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| 1 | Responses of the Toll-like receptor and melanoma differentiation-associated protein 5 signaling pathways to avian infectious bronchitis virus infection in chicks显示文摘Avian infectious bronchitis virus(IBV) is a Gammacoronavirus in the family Coronaviridae and causes highly contagious respiratory disease in chickens. Innate immunity plays significant roles in host defense against IBV. Here, we explored the interaction between IBV and the host innate immune system. Severe histopathological lesions were observed in the tracheal mucosa at 3–5days post inoculation(dpi) and in the kidney at 8 dpi, with heavy viral loads at 1–11 and 1–28 dpi,respectively. The expression of m RNAs encoding Toll-like receptor(TLR) 3 and TLR7 were upregulated at 3–8 dpi, and that of TIR-domain-containing adapter-inducing interferon(IFN) β(TRIF) was upregulated at 21 dpi in the trachea and kidney. Myeloid differentiation primary response protein 88(My D88) was upregulated in the trachea during early infection. Tumor necrosis factor receptor-associated factor(TRAF) 3 and TRAF6 were upregulated expression in both tissues.Moreover, melanoma differentiation-associated protein 5(MDA5), laboratory of genetics and physiology 2(LGP2), stimulator of IFN genes(STING), and mitochondrial antiviral signaling protein(MAVS), as well as TANK binding kinase 1(TBK1), inhibitor of kappa B kinase(IKK) ?, IKKα, IKKβ,IFN regulatory factor(IRF) 7, nuclear factor of kappa B(NF-κB), IFN-α, IFN-β, various interleukins(ILs), and macrophage inflammatory protein-1β(MIP-1β) were significantly upregulated in the trachea and downregulated in the kidney. These results suggested that the TLR and MDA5 signaling pathways and innate immune cytokine were induced after IBV infection. Additionally,consistent responses to IBV infection were observed during early infection, with differential and complicated responses in the kidney. | Yining He Zhiwen Xie Jinglong Dai Yanjie Cao Jinlian Hou Yansheng Zheng Tianchao Wei Meilan Mo Ping Wei | 2016 | Virologica Sinica2016，31，1： | 14 |
| 2 | Relationship of energy charge and toxin content of Microcystis aeruginosa in nitrogen-limited or phosphorous-limited cultures显示文摘 | Ruihua Dai Huijuan Liu Jiuhui Qu Xu Zhao Jia Ru Yining Hou | 2007 | Toxicon2007，，4： | 1 |
| 3 | Late Jurassic to early Cretaceous magnetostratigraphy of scientific drilling core LK-1 in the Lingshan Island of Riqingwei Basin,eastern China显示文摘The Sulu orogenic belt is an uplift zone that was formed in the Late Triassic.Several Jurassic to Cretaceous sedimentary successions have been recognized within the Sulu orogenic belt in recent studies,including outcrops that are considered to be related to the newly discovered Riqingwei Basin.This basin has been the focus of extensive study due to its continuous Cretaceous rock sequence,geological location and petroleum resource potential.However,the lack of a consolidated chronology for the strata has precluded a better understanding of stratigraphy,tectonic evolution and resource potential of the Riqingwei Basin.Here,we present the results of a new magnetostratigraphic study of the continental scientific drilling borehole LK-1,which is located on Lingshan Island,offshore Shandong province,eastern China.The goals of this study are to(1)refine the Late Jurassic to Early Cretaceous chronostratigraphic framework of the Riqingwei Basin,and(2)investigate the location of the J/K boundary in the Borehole Core LK-1.The observed patterns of the paleomagnetic polarity zone in the LK-1 borehole correlate well with the geomagnetic polarity time scale(GPTS),and the continuous magnetostratigraphy profile defined in this core indicates an age ranging from 146.5 to 125.8 Ma for the samples interval.The sediment accumulation rates(SAR)of LK-1 show one period of high SAR(~10.5 cm kyr^(-1))at 135.3–130.6 Ma and two periods of low SAR(~4.8 and~2.2 cm kyr^(-1))at145.7–135.3 and 130.6–125.8 Ma,respectively.In addition,the magnetostratigraphic results suggest that the Jurassic-Cretaceous(J/K)boundary of the LK-1 is located within the magnetozone N21.2 n(~1254 m).This comprehensive geochronologic framework provides a good correlation of the marine Upper Jurassic to Lower Cretaceous strata in the Riqingwei Basin to other marine strata and continental sequences,in addition to providing a foundation for the study of the structural evolution of eastern China. | Yanjun CHENG Zhiping WU Xiaoyu LIU Yaoqi ZHOU Yining DAI Tongjie ZHANG Tengfei ZHOU | 2022 | Science China Earth Sciences2022，65，4： | 1 |
| 4 | Effects of amino acids on microcystin production of the Microcystis aeruginosa显示文摘 | Ruihua Dai Huijuan Liu Jiuhui Qu Xu Zhao Yining Hou | 2008 | Journal of Hazardous Materials2008，，2： | 1 |
| 5 | Atherosclerosis,its risk factors,and cognitive impairment in older adults显示文摘Objective To examine the association of atherosclerotic cardiovascular disease(ASCVD)and its risk factors with cognitive impairment in older adults.Methods Six hundred and fourteen subjects,aged≥65 years,from one center(2016–2018)underwent clinical,laboratory assessments and the Montreal Cognitive Assessment(Mo CA).Using regression analysis,the relationship between ASCVD and its risk factors was evaluated in subjects with and without cognitive impairment(MoCA score<26).Results Older age(b=-1.3 per 5 years,95%CI:-1.7 to-0.9,P<0.001),history of stroke(b=-1.6,95%CI:-3.0 to-0.3,P=0.01),and myocardial infarction(MI;b=-2.2,95%CI:-3.6 to-0.8,P=0.003)were independently associated with lower MoCA scores,whereas more education(b=1.5 per 3 years,95%CI:1.1 to 1.9,P<0.001),higher body mass index(BMI;b=0.5 per 3 kg/m^2,95%CI:0.0 to 1.0,P=0.04),higher estimated glomerular filtration rate(eGFR;b=0.8 per 15 U,95%CI:0.1 to 1.4,P=0.03),left ventricular ejection fraction(LVEF;b=0.4 per 5%,95%CI:0 to 0.8,P=0.04)and statin use(b=1.3,95%CI:0.3 to 2.3,P=0.01)were associated with a higher MoCA score.Cognitive impairment was independently associated with older age(OR=1.51 per 5 yrs,95%CI:1.28 to 1.79,P<0.001),less education(OR=0.55 per 3 years,95%CI:0.45 to 0.68,P<0.001),lower BMI(OR=0.78 per 3 kg/m^2,95%CI:0.62 to 0.98,P=0.03)and higher levels of high sensitivity c-reactive protein(hsCRP;OR=1.08 per 1 mg/L,95%CI:1.02 to 1.15,P=0.01).Conclusions Beyond age,cognitive impairment was associated with prior MI/stroke,higher hsCRP,statin use,less education,lower eGFR,BMI and LVEF. | Yun-Li XING Michael A Chen Ying SUN Moni B Neradilek Xi-Ting WU Dai ZHANG Wei HUANG Yining CUI Qi-Qi YANG Hong-Wei LI Xue-Qiao ZHAO | 2020 | Journal of Geriatric Cardiology2020，17，7： | 1 |
| 6 | Maillard reaction-derived laser lithography for printing functional inorganics显示文摘Photopolymerization-based additive printing of functional inorganics has drawn great attention in recent years and one important challenge is the photoresin loading with diverse inorganics. Here, we introduce a Maillard reaction-derived laser lithography strategy for an unprecedented direct printing of diverse inorganic compounds. The sugar-assisted laser lithography(SLL) is powerful to carry choice metal ions and versatile for the generation of patterned inorganic materials comprising metal oxides,metal sulfides, and metal nitrides, characterized by ferroelectric, magnetic, semiconductivity, superconductivity, or other properties. The material architecture is flexibly manipulated by the laser intensity, power, printing speed, precursor solution, and computer-aided design to satisfy the practical requirements. This work demonstrates a new possibility for the further development of laser lithography in the directly printing of feature-rich inorganic materials and devices. | Xiao Dai Yining Jiang Xiaohan Wang Fengnan Chen Liang Gao Xiaofeng Li Guifu Zou | 2022 | Science China Chemistry2022，65，7： | 0 |
| 7 | Facile and controllable synthesis of amino-modified carbon dots for efficient oil displacement显示文摘Zero-dimensional(0D)carbon dots exhibit excellent potential as a new oil-displacing agent for unconventional reservoir development.However,the difficulty in size/surface properties control and unclear mechanism hinder their further applications.In this study,amino-modified carbon dots(am-CDs)for oil displacement were facilely synthesized through the rapid polymerization of D-glucose(D-Glc)and 3-aminopropyltriethoxysilane(APTES).The size of am-CDs could be precisely controlled by the reaction condition and quenching achieved by adjusting the pH value to neutral.The surface amine groups endow am-CDs with excellent hydrophilicity and dispersion stability.The 0.30 wt.%nanofluid based on am-CDs with an average size of 2.6±0.040 nm showed remarkable oil recovery efficiency(54.09%)without the addition of surfactant.The oil recovery efficiency of am-CDs is much higher than those of water flooding(30.25%),nano-SiO_(2) flooding(36.45%),and amino-free carbon dots(af-CDs)flooding(37.80%).Experimental and theoretical results reveal that am-CDs can be favorably adsorbed on the core surface to modulate the micro-scale wettability,changing the surface from oil-wet to relatively uniform water-wet.Meanwhile,am-CDs can effectively reduce the adhesion force between alkanes and sandstone surfaces,contributing to oil droplets peeling off and oil displacement.This study provides a new strategy for developing efficient carbon dots-based nanofluids for enhanced oil recovery. | Yining Wu Lisha Tang Mengjiao Cao Li Li Kai Liu Demin Kong Qingshan Zhao Xu Jin He Liu Caili Dai | 2023 | Nano Research2023，16，5： | 0 |
| 8 | Modified enzymatic collagen digestion-mediated isolation of osteocytes显示文摘This study established a method for isolating large numbers of high-purity osteocytes from high-density bone.Bone fragments derived from mice tibia and femurs were alternately digested with type I collagenase and EDTA nine times,and the digested cells and bone chips(BC)were cultured,digested,and passaged when cells were fully grown.The types of cells obtained were identified by morphology,viable cell counts,alkaline phosphatase staining,and biochemical activity analyses,and specific osteocyte and osteoblast markers were evaluated by quantitative real-time polymerase chain reaction.Our results showed that among the cells obtained from the third digestion(fractions 7–9)of wild mice tibias and femurs and the remaining BCs,85%–90%of the cells were osteocytes.Moreover,their morphology was approximately one-tenth to one-fifth the size of osteoblasts,star-shaped or polygonal,with a dendritic structure,negative for alkaline phosphatase staining,and showed a high expression of dmp1 and sclerostin.Ninety percent of the cells in fractions 1–3 were osteoblasts,and were fusiform or polygonal shape.The activity of osteoblast-specific alkaline phosphatase and mRNA expression were high in this fraction,while the expression of osteocyte-specific dmp1 and sclerostin was not detected.In the second portion(fractions 4–6),a large number were osteoblasts,mixed with a small number of osteocytes,and had high alkaline phosphatase activity and osteocyte mRNA levels,a specific level of the osteocyte marker dmp1,and no sclerostin was detected.Osteocytes in daβcatot mice were also successfully isolated by this method,and we found that Wnt signaling increased the proliferation of these osteocytes.The proposed method can be used to culture osteocytes and osteoblasts of high purity and can be used for isolation and culture of these two kinds of cells from high-density bone,which provides an avenue for the study of osteocyte function in vitro. | WENJUAN XU GUANGMING DAI YIFEI LYU YINING ZHANG XIAOLIN TU | 2022 | BIOCELL2022，46，4： | 0 |
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