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| 1 | Tissue-specific transcription reprogramming promotes liver metastasis of colorectal cancer显示文摘Metastasis,the development of secondary malignant growths at a distance from a primary tumor,is the cause of death for 90%of cancer patients,but little is known about how metastatic cancer cells adapt to and colonize new tissue environments.Here,using clinical samples,patient-derived xenograft(PDX)samples,PDX cells,and primary/metastatic cell lines,we discovered that liver metastatic colorectal cancer(CRC)cells lose their colon-specific gene transcription program yet gain a liver-specific gene transcription program.We showed that this transcription reprogramming is driven by a reshaped epigenetic landscape of both typical enhancers and super-enhancers.Further,we identified that the liver-specific transcription factors FOXA2 and HNF1A can bind to the gained enhancers and activate the liver-specific gene transcription,thereby driving CRC liver metastasis.Importantly,similar transcription reprogramming can be observed in multiple cancer types.Our data suggest that reprogrammed tissue-specific transcription promotes metastasis and should be targeted therapeutically. | Shuaishuai Teng Yang Eric Li Ming Yang Rui Qi Yiming Huang Qianyu Wang Yanmei Zhang Shanwen Chen Shasha Li Kequan Lin Yang Cao Qunsheng Ji Qingyang Gu Yujing Cheng Zai Chang Wei Guo Pengyuan Wang Ivan Garcia-Bassets Zhi John Lu Dong Wang | 2020 | Cell Research2020，30，1： | 11 |
| 2 | Characteristics,sources and health risks assessment of VOCs in Zhengzhou,China during haze pollution season显示文摘Zhengzhou is one of the most haze-polluted cities in Central China with high organic carbon emission,which accounts for 15%-20%of particulate matter(PM_(2.5))in winter and causes significantly adverse health effects.Volatile organic compounds(VOCs)are the precursors of secondary PM_(2.5)and O_(3)formation.An investigation of characteristics,sources and health risks assessment of VOCs was carried out at the urban area of Zhengzhou from 1^(st) to 31^(st) December,2019.The mean concentrations of total detected VOCs were 48.8±23.0 ppbv.Alkanes(22.0±10.4 ppbv),halocarbons(8.1±3.9 ppbv)and aromatics(6.5±3.9 ppbv)were the predominant VOC species,followed by alkenes(5.1±3.3 ppbv),oxygenated VOCs(3.6±1.8 ppbv),alkyne(3.5±1.9,ppbv)and sulfide(0.5±0.9 ppbv).The Positive Matrix Factorization model was used to identify and apportion VOCs sources.Five major sources of VOCs were identified as vehicular exhaust,industrial processes,combustion,fuel evaporation,and solvent use.The carcinogenic and non-carcinogenic risk values of species were calculated.The carcinogenic and non-carcinogenic risks of almost all air toxics increased during haze days.The total non-carcinogenic risks exceeded the acceptable ranges.Most VOC species posed no non-carcinogenic risk during three haze events.The carcinogenic risks of chloroform,1,2-dichloroethane,1,2-dibromoethane,benzyl chloride,hexachloro-1,3-butadiene,benzene and naphthalene were above the acceptable level(1.0×10^(-6))but below the tolerable risk level(1.0×10^(-4)).Industrial emission was the major contributor to non-carcinogenic,and solvent use was the major contributor to carcinogenic risks. | Dong Zhang Bing He Minghao Yuan Shijie Yu Shasha Yin Ruiqin Zhang | 2021 | Journal of Environmental Sciences2021，33，10： | 10 |
| 3 | Shale Gas Formation and Occurrence in China: An Overview of the Current Status and Future Potential显示文摘Shale gas is one of the most promising unconventional resources both in China and abroad. It is known as a form of self-contained source-reservoir system with large and continuous dimensions. Through years of considerable exploration efforts, China has identified three large shale gas fields in the Fuling, Changning and Weiyuan areas of the Sichuan Basin, and has announced more than 540 billion m^3 of proven shale gas reserves in marine shale systems. The geological theories for shale gas development have progressed rapidly in China as well. For example, the new depositional patterns have been introduced for deciphering the paleogeography and sedimentary systems of the Wufeng shale and Longmaxi shale in the Sichuan Basin. The shale gas storage mechanism has been widely accepted as differing from conventional natural gas in that it is adsorbed on organic matter or a mineral surface or occurs as free gas trapped in pores and fractures of the shale. Significant advances in the techniques of microstructural characterization have provided new insights on how gas molecules are stored in micro- and nano-scale porous shales. Furthermore, newly-developed concepts and practices in the petroleum industry, such as hydraulic fracturing, microseismic monitoring and multiwell horizontal drilling, have made the production of this unevenly distributed but promising unconventional natural gas a reality. China has 10–36 trillion m^3 of promising shale gas among the world's whole predicted technically recoverable reserves of 206.6 trillion m^3. China is on the way to achieving its goal of an annual yield of 30–50 billion m^3 by launching more trials within shale gas projects. | ZOU Caineng YANG Zhi PAN Songqi CHEN Yanyan LIN Senhu HUANG Jinliang WU Songtao DONG Dazhong WANG Shufang LIANG Feng SUN Shasha HUANG Yong WENG Dingwei | 2016 | Acta Geologica Sinica(English Edition)2016，90，4： | 9 |
| 4 | Chemical genomics reveals inhibition of breast cancer lung metastasis by Ponatinib via c-Jun显示文摘Metastasis is the leading cause of human cancer deaths.Unfortunately,no approved drugs are available for antimetastatic treatment.In our study,high-throughput sequencing-based high-throughput screening(HTS^2)and a breast cancer lung metastasis(BCLM)-associated gene signature were combined to discover anti-metastatic drugs.After screening of thousands of compounds,we identified Ponatinib as a BCLM inhibitor.Ponatinib significantly inhibited the migration and mammosphere formation of breast cancer cells in vitro and blocked BCLM in multiple mouse models.Mechanistically,Ponatinib represses the expression of BCLM-associated genes mainly through the ERK/c-Jun signaling pathway by inhibiting the transcription of JUN and accelerating the degradation of c-Jun protein.Notably,JUN expression levels were positively correlated with BCLM-associated gene expression and lung metastases in breast cancer patients.Collectively,we established a novel approach for the discovery of anti-metastatic drugs,identified Ponatinib as a new drug to inhibit BCLM and revealed c-Jun as a crucial factor and potential drug target for BCLM.Our study may facilitate the therapeutic treatment of BCLM as well as other metastases. | Wei Shao Shasha Li Lu Li Kequan Lin Xinhong Liu Haiyan Wang Huili Wang Dong Wang | 2019 | Protein & Cell2019，10，3： | 7 |
| 5 | A review for the breeding of orchids: Current achievements and prospects显示文摘Orchids are horticultural plants with significant ornamental and economic value.Increasing market circulation and rising trade in orchids is forcing breeders to develop varieties with unique characteristics,including flower color,morphology,and resistance using a range of approaches,including traditional and molecular breeding.Advances in high-throughput technologies have generated extensive data sets with greater sequencing depths and broader coverage,providing the potential for discovering new genes/pathways that give rise to key traits.Several attempts have been made to use emerging molecular and omics methods to accelerate the breeding process in certain of the commercially valuable orchids.This review consolidates current approaches and achievements in orchid breeding and discusses their future applications for improving the resistance,ornamental,and other valuable characteristics of these plants. | Chengru Li Na Dong Yamei Zhao Shasha Wu Zhongjian Liu Junwen Zhai | 2021 | Horticultural Plant Journal2021，7，5： | 5 |
| 6 | Combined deficiency of SLAMF8 and SLAMF9 prevents endotoxin-induced liver inflammation by downregulating TLR4 expression on macrophages显示文摘Classical signaling lymphocyte activating molecule(SLAM)family receptors are abundant within many types of immune cells,whereas the nonclassical SLAM family receptors SLAMF8 and SLAMF9,which uniquely lack cytoplasmic signaling motifs,are highly expressed by myeloid cells.Due to the potential redundancy,whether these two receptors regulate macrophage function remains largely unknown.Here,we show that SLAMF8 and SLAMF9 co-regulate macrophage-mediated liver inflammation.To overcome the redundancy,we generated mice that simultaneously lacked SLAMF8 and SLAMF9 using CRISPR-Cas9 technology.Although macrophage differentiation was not altered by the combined deficiency of SLAMF8 and SLAMF9,the loss of these two receptors significantly protected against lipopolysaccharide(LPS)-induced liver injury.SLAMF8 and SLAMF9 double-deficient mice had a prolonged survival rate and less infiltration of inflammatory cells.The depletion of macrophages using clodronate liposomes abolished the effects of SLAMF8 and SLAMF9 deficiencies on LPS-induced liver injury,which demonstrates that these receptors are required for macrophage activation following LPS challenge.Moreover,the deficiency of SLAMF8 and SLAMF9 suppressed the secretion of inflammatory cytokines by downregulating the expression of Toll-like receptor-4(TLR4),a receptor that specifically binds LPS,which led to decreased mitogen-activated protein kinases(MAPK)signaling activation.Notably,combined injections of truncated extracellular SLAMF8 and SLAMF9 proteins significantly alleviated LPS-induced liver injury.Thus,our findings provide insights into the role of SLAMF8 and SLAMF9 in endotoxin-induced liver injury and suggest that SLAMF8 and SLAMF9 are potential therapeutic targets for acute hepatic injury. | Xiaokang Zeng Guangao Liu Wanwen Peng Junming He Chenxu Cai Wei Xiong Shasha Chen Meixiang Yang Zhongjun Dong | 2020 | Cellular & Molecular Immunology2020，17，2： | 5 |
| 7 | NEDD9 promotes cancer stemness by recruiting myeloid-derived suppressor cells via CXCL8 in esophageal squamous cell carcinoma显示文摘Objective:Esophageal squamous cell carcinoma(ESCC)has high morbidity and mortality rates worldwide.Cancer stem cells(CSCs)may cause tumor initiation,metastasis,and recurrence and are also responsible for chemotherapy and radiotherapy failures.Myeloid-derived suppressor cells(MDSCs),in contrast,are known to be involved in mediating immunosuppression.Here,we aimed to investigate the mechanisms of interaction of CSCs and MDSCs in the tumor microenvironment.Methods:ESCC tissues and cell lines were evaluated.Neural precursor cell expressed,developmentally downregulated 9(NEDD9)was knocked down and overexpressed by lentiviral transfection.Quantitative PCR,Western blot,immunohistochemistry,cell invasion,flow cytometry,cell sorting,multiplex chemokine profiling,and tumor growth analyses were performed.Results:Microarray analysis revealed 10 upregulated genes in esophageal CSCs.Only NEDD9 was upregulated in CSCs using the sphere-forming method.NEDD9 expression was correlated with tumor invasion(P=0.0218),differentiation(P=0.0153),and poor prognosis(P=0.0373).Additionally,NEDD9 was required to maintain the stem-like phenotype.Screening of chemokine expression in ESCC cells with NEDD9 overexpression and knockdown showed that NEDD9 regulated C-X-C motif chemokine ligand 8(CXCL8)expression via the ERK pathway.CXCL8 mediated the recruitment of MDSCs induced by NEDD9 in vitro and in vivo.MDSCs promoted the stemness of ESCC cells through NEDD9 via the Notch pathway.Conclusions:As a marker of ESCC,NEDD9 maintained the stemness of ESCC cells and regulated CXCL8 through the ERK pathway to recruit MDSCs into the tumor,suggesting NEDD9 as a therapeutic target and novel prognostic marker for ESCC. | Dongli Yue Shasha Liu Tengfei Zhang Yong Wang Guohui Qin Xinfeng Chen Huanyu Zhang Dong Wang Lan Huang Feng Wang Liping Wang Song Zhao Yi Zhang | 2021 | Cancer Biology & Medicine2021，18，3： | 4 |
| 8 | Community structure and carbon and nitrogen storage of sagebrush desert under grazing exclusion in Northwest China显示文摘Overgrazing is regarded as one of the key factors of vegetation and soil degradation in the arid and semi-arid regions of Northwest China.Grazing exclusion(GE)is one of the most common pathways used to restore degraded grasslands and to improve their ecosystem services.Nevertheless,there are still significant controversies concerning GE’s effects on grassland diversity as well as carbon(C)and nitrogen(N)storage.It remains poorly understood in the arid desert regions,whilst being essential for the sustainable use of grassland resources.To assess the effects of GE on community characteristics and C and N storage of desert plant community in the arid desert regions,we investigated the community structure and plant biomass,as well as C and N storage of plants and soil(0-100 cm depth)in short-term GE(three years)plots and adjacent long-term freely grazing(FG)plots in the areas of sagebrush desert in Northwest China,which are important both for spring-autumn seasonal pasture and for ecological conservation.Our findings indicated that GE was beneficial to the average height,coverage and aboveground biomass(including stems,leaves and inflorescences,and litter)of desert plant community,to the species richness and importance values of subshrubs and perennial herbs,and to the biomass C and N storage of aboveground parts(P<0.05).However,GE was not beneficial to the importance values of annual herbs,root/shoot ratio and total N concentration in the 0-5 and 5-10 cm soil layers(P<0.05).Additionally,the plant density,belowground biomass,and soil organic C concentration and C storage in the 0-100 cm soil layer could not be significantly changed by short-term GE(three years).The results suggest that,although GE was not beneficial for C sequestration in the sagebrush desert ecosystem,it is an effective strategy for improving productivity,diversity,and C and N storage of plants.As a result,GE can be used to rehabilitate degraded grasslands in the arid desert regions of Northwest China. | DONG Yiqiang SUN Zongjiu AN Shazhou JIANG Shasha WEI Peng | 2020 | Journal of Arid Land2020，12，2： | 3 |
| 9 | Cross-Scale Synthesis of Organic High-k Semiconductors Based on Spiro-Gridized Nanopolymers显示文摘High dielectric constants in organic semiconductors have been identified as a central challenge for the improvement in not only piexoelectric,preolecric,and freeltric efcts but also photoclecric conversion eficiency in OPVs,carrier mobility in OFETS,and charge density in charge-trapping memories.Herein,we report an ultralong persistence length(≈41 nm)efet of spiro-fused organic nanopolymers on dielectric properties,together with excitonic and charge carrier behaviors.The state-of-the-art nanopolymers,namely,nanopolyspirogrids(NPSGs),are synthesized via the simple crossscale Friedel-Crafts polygridlization of AjB-type nanomonomers.The high dielectric constant(k=8.43)of NPSG is firstly achieved by locking spiro-polygridization efect that results in the enhancement of dipole polarization.When doping into a polystyrene-based dielectric layer,such a high-k feature of NPSG increases the feld-ffct carrier mobility from 0.20 to 0.90cm^(2)Vl s'in pentacene OFET devices.Meanwhile,amorphous NPSG film exhibits an ultralow energy disorder(<50 meV)for an exellent zero-field hole mobility of 3.94×10^(-1)cm^(2)V^(-1)s^(-1).surpassing most of the amorphousπconjugated polymers Onganic nanopolymers with high dielectric constants open a new way to break through the bottleneck of eficiency and multifunctionality in the blueprint of the fourth generation semiconductors. | Dongqing Lin Wenhua Zhang Hang Yin Haixia Hu Yang Li He Zhang Le Wang Xinmiao Xie Hongkai Hu Yongxia Yan Haifeng Ling Jin'an Liu Yue Qian Lei Tang Yongxia Wang Chaoyang Dong Linghai Xie Hao Zhang Shasha Wang Ying Wei Xuefeng Guo Dan Lu Wei Huang | 2022 | Research2022，，2： | 3 |
| 10 | Large-range tunable fractional-order differentiator based on cascaded microring resonators显示文摘在这份报纸,我们试验性地证明用电子上串联的在薄片上的一个所有光的连续地悦耳的部分顺序的微分器调节了 microring 共鸣器(MRR ) 。由改变在 MRR 上使用的电压,在 MRR 的回声频率的阶段移动变化,它能被用来实现悦耳的部分顺序的微分器。有一个更大的悦耳的范围的因此部分顺序的微分器能被在一个单个薄片上串联更多的 MRR 单位获得。在实验,我们分别地在二串联 MRR 上使用了二直接当前的电压来源,并且 0.57 ~ 2 的一个悦耳的顺序范围与 Gaussian 脉搏注射被表明了,它是到我们的知识的最大的调节范围。 | Ting YANG Shasha LIAO Li LIU Jianji DONG | 2016 | Frontiers of Optoelectronics2016，9，3： | 2 |
| 11 | NK cell recognition of hematopoietic cells by SLAM-SAP families显示文摘The signaling lymphocyte activation molecule(SLAM)family of receptors(SFRs)are ubiquitously expressed on immune cells,and they regulate multiple immune events by recruiting SH2(Src homology 2)domain-containing SAP family adapters,including SAP and its homologs,Ewing’s sarcoma-associated transcript 2(EAT-2)and EAT-2 related transducer(ERT).In human patients with X-linked lymphoproliferative(XLP)disease,which is caused by SAP mutations,SFRs alternatively bind other inhibitory SH2 domain-containing molecules to suppress immune cell activation and development.NK cells express multiple SFRs and all SAP family adapters.In recent decades,SFRs have been found to be critical for enhancing NK cell activation in response to abnormal hematopoietic cells in SAP-family-intact NK cells;however,SFRs might suppress NK cell activation in SAP-family-deficient mice or patients with XLP1.In this paper,we review how these two distinct SFR signaling pathways orchestrate NK cell activation and inhibition and highlight the importance of SFR regulation of NK cell biology and their physiological status and pathological relevance in patients with XLP1. | Shasha Chen Zhongjun Dong | 2019 | Cellular & Molecular Immunology2019，16，5： | 2 |
| 12 | Recent research progress of bimetallic phosphides-based nanomaterials as cocatalyst for photocatalytic hydrogen evolution显示文摘Hydrogen energy(H_(2)) has been considered as the most possible consummate candidates for replacing the traditional fossil fuels because of its higher combustion heat value and lower environmental pollution.Photocatalytic hydrogen evolution(PHE) from water splitting based on semiconductors is a promising technology towards converting solar energy into sustainable H_(2)fuel evolution. Developing high-activity and abundant source semiconductor materials is particularly important to realize highly efficient hydrogen evolution as for photocatalysis technology. However, unmodified pristine photocatalysts are often unable to overcome the weakness of low performance due to their limitations. In recent years, transition metal phosphides(TMPs) were used as valid co-catalysts to replace the classic precious metal materials in the process of photocatalytic reaction owing to their lower cost and higher combustion heat value.What is more, bimetallic phosphides have been also caused widespread concern in H_(2)evolution reaction owing to its much lower overpotential, more superior conductivity, and weaker charge carriers transfer impedance in comparison to those of single metal phosphides. In this minireview, we concluded the latest developments of bimetallic phosphides for a series of photocatalytic reactions. Firstly, we briefly summarize the present loading methods of bimetallic phosphides(BMPs) anchored on the photocatalyst. After that, the H;evolution efficiency based on BMPs as cocatalyst is also studied in detail. Besides, the application of BMPs-based host photocatalyst for H_(2)evolution under dye sensitization effect has also been discussed. At last, the current development prospects and prospective challenges in many ways of BMPs are proposed. We sincerely hope this minireview has certain reference value for great developments of BMPs in the future research. | Chunmei Li Daqiang Zhu Shasha Cheng Yan Zuo Yun Wang Changchang Ma Hongjun Dong | 2022 | Chinese Chemical Letters2022，33，3： | 2 |
| 13 | The histone methyltransferase SUVR2 promotes DSB repair via chromatin remodeling and liquidliquid phase separation显示文摘Maintaining genomic integrity and stability is particularly important for stem cells,which are at the top of the cell lineage origin.Here,we discovered that the plant-specific histone methyltransferase SUVR2 maintains the genome integrity of the root tip stem cells through chromatin remodeling and liquid-liquid phase separation(LLPS)when facing DNA double-strand breaks(DSBs).The histone methyltransferase SUVR2(MtSUVR2)has histone methyltransferase activity and catalyzes the conversion of histone H3 lysine 9 monomethylation(H3K9me1)to H3K9me2/3 in vitro and in Medicago truncatula.Under DNA damage,the proportion of heterochromatin decreased and the level of DSB damage marker y-H2AX increased in suvr2 mutants,indicating that MtSUVR2 promotes the compaction of the chromatin structure through H3K9 methylation modification to protect DNA from damage.Interestingly,MtSUVR2 was induced by DSBs to phase separate and form droplets to localize at the damage sites,and this was confirmed by immunofluorescence and fluorescence recovery after photobleaching experiments.The IDR1 and lowcomplexity domain regions of MtSUVR2 determined its phase separation in the nucleus,whereas the IDR2 region determined the interaction with the homologous recombinase MtRAD51.Furthermore,we found that MtSUVR2 drove the phase separation of MtRAD51 to form'DNA repair bodies,'which could enhance the stability of MtRAD51 proteins to facilitate error-free homologous recombination repair of stem cells.Taken together,our study reveals that chromatin remodeling-associated proteins participate in DNA repair through LLPS. | Qianwen Liu Peng Liu Tuo Ji Lihua Zheng Chen Shen Shasha Ran Jinling Liu Yafei Zhao Yiding Niu Tao Wang Jiangli Dong | 2022 | Molecular Plant2022，15，7： | 1 |
| 14 | Intracellular effects of prodrug-like wortmannin probes显示文摘Wortmannin, a known inhibitor of phosphoinositide 3-kinases(PI3 Ks), their low selectivity and high toxicity is still problematic and less is known about their effects on PI3 Ks in cellular systems. Hence, we have synthesized a series of multifunctional wortmannin probes with the ability to self-activate, by installing a clickable handle at C11 site, and secondary amine and cancer-targeting moiety at C20 site respectively. MTT assay first confirmed that self-activating probes have better inhibition potency and biotin enhanced their cancer cell uptake. Further experiments showed most of probes can target PI3 K/Akt/mTOR pathway with prolonged turn-over time. Protein profiling and pull-down results were observed that the derivatives not only labelled four PI3 Ks with selectivity, but also engaged in covalent interactions with numerous cellular proteins which could be the major reason of their high toxicity. | Shasha Ying Shubo Du Jia Dong Bi Xuan Ng Chengwu Zhang Lin Li Jingyan Ge Qing Zhua | 2019 | Chinese Chemical Letters2019，30，1： | 1 |
| 15 | Differential expression of ion transporters and aquaporins in leaves may contribute to different salt tolerance in Malus species显示文摘 | Changhai Liu Chao Li Dong Liang Zhiwei Wei Shasha Zhou Rongchao Wang Fengwang Ma | 2012 | Plant Physiology and Biochemistry2012，，： | 1 |
| 16 | Transplantation of neural progenitor cells differentiated from adipose tissue-derived stem cells for treatment of sciatic nerve injury显示文摘Objectives: Currently, the clinical repair of sciatic nerve injury remains difficult.Previous studies have confirmed that transplantation of adipose tissue-derived stem cells promotes nerve regeneration and restoration at peripheral nerve injury sites. Methods: In this study, adipose tissue-derived stem cells were induced to differentiate into neural progenitor cells, transfected with a green fluorescent protein-containing lentivirus, and then transplanted into the lesions of rats with sciatic nerve compression injury. Results: Fluorescence microscopy revealed that the transplanted cells survived,migrated, and differentiated in rats. At two weeks post-operation, a large number of transplanted cells had migrated to the injured lesions; at six weeks post-operation, transplanted cells were visible around the injured nerve and several cells were observed to express a Schwann cell marker. Sciatic function index and electrophysiological outcomes of the transplantation group were better than those of the control group. Cell transplantation promoted the recovery of motor nerve conduction velocity and compound muscle action potential amplitude, and reduced gastrocnemius muscle atrophy.Conclusions: Our experimental findings indicate that neural progenitor cells,differentiated from adipose tissue-derived stem cells, are potential seed stem cells that can be transplanted into lesions to treat sciatic nerve injury. This provides a theoretical basis for their use in clinical applications. | Shasha Dong Na Liu Yang Hu Ping Zhang Chao Pan Youping Zhang Yingxin Tang Zhouping Tang | 2016 | Translational Neuroscience and Clinics2016，2，2： | 1 |
| 17 | The genome sequence of star fruit(Averrhoa carambola)显示文摘Oxalidaceae is one of the most important plant families in horticulture,and its key commercially relevant genus,Averrhoa,has diverse growth habits and fruit types.Here,we describe the assembly of a high-quality chromosomescale genome sequence for Averrhoa carambola(star fruit).Ks distribution analysis showed that A.carambola underwent a whole-genome triplication event,i.e.,the gamma event shared by most eudicots.Comparisons between A.carambola and other angiosperms also permitted the generation of Oxalidaceae gene annotations.We identified unique gene families and analyzed gene family expansion and contraction.This analysis revealed significant changes in MADS-box gene family content,which might be related to the cauliflory of A.carambola.In addition,we identified and analyzed a total of 204 nucleotide-binding site,leucine-rich repeat receptor(NLR)genes and 58 WRKY genes in the genome,which may be related to the defense response.Our results provide insights into the origin,evolution and diversification of star fruit. | Shasha Wu Wei Sun Zhichao Xu Junwen Zhai Xiaoping Li Chengru Li Diyang Zhang Xiaoqian Wu Liming Shen Junhao Chen Hui Ren Xiaoyu Dai Zhongwu Dai Yamei Zhao Lei Chen Mengxia Cao Xinyu Xie Xuedie Liu Donghui Peng Jianwen Dong Yu-Yun Hsiao Shi-lin Chen Wen-Chieh Tsai Siren Lan Zhong-Jian Liu | 2020 | Horticulture Research2020，7，1： | 1 |
| 18 | Characterization of natural fractures in deep-marine shales: a case study of the Wufeng and Longmaxi shale in the Luzhou Block Sichuan Basin, China显示文摘Natural fractures are of crucial importance for oil and gas reservoirs,especially for those with ultralow permeability and porosity.The deep-marine shale gas reservoirs of the Wufeng and Longmaxi Formations are typical targets for the study of natural fracture characteristics.Detailed descriptions of full-diameter shale drill core,together with 3D Computed Tomography scans and Formation MicroScanner Image data acquisition,were carried out to characterize microfracture morphology in order to obtain the key parameters of natural fractures in such system.The fracture type,orientation,and their macroscopic and microscopic distribution features are evaluated.The results show that the natural fracture density appears to remarkably decrease in the Wufeng and Longmaxi Formations with increasing the burial depth.Similar trends have been observed for fracture length and aperture.Moreover,the natural fracture density diminishes as the formation thickness increases.There are three main types of natural fractures,which we interpret as(I)mineral-filled fractures(by pyrite and calcite),i.e.,veins,(II)those induced by tectonic stress,and(III)those formed by other processes(including diagenetic shrinkage and fluid overpressure).Natural fracture orientations estimated from the studied natural fractures in the Luzhou block are not consistent with the present-day stress field.The difference in tortuosity between horizontally and vertically oriented fractures reveals their morphological complexity.In addition,natural fracture density,host rock formation thickness,average total organic carbon and effective porosity are found to be important factors for evaluating shale gas reservoirs.The study also reveals that the high density of natural fractures is decisive to evaluate the shale gas potential.The results may have significant implications for evaluating favorable exploration areas of shale gas reservoirs and can be applied to optimize hydraulic fracturing for permeability enhancement. | Shasha SUN Saipeng HUANG Enrique GOMEZ-RIVAS Albert GRIERA ΒοLIU Lulu XU Yaru WEN Dazhong DONG Zhensheng SHI Yan CHANG Yin XING | 2023 | Frontiers of Earth Science2023，17，1： | 0 |
| 19 | Artificial intelligence-aided discovery of prolyl hydroxylase 2 inhibitors to stabilize hypoxia inducible factor-1α and promote angiogenesis显示文摘From ZINC database with a total of 1.8 million small molecules, four compounds are identified as prolyl hydroxylase 2 inhibitors through a virtual screening workflow that sequentially incorporates machine learning, molecular docking, and molecular dynamics. Among them, compound 103,(E)-5-(5-((2-(1Htetrazol-5-yl)hydrazineylidene)methyl)furan-2-yl)isoindoline-1,3-dione, promotes the migration and capillary tube formation capacity of human umbilical vein endothelial cells through enhancing the stability of hypoxia inducible factor-1α and increasing the level of vascular endothelial growth factor. | Jianzhong Zhu Cheng Chen Jie Dong Shasha Cheng Guodong Li Chunming Wang Defang Ouyang Chung-Hang Leung Ligen Lin | 2023 | Chinese Chemical Letters2023，34，2： | 0 |
| 20 | Self-assembly into Polymorphic 2D Nanosheets with Crystallization-Induced Emission Enhancement显示文摘Organic micro/nanocrystals with polymorphic tailorability and perfect platform to modulate decode the complex relationship among molecular structures,supramolecular/noncovalent interactions,aggregates and exciton behaviors.Herein,we precisely tune the polymorphic two-dimensional organic nanosheets(2DONs)of cyano-spirocyclic aromatic hydrocarbon(2'-CN-SFX),where the crystal growth processes are dominated by precursor concentration.The low concentration(ca.2 mmol/L)affords the rhombus-like nanosheets with monoclinic P21/c space group,in which molecules adopt antiparallel and slipped stacking mode.In contrast,the high concentration(ca.4 mmol/L)favors herringbone-like molecular packing pattern and then generates shuttle-like nanosheets with monoclinic C2/c space group.Both above polymorphic nanosheets exhibit unprecedented crystallization-induced emission en-hancement(CIEE)feature that increases the photoluminescence quantum yields(PLQYs)from 16%in solution,21%in amorphous film to 37%-39%in crystalline states.This result will offer promising opportunities for nanophotonics and organic intelligent semi-conductors. | He Zhang Dong Jin Dongqing Lin Lei Huang Jin Wang Shasha Wang Linghai Xie | 2022 | Chinese Journal of Chemistry2022，40，7： | 0 |
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