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| 1 | The role of γ-aminobutyric acid in aluminum stress tolerance in a woody plant, Liriodendron chinense×tulipifera显示文摘The aluminum(Al)cation Al^(3+)in acidic soil shows severe rhizotoxicity that inhibits plant growth and development.Most woody plants adapted to acidic soils have evolved specific strategies against Al^(3+)toxicity,but the underlying mechanism remains elusive.The four-carbon amino acid gamma-aminobutyric acid(GABA)has been well studied in mammals as an inhibitory neurotransmitter;GABA also controls many physiological responses during environmental or biotic stress.The woody plant hybrid Liriodendron(L.chinense×tulipifera)is widely cultivated in China as a horticultural tree and provides high-quality timber;studying its adaptation to high Al stress is important for harnessing its ecological and economic potential.Here,we performed quantitative iTRAQ(isobaric tags for relative and absolute quantification)to study how protein expression is altered in hybrid Liriodendron leaves subjected to Al stress.Hybrid Liriodendron shows differential accumulation of several proteins related to cell wall biosynthesis,sugar and proline metabolism,antioxidant activity,cell autophagy,protein ubiquitination degradation,and anion transport in response to Al damage.We observed that Al stress upregulated glutamate decarboxylase(GAD)and its activity,leading to increased GABA biosynthesis.Additional GABA synergistically increased Al-induced antioxidant enzyme activity to efficiently scavenge ROS,enhanced proline biosynthesis,and upregulated the expression of MATE1/2,which subsequently promoted the efflux of citrate for chelation of Al^(3+).We also showed similar effects of GABA on enhanced Al^(3+)tolerance in Arabidopsis.Thus,our findings suggest a function of GABA signaling in enhancing hybrid Liriodendron tolerance to Al stress through promoting organic acid transport and sustaining the cellular redox and osmotic balance. | Pengkai Wang Yini Dong Liming Zhu Zhaodong Hao LingFeng Hu Xiangyang Hu Guibin Wang Tielong Cheng Jisen Shi Jinhui Chen | 2021 | Horticulture Research2021，8，1： | 3 |
| 2 | Cancer-cell-intrinsic mechanisms shaping the immunosuppressive landscape of prostate cancer显示文摘Although immunotherapy has revolutionized cancer treatment and achieved remarkable success across many different cancer types,only a subset of patients shows meaningful clinical responses.In particular,advanced prostate cancer exhibits overwhelming de novo resistance to immune checkpoint blockade therapy.This is primarily due to the immunosuppressive tumor microenvironment of prostate cancer.Therefore,it is paramount to understand how prostate cancer cell-intrinsic mechanisms promote immune evasion and foster an immunosuppressive microenvironment.Here,we review recent findings that reveal the roles of the genetic alterations,androgen receptor signaling,cancer cell plasticity,and oncogenic pathways in shaping the immunosuppressive microenvironment and thereby driving immunotherapy resistance.Based on preclinical and clinical observations,a variety of therapeutic strategies are being developed that may illuminate new paths to enhance immunotherapy efficacy in prostate cancer. | Yini Zhu Loan Duong Xuemin Lu Xin Lu | 2023 | Asian Journal of Andrology2023，25，2： | 1 |
| 3 | Activating glucocorticoid receptor-ERK signaling pathway contributes to ginsenoside Rg1 protection against β-amyloid peptide-induced human endothelial cells apoptosis显示文摘 | Jieping Yan Qibing Liu Yuan Dou Yini Hsieh Yan Liu Rongrong Tao Danyan Zhu Yijia Lou | 2013 | Journal of Ethnopharmacology2013，，2： | 1 |
| 4 | Effect of dissolved organic matter from Guangzhou landfill leachate on sorption of phenanthrene by Montmorillonite显示文摘 | Pingxiao Wu Yini Tang Wanmu Wang Nengwu Zhu Ping Li Jinhua Wu Zhi Dang Xiangde Wang | 2011 | Journal of Colloid And Interface Science2011，，2： | 1 |
| 5 | Impact of dissolved oxygen on the production of nitrous oxide in biological aerated filters显示文摘 | Qiang He Yinying Zhu Guo Li Leilei Fan Hainan Ai Xiaoliu Huangfu Hong Li | 2017 | Frontiers of Environmental Science & Engineering2017，11，6： | 0 |
| 6 | A novel strategy for identifying biomarker in serum of patient with COVID-19 using immune complex显示文摘Dear Editor,COVID-19(Coronavirus Disease 2019)is a disease caused by the single-stranded sense RNA virus SARS-CoV-2(severe acute respiratory syndrome coronavirus 2),which has caused a global public health crisis.1 However,so far no effective serum marker has been found as a biomarker for COVID-19 diagnosis,except that viral nucleic acid detection is an effective evidence of SARS-CoV-2 infection. | Fugang Duan Yifan Wang Taoyu Chen Zhu Zhu Meng Yu Hui Dai Shangen Zheng Yinying Lu Tingting Li Xiaoyan Qiu | 2022 | Signal Transduction and Targeted Therapy2022，7，3： | 0 |
| 7 | Solar radiation effects on leaf nitrogen and phosphorus stoichiometry of Chinese fir across subtropical China显示文摘Background:Solar radiation(SR)plays critical roles in plant physiological processes and ecosystems functions.However,the exploration of SR influences on the biogeochemical cycles of forest ecosystems is still in a slow progress,and has important implications for the understanding of plant adaption strategy under future environmental changes.Herein,this research was aimed to explore the influences of SR on plant nutrient characteristics,and provided theoretical basis for introducing SR into the establishment of biochemical models of forest ecosystems in the future researches.Methods:We measured leaf nitrogen(N)and phosphorus(P)stoichiometry in 19 Chinese fir plantations across subtropical China by a field investigation.The direct and indirect effects of SR,including global radiation(Global R),direct radiation(Direct R)and diffuse radiation(Diffuse R)on the leaf N and P stoichiometry were investigated.Results:The linear regression analysis showed that leaf N concentration had no association with SR,while leaf P concentration and N:P ratio were negatively and positively related to SR,respectively.Partial least squares path model(PLS-PM)demonstrated that SR(e.g.Direct R and Diffuse R),as a latent variable,exhibited direct correlations with leaf N and P stoichiometry as well as the indirect correlation mediated by soil P content.The direct associations(path coefficient=−0.518)were markedly greater than indirect associations(path coefficient=−0.087).The covariance-based structural equation modeling(CB-SEM)indicated that SR had direct effects on leaf P concentration(path coefficient=−0.481),and weak effects on leaf N concentration.The high SR level elevated two temperature indexes(mean annual temperature,MAT;≥10°C annual accumulated temperature,≥10℃ AAT)and one hydrological index(mean annual evapotranspiration,MAE),but lowered the soil P content.MAT,MAE and soil P content could affect the leaf P concentration,which cause the indirect effect of SR on leaf P concentration(path coefficient=0.004).Soil N content had positive effect on the leaf N concentration,which was positively and negatively regulated by MAP and≥10℃ AAT,respectively.Conclusions:These results confirmed that SR had negatively direct and indirect impacts on plant nutrient status of Chinese fir based on a regional investigation,and the direct associations were greater than the indirect associations.Such findings shed light on the guideline of taking SR into account for the establishment of global biogeochemical models of forest ecosystems in the future studies. | Ran Tong Yini Cao Zhihong Zhu Chenyang Lou Benzhi Zhou Tonggui Wu | 2021 | Forest Ecosystems2021，8，4： | 0 |
| 8 | Molecular deconvolution of the neutralizing antibodies in duced by an in activated SARS-CoV-2 virus vaccine显示文摘Dear Editor,The rapid emerge nee and persistence of the pan demic caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)has had enormous impacts on global health and the economy.Effective vaccines against SARS-CoV-2 are urgently needed to control the coronavirus disease 2019(COVID-19)pandemic,and multiple vaccines have been found to be efficacious in preventing symptomatic COVID-19(Polack et al.,2020;Wu et al.,2020;Jones and Roy,2021). | Xingdong Zhou Hui Wang Qun Ji Mingjuan Du Yuexia Liang Huanhuan Li Fan Li Hang Shang Xiujuan Zhu Wei Wang Lichun Jiang Alexey V.Stepanov Tianyu Ma Nanxin Gong Xiaodong Jia Alexander G.Gabibov Zhiyong Lou Yinying Lu Yu Guo Hongkai Zhang Xiaoming Yang | 2021 | Protein & Cell2021，12，10： | 0 |
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