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| 1 | N-doped honeycomb-like porous carbon towards high-performance supercapacitor显示文摘Biomass-derived porous carbon with developed pore structure is critical to achieving high performance electrode materials.In this work,we report a grape-based honeycomb-like porous carbon(GHPC)prepared by KOH activation and carbonization,followed by N-doping(NGHPC).The obtained NGHPC exhibits a unique honeycomb-like structure with hierarchically interconnected micro/mesopores,and high specific surface area of 1268 m^2/g.As a supercapacitor electrode,the NGPHC electrode exhibits a remarkable specific capacitance of 275 F/g at 0.5 A/g in a three-electrode cell.Moreover,the NGHPC//NGHPC symmetric supercapacitor displays a high energy density of 12.6 Wh/kg,and excellent cycling stability of approximately 95.2% capacitance retention after 5000 cycles at 5 A/g.The excellent electrochemical performance of NGHPC is ascribed to its high specific surface area,honeycomb-like structure and high-content of pyrodinic-N(36.29%).It is believed that grape-based carbon materials show great potential as advanced electrode materials for supercapacitors. | Feng Wang Lian Chen Huiling Li Gaigai Duan Shuijian He Lin Zhang Guoying Zhang Zhengping Zhou Shaohua Jiang | 2020 | Chinese Chemical Letters2020，31，7： | 2 |
| 2 | Operation reliability as- sessment for cutting tools by applying a proportional eovariate model to condition monitoring information 显示文摘 | Gaigai Cai Xuefeng Chen Bing Li | 2012 | Sensors2012，12，12： | 1 |
| 3 | Manipulating the antioxidative capacity of melanin-like nanoparticles by involving condensation polymerization显示文摘Melanin is ubiquitous in nature and plays important roles in physiological activities especially in keeping the oxidative balance.Both natural and synthetic melanin were synthesized via the free radical polymerization of 5,6-dihydroxyindole(DHI)monomer,which may lead to the inherent compactπ-conjugation stacking microstructures and finally results in limited antioxidative capacities.To address this issue,we have strived to involve condensation polymerization during the melanin synthetic process,aiming to disrupt the compact stacking microstructures and improve the total antioxidative performance.The resulting melaninlike nanoparticles(NPs)indeed possessed less compact stackingπ-conjugation structures and decreased density,which further demonstrated enhanced antioxidative abilities compared with conventional melanin-like polymers such as poly-5,6-dihydroxyindole(Poly-DHI)and polydopamine(PDA).Their excellent free radical scavenging capability was further confirmed by the intracellular cell protection effects against reactive oxygen species(ROS)as well as in vivo therapy for acute diseases including acute kidney injury and acute liver injury.This work would promote future work toward new types of melanin-inspired nanomaterials with tunable and improved functions beyond nature. | Peng Yang Tianyou Wang Jianhua Zhang Hengjie Zhang Wanjie Bai Gaigai Duan Wei Zhang Jinrong Wu Zhipeng Gu Yiwen Li | 2023 | Science China Chemistry2023，66，5： | 1 |
| 4 | A concise total synthesis of natural flavonols显示文摘In this study,we designed a convenient method,to total synthesis of fl avonols especially for C-5 substituted ones and derivatives on a large scale.Beginning from the inexpensively available 2,4,6-trihydroxyacetophenone through Aldol condensation reaction,I2/DMSO cyclization reaction,Oxone“one pot”oxidation,kaempferol(1)and derivative(2)was obtained in an overall yield of 35%.The structures of the target compound and key intermediates were verifi ed by MS,IR,1H-NMR and 13C-NMR techniques,and the structure of 5a was further confi rmed by X-ray diff raction analysis. | Gaigai Liu Shunqiang Gong Zhan Li Xingyi Du Xiaolou Miao Xuhong Ren | 2020 | Journal of Polyphenols2020，2，1： | 0 |
| 5 | The concordance between the evolutionary trend and the clinical manifestation of the two SARS-CoV-2 variants显示文摘Coronavirus disease 2019(COVID-19),the disease caused by infection with severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),has developed into a global pandemic that continues to pose an enormous threat to public health and the global economy.Since the first SARS-CoV-2 genome was released[1],thousands of genetic variants have been identified in SARS-CoV-2 strains isolated from worldwide patients. | Ben Hu Ran Liu Xiaolu Tang Yuchen Pan Ming Wang Yongqing Tong Guangming Ye Gaigai Shen Ruochen Ying Aisi Fu Di Li Wanxu Zhao Jing Peng Jie Guo Dong Men Xinmin Yao Yirong Wang Hong Zhang Zhihui Feng Junping Yu Liangjun Chen Zixin Deng Xuemei Lu Ya-Ping Zhang Yirong Li Bende Liu Lilei Yu Yan Li Jian Lu Tiangang Liu | 2021 | National Science Review2021，8，8： | 0 |
| 6 | Strategies to improve the migration of mesenchymal stromal cells in cell therapy显示文摘Mesenchymal stromal/stem cells(MSCs) are multipotent cells under consideration as a potential new therapy for a variety of inflammatory diseases including certain neurological disorders. It is generally thought that the efficacy of cell therapy in attenuating damage after ischemia, inflammation, or injury depends on the quantity of transplanted cells recruited to the target tissue. However, only a small number of systematically infused MSCs can effectively migrate to target sites, which significantly decreases the efficacy of exogenous cell-based therapy. In this review, we discuss specific factors influencing MSC migration, and summarize current strategies that effectively promote the motility of MSCs. In addition, we describe several protocols to improve the migration of stromal cells into the nervous system and, therefore,enhance the efficiency of engraftment as means of treating neurological disorders. | Gaigai Li Yang Hu Yanfang Chen Zhouping Tang | 2017 | Translational Neuroscience and Clinics2017，3，3： | 0 |
| 7 | Ultrasound-responsive spherical nucleic acid against c-Myc/PD-L1 to enhance anti-tumoral macrophages in triple-negative breast cancer progression显示文摘Triple-negative breast cancer(TNBC)is the most challenging breast cancer subtype because of its aggressive behavior and limited therapeutic targets.c-Myc is hyperactivated in the majority of TNBC tissues,however,it has been considered an“undruggable”target due to its disordered structure.Herein,we developed an ultrasound-responsive spherical nucleic acid(SNA)against c-Myc and PD-L1 in TNBC.It is a self-assembled and carrier-free system composed of a hydrophilic small-interfering RNA(si RNA)shell and a hydrophobic core made of a peptide nucleic acid(PNA)-based antisense oligonucleotide(ASO)and a sonosensitizer.We accomplished significant enrichment in the tumor by enhanced permeability and retention(EPR)effect,the controllable release of effective elements by ultrasound activation,and the combination of targeted therapy,immunotherapy and physiotherapy.Our study demonstrated significant anti-tumoral effects in vitro and in vivo.Mass cytometry showed an invigorated tumor microenvironment(TME)characterized by a significant alteration in the composition of tumor-associated macrophages(TAM)and decreased proportion of PD-1-positive(PD-1+)T effector cells after appropriate treatment of the ultrasound-responsive SNA(USNA).Further experiments verified that tumor-conditioned macrophages residing in the TME were transformed into the anti-tumoral population.Our finding offers a novel therapeutic strategy against the“undruggable”c-Myc,develops a new targeted therapy for c-Myc/PD-L1 and provides a treatment option for the TNBC. | Runtian Wang Gaigai Li Fangyan Gao Feng Xu Xintong Li Jian Zhang Jinbo Li Xiaoxiang Guan | 2024 | Science China(Life Sciences)2024，67，4： | 0 |
| 8 | Homocysteine impedes neurite outgrowth recovery after intracerebral haemorrhage by downregulating pCAMK2A显示文摘Hyperhomocysteinemia(HHcy)is independently associated with poorer long-term prognosis in patients with intracerebral haemorrhage(ICH);however,the effect and mechanisms of HHcy on ICH are still unclear.Here,we evaluated neurite outgrowth and neurological functional recovery using simulated models of ICH with HHcy in vitro and in vivo.We found that the neurite outgrowth velocity and motor functional recovery in the ICH plus HHcy group were significantly slower than that in the control group,indicating that homocysteine(Hcy)significantly impedes the neurite outgrowth recovery after ICH.Furthermore,phosphoproteomic data and signalome analysis of perihematomal brain tissues suggested that calmodulin-dependent protein kinases 2(CAMK2A)kinase substrate pairs were significantly downregulated in ICH with HHcy compared with autologous blood injection only,both western blot and immunofluorescence staining confirmed this finding.Additionally,upregulation of pCAMK2A significantly increased neurite outgrowth recovery in ICH with HHcy.Collectively,we clarify the mechanism of HHcy-hindered neurite outgrowth recovery,and pCAMK2A may serve as a therapeutic strategy for promoting neurological recovery after ICH. | Guangyu Guo Jingfei Yang Wenliang Guo Hong Deng Haihan Yu Shuang Bai Gaigai Li Yingxin Tang Ping Zhang Yuming Xu Chao Pan Zhouping Tang | 2023 | Stroke & Vascular Neurology2023，8，4： | 0 |
| 9 | Sequence variations of phase-separating proteins and resources for studying biomolecular condensates显示文摘Phase separation(PS)is an important mechanism underlying the formation of biomolecular condensates.Physiological condensates are associated with numerous biological processes,such as transcription,immunity,signaling,and synaptic transmission.Changes in particular amino acids or segments can disturb the protein’s phase behavior and interactions with other biomolecules in condensates.It is thus presumed that variations in the phase-separating-prone domains can significantly impact the properties and functions of condensates.The dysfunction of condensates contributes to a number of pathological processes.Pharmacological perturbation of these condensates is proposed as a promising way to restore physiological states.In this review,we characterize the variations observed in PS proteins that lead to aberrant biomolecular compartmentalization.We also showcase recent advancements in bioinformatics of membraneless organelles(MLOs),focusing on available databases useful for screening PS proteins and describing endogenous condensates,guiding researchers to seek the underlying pathogenic mechanisms of biomolecular condensates. | Gaigai Guo Xinxin Wang Yi Zhang Tingting Li | 2023 | Acta Biochimica et Biophysica Sinica2023，55，7： | 0 |
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