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| 1 | Whole-Genome Resequencing of a Worldwide Collection of Rapeseed Accessions Reveals the Genetic Basis of Ecotype Divergence显示文摘Rapeseed (Brassica napus),an important oilseed crop,has adapted to diverse climate zones and latitudes by forming three main ecotype groups,namely winter,semiwinter,and spring types. However,genetic variations underlying the divergence of these ecotypes are largely unknown. Here,we report the global pattern of genetic polymorphisms in rapeseed determined by resequencing a worldwide collection of 991 germplasm accessions.A total of 5.56 and 5.53 million singlenucleotide polymorphisms (SNPs)as Well as 1.86 and 1.92 million InDels were identified by mapping reads to the reference genomes of 'Darmor-bzh'and 'Tapidor,'respectively.We generated a map of allelic drift paths that shows splits and mixtures of the main populations,and revealed an asymmetric evolution of the two subgenomes of B.napus by calculating the genetic diversity and linkage disequilibrium parameters.Selective-sweep analysis revealed genetic changes in genes orthologous to those regulating various aspects of plant development and response to stresses.A genome-wide association study identified SNPs in the promoter regions of FLOWERING LOCUS T and FLOWERING LOCUS C orthologs that corresponded to the different rapeseed ecotype groups. Our study provides important insights into the genomic footprints of rapeseed evolution and flowering-time divergence among three ecotype groups,and will facilitate screening of molecular markers for accelerating rapeseed breeding. | Dezhi Wu Zhe Liang Tao Yan Ying Xu Lijie Xuan Juan Tang Gang Zhou Ulrike Lohwasser Shuijin Hua Haoyi Wang Xiaoyang Chen Qian Wang Le Zhu Antony Maodzeka Nazim Hussain Zhilan Li Xuming Li Imran Haider Shamsi Ghulam Jilani Linde Wu Hongkun Zheng Guoping Zhang Boulos Chalhoub Lisha Shen Hao Yu Lixi Jiang | 2019 | Molecular Plant2019，12，1： | 10 |
| 2 | Neuroprotective effects of total saponins from Rubus parvifolius L. on cerebral ischemia/reperfusion injury in rats显示文摘This study examines the neuroprotective effects and mechanisms of action of total saponins from Rubus parvifolius L. (TSRP) on focal cerebral ischemia and reperfusion injury in rats. Focal cerebral ischemia and reperfusion injury was performed in rats using the suture method. The results indicate that intragastric injection of TSRP, at 5, 10 and 20 mg/kg, could decrease neurological impairment, reduce cerebral infarct volume, diminish pathological changes, and significantly inhibit the apoptosis of neurons surrounding the ischemic area. In addition, TSRP upregulated the expression of the anti-apoptotic factor Bcl-2, at the protein and mRNA levels, and it downregulated the expression of the pro-apoptotic factor Bax, at the protein and mRNA levels. These findings indicate that TSRP protects against cerebral ischemia/reperfusion injury, and that it may do so by regulating the expression of Bcl-2 and Bax. | Jisheng Wang Fang Zhang Li Tang Liqiong Sun Xiaolin Song] Lisha Cao Zongyin Qiu Chenglin Zhou | 2012 | Neural Regeneration Research2012，7，3： | 5 |
| 3 | The dichotomous and incomplete adaptive immunity in COVID-19 patients with different disease severity显示文摘The adaptive immunity that protects patients from coronavirus disease 2019(COVID-19),caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),is not well characterized.In particular,the asymptomatic patients have been found to induce weak and transient SARS-CoV-2 antibody responses,but the underlying mechanisms remain unknown;meanwhile,the protective immunity that guide the recovery of these asymptomatic patients is elusive.Here,we characterized SARS-CoV-2-specific B-cell and T-cell responses in 10 asymptomatic patients and 64 patients with other disease severity(mild,n=10,moderate,n=32,severe,n=12)and found that asymptomatic or mild symptomatic patients failed to mount virus-specific germinal center(GC)B cell responses that result in robust and prolonged humoral immunity,assessed by GC response indicators including follicular helper T(TFH)cell and memory B cell responses as well as serum CXCL13 levels.Alternatively,these patients mounted potent virus-specific TH1 and CD8+T cell responses.In sharp contrast,patients of moderate or severe disease induced vigorous virus-specific GC B cell responses and associated TFH responses;however,the virus-specific TH1 and CD8+T cells were minimally induced in these patients.These results,therefore,uncovered the protective immunity in asymptomatic patients and also revealed the strikingly dichotomous and incomplete humoral and cellular immune responses in COVID-19 patients with different disease severity,providing important insights into rational design of effective COVID-19 vaccines. | Leiqiong Gao Jing Zhou Sen Yang Lisha Wang Xiangyu Chen Yang Yang Ren Li Zhiwei Pan Jing Zhao Zhirong Li Qizhao Huang Jianfang Tang Li Hu Pinghuang Liu Guozhong Zhang Yaokai Chen Lilin Ye | 2021 | Signal Transduction and Targeted Therapy2021，6，4： | 2 |
| 4 | Electrodeposition and characterization of nanocrystalline cuprous oxide thin films on TiO 2 films显示文摘 | Yiwen Tang Zhigang Chen Zhijie Jia Lisha Zhang Jialin Li | 2004 | Materials Letters2004，，4： | 1 |
| 5 | Adsorption of nic- otime and tar from the mainstream smoke of cigarettes by oxidized carbon nanotubes 显示文摘 | Zhigang Chen Lisha Zhang Yiwen Tang | 2006 | Applied Surface Science2006，252，29： | 1 |
| 6 | Reversal of P-gp and MRPl-mediated multidrug resistance by H6, a gypenoside aglyeon from Gynostemma pen- taphyllurn, in vincristine-resistant human oral cancer (KB/VCR) cells显示文摘 | Hengrui Zbu Zulong Liu Lisha Tang | 2012 | Eur J Med Chem2012，696，13： | 1 |
| 7 | Chronic low level trimethyltin exposure and the risk of developing nephrolithiasis 显示文摘 | Tang Xiaojiang Li Nanchun Kang Lisha | 2013 | Occup Environ Med2013，70，8： | 1 |
| 8 | Adsorption of Nicotine and Tar From the Mainstream Smoke of Cigarettes by Oxidized Carbon Nanotubes 显示文摘 | Chen Zhigang Zhang Lisha Tang Yiwen | 2006 | Applied Surface Science2006，252，： | 1 |
| 9 | Healing Effect and Underlying Mechanism of Silver Nanoparticles Prepared Using Carboxymethyl Chitosan under Solar Irradiation显示文摘In our previous study,silver nanoparticles were prepared using AgNO_(3) and carboxymethyl chitosan(CMCS)which is commercially available with solar irradiation.In this study,the efficacy and safety of silver nanoparticles prepared by this method were evaluated for healing wounds in rats with diabetes.We also attempted to determine the underlying mechanism and influencing factors of the silver nanomaterial preparation method.Compared with growth factors,silver nanoparticles exhibit better healing effects for rats with diabetes.No remnant silver ions were detected in the major organs of these rats after the application of silver nanoparticles.Silver nanoparticles prepared using CMCS are less toxic than those prepared from the conventional method,promote the proliferation of skin fibroblasts,and are promising as a topical medication for infected wounds.An obvious breakage process of the particles is observed during the growth of nanocrystalline silver in CMCS.In this study,we also attempted to determine whether this method is suitable for synthesizing silver nanoparticles using N-trimethyl chitosan chloride and sodium alginate were used in this particular experiment.The characteristic UV-vis absorbance peak of silver nanoparticles was found only in the reaction mixture containing N-trimethyl chitosan chloride.Our study demonstrates that free radicals are the key factor in this silver nanoparticle preparation method. | Yi Long Chunling Zhang Lan Chen Tietao Di Lu Chen Lisha Tang Kaizhong Luo Yu Yan Pingzhen Tong Jie Xiang | 2021 | Journal of Renewable Materials2021，9，6： | 0 |
| 10 | Literature and patent analysis of the cloning and identification of human functional genes in China显示文摘The Human Genome Project was launched at the end of the 1980s.Since then,the cloning and identification of functional genes has been a major focus of research across the world.In China too,the potentially profound impact of such studies on the life sciences and on human health was realized,and relevant studies were initiated in the 1990s.To advance China's involvement in the Human Genome Project,in the mid-1990s,Committee of Experts in Biology from National High Technology Research and Development Program of China(863 Program) proposed the 'two 1%' goal.This goal envisaged China contributing 1% of the total sequencing work,and cloning and identifying 1% of the total human functional genes.Over the past 20 years,tremendous achievement has been accomplished by Chinese scientists.It is well known that scientists in China finished the 1% of sequencing work of the Human Genome Project,whereas,there is no comprehensive report about 'whether China had finished cloning and identifying 1% of human functional genes'.In the present study,the GenBank database at the National Center of Biotechnology Information,the PubMed search tool,and the patent database of the State Intellectual Property Office,China,were used to retrieve entries based on two screening standards:(i) Were the newly cloned and identified genes first reported by Chinese scientists?(ii) Were the Chinese scientists awarded the gene sequence patent? Entries were retrieved from the databases up to the cut-off date of 30 June 2011 and the obtained data were analyzed further.The results showed that 589 new human functional genes were first reported by Chinese scientists and 159 gene sequences were patented(http:gene.fudan.sh.cn/introduction/database/chinagene/chinagene.html).This study systematically summarizes China's contributions to human functional genomics research and answers the question 'has China finished cloning and identifying 1% of human functional genes?' in the affirmative. | XIA Yan TANG LiSha YAO Lei WAN Bo YANG XianMei YU Long | 2012 | Science China(Life Sciences)2012，55，3： | 0 |
| 11 | A PO-CI/MC-CDMA scheme for high modulation styles显示文摘Through analyzing the theoretical spreading principle,it has been proved in this paper that the benefit of pseudo-orthogonal carrier interferometry(PO-CI)spreading code is not supported when complex signal modulation(e.g.,quadrature phase-shift keying(QPSK)and quadrature amplitude modulation(QAM))types are employed.On this basis,a novel and feasible structure for this problem is brought forward.Within the structure mentioned,instead of complex modulation patterns,pulse amplitude modulation(PAM)combined with PO-CI spreading code is utilized.This allows us to maintain the throughput increase of a multi-carrier code division multiple access(MC-CDMA)system with minimal loss in performance and no bandwidth expansion. | Yanyan ZHANG Lisha TANG Xiaofeng TAO Xiaoxuan ZHU Ping ZHANG | 2008 | Frontiers of Electrical and Electronic Engineering in China2008，3，2： | 0 |
| 12 | Tumor-specific memory CD8^(+)T cells are strictly resident in draining lymph nodes during tumorigenesis显示文摘The functional exhaustion of CD8^(+)T cells represents a fundamental hallmark of chronic viral infection and cancer and,in both scenarios,is driven by prolonged exposure to persistent cognate antigens in the context of an immunoinhibitory microenvironment.Exhausted CD8^(+)T cells upregulate the expression of a wide diversity of coinhibitory immunoreceptors(also referred to as immune checkpoint receptors),such as PD-1,Tim-3,LAG-3,and TIGIT.Concomitantly,exhausted CD8^(+)T cells lose their potential to differentiate into functional memory cells and are characterized by hierarchical loss of effector function,leading to compromised tumor control and viral eradication[1,2]. | Qiao Liu Ling Ran Zhengliang Yue Xingxing Su Lisha Wang Shuqiong Wen Shun Lei Xiaofan Yang Yan Zhang Jianjun Hu Jianfang Tang Zhirong Li Li Hu Bo Zhu Lifan Xu Lilin Ye Qizhao Huang | 2023 | Cellular & Molecular Immunology2023，20，4： | 0 |
| 13 | Author Correction:Tumor-specific memory CD8^(+)T cells are strictly resident in draining lymph nodes during tumorigenesis显示文摘 | Qiao Liu Ling Ran Zhengliang Yue Xingxing Su Lisha Wang Shuqiong Wen Shun Lei Xiaofan Yang Yan Zhang Jianjun Hu Jianfang Tang Zhirong Li Li Hu Bo Zhu Lifan Xu Lilin Ye Qizhao Huang | 2023 | Cellular & Molecular Immunology2023，20，7： | 0 |
| 14 | Covalent coupling promoting charge transport of CdSeTe/UiO-66 for boosting photocatalytic CO_(2)reduction显示文摘Quantum dots(QDs)based heterojunction is a candidate for the photocatalytic CO_(2)reduction,owing to the large extinction coefficient and easy modification of band structures.However,the van der Waals interaction causes the large charge resistance and strong recombination centers between QDs and host materials,which makes the poor photocatalytic performance.Herein,a covalent bonded CdSeTeQDs and NH_(2)-UiO-66 heterojunction(NUC-x)is constructed through an acylamino(-CONH-).The results indicate that the acylamino between NH_(2)-UiO-66 and Cd Se Te QDs can serve as the transfer channels for the photogenerated charges and stabilize the QDs.The optimized NUC-1200 achieved a CO generation rate of 228.68μmol/g,which is 13 and 4 times higher than that of NH_(2)-UiO-66 and Cd Se Te QDs,respectively.This work provides a new avenue for efficient and stable photocatalysis of QDs. | Lisha Chen Qianqian Tang Shihao Wu Longshuai Zhang Lifang Feng Yuan Wang Yiling Xie Yan Li Jian-Ping Zou Sheng-Lian Luo | 2023 | Chinese Chemical Letters2023，34，6： | 0 |
| 15 | Facile and controllable synthesis of amino-modified carbon dots for efficient oil displacement显示文摘Zero-dimensional(0D)carbon dots exhibit excellent potential as a new oil-displacing agent for unconventional reservoir development.However,the difficulty in size/surface properties control and unclear mechanism hinder their further applications.In this study,amino-modified carbon dots(am-CDs)for oil displacement were facilely synthesized through the rapid polymerization of D-glucose(D-Glc)and 3-aminopropyltriethoxysilane(APTES).The size of am-CDs could be precisely controlled by the reaction condition and quenching achieved by adjusting the pH value to neutral.The surface amine groups endow am-CDs with excellent hydrophilicity and dispersion stability.The 0.30 wt.%nanofluid based on am-CDs with an average size of 2.6±0.040 nm showed remarkable oil recovery efficiency(54.09%)without the addition of surfactant.The oil recovery efficiency of am-CDs is much higher than those of water flooding(30.25%),nano-SiO_(2) flooding(36.45%),and amino-free carbon dots(af-CDs)flooding(37.80%).Experimental and theoretical results reveal that am-CDs can be favorably adsorbed on the core surface to modulate the micro-scale wettability,changing the surface from oil-wet to relatively uniform water-wet.Meanwhile,am-CDs can effectively reduce the adhesion force between alkanes and sandstone surfaces,contributing to oil droplets peeling off and oil displacement.This study provides a new strategy for developing efficient carbon dots-based nanofluids for enhanced oil recovery. | Yining Wu Lisha Tang Mengjiao Cao Li Li Kai Liu Demin Kong Qingshan Zhao Xu Jin He Liu Caili Dai | 2023 | Nano Research2023，16，5： | 0 |
| 16 | Evidence for GAL3ST4 mutation as the potential cause of Dectus excavatum显示文摘 | Song Wu Xiaojuan Sun Weimin Zhu Yi Huang Lisha Mou Mingming Liu Xia Li Feiyang Li Xianxin Li Yong Zhang Zheng Wang Wencui Li Zesong Li Aifa Tang Yaoting Gui Rongfu Wang Weiping Li Zhiming Cai Daping Wang | 2012 | Cell Research2012，22，12： | 0 |
| 17 | Breeding and Cultivation Techniques for New Edible Orange-Fleshed Sweet Potato Variety Nanshu 012显示文摘The carotenoid in sweet potato has a high health value for the human body,and Harvest Plus has also carried out the breeding to improve the nutritional quality of sweet potatoes in order to address the health problems of people nutrient-deficient areas.Nanshu 012 is a new high-quality orange-fleshed sweet potato variety rich in carotenoid,bred by Nanchong Academy of Agricultural Sciences from the ' Boga × Sanheshu' hybrid.In the regional test of sweet potato varieties in Sichuan Province during 2009-2010,the average fresh potato yield was 24600 kg/ha,the average dry matter percentage was 29.0 % and the average preserved sweet potato yield was 7152.0 kg/ha;in the production test,the average fresh potato yield was 28410.0 kg/ha and the average preserved sweet potato yield was 8734.5 kg/ha.The multi-point sampling analysis showed that the total sugar content of fresh potato was 5.28 %,protein content was 1.43 %,vitamin C content was 28.9 mg/100 g and carotenoid content was 5.21 mg/100 g.This variety was identified by Sichuan Crop Variety Approval Committee in March 2012,with high fresh potato yield,sweetness,rich carotenoid and resistance to black spot.It is an orange-fleshed sweet potato variety suitable for eating and food processing,and it should be planted in the plot with moderate fertility or above,and should be planted and harvested as early as possible. | Mingshuang TANG Lisha LIU Quanlu ZHOU Yingdong HUANG Sulan HE Sheng LI Dongbo LI Hongqing ZHU Mei WANG Yujuan ZHANG Yuming LI | 2017 | Asian Agricultural Research2017，9，8： | 0 |
| 18 | In-situ synthesis of high thermal stability and salt resistance carbon dots for injection pressure reduction and enhanced oil recovery显示文摘Carbon dots(CDs)show great potential as a new type of oil-displacing agent for unconventional oil and gas development.However,the instability and easy aggregation epitomize the challenges that accompany the application of CDs in high temperature and high salinity(HT/HS)reservoirs.In this research,novel benzene sulfonate-modified carbon dots(BS-CDs)with remarkable thermal stability and salt resistance were fabricated through an in-situ electrochemical exfoliation method.Molecular simulation verifies that the introduction of benzene sulfonate groups substantially strengthens the electrostatic repulsion between BS-CDs,leading to outstanding dispersibility and stability even at a temperature of 100℃ and salinity of 14×10^(4) mg/L.Core flooding tests show that 0.05 wt.%BS-CDs nanofluid can significantly reduce the water injection pressure by 50.00%and enhanced oil recovery(EOR)to 68.39%under HT/HS conditions.According to the atomic force microscopy(AFM)scanning results,the adhesion force between the core(after BS-CDs treatment)and oil decreased by 11.94 times,indicating that the hydrophilicity of the core surface was increased.In addition,the distribution of the adhesion force curve is more concentrated,which means that the micro-scale wettability of the core changes from oil-wet to more homogeneous water-wet.This study provides a feasible way for the development and application of good thermal stability and salt resistance CDs in unconventional reservoir development. | Yining Wu Lisha Tang Dayu Liu Demin Kong Liu Kai Mengjiao Cao Qingshan Zhao | 2023 | Nano Research2023，16，10： | 0 |
| 19 | Diagnostic accuracy and safety of Dermatophagoides pteronyssinus extracts used for skin prick test显示文摘Background:Dermatophagoides pteronyssinus is a common allergen causing allergic diseases in China.The aim of this study was to evaluate the efficacy and safety of D.pteronyssinus extracts produced by Peking Union Medical College Hospital(PUMCH)for the skin prick test(SPT)in the diagnosis of D.pteronyssinus allergy.Methods:A total of 910 subjects with allergic diseases were prescribed D.pteronyssinus SPT and specific sIgE(sIgE)test among the Outpatients of Department of Allergy,PUMCH from August 10,2015 to August 30,2017.Receiver operating characteristic curve(ROC)analysis was performed according to the results of D.pteronyssinus-sIgE detection.The accuracy of D.pteronyssinus extracts used for SPT in the diagnosis of D.pteronyssinus allergy was evaluated under different cutoff values.Adverse events after SPT were recorded to evaluate safety.Results:There were 796 and 618 subjects in the full analysis set(FAS)and the per protocol set(PPS),respectively.The areas under the curve of FAS and PPS were 0.871 and 0.873,respectively.According to the ROC of PPS,the optimal and 95%specificity diagnostic cutoff values of D.pteronyssinus SPT mean wheal diameter were 3.25 and 3.75 mm,respectively.No adverse events occurred.Conclusion:The extracts of D.pteronyssinus for SPT were simple,highly accurate,and safe and should be considered for recommendation in the clinical diagnosis of D.pteronyssinus allergy. | Rui Tang Xiaohong Lyu Yuxi Liu Ruiqi Wang Lianglu Wang Hong Li Jinlyu Sun Yuxiang Zhi Jianqing Gu Kai Guan Liping Wen Zixi Wang Lisha Li Le Cui Yingyang Xu Junxiong Zhou Tao Xu Jia Yin | 2022 | Chinese Medical Journal2022，135，21： | 0 |
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