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| 1 | Distributed Brillouin frequency shift extraction via a convolutional neural network显示文摘Distributed optical fiber Brillouin sensors detect the temperature and strain along a fiber according to the local Brillouin frequency shift(BFS),which is usually calculated by the measured Brillouin spectrum using Lorentzian curve fitting.In addition,cross-correlation,principal component analysis,and machine learning methods have been proposed for the more efficient extraction of BFS.However,existing methods only process the Brillouin spectrum individually,ignoring the correlation in the time domain,indicating that there is still room for improvement.Here,we propose and experimentally demonstrate a BFS extraction convolutional neural network(BFSCNN)to retrieve the distributed BFS directly from the measured two-dimensional data.Simulated ideal Brillouin spectra with various parameters are used to train the BFSCNN.Both the simulation and experimental results show that the extraction accuracy of the BFSCNN is better than that of the traditional curve fitting algorithm with a much shorter processing time.The BFSCNN has good universality and robustness and can effectively improve the performances of existing Brillouin sensors. | YIQING CHANG HAO WU CAN ZHAO LI SHEN SONGNIAN FU MING TANG | 2020 | Photonics Research2020，8，5： | 6 |
| 2 | into the Role of Additives in Catalytic Synthesis of Insight Cyclohexylamine from Nitrobenzene显示文摘Cyclohexylamine is a versatile intermediate in various chemical industries,which can be expediently synthesized via hydrogenation of aniline or nitrobenzene.However,such processes always suffer from side reactions.Many reports have found that specific additives can suppress the formation of side products,but the mechanism is still not clear.In this work,results suggest that it is the hydroxide ion of alkali metal hydroxides,rather than the cations,which plays a key role in suppressing the side reactions on supported Ru-based catalysts.With the assistance of LiOH,the selectivity toward cy- clohexylamine increased from 85.4% to 100%.Side products,such as dicyciohexylamine,cyclohexanol and N-isopropyl cyclohexylamine,could no longer be detected.Theoretical calculations further disclosed that addition of alkali metal hydroxides inhibited the dissociation of enamine and decreased the adsorption energy of cyclohexylamine,which might be the reasons for a better selectivity.However,the addition of alkali metal hydroxides reduced the activity of nitrobenzene hydrogenation by unfolding the condensation reaction route.To recover or even further enhance the catalytic performance,a second metal component was introduced and the resultant RuNi/AC exhibited a significant improvement in activity compared with Ru/AC. | Xuefeng Li Zhe Wang Shanjun Mao Yiqing chen Minghui Tang Haoran Li Yong Wang | 2018 | Chinese Journal of Chemistry2018，36，12： | 4 |
| 3 | Haplotype-resolved genome of diploid ginger (Zingiber officinale) and its unique gingerol biosynthetic pathway显示文摘Ginger(Zingiber officinale),the type species of Zingiberaceae,is one of the most widespread medicinal plants and spices.Here,we report a high-quality,chromosome-scale reference genome of ginger‘Zhugen’,a traditionally cultivated ginger in Southwest China used as a fresh vegetable,assembled from PacBio long reads,Illumina short reads,and high-throughput chromosome conformation capture(Hi-C)reads.The ginger genome was phased into two haplotypes,haplotype 1(1.53 Gb with a contig N50 of 4.68 M)and haplotype 0(1.51 Gb with a contig N50 of 5.28 M).Homologous ginger chromosomes maintained excellent gene pair collinearity.In 17,226 pairs of allelic genes,11.9%exhibited differential expression between alleles.Based on the results of ginger genome sequencing,transcriptome analysis,and metabolomic analysis,we proposed a backbone biosynthetic pathway of gingerol analogs,which consists of 12 enzymatic gene families,PAL,C4H,4CL,CST,C3’H,C3OMT,CCOMT,CSE,PKS,AOR,DHN,and DHT.These analyses also identified the likely transcription factor networks that regulate the synthesis of gingerol analogs.Overall,this study serves as an excellent resource for further research on ginger biology and breeding,lays a foundation for a better understanding of ginger evolution,and presents an intact biosynthetic pathway for species-specific gingerol biosynthesis. | Hong-Lei Li Lin Wu Zhaoming Dong Yusong Jiang Sanjie Jiang Haitao Xing Qiang Li Guocheng Liu Shuming Tian Zhangyan Wu Bin Wu Zhexin Li Ping Zhao Yan Zhang Jianmin Tang Jiabao Xu Ke Huang Xia Liu Wenlin Zhang Qinhong Liao Yun Ren Xinzheng Huang Qingzhi Li Chengyong Li Yi Wang Baskaran Xavier-Ravi Honghai Li Yang Liu Tao Wan Qinhu Liu Yong Zou Jianbo Jian Qingyou Xia Yiqing Liu | 2021 | Horticulture Research2021，8，1： | 2 |
| 4 | Antagonism between coral pathogen Vibrio coralliilyticus and other bacteria in the gastric cavity of scleractinian coral Galaxea fascicularis显示文摘Scleractinian corals host numerous microbial symbionts with different types of interactions. The gastric cavity of scleractinian coral, as a semiclosed subenvironment with distinct chemical characteristics(e.g., dissolved O2, pH, alkalinity, and nutrients), harbors a distinct microbial community and a diverse array of bacteria that can be pathogenic or beneficial. Galaxea fascicularis is one of the dominant massive scleractinian coral species on inshore fringing reefs in the northern South China Sea.Although the abundance of coral-associated bacteria has been investigated in G. fascicularis, less is known about the microorganisms in the gastric cavity. In this study, we specially isolated cultivable bacterial strains from the gastric cavity of G.fascicularis collected from Hainan Island using a noninvasive sampling approach. Among the 101 representative bacterial strains, one Vibrio coralliilyticus strain, SCSIO 43001, was found to be a temperature-dependent opportunistic pathogen of G.fascicularis. The antagonistic activity between the 100 strains and V. coralliilyticus SCSIO 43001 was tested using a modified Burkholder diffusion assay. Our results showed that V. coralliilyticus SCSIO 43001 inhibits the growth of Erythrobacter flavus and Sphingomonas yabuuchiae. Additionally, we found that three Pseudoalteromonas strains showed moderate to high antibacterial activity against V. coralliilyticus SCSIO 43001 and several other coral-associated Gram-negative bacterial strains.These results suggest that competition between the coral pathogen and other bacteria also occurs in the gastric cavity of coral, and Pseudoalteromonas strains in the gastric cavity of G. fascicularis may provide a protective role in the defense against coinhabiting coral pathogens at elevated temperature. | Kaihao TANG Waner ZHAN Yiqing ZHOU Tao XU Xiaoqing CHEN Weiquan WANG Zhenshun ZENG Yan WANG Xiaoxue WANG | 2020 | Science China Earth Sciences2020，63，1： | 2 |
| 5 | Development of a combination drug-eluting bead: towards enhanced efficacy for locoregional tumour therapies显示文摘 | Richard E.J. Forster Yiqing Tang Cressida Bowyer Andrew W. Lloyd Wendy Macfarlane Gary J. Phillips Andrew L. Lewis | 2012 | Anti-Cancer Drugs2012，，4： | 1 |
| 6 | NAT 10 promotes gastric cancer metastasis via N4-acetylated COL5A1显示文摘Dear Editor,Gastric cancer(GC)is among the most prevalent gastrointestinal malignancies.The occurrence of local deep infiltration or distant metastasis in GC is commonly associated with weak treatment and poor prognosis.1 Although,N4-Acetylcytidine(ac4C)represents one of the extensive chemical modifications in mRNAs that plays a pivotal role in modulating mRNA stability and the mRNA translation process(Fig.1b). | Yigan Zhang Yuanxue Jinq Yinxue Wanq Jianming Tang Xiaoran Zhu Wei-Lin Jin Yiqing Wang Wenzhen Yuan Xiangkai Li Xun Li | 2021 | Signal Transduction and Targeted Therapy2021，6，6： | 1 |
| 7 | Comparison of DC Bead-irinotecan and DC Bead-topotecan drug eluting beads for use in locoregional drug delivery to treat pancreatic cancer显示文摘 | Richard E. J. Forster Sharon A. Small Yiqing Tang Clare L. Heaysman Andrew W. Lloyd Wendy Macfarlane Gary J. Phillips Milan D. Antonijevic Andrew L. Lewis | 2010 | Journal of Materials Science: Materials in Medicine2010，，9： | 1 |
| 8 | Clinical benefit and tolerability of adjuvant intraperitoneal chemotherapy in patients who have or have not received neoadjuvant chemotherapy for advanced ovarian cancer显示文摘BACKGROUND Adjuvant chemotherapy using intraperitoneal(IP)treatment has demonstrated survival benefit over intravenous(IV)therapy alone in patients treated with upfront debulking surgery for advanced stage ovarian cancer.Neoadjuvant chemotherapy followed by interim surgery and adjuvant chemotherapy has similar outcome in survival as compared to upfront surgery followed by adjuvant IV chemotherapy.IP chemotherapy has not been widely adopted in clinical practice for a number of reasons.Whether IP chemotherapy delivered in the patients who received neoadjuvant chemotherapy can be well tolerated or confers any clinical benefit has not been well studied.AIM To evaluate the experience of adjuvant IP chemotherapy in the community cancer clinic setting,and the clinical benefit and tolerability of incorporating IP chemotherapy in patients who received neoadjuvant treatment.METHODS We retrospectively evaluated toxicities and outcomes of patients with stage III and IV ovarian cancer diagnosed at our institution between 07/2007 and 07/2015 who received intraperitoneal chemotherapy after cytoreductive surgery(group 1)or after neoadjuvant chemotherapy followed by interim surgery(group 2).RESULTS Thirty eight patients were treated with IP chemotherapy,median age was 54 years old(range 38.6 to 71 years).In group 1(n=25),12(48%)of the patients completed 4 or more cycle of IP treatment after upfront debulking surgery;while in group 2(n=13),8(61.5%)of the patients completed all 3 cycles of the assigned IP chemotherapy after receiving neoadjuvant IV chemotherapy followed by surgery,and 2(15.4%)more patients tolerated more than 3 cycles.In those patients who did not get planned IP chemotherapy,most of them were treated with substitutional IV chemotherapy,and the completion rate for 6 cycles of IV+IP was 92%.Abdominal pain,(64%in group 1 and 38%in group 2),vomiting,(36%in group 1 and 30.8%in group 2),dehydration(16%in group 1 and 15.4%in group 2),and hypomagnesemia(12%in group 1 and 15.4%in group 2)were the most common adverse effects in all patients,while patients who have received neoadjuvant chemotherapy were more likely to get hypokalemia,fatigue and renal insufficiency.Progression free survival(PFS)was 26.5 mo(95%CI 14.9,38.0)in group 1 and 27.6 mo(95%CI 13.1,42.1)in group 2.The overall survival was 100.2 mo(95%CI 67.9,132.5)for group 1 and 68.2 mo(95%CI 32.2,104.0)for group 2.For the entire cohort,PFS was 26.5 mo(95%CI 15.9,37.0)and OS was 78.8 mo(95%CI 52.3,105.4).CONCLUSION The use of IP/IV chemotherapy can be safely administrated in the community cancer clinic setting.The use of IP/IV chemotherapy in patients who have received neoadjuvant chemotherapy followed by surgery is feasible and tolerable.Despite various modification of the IP regimen,incorporation of IP chemotherapy in the adjuvant setting appears to be associated with improved PFS and overall survival. | Trishala Meghal Vishangi Dave Horace Tang Vivek Kumar Yiqing Xu | 2019 | World Journal of Clinical Oncology2019，10，5： | 1 |
| 9 | Doxorubicin eluting beads—2: methods for evaluating drug elution and in-vitro:in-vivo correlation显示文摘 | M. Victoria Gonzalez Yiqing Tang Gary J. Phillips Andrew W. Lloyd Brenda Hall Peter W. Stratford Andrew L. Lewis | 2008 | Journal of Materials Science: Materials in Medicine2008，，2： | 1 |
| 10 | DC Bead: In Vitro Characterization of a Drug-delivery Device for Transarterial Chemoembolization显示文摘 | Andrew L. Lewis M. Victoria Gonzalez Andrew W. Lloyd Brenda Hall Yiqing Tang Sean L. Willis Simon W. Leppard Laura C. Wolfenden Rosemary R. Palmer Peter W. Stratford | 2006 | Journal of Vascular and Interventional Radiology2006，，2： | 1 |
| 11 | Correction:Haplotype-resolved genome of diploid ginger (Zingiber officinale)and its unique gingerol biosynthetic pathway显示文摘After online publication of the article 1,the authors noticed the affiliation“College of Landscape Architecture and Life Science/Institute of Special Plants,Chongqing University of Arts and Sciences,Yongchuan,Chongqing,China”for author Yiqing Liu was missing. | Hong-Lei Li Lin Wu Zhaoming Dong Yusong Jiang Sanjie Jiang Haitao Xing Qiang Li Guocheng Liu Shuming Tian Zhangyan Wu Bin Wu Zhexin Li Ping Zhao Yan Zhang Jianmin Tang Jiabao Xu Ke Huang Xia Liu Wenlin Zhang Qinhong Liao Yun Ren Xinzheng Huang Qingzhi Li Chengyong Li Yi Wang Baskaran Xavier-Ravi Honghai Li Yang Liu Tao Wan Qinhu Liu Yong Zou Jianbo Jian Qingyou Xia Yiqing Liu | 2021 | Horticulture Research2021，8，1： | 1 |
| 12 | Irinotecan drug eluting beads for use in chemoembolization: In vitro and in vivo evaluation of drug release properties显示文摘 | Rachel R. Taylor Yiqing Tang M. Victoria Gonzalez Peter W. Stratford Andrew L. Lewis | 2006 | European Journal of Pharmaceutical Sciences2006，，1： | 1 |
| 13 | Localization of indoleamine 2,3-dioxygenase in human esophageal squamous cell carcinomas显示文摘 | Jinzhong Liu Gaofeng Lu Fuai Tang Yiqing Liu Guanglin Cui | 2009 | Virchows Archiv2009，，： | 1 |
| 14 | Analysis of polished polycrystalline diamond using dual beam focused ion beam microscopy 显示文摘 | Fengzai Tang Yiqing Chen Liangchi Zhang | 2012 | Philosophical Magazine2012，92，： | 1 |
| 15 | Effect of crystalline structure on terbuthylazine degradation by H_2O_2-assisted TiO_2 photocatalysis under visible irradiation显示文摘Various methods for shifting the optical response of TiO_2 into the visible(Vis) range have been reported. Herein, we reported the application of a TiO_2/H_2O_2/Vis process and the effects of TiO_2 crystalline structure on the degradation of terbuthylazine. The results indicated that TiO_2 crystalline structure and H_2O_2 addition had significant effects on terbuthylazine degradation: its degradation rate could be increased from 7% to 70% with H_2O_2 addition after 180 min of reaction, the synergistic degradation of terbuthylazine by TiO_(2-)Fe^(3+) was substantially accelerated, with the degradation rate reaching up to 100% after20 min of reaction, and rutile TiO_2 showed better photocatalytic activity and a more obvious synergistic effect than anatase TiO_2. The addition of free-radical scavengers(tert-butyl alcohol or methanol) inhibited the degradation efficiency of rutile TiO_2, but had a relatively minor effect on anatase TiO_2. Fluorescence spectrophotometry analysis indicated that hydroxyl free radicals could be continuously produced when using rutile TiO_2 as the photocatalyst. Degradation of terbuthylazine catalyzed by rutile TiO_2 occurred mainly in solution, but occurred on the particle surface of the photocatalyst when catalyzed by anatase TiO_2. This study provides new insight into the role of TiO_2 crystalline structure on the degradation of terbuthylazine and its photocatalytic degradation mechanism. | Jianjun Tang Yiqing Chen Zijun Dong | 2019 | Journal of Environmental Sciences2019，31，5： | 1 |
| 16 | Antibiotics in global rivers显示文摘Antibiotics have received extensive attention due to their sophisticated effects on human health and ecosystems.However,there is an extreme scarcity of information on composition,content,geographic distribution,and risk of riverine antibiotics at a large spatial scale.Based on a systematic review of over 600 pieces of literature(1999-2021),we established a global dataset containing more than 90,000 records covering 169 antibiotics and their metabolites in surface water and sediment across 76 countries.The occurrence of prioritized antibiotics largely depended on socioeconomic developmental levels,and the current“hotspots”of polluted rivers were found mostly in less developed countries or emerging economies(e.g.,some in Africa,South America,and Asia).By developing the screening protocol for risk-based prioritization of antibiotics,we advanced a rank list of antibiotics for guiding formulation of region-specific strategies,which highlighted the importance of whole life cycle management of antibiotics in health maintenance of the world’s rivers. | Si Li Yi Liu Yang Wu Jingrun Hu Yiqing Zhang Qian Sun Weiling Sun Jiagen Geng Xiaoying Liu Dantong Jia Xiuqi You Dianqing Qi Moran Tang Yitao Lyu Fanguang Kong Leilei Cai Yufan Ai Yichu Wang Jinren Ni | 2022 | National Science Open2022，1，2： | 1 |
| 17 | USP9x promotes CD8^(+)T-cell dysfunction in association with autophagy inhibition in septic liver injury显示文摘Sepsis is a life-threatening condition manifested by concurrent inflammation and immunosuppression.Ubiquitin-specific peptidase 9,X-linked(USP9x),is a USP domain-containing deubiquitinase which is required in T-cell development.In the present study,we investigate whether USP9x plays a role in hepatic CD8^(+)T-cell dysfunction in septic mice.We find that CD8^(+)T cells are decreased in the blood of septic patients with liver injury compared with those without liver injury,the CD4/CD8 ratio is increased,and the levels of cytolytic factors,granzyme B and perforin are downregulated.The number of hepatic CD8^(+)T cells and USP9x expression are both increased 24 h after cecal ligation and puncture-induced sepsis in a mouse model,a pattern similar to liver injury.The mechanism involves promotion of CD8^(+)T-cell dysfunction by USP9x associated with suppression of cell cytolytic activity via autophagy inhibition,which is reversed by the USP9x inhibitor WP1130.In the in vivo studies,autophagy is significantly increased in hepatic CD8^(+)T cells of septic mice with conditional knockout of mammalian target of rapamycin.This study shows that USP9x has the potential to be used as a therapeutic target in septic liver injury. | Lulu Sheng Juntao Chen Yiqing Tong Yi Zhang Qiming Feng Zhenghao Tang | 2022 | Acta Biochimica et Biophysica Sinica2022，54，12： | 0 |
| 18 | Comparative study on consumption behaviors in private car markets between large and medium-small cities in China显示文摘With the economic development and the acceleration of motorization in China,the number of private cars increases rapidly in urban areas.However,the limit of urban resources and the contradiction between traffic supply and demand are increasingly prominent in large cities,while private car consumption has been a new 'light' in medium and small cities.Consumers' behaviors differ from region to region.Aiming at the above problems,we formulate structural equation modeling and carry out empirical research.In this paper,a comparative study about the main influential factors that affect the consumption of private cars in large and small cities in China is made,and it is hoped that some guidance for policy recommendations can be obtained. | Deqing Tan Yiqing Tang Ning Lu | 2016 | Chinese Journal of Population,Resources and Environment2016，16，2： | 0 |
| 19 | Identification of bacteria-derived urease in the coral gastric cavity显示文摘Nitrogen cycle is critical to maintain a healthy coral reef ecosystem.Urea can provide a source of nitrogen for coral holobiont and is important for coral calcification through degradation by urease.Despite the involvement of coral-associated bacteria in nitrogen fixation,nitrification and denitrification are well recognized,to what extend urea degradation by bacteria contributing to the urea utilization by coral holobiont remains to be investigated.In this study,we demonstrate that the urea utilization is a common feature of Halomonas spp.that is a dominant genus in cultivable coral-associated bacteria.A urease operon was characterized by genome sequencing and gene knock-out technique in Halomonas meridiana SCSIO 43005,isolated from the gastric cavity of healthy scleractinian coral Galaxea fascicularis.H.meridiana showed high urease activity which was induced by urea and deletion of the urease operon reduced the capability to use urea as solo nitrogen source.Furthermore,approximately 1/3 coral-associated bacteria in the IMG/M database possess complete urease operons indicating the involvement of bacteria-derived ureases in coral holobiont.These results suggest that urease from coral-associated bacteria might be important player in the nitrogen cycling of coral reefs. | Yiqing ZHOU Kaihao TANG Pengxia WANG Weiquan WANG Yan WANG Xiaoxue WANG | 2020 | Science China Earth Sciences2020，63，10： | 0 |
| 20 | Selective deletion of zinc transporter 3 in amacrine cells promotes retinal ganglion cell survival and optic nerve regeneration after injury显示文摘Vision depends on accurate signal conduction from the retina to the brain through the optic nerve,an important part of the central nervous system that consists of bundles of axons originating from retinal ganglion cells.The mammalian optic nerve,an important part of the central nervous system,cannot regenerate once it is injured,leading to permanent vision loss.To date,there is no clinical treatment that can regenerate the optic nerve and restore vision.Our previous study found that the mobile zinc(Zn^(2+))level increased rapidly after optic nerve injury in the retina,specifically in the vesicles of the inner plexiform layer.Furthermore,chelating Zn^(2+)significantly promoted axonal regeneration with a long-term effect.In this study,we conditionally knocked out zinc transporter 3(ZnT3)in amacrine cells or retinal ganglion cells to construct two transgenic mouse lines(VGAT^(Cre)ZnT3^(fl/fl)and VGLUT2^(Cre)ZnT3^(fl/fl),respectively).We obtained direct evidence that the rapidly increased mobile Zn^(2+)in response to injury was from amacrine cells.We also found that selective deletion of ZnT3 in amacrine cells promoted retinal ganglion cell survival and axonal regeneration after optic nerve crush injury,improved retinal ganglion cell function,and promoted vision recovery.Sequencing analysis of reginal ganglion cells revealed that inhibiting the release of presynaptic Zn^(2+)affected the transcription of key genes related to the survival of retinal ganglion cells in postsynaptic neurons,regulated the synaptic connection between amacrine cells and retinal ganglion cells,and affected the fate of retinal ganglion cells.These results suggest that amacrine cells release Zn^(2+)to trigger transcriptomic changes related to neuronal growth and survival in reginal ganglion cells,thereby influencing the synaptic plasticity of retinal networks.These results make the theory of zinc-dependent retinal ganglion cell death more accurate and complete and provide new insights into the complex interactions between retinal cell networks. | Zhe Liu Jingfei Xue Canying Liu Jiahui Tang Siting Wu Jicheng Lin Jiaxu Han Qi Zhang Caiqing Wu Haishun Huang Ling Zhao Yehong Zhuo Yiqing Li | 2023 | Neural Regeneration Research2023，18，12： | 0 |
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