|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Erianin,a novel dibenzyl compound in Dendrobium extract,inhibits lung cancer cell growth and migration via calcium/calmodulin-dependent ferroptosis显示文摘Ferroptosis,a novel form of programmed cell death,is characterized by iron-dependent lipid peroxidation and has been shown to be involved in multiple diseases,including cancer.Stimulating ferroptosis in cancer cells may be a potential strategy for cancer therapy.Therefore,ferroptosis-inducing drugs are attracting more attention for cancer treatment.Here,we showed that erianin,a natural product isolated from Dendrobium chrysotoxum Lindl,exerted its anticancer activity by inducing cell death and inhibiting cell migration in lung cancer cells.Subsequently,we demonstrated for the first time that erianin induced ferroptotic cell death in lung cancer cells,which was accompanied by ROS accumulation,lipid peroxidation,and GSH depletion.The ferroptosis inhibitors Fer-1 and Lip-1 but not Z-VAD-FMK,CQ,or necrostatin-1 rescued erianin-induced cell death,indicating that ferroptosis contributed to erianin-induced cell death.Furthermore,we demonstrated that Ca^(2+)/CaM signaling was a critical mediator of erianin-induced ferroptosis and that blockade of this signaling significantly rescued cell death induced by erianin treatment by suppressing ferroptosis.Taken together,our data suggest that the natural product erianin exerts its anticancer effects by inducing Ca^(2+)/CaMdependent ferroptosis and inhibiting cell migration,and erianin will hopefully serve as a prospective compound for lung cancer treatment. | Peng Chen Qibiao Wu Jiao Feng Lili Yan Yitian Sun Shuiping Liu Yu Xiang Mingming Zhang Ting Pan Xiaying Chen Ting Duan Lijuan Zhai Bingtao Zhai Wengang Wang Ruonan Zhang Bi Chen Xuemeng Han Yicong Li Liuxi Chen Ying Liu Xingxing Huang Ting Jin Wenzheng Zhang Hong Luo Xiaohui Chen Yongqiang Li Qiujie Li Guohua Li Qin Zhang Lvjia Zhuo Zuyi Yang Huifen Tang Tian Xie Xiaoping Ouyang Xinbing Sui | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 42 |
| 2 | Iron-based oxygen carriers in chemical looping conversions:A review显示文摘A solid oxygen carrier is usually applied in a chemical looping conversion process to transfer oxygen from the gaseous oxygen source to the fuel,which can avoid the direct contact of these two reactants and hence decrease the energy penalty of separation.Among the solid oxygen carriers,iron-based oxygen carrier is an attractive option due to its inherent properties of low cost and environmentally-friendly.Several processes such as chemical looping combustion(CLC),chemical looping gasification(CLG),chemical looping reforming(CLR),and chemical looping hydrogen generation(CLHG)have been proposed and investigated based on the iron-based oxygen carrier.In this review,the relevant researches on the iron-based oxygen carrier are summarized,which include the characteristics of iron oxides,the preparations of the iron-based oxygen carrier based on the iron ores and some other low-cost iron contained materials,and their applications in the continuous operated chemical looping conversion processes.It is expected to provide a better understanding for the development and utilization of iron-based oxygen carrier in the practical chemical looping processes. | Zhongliang Yu Yanyan Yang Song Yang Qian Zhang Jiantao Zhao Yitian Fang Xiaogang Hao Guoqing Guan | 2019 | Carbon Resources Conversion2019，2，1： | 9 |
| 3 | Wnt/β-catenin signaling in cancers and targeted therapies显示文摘Wnt/β-catenin signaling has been broadly implicated in human cancers and experimental cancer models of animals.Aberrant activation of Wnt/β-catenin signaling is tightly linked with the increment of prevalence,advancement of malignant progression,development of poor prognostics,and even ascendence of the cancer-associated mortality.Early experimental investigations have proposed the theoretical potential that efficient repression of this signaling might provide promising therapeutic choices in managing various types of cancers.Up to date,many therapies targeting Wnt/β-catenin signaling in cancers have been developed,which is assumed to endow clinicians with new opportunities of developing more satisfactory and precise remedies for cancer patients with aberrant Wnt/β-catenin signaling. | Fanyuan Yu Changhao Yu Feifei Li Yanqin Zuo Yitian Wang Lin Yao Chenzhou Wu Chenglin Wang Ling Ye | 2021 | Signal Transduction and Targeted Therapy2021，6，9： | 8 |
| 4 | PCDH17 increases the sensitivity of colorectal cancer to 5-fluorouracil treatment by inducing apoptosis and autophagic cell death显示文摘5-Fluorouracil(5-FU)is known as a first-line chemotherapeutic agent against colorectal cancer(CRC),but drug resistance occurs frequently and significantly limits its clinical success.Our previous study showed that the protocadherin 17(PCDH17)gene was frequently methylated and functioned as a tumor suppressor in CRC.However,the relationship between PCDH17 and 5-FU resistance in CRC remains unclear.Here,we revealed that PCDH17 was more highly expressed in 5-FU-sensitive CRC tissues than in 5-FU-resistant CRC tissues,and high expression of PCDH17 was correlated with high BECN1 expression.Moreover,this expression profile contributed to superior prognosis and increased survival in CRC patients.Restoring PCDH17 expression augmented the 5-FU sensitivity of CRC in vitro and in vivo by promoting apoptosis and autophagic cell death.Furthermore,autophagy played a dominant role in PCDH17-induced cell death,as an autophagy inhibitor blocked cell death to a greater extent than the pancaspase inhibitor Z-VAD-FMK.PCDH17 inhibition by siRNA decreased the autophagy response and 5-FU sensitivity.Mechanistically,we showed that c-Jun NH2-terminal kinase(JNK)activation was a key determinant in PCDH17-induced autophagy.The compound SP600125,an inhibitor of JNK,suppressed autophagy and 5-FU-induced cell death in PCDH17-reexpressing CRC cells.Taken together,our findings suggest for the first time that PCDH17 increases the sensitivity of CRC to 5-FU treatment by inducing apoptosis and JNK-dependent autophagic cell death.PCDH17 may be a potential prognostic marker for predicting 5-FU sensitivity in CRC patients. | Shuiping Liu Haoming Lin Da Wang Qiang Li Hong Luo Guoxiong Li Xiaohui Chen Yongqiang Li Peng Chen Bingtao Zhai Wengang Wang Ruonan Zhang Bi Chen Mingming Zhang Xuemeng Han Qiujie Li Liuxi Chen Ying Liu Xiaying Chen Guohua Li Yu Xiang Ting Duan Jiao Feng Jianshu Lou Xingxing Huang Qin Zhang Ting Pan Lili Yan Ting Jin Wenzheng Zhang Lvjia Zhuo Yitian Sun Tian Xie Xinbing Sui | 2019 | Signal Transduction and Targeted Therapy2019，4，1： | 4 |
| 5 | Effect of potential HONO sources on peroxyacetyl nitrate(PAN)formation in eastern China in winter显示文摘As an important secondary photochemical pollutant,peroxyacetyl nitrate(PAN)has been studied over decades,yet its simulations usually underestimate the corresponding observations,especially in polluted areas.Recent observations in north China found unusually high concentrations of PAN during wintertime heavy haze events,but the current model still cannot reproduce the observations,and researchers speculated that nitrous acid(HONO)played a key role in PAN formation.For the first time we systematically assessed the impact of potential HONO sources on PAN formation mechanisms in eastern China using the Weather Research and Forecasting/Chemistry(WRF-Chem)model in February of 2017.The results showed that the potential HONO sources significantly improved the PAN simulations,remarkably accelerated the RO x(sum of hydroxyl,hydroperoxyl,and organic peroxy radicals)cycles,and resulted in 80%–150%enhancements of PAN near the ground in the coastal areas of eastern China and 10%–50%enhancements in the areas around 35–40°N within 3 km during a heavy haze period.The direct precursors of PAN were aldehyde and methylglyoxal,and the primary precursors of PAN were alkenes with C>3,xylenes,propene and toluene.The above results suggest that the potential HONO sources should be considered in regional and global chemical transport models when conducting PAN studies. | Jingwei Zhang Yitian Guo Yu Qu Yong Chen Ruipeng Yu Chaoyang Xue Rui Yang Qiang Zhang Xingang Liu Yujing Mu Jing Wang Can Ye Haihan Zhao Qiangqiang Sun Ziwen Wang Junling An | 2020 | Journal of Environmental Sciences2020，32，8： | 3 |
| 6 | Molybdenite Re–Os and albite 40 Ar/ 39 Ar dating of Cu–Au–Mo and magnetite porphyry systems in the Yangtze River valley and metallogenic implications显示文摘 | Jingwen Mao Yitian Wang Bernd Lehmann Jinjie Yu Andao Du Yanxiong Mei Yongfeng Li Wenshuan Zang Holly J. Stein Taofa Zhou | 2005 | Ore Geology Reviews2005，，3： | 2 |
| 7 | Geodynamic settings of Mesozoic large-scale mineralization in North China and adjacent areas显示文摘 | Jingwen Mao Yitian Wang Zuoheng Zhang Jinjie Yu Baogui Niu | 2003 | Science in China Series D: Earth Sciences2003，，8： | 1 |
| 8 | Geodynamic settings of Mesozoic large-scale mineralization in North China and adjacent areas显示文摘 | Jingwen Mao Yitian Wang Zuoheng Zhang Jinjie Yu Baogui Niu | 2003 | Science in China Series D: Earth Sciences2003，，8： | 1 |
| 9 | Geodynamic settings of Mesozoic large-scale mineralization in North China and adjacent areas显示文摘 | Jingwen Mao Yitian Wang Zuoheng Zhang Jinjie Yu Baogui Niu | 2003 | Science in China Series D: Earth Sciences2003，，8： | 1 |
| 10 | Geodynamic settings of Mesozoic large-scale mineralization in North China and adjacent areas显示文摘 | Jingwen Mao Yitian Wang Zuoheng Zhang Jinjie Yu Baogui Niu | 2003 | Science in China Series D: Earth Sciences2003，，8： | 1 |
| 11 | Geodynamic settings of Mesozoic large-scale mineralization in North China and adjacent areas显示文摘 | Jingwen Mao Yitian Wang Zuoheng Zhang Jinjie Yu Baogui Niu | 2003 | Science in China Series D: Earth Sciences2003，，8： | 1 |
| 12 | Geodynamic settings of Mesozoic large-scale mineralization in North China and adjacent areas显示文摘 | Jingwen Mao Yitian Wang Zuoheng Zhang Jinjie Yu Baogui Niu | 2003 | Science in China Series D: Earth Sciences2003，，8： | 1 |
| 13 | Simulation-Guided Design of Bamboo Leaf-Derived Carbon-Based High-Efficiency Evaporator for Solar-Driven Interface Water Evaporation显示文摘Solar interface water evaporation has been demonstrated to be an advanced method for freshwater production with high solar energy utilization.The development of evaporators with lower cost and higher efficiency is a key challenge in the manufacture of practical solar interface water evaporation devices.Herein,a bamboo leaf-derived carbon-based evaporator is designed based on the light trace simulation.And then,it is manufactured by vertical arrangement and carbonization of bamboo leaves and subsequent polyacrylamide modification.The vertically arranged carbon structure can extend the light path and increase the light-absorbing area,thus achieving excellent light absorption.Furthermore,the continuous distribution of polyacrylamide hydrogel between these vertical carbons can support high-speed water delivery and shorten the evaporation path.Therefore,this evaporator exhibits an ultrahigh average light absorption rate of~96.1%,a good water evaporation rate of 1.75 kg m^(-2) h^(-1),and an excellent solar-to-vapor efficiency of 91.9%under one sun irradiation.Furthermore,the device based on this evaporator can effectively achieve seawater desalination,heavy metal ion removal,and dye separation while completing water evaporation.And this device is highly available for actual outdoor applications and repeated recycling. | Yitian Wu Rui Kong Chaoliang Ma Lanze Li Yu Zheng Yingzhuo Lu Lulu Liang Yajun Pang Qiang Wu Zhehong Shen Hao Chen | 2022 | Energy & Environmental Materials2022，5，4： | 1 |
| 14 | Molybdenite Re–Os and albite 40 Ar/ 39 Ar dating of Cu–Au–Mo and magnetite porphyry systems in the Yangtze River valley and metallogenic implications显示文摘 | Jingwen Mao Yitian Wang Bernd Lehmann Jinjie Yu Andao Du Yanxiong Mei Yongfeng Li Wenshuan Zang Holly J. Stein Taofa Zhou | 2005 | Ore Geology Reviews2005，，3： | 1 |
| 15 | Molybdenite Re-Os and albite ^40Ar/^39Ar dating of Cu-Au-Mo and magnetite porphyry systems in the Yangtze River valley and metallogenic implications显示文摘 | Mao Jingwen Wang Yitian Bernd Lehmann Yu Jinjie Du Andao Mei Yanxiong Li Yongfeng Zang Wenshuan Holly J Stein Zhou Tafa | 2006 | Ore Geology Reviews2006，29，： | 1 |
| 16 | Nanofriction characteristics of h-BN with electric field induced electrostatic interaction显示文摘The nanofriction properties of hexagonal boron nitride(h-BN)are vital for its application as a substrate for graphene devices and solid lubricants in micro-and nano-electromechanical devices.In this work,the nanofriction characteristics of h-BN on Si/SiO_(2) substrates with a bias voltage are explored using a conductive atomic force microscopy(AFM)tip sliding on the h-BN surface under different substrate bias voltages.The results show that the nanofriction on h-BN increases with an increase in the applied bias difference(V_(t–s))between the conductive tip and the substrate.The nanofriction under negative V_(t–s) is larger than that under positive V_(t–s).The variation in nanofriction is relevant to the electrostatic interaction caused by the charging effect.The electrostatic force between opposite charges localized on the conductive tip and at the SiO2/Si interface increases with an increase in V_(t–s).Owing to the characteristics of p-type silicon,a positive V_(t–s) will first cause depletion of majority carriers,which results in a difference of nanofriction under positive and negative V_(t–s).Our findings provide an approach for manipulating the nanofriction of 2D insulating material surfaces through an applied electric field,and are helpful for designing a substrate for graphene devices. | Kemeng YU Kun ZOU Haojie LANG Yitian PENG | 2021 | Friction2021，9，6： | 0 |
| 17 | Profiling seed soluble sugar compositions in 1164 Chinese soybean accessions from major growing ecoregions显示文摘Soluble sugar is a key quality trait of soybean seeds.We developed rapid and economic extraction and quantification methods for seed soluble sugars using an ultra-high performance liquid chromatography system with a refractive index detector.We evaluated the soluble sugar compositions of 1164 soybean accessions collected from diverse ecoregions and grown in multiple locations and years.Total soluble sugar(TSS)content was influenced by accession type,year of cultivation,and ecoregion.The mean contents of fructose,glucose,sucrose,raffinose,stachyose and TSS were 3.31,5.21,55.60,6.60,35.47,and 106.19 mg g^(-1),respectively.The highest mean TSS content(108.71 mg g^(-1)) was observed in accessions from Northern Region of China.Cultivars contained higher contents of sucrose,raffinose,and TSS,whereas landraces had a higher content of stachyose.Fourteen accessions with mean TSS contents>130 mg g^(-1) were identified as elite soybean resources.TSS was correlated with sucrose,raffinose,stachyose,protein,oil and total tocopherol.The main soluble sugar components were correlated with latitude and longitude,indicating that the geographical origin of the accessions affected their seed soluble sugar compositions.The developed methods and elite identified accessions can be used in the food and feed industry and in soybean breeding programs aimed at improving soybean seed nutrition. | Jie Qi Shengrui Zhang Muhammad AzamAbdul wahab S.Shaibu Ahmed M.Abdelghany Yue Feng Yuanyuan HuaiHuoyi Feng Yitian Liu Caiyou Ma Berhane S.Gebregziabher Suprio Ghosh Jing Li Deyue Yu Bin Li Lijuan Qiu Junming Sun | 2022 | The Crop Journal2022，10，6： | 0 |
| 18 | Assessment of residual chlorine in soil microbial community using metagenomics显示文摘Chlorine-containing disinfectants have been widely used around the world for the prevention and control of the COVID-19 pandemic.However,at present,little is known about the impact of residual chlorine on the soil micro-ecological environment.Herein,we treated an experimental soil-plant-microbiome microcosm system by continuous irrigation with a low concentration of chlorine-containing water,and then analyzed the influence on the soil microbial community using metagenomics.After 14-d continuous chlorine treatment,there were no significant lasting effect on soil microbial community diversity and composition either in the rhizosphere or in bulk soil.Although metabolic functions of the rhizosphere microbial community were affected slightly by continuous chlorine treatment,it recovered to the original status.The abundance of several resistance genes changed by 7 d and recovered by 14 d.According to our results,the chlorine residue resulting from daily disinfection may present a slight long-term effect on plant growth(shoot length and fresh weight)and soil micro-ecology.In general,our study assisted with environmental risk assessments relating to the application of chlorine-containing disinfectants and minimization of risks to the environment during disease control,such as COVID-19. | Yitian Yu Qi Zhang Zhenyan Zhang Nuohan Xu Yan Li Mingkang Jin Guoqiang Feng Haifeng Qian Tao Lu | 2023 | Soil Ecology Letters2023，5，1： | 0 |
| 19 | Analysis of the Relation between Ground Electric Field and the First Lightning Strike显示文摘 | YU Aimin Sill Min LAI Shengli CHEN Yitian | 2005 | 通讯和计算机(中英文版)2005，2，3： | 0 |
| 20 | Microbiome and metabolome dysbiosis analysis in impaired glucose tolerance for the prediction of progression to diabetes mellitus显示文摘Gut microbiota and circulating metabolite dysbiosis predate important pathological changes in glucose metabolic disorders;however,comprehensive studies on impaired glucose tolerance(IGT),a diabetes mellitus(DM)precursor,are lacking.Here,we perform metagenomic sequencing and metabolomics on 47 pairs of individuals with IGT and newly diagnosed DM and 46 controls with normal glucose tolerance(NGT);patients with IGT are followed up after 4 years for progression to DM.Analysis of baseline data reveals significant differences in gut microbiota and serum metabolites among the IGT,DM,and NGT groups.In addition,13 types of gut microbiota and 17 types of circulating metabolites showed significant differences at baseline before IGT progressed to DM,including higher levels of Eggerthella unclassified,Coprobacillus unclassified,Clostridium ramosum,L-valine,L-norleucine,and L-isoleucine,and lower levels of Eubacterium eligens,Bacteroides faecis,Lachnospiraceae bacterium 3_1_46FAA,Alistipes senegalensis,Megaspaera elsdenii,Clostridium perfringens,α-linolenic acid,10E,12Z-octadecadienoic acid,and dodecanoic acid.A random forest model based on differential intestinal microbiota and circulating metabolites can predict the progression from IGT to DM(AUC=0.87).These results suggest that microbiome and metabolome dysbiosis occur in individuals with IGT and have important predictive values and potential for intervention in preventing IGT from progressing to DM. | Boxun Zhang Xuan Zhang Zhen Luo Jixiang Ren Xiaotong Yu Haiyan Zhao Yitian Wang Wenhui Zhang Weiwei Tian Xiuxiu Wei Qiyou Ding Haoyu Yang Zishan Jin Xiaolin Tong Jun Wang Linhua Zhao | 2024 | Journal of Genetics and Genomics2024，51，1： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员