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| 1 | Special Section:SARS-CoV-2 Preliminary evidence from a multicenter prospective observational study of the safety and efficacy of chloroquine for the treatment of COVID-19显示文摘Effective therapies are urgently needed for the SARS-CoV-2 pandemic.Chloroquine has been proved to have antiviral effect against coronavirus in vitro.In this study,we aimed to assess the efficacy and safety of chloroquine with different doses in COVID-19.In this multicenter prospective observational study,we enrolled patients older than 18 years old with confirmed SARS-CoV-2 infection excluding critical cases from 12 hospitals in Guangdong and Hubei Provinces.Eligible patients received chloroquinephosphate s00 mg,orally,once(half dose)or twice(full dose)daily.Patients treated with non-chloroquine therapy were included as historical controls.The primary endpoint is the time to undetectable viral RNA.Secondary outcomes include the proportion of patients with undetectable viral RNA by day 10 and 14,hospitalization time,duration of fever,and adverse events.A total of 197 patients completed chloroquine treatment,and 176patients were included as historical controls.The median time to achieve an undetectable viral RNA was shorter in chloroquine than in non-chloroquine(absolute difference in medians-6.0 days;95%CI-6.0 to—4.0).The duration of fever is shorter in chloroquine(geometric mean ratio 0.6;95%CIO.5 to 0.8).No serious adverse events were observed in the chloroquine group.Patients treated with half dose experienced lower rate of adverse events than with full dose.Although randomized trials are needed for further evaluation,this study provides evidence for safety and efficacy of chloroquine in COVID-19 and suggests that chloroquine can be a cost-effective therapy for combating the COVID-19 pandemic. | Mingxing Huang Man Li Fei Xiao Pengfei Pang Jiabi Liang Tiantian Tang Shaoxuan Liu Binghui Chen Jingxian Shu Yingying You Yang Li Meiwen Tang Jianhui Zhou Guanmin Jiang Jingfen Xiang Wenxin Hong Songmei He Zhaoqin Wang Jianhua Feng Changqing Lin Yinong Ye Zhilong Wu Yaocai Li Bei Zhong Ruilin Sun Zhongsi Hong Jing Liu Huili Chen Xiaohua Wang Zhonghe Li Duanqing Pei Lin Tian Jinyu Xia Shanping Jiang Nanshan Zhong Hong Shan | 2020 | National Science Review2020，7，9： | 20 |
| 2 | Spatial distribution and pollution assessment of mercury in sediments of Lake Taihu,China显示文摘Spatial distribution patterns of total mercury (THg) in 36 surficial sediment samples representing five regions of Lake Taihu were assessed using the ArcGis geostatistical analyst module. The pollution levels of THg were also evaluated from the same five lake regions. Concentrations of THg were in a ranged of 23-168 ng/g (mean 55 ng/g) in surfical sediments, which was significantly higher than those established baseline levels of the lake. Results of THg indicated that the northern region exhibited notably higher values, the bay regions showed elevated values relative to open areas, and the lakeside regions were higher than those observed in the central area. Lake Taihu suffered moderate to high Hg pollution, and expressed clear Hg enrichment status according to monomial pollution index I geo and human activity factors. The concentrations of THg in the surficial sediments of Lake Taihu showed moderate-strong variation (coefficient of variation 52%). Geostatistical analysis indicated a weak spatial self-correlation, suggesting the contamination of Hg in Lake Taihu is primarily the result of anthropogenic activities. | Chunxiao Chen Binghui Zheng Xia Jiang Zheng Zhao Yuzhu Zhan Fengjiao Yi Jiaying Ren | 2013 | Journal of Environmental Sciences2013，25，2： | 16 |
| 3 | Eutrophication and algal blooms in channel type reservoirs:A novel enclosure experiment by changing light intensity显示文摘To explore eutrophication and algal bloom mechanisms in channel type reservoirs,a novel enclosure experiment was conducted by changing light intensity (LI) in the Daning River of the Three Gorges Reservoir (TGR).Square enclosures (side 5.0 m) were covered on the surface with shading materials of different thickness,and with their bases open to the river.Changes and characteristics of the main eutrophication factors under the same water quality and hydrodynamic conditions but different LI were evaluated.All experimental water samples were neutral and alkalescent,with high nitrogen and phosphate concentrations,low potassium permanganate index,stable water quality,and different LI.At the same water depth,LI decreased with increasing shade material,while dissolved oxygen and water temperature were both stable.The growth peak of phytoplankton was with light of 345-4390 lux underwater or 558-7450 lux above the water surface,and water temperature of 25.6-26.5 C.Algae were observed in all water samples,accounting for 6 phylum and 57 species,with algal density changing frequently.The results showed that significantly strong or weak light was unfavorable for phytoplankton growth and the function together with suitable temperature and LI and ample sunshine encouraged algal blooms under the same water quality and hydrodynamic conditions.Correlation analysis indicated that algae reduced gradually lengthwise along water depth in the same enclosure while pH became high.The power exponent relationship between chlorophyll a (Chl-a) and LI was found by curve fitting,that is Chl-a=K(LI) n. | Chengjin Cao Binghui Zheng Zhenlou Chen Minsheng Huang Jialei Zhang | 2011 | Journal of Environmental Sciences2011，23，10： | 13 |
| 4 | Interfacial Activation of Catalytically Inert Au(6.7 nm)-Fe_(3)O_(4)Dumbbell Nanoparticles for CO Oxidation显示文摘Au nanoparticles epitaxially grown on Fe_(3)O_(4)in Au(6.7 nm)-Fe_(3)O_(4)dumbbell nanoparticles exhibit excellent stability against sintering,but display negligible catalytic activity in CO oxidation.Starting from various supported Au(6.7 nm)-Fe_(3)O_(4)catalysts prepared by the colloidal deposition method,we have unambiguously identifi ed the significance of the Au-TiO_(2)interface in CO oxidation,without any possible size effect of Au.In situ thermal decomposition of TiO_(2)precursors on Au-Fe_(3)O_(4)was found to be an effective way to increase the Au-TiO_(2)interface and thereby optimize the catalytic performance of TiO_(2)-supported Au-Fe_(3)O_(4)dumbbell nanoparticles.By reducing the size of Fe_(3)O_(4)from 15.2 to 4.9 nm,the Au-TiO_(2)contact was further increased so that the resulting TiO_(2)-supported Au(6.7 nm)-Fe_(3)O_(4)(4.9 nm)dumbbell particles become highly efficient catalysts for CO oxidation at room temperature. | Binghui Wu Hai Zhang Cheng Chen Shuichao Lin Nanfeng Zheng | 2009 | Nano Research2009，2，12： | 7 |
| 5 | Manipulation of Band Degeneracy and Lattice Strain for Extraordinary PbTe Thermoelectrics显示文摘Maximizing band degeneracy and minimizing phonon relaxation time are proven to be successful for advancing thermoelectrics.Alloying with monotellurides has been known to be an effective approach for converging the valence bands of PbTe for electronic improvements,while the lattice thermal conductivity of the materials remains available room for being further reduced.It is recently revealed that the broadening of phonon dispersion measures the strength of phonon scattering,and lattice dislocations are particularly effective sources for such broadening through lattice strain fluctuations.In this work,a fine control of MnTe and EuTe alloying enables a significant increase in density of electron states near the valence band edge of PbTe due to involvement of multiple transporting bands,while the creation of dense in-grain dislocations leads to an effective broadening in phonon dispersion for reduced phonon lifetime due to the large strain fluctuations of dislocations as confirmed by synchrotron X-ray diffraction.The synergy of both electronic and thermal improvements successfully leads the average thermoelectric figure of merit to be higher than that ever reported for p-type PbTe at working temperatures. | Yixuan Wu Pengfei Nan Zhiwei Chen Zezhu Zeng Siqi Lin Xinyue Zhang Hongliang Dong Zhiqiang Chen Hongkai Gu Wen Li Yue Chen Binghui Ge Yanzhong Pei | 2020 | Research2020，，1： | 6 |
| 6 | Pore water pressure increment model for saturated Nanjing fine sand subject to cyclic loading显示文摘Three groups of dynamic triaxial tests were performed for saturated Nanjing fine sand subjected to uniform cyclic loading. The tested curves of the excess pore water pressure (EPWP) ratio variation with the ratio of the number of cycles are provided. The concept of the EPWP increment ratio is introduced and two new concepts of the effective dynamic shear stress ratio and the log decrement of effective stress are defined. It is found that the development of the EPWP increment ratio can be divided into three stages: descending, stable and ascending. Furthermore, at the stable and ascending stages, a satisfactory linear relationship is obtained between the accumulative EPWP increment ratio and natural logarithm of the effective dynamic shear stress ratio. Accordingly, the EPWP increment ratio at the number of cycles N has been deduced that is proportional to the log decrement of effective stress at the cycle number N-1, but is independent of the cyclic stress amplitude. Based on the analysis, a new EPWP increment model for saturated Nanjing fine sand is developed from tested data fitting, which provides a better prediction of the curves of EPWP generation, the number of cycles required for initial liquefaction and the liquefaction resistance. | Wang Binghui Chen Guoxing Jin Dandan | 2010 | Earthquake Engineering and Engineering Vibration2010，9，4： | 6 |
| 7 | In situ trapped high-density single metal atoms within graphene: Iron-containing hybrids as representatives for efficient oxygen reduction显示文摘因为他们为特殊催化作用的效率和 chemoselectivity 比传统的催化剂的那些优异,原子地驱散的催化剂在精力变换应用吸引了注意。然而,他们在支持上由于极其低的装载金属的内容有限制,在在高温度的金属地点和数量以及低稳定性的精确控制的困难。我们经由葡萄糖, dicyandiamide,和无机的金属盐的单个步的热热分解准备了一个高度做的单个金属原子混血儿。高角度的环形的黑暗扫描地的传播电子显微镜学(HAADF 茎) 和 X 光检查吸收罚款结构光谱学(XAFS ) 表明做进 graphene 矩阵的氮原子为由产生 metal-Nx 协作结构的金属原子稳定是枢轴的。由于 graphene 矩阵的强壮的抛锚效果,装载内容的金属是在孤立的原子混血儿的超过 4 wt.%( 磅内容象在做磅的混血儿的 9.26 wt.% 一样高) 。而且,单个做铁的混血儿(做 Fe@N 的 graphene ) 为氧减小反应显示出显著 electrocatalytic 表演。山峰力量密度是 199 | Daobin Liu Chuanqiang Wu Shuangming Chen Shiqing Ding Yaofeng Xie Changda Wang Tao Wang Yasir A. Haleem Zia ur Rehman Yuan Sang Qin Liu Xusheng Zheng Yu Wang Binghui Ge Hangxun Xu Li Song | 2018 | Nano Research2018，11，4： | 6 |
| 8 | An Adaptive Rapidly-Exploring Random Tree显示文摘Sampling-based planning algorithms play an important role in high degree-of-freedom motion planning(MP)problems,in which rapidly-exploring random tree(RRT)and the faster bidirectional RRT(named RRT-Connect)algorithms have achieved good results in many planning tasks.However,sampling-based methods have the inherent defect of having difficultly in solving planning problems with narrow passages.Therefore,several algorithms have been proposed to overcome these drawbacks.As one of the improved algorithms,Rapidlyexploring random vines(RRV)can achieve better results,but it may perform worse in cluttered environments and has a certain environmental selectivity.In this paper,we present a new improved planning method based on RRT-Connect and RRV,named adaptive RRT-Connect(ARRT-Connect),which deals well with the narrow passage environments while retaining the ability of RRT algorithms to plan paths in other environments.The proposed planner is shown to be adaptable to a variety of environments and can accomplish path planning in a short time. | Binghui Li Badong Chen | 2022 | IEEE/CAA Journal of Automatica Sinica2022，9，2： | 6 |
| 9 | Topic hypergraph:hierarchical visualization of thematic structures in long documents显示文摘Thematic information of a long document(i.e.,a novel) can be multi-faceted:an interleaving of multiple topics,a sequential evolution of a set of themes,or a crossing superimposition of topics and themes.Conventional topic-based visualization approaches are inefficient to capture this complicated thematic structure.This paper introduces a novel topic-based model,called the topic hypergraph,that characterizes the thematic structure of a long document with a hypergraph representation.Each hypergraph node represents a unique document piece,and encodes its theme as a composition of multiple topics.Two types of relationships among nodes are modeled:an edge that connects two consecutive themes to present their sequential transition,and a hyperedge that encodes a topic.The new representation is essentially a 2D reformulation of the linear streamgraph representation,and can be adaptive by constructing a multi-level hierarchy.We design a suite of visualization and interaction tools to allow users to interactively analyze the theme evolution,theme diversities,and topic interleaving.Our approach is also suitable for comparing multiple long documents. | WANG GuiZhen WEN ChaoKai YAN BingHui XIE Cong LIANG RongHua CHEN Wei | 2013 | Science China(Information Sciences)2013，56，5： | 4 |
| 10 | Root tensile strength of terrace hedgerow plants in the karst trough valleys of SW China:Relation with root morphology and fiber content显示文摘Root tensile strength is commonly affected by root morphology and fiber content,which combinedly affect the effectiveness of terrace hedgerow on controlling soil erosion in sloping farmland.However,the relationships between these root characteristics are still elusive.This study aimed to compare the root tensile strength,root morphologies,and root fiber contents,and quantify their differences among different plant species.Complete root systems of three terrace hedgerow plant species,i.e.,O.bodinieri,V.villosa,and D.lablab L.were sampled for detecting root morphologies and fiber contents at different slope positions on a representative hillslope in karst trough valley.Single root specimens were collected to measure root tensile properties for these three plant species.Results showed that most root morphological parameters were the highest in O.bodinieri,followed by D.lablab L.Three plant species presented the same dominant diameter class as<1.0 mm,and root volumes as<1.50 cm3.Cellulose with contents closing to 50%was the main fiber type,and increased significantly linearly with the increasing root diameter in both O.bodinieri and V.villosa.The highest tensile strength and Young's modulus were found in D.lablab L.,while the best ultimate tensile force and ultimate elongation were displayed in O.bodinieri.Root diameter showed negative power relationships with tensile strength and Young's modulus,a positive power relationship with ultimate tensile force,and a positive linear relationship with ultimate elongation.Our results will deepen the understanding of the terrace hedgerow functions for controlling soil erosion worldwide. | Yun Chen Han Tang Binghui He Zhehao Yan Xiaohong Liu Jiaojiao Qiang | 2022 | International Soil and Water Conservation Research2022，10，4： | 3 |
| 11 | Laboratory creep tests for time-dependent properties of a marble in Jinping Ⅱ hydropower station显示文摘In order to investigate the time-dependent behaviors of deep hard rocks in the diversion tunnel of Jinping II hydropower station,uniaxial creep tests were carried out by using the triaxial testing machine RC-2000.The axial compressive load was applied step by step and each creep stage was kept for over several days.Test results show that:(1) The lateral deformation of rock specimens is 2-3 times the axial compressive deformation and accelerates drastically before damage,which may be employed as an indicator to predict the excavation-induced instability of rocks.(2) The resultant deformation changes from compression to expansion when the Poisson's ratio is larger than 0.5,indicating the starting point of damage.(3) In the step-loading stages,the Poisson's ratio approximately remains constant;under constantly imposed load,the Poisson's ratio changes with elapsed time,growing continuously before the specimen is damaged.(4) When the applied load reaches a certain threshold value,the rock deteriorates with time,and the strength of rocks approximately has a negative exponent relation with time.(5) The failure modes of the deep marble are different in long-and short-term loading conditions.Under the condition of short-term loading,the specimen presents a mode of tensile failure;while under the condition of long-term loading,the specimen presents a mode of shear failure,followed by tensile failure. | Xiaojun Zhao Bingrui Chen Hongbo Zhao Binghui Jie Zhengfang Ning | 2012 | Journal of Rock Mechanics and Geotechnical Engineering2012，4，2： | 3 |
| 12 | Behavior of large post-liquefaction deformation in saturated Nanjing fine sand显示文摘Laboratory tests on the large post-liquefaction deformation of saturated Nanjing fine sand were performed by using a hollow cylinder apparatus. The stress-strain responses and the characteristics of excess pore water pressure after liquefaction were studied. It was found that the relationship between deviatoric stress and axial strain presented a sigmoid curve, and there was a good linearity relationship between normalized pore water pressure and deviatoric stress. On this basis, a constitutive model of stress-strain responses and a dissipation model of excess pore water pressure were established. It was found that the results predicted by the two models were in good agreement with the experimental data. The influence of relative densities and confi ning pressure on the characteristics of liquef ied soil were studied. The results showed the relative densities and initial effective confining pressure all had an important influence on the stress-strain responses of liquefi ed saturated Nanjing fine sand. However, the dissipation model of excess pore water pressure after liquefaction was only affected by the confining pressure. | Pan Hua Chen Guoxing Liu Hanlong Wang Binghui | 2011 | Earthquake Engineering and Engineering Vibration2011，10，2： | 3 |
| 13 | The microbial metallogeny of weathering crust REE deposits in South China显示文摘VERY little is known about the roles of microorganisms in the metallogeny of weathering crust REE deposits, although there has been much literature on REE behavior in weathering conditions. The present note deals with the microorganisms in 4 weathering profiles of an REE deposit and their roles in migration and accumulation of REE in weathering conditions. 1 Cultivation and identification of microorganisms Under strict sterilization, samples were collected from various parts of 4 weathering profiles of granites in a weathering crust REE deposit in South China. The samples were then cultivated for microorganisms with ordinary agars as culture media and then the cultivated microorganisms were dyed and identifiedunder a microscope. The sampled positions and cultivated numbers of microbial colonies are shown | CHEN Binghui~(1,2), WANG Zhimei~3, HUANG Limei~3, WU Fuhai~3, CHEN Jingde~2 and XU Wenlie~2 1. Department of Earth Sciences, Nanjing University, Nanjing 210093, China 2. Department of Earth Sciences, Zhongshan University, Guangzhou 510275, China 3. Guangdong Pharmaceutical College, Guangzhou 510244, China | 1999 | Chinese Science Bulletin1999，44，S2： | 3 |
| 14 | Study of severe and rare complications of transarterial chemoembolization (TACE) for liver cancer显示文摘 | Jinglin Xia Zhenggang Ren Shenglong Ye Dilip Sharma Zhiying Lin Yuhong Gan Yi Chen Ninglin Ge Zengchen Ma Zhiquan Wu Jia Fan Lunxiu Qin Xinda Zhou Zhaoyou Tang Binghui Yang | 2006 | European Journal of Radiology2006，，3： | 2 |
| 15 | High-metallic-phase-concentration MO1-xWxS2 nanosheets with expanded interlayers as efficient electrocatalysts显示文摘 | Qun He Yangyang Wan Hongliang Jiang Chuanqiang Wu Zhongti Sun Shuangming Chen Yu Zhou Haiping Chen Daobin Liu Yasir A. Haleem Binghui Ge Xiaojun Wu Li Song | 2018 | Nano Research2018，11，3： | 1 |
| 16 | Active {010} facet-exposed Cu2MoS4 nanotube as high-efficiency photocatalyst显示文摘 | Ke Zhang Yunxiang Lin Zahir Muhammad Chuanqiang Wu Shuang Yang Qun He Xusheng Zheng Shuangming Chen Binghui Ge Li Song | 2017 | Nano Research2017，10，11： | 1 |
| 17 | SUMO-1 modification of FEN1 facilitates its interaction with Rad9-Radl-Husl to counteract DNA replication stress显示文摘 | Xiaoli Xu Rongyi Shi Li Zheng Zhigang Guo Liangyan Wang Mian Zhou Ye Zhao Bing Tian Khue Truong Yuan Chen Binghui Shen Yuejin Hua Hong Xu | 2018 | Journal of Molecular Cell Biology2018，10，5： | 1 |
| 18 | Multi-walled carbon nanotubes as novel promoter of catalysts for certain hydrogenation and dehydrogenation reactions显示文摘From the chemical catalysis viewpoint,the excellent performance of CNTs in adsorption-activation of H2 and in promoting spillover of adsorbed H-species is very attractive,in addition to their nanosize channels,sp2-C constructed surfaces,and high thermal/electrical conductivity.This review examines some recent progresses of CNTs as a novel support or promoter of catalysts for certain hydrogenation or dehydrogenation reactions,e.g.,hydrogenation-conversion of syngas to yield alcohols and decomposition or steam-reforming of methanol to generate H2,mainly based on recent work carried out in our laboratory. | Guodong Lin Xuelian Liang Zhiming Liu Jianrong Xie Binghui Chen Hongbin Zhang | 2015 | Science China Chemistry2015，58，1： | 1 |
| 19 | Optical design of a freeform TIR lens for LED streetlight显示文摘 | CHEN Wenchin LIU Kaiping LIU Binghui | 2013 | Neural Computing and Applications2013，22，3： | 1 |
| 20 | Glucose-6-phosphate dehydrogenase neutralizes stresses by supporting reductive glutamine metabolism and AMPK activation显示文摘Dear Editor,Glucose-6-phosphate dehydrogenase(G6PD)is the rate-limiting enzyme in the oxidative pentose phosphate pathway(oxPPP)that can generate cytosolic NADPH(Fig.1a)for biosynthesis and oxidative defence.Here,we reveal a previously unidentified function of G6PD.It,even the natural G6PD deficiency-associated mutant without the activity to maintain the normal oxPPP,can antagonize the stresses by supporting the reductive glutamine metabolism and AMPK activation,independently of the NADPH generation by the oxPPP. | Benfu Zhong Dewei Jiang Yang Hong Lifang Li Li Qiu Ronghui Yang Xiaohan Jin Yawen Song Ceshi Chen Binghui Li | 2021 | Signal Transduction and Targeted Therapy2021，6，3： | 1 |
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