile flow during cardiopulmonary bypass(CPB).METHODS: A total of 34 adults with heart disease who underwent open-heart surgery between April2010 and January 2011 were randomized into a pulsatile perfusion group(n=17) and a non-pulsatile perfusion group(n=17). Radial arterial pulse waveforms of pulsatile and non-pulsatile perfusion patients were observed and compared before and during CPB.RESULTS: No pulse waveform could be detected at patients' radial artery in both groups when the aorta was cross-clamped. Pulse waveforms could be detected at pulsatile perfusion patients' radial artery, but could not be detected at non-pulsatile perfusion patients' radial artery during CPB. Additionally, patients' pulse waveforms during pulsatile perfusion were lower than those before the operation.CONCLUSION: Our findings indicate that radial artery sphygmogram can be used as a valid indicator to evaluate the effectiveness of pulsatile perfusion during CPB. | Zhifeng Zhang Jiatuo Xu Enyuan Zhu Qi Zhang Lu Yu Yongbing Qiu Jianguo Tang Zhaofu Fei Xin Li Liping Tu Chouping Han Ying Liu Zhen Guo Changle Zhou Meiyu Shi Yingxin Qian Yimin Bao Xinming Ji | 2014 | Journal of Traditional Chinese Medicine2014，34，6： | 2 |
| 2 | Enhanced chemical trapping and catalytic conversion of polysulfides by diatomite/MXene hybrid interlayer for stable Li-S batteries显示文摘Lithium-Sulfur (Li-S) batteries with high theoretical energy density are promising energy storage systems in the next decades, while the lithium polysulfides (LiPSs) shuttling caused by the sluggish sulfur redox reaction severely lowers the practical performance. The use of interlayer between the cathode and separator has been widely investigated to physically or chemically block the LiPSs, while the introduction of catalytic materials is a more effective strategy to accelerate the conversion of LiPSs. MXene with rich surface chemistry has shown its potential for facilitating the catalytic conversion, however, the aggregation of MXene sheets usually leads to the loss of the catalytic active sites. Herein, we report a diatomite/MXene (DE/MX) hybrid material as the bifunctional interlayer for improving the adsorption/conversion of LiPSs in Li-S batteries. The diatomite with porous structure and rich silica-hydroxyl functional groups could trap LiPSs effectively, while prevent the aggregation of MXene. The DE/MX based interlayer showed bifunctions of enhancing the chemical adsorption and promoting the conversion of LiPSs. The Li-S batteries with the DE/MX interlayer delivered an improved cycling stability with a low capacity decay of 0.059% per cycle over 1000 cycles at 1.0 C. Moreover, stable 200 cycles can be realized with a high sulfur loading electrode up to 6.0 mg cm^(−2). This work provides an effective strategy to construct bifunctional interlayers for hindering the shuttling of LiPSs and boosting the practical application of Li-S batteries. | Zehui Fan Chen Zhang Wuxing Hua Huan Li Yan Jiao Jingyi Xia Chuan-Nan Geng Rongwei Meng Yingxin Liu Quanjun Tang Ziyang Lu Tongxin Shang Guowei Ling Quan-Hong Yang | 2021 | Journal of Energy Chemistry2021，30，11： | 1 |
| 3 | Transplantation of neural progenitor cells differentiated from adipose tissue-derived stem cells for treatment of sciatic nerve injury显示文摘Objectives: Currently, the clinical repair of sciatic nerve injury remains difficult.Previous studies have confirmed that transplantation of adipose tissue-derived stem cells promotes nerve regeneration and restoration at peripheral nerve injury sites. Methods: In this study, adipose tissue-derived stem cells were induced to differentiate into neural progenitor cells, transfected with a green fluorescent protein-containing lentivirus, and then transplanted into the lesions of rats with sciatic nerve compression injury. Results: Fluorescence microscopy revealed that the transplanted cells survived,migrated, and differentiated in rats. At two weeks post-operation, a large number of transplanted cells had migrated to the injured lesions; at six weeks post-operation, transplanted cells were visible around the injured nerve and several cells were observed to express a Schwann cell marker. Sciatic function index and electrophysiological outcomes of the transplantation group were better than those of the control group. Cell transplantation promoted the recovery of motor nerve conduction velocity and compound muscle action potential amplitude, and reduced gastrocnemius muscle atrophy.Conclusions: Our experimental findings indicate that neural progenitor cells,differentiated from adipose tissue-derived stem cells, are potential seed stem cells that can be transplanted into lesions to treat sciatic nerve injury. This provides a theoretical basis for their use in clinical applications. | Shasha Dong Na Liu Yang Hu Ping Zhang Chao Pan Youping Zhang Yingxin Tang Zhouping Tang | 2016 | Translational Neuroscience and Clinics2016，2，2： | 1 |
| 4 | Cloning and characterization of a gene (msdA) encoding methylmalonic acid semialdehyde dehydrogenase from streptomyces coelicolor显示文摘 | Zhang Yingxin Tang Li Hutchinson C R | 1996 | Journal of Bacteriology1996，178，2： | 1 |
| 5 | Alterations of Audiovisual Integration in Alzheimer’s Disease显示文摘Audiovisual integration is a vital information process involved in cognition and is closely correlated with aging and Alzheimer’s disease(AD).In this review,we evaluated the altered audiovisual integrative behavioral symptoms in AD.We further analyzed the relationships between AD pathologies and audiovisual integration alterations bidirectionally and suggested the possible mechanisms of audiovisual integration alterations underlying AD,including the imbalance between energy demand and supply,activity-dependent degeneration,disrupted brain networks,and cognitive resource overloading.Then,based on the clinical characteristics including electrophysiological and imaging data related to audiovisual integration,we emphasized the value of audiovisual integration alterations as potential biomarkers for the early diagnosis and progression of AD.We also highlighted that treatments targeted audiovisual integration contributed to widespread pathological improvements in AD animal models and cognitive improvements in AD patients.Moreover,investigation into audiovisual integration alterations in AD also provided new insights and comprehension about sensory information processes. | Yufei Liu Zhibin Wang Tao Wei Shaojiong Zhou Yunsi Yin Yingxin Mi Xiaoduo Liu Yi Tang | 2023 | Neuroscience Bulletin2023，39，12： | 0 |
| 6 | Homocysteine impedes neurite outgrowth recovery after intracerebral haemorrhage by downregulating pCAMK2A显示文摘Hyperhomocysteinemia(HHcy)is independently associated with poorer long-term prognosis in patients with intracerebral haemorrhage(ICH);however,the effect and mechanisms of HHcy on ICH are still unclear.Here,we evaluated neurite outgrowth and neurological functional recovery using simulated models of ICH with HHcy in vitro and in vivo.We found that the neurite outgrowth velocity and motor functional recovery in the ICH plus HHcy group were significantly slower than that in the control group,indicating that homocysteine(Hcy)significantly impedes the neurite outgrowth recovery after ICH.Furthermore,phosphoproteomic data and signalome analysis of perihematomal brain tissues suggested that calmodulin-dependent protein kinases 2(CAMK2A)kinase substrate pairs were significantly downregulated in ICH with HHcy compared with autologous blood injection only,both western blot and immunofluorescence staining confirmed this finding.Additionally,upregulation of pCAMK2A significantly increased neurite outgrowth recovery in ICH with HHcy.Collectively,we clarify the mechanism of HHcy-hindered neurite outgrowth recovery,and pCAMK2A may serve as a therapeutic strategy for promoting neurological recovery after ICH. | Guangyu Guo Jingfei Yang Wenliang Guo Hong Deng Haihan Yu Shuang Bai Gaigai Li Yingxin Tang Ping Zhang Yuming Xu Chao Pan Zhouping Tang | 2023 | Stroke & Vascular Neurology2023，8，4： | 0 |
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