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| 1 | Positive impact of adding No.14v lymph node to D2 dissection on survival for distal gastric cancer patients after surgery with curative intent显示文摘Background:D2 lymphadenectomy has been increasingly regarded as standard surgical procedure for advanced gastric cancer(GC),while the necessity of No.14 v lymph node(14v) dissection for distal GC is still controversial.Methods:A total of 920 distal GC patients receiving at least a D2 lymph node dissection in Department of Gastric Cancer,Tianjin Medical University Cancer Institute and Hospital were enrolled in this study,of whom,243 patients also had the 14 v dissected.Other 677 patients without 14 v dissection were used for comparison.Results:Forty-five(18.5%) patients had 14 v metastasis.There was no significant difference in 3-year overall survival(OS) rate between patients with and without 14 v dissection.Following stratified analysis,in TNM stages I,II,IIIa and IV,14 v dissection did not affect 3-year OS;in contrast,patients with 14 v dissection had a significant higher 3-year OS than those without in TNM stages IIIb and IIIc.In multivariate analysis,14 v dissection was found to be an independent prognostic factor for GC patients with TNM stage IIIb/IIIc disease [hazard ratio(HR),1.568;95% confidence interval(CI):1.186-2.072;P=0.002].GC patients with 14 v dissection had a significant lower locoregional,especially lymph node,recurrence rate than those without 14 v dissection(11.7 % vs.21.1%,P=0.035).Conclusions:Adding 14 v to D2 lymphadenectomy may be associated with improved 3-year OS for distal GC staged TNM Ⅲb/Ⅲc. | Yuexiang Liang Liangliang Wu Xiaona Wang Xuewei Ding Hongmin Liu Bin Li Baogui Wang Yuan Pan Rupeng Zhang Ning Liu Han Liang | 2015 | Chinese Journal of Cancer Research2015，27，6： | 22 |
| 2 | Relations between sedimentary sequence and paleoclimatic changes during last 200 ka in the southern South China Sea显示文摘Core NS-93-5 was taken from the mild slope terrace of the southern South China Sea (SCS), which has preserved the steadiness depositional record of the normal marine environment since late Quaternary. Sedimentary sequence and oxygen isotopic stratigraphy of high resolution in the near 200 ka of the southern SCS has been established. By the comparative analysis with GISP2’s ice core, the depositional record of D/O’s events 1-21 and Heinrich’s events H1-H6 in the southern SCS that reflected the quick climate change in short time scale since the last interglacial stage is revealed, which indicates that in the last 200 ka in the southern SCS and the Arctic area there was tele-connection of paleoclimate and the unstability of the Western Pacific Warm Pool. This note shows that the sedimentary layers order of this sea area classified by color identification and by oxygen isotope stratum has the very good corresponding relation. The color feature of sediment changes along with the climate and the former | Muhong Chen Xia Tu Fan Zheng Wen Yan Xianzan Tang Jun Lu Baogui Wang Miao’an Lu | 2000 | Chinese Science Bulletin2000，45，14： | 12 |
| 3 | A Truncated SVD-Based ARIMA Model for Multiple QoS Prediction in Mobile Edge Computing显示文摘In the mobile edge computing environments,Quality of Service(QoS)prediction plays a crucial role in web service recommendation.Because of distinct features of mobile edge computing,i.e.,the mobility of users and incomplete historical QoS data,traditional QoS prediction approaches may obtain less accurate results in the mobile edge computing environments.In this paper,we treat the historical QoS values at different time slots as a temporal sequence of QoS matrices.By incorporating the compressed matrices extracted from QoS matrices through truncated Singular Value Decomposition(SVD)with the classical ARIMA model,we extend the ARIMA model to predict multiple QoS values simultaneously and efficiently.Experimental results show that our proposed approach outperforms the other state-of-the-art approaches in accuracy and efficiency. | Chao Yan Yankun Zhang Weiyi Zhong Can Zhang Baogui Xin | 2022 | Tsinghua Science and Technology2022，27，2： | 9 |
| 4 | Cooperative path planning for multi-AUV in time-varying ocean flows显示文摘For low-speed underwater vehicles, the ocean currents has a great influence on them, and the changes in ocean currents is complex and continuous, thus whose impact must be taken into consideration in the path planning. There are still lack of authoritative indicator and method for the cooperating path planning. The calculation of the voyage time is a difficult problem in the time-varying ocean, for the existing methods of the cooperating path planning, the computation time will increase exponentially as the autonomous underwater vehicle(AUV) counts increase, rendering them unfeasible. A collaborative path planning method is presehted for multi-AUV under the influence of time-varying ocean currents based on the dynamic programming algorithm. Each AUV cooperates with the one who has the longest estimated time of sailing, enabling the arrays of AUV to get their common goal in the shortest time with minimum timedifference. At the same time, they could avoid the obstacles along the way to the target. Simulation results show that the proposed method has a promising applicability. | Mingyong Liu Baogui Xu Xingguang Peng | 2016 | Journal of Systems Engineering and Electronics2016，27，3： | 8 |
| 5 | Elevated preoperative plasma D-dimer dose not adversely affect survival of gastric cancer after gastrectomy with curative intent: A propensity score analysis显示文摘Objective: Elevated plasma D-dimer has been reported to be associated with advanced tumor stage and poor survival in several types of malignancies. The purpose of this study was to assess the potential impact of preoperative plasma D-dimer level(PDL) on overall survival(OS) of gastric cancer(GC) patients undergoing curative surgery by applying propensity score analysis.Methods: A total of 1,025 curatively resected GC patients in Tianjin Medical University Cancer Institute &Hospital were enrolled. Patients were categorized into two groups based on preoperative PDL: the elevated group(EG) and the normal group(NG). To overcome bias due to the different distribution of covariates for the two groups, a one-to-one match was applied using propensity score analysis, after matching, prognostic factors were analyzed.Results: In analysis for the whole study series, patients in the EG were more likely to have a larger proportion of tumor size ≥5 cm(67.5% vs. 55.8%, P=0.006), elder mean age(64.0±10.8 years vs. 60.5±11.6 years, P<0.001) and advanced tumor(T), node(N), and TNM stage. Patients with elevated PDL demonstrated a significantly lower 5-year OS than those with normal PDL(27.0% vs. 42.6%, P<0.001), however, the PDL was not an independent prognostic factor for OS in multivariate analysis [hazard ratio: 1.13, 95% confidence interval(95% CI): 0.92–1.39,P=0.236]. After matching, 163 patients in the EG and 163 patients in the NG had the same characteristics. The 5-year OS rate for patients in the EG was 27.0% compared with 25.8% for those in the NG(P=0.809, log-rank).Conclusions: The poor prognosis of GC patients with elevated preoperative PDL was due to the advanced tumor stage and elder age rather than the elevated D-dimer itself. | Yuexiang Liang Donglei He Liangliang Wu Xuewei Ding Xiaona Wang Baogui Wang Rupeng Zhang Han Liang | 2018 | Chinese Journal of Cancer Research2018，30，2： | 6 |
| 6 | An App knock-in rat model for Alzheimer’s disease exhibiting Aβand tau pathologies,neuronal death and cognitive impairments显示文摘A major obstacle in Alzheimer’s disease(AD)research is the lack of predictive and translatable animal models that reflect disease progression and drug efficacy.Transgenic mice overexpressing amyloid precursor protein(App)gene manifest non-physiological and ectopic expression of APP and its fragments in the brain,which is not observed in AD patients.The App knock-in mice circumvented some of these problems,but they do not exhibit tau pathology and neuronal death.We have generated a rat model,with three familiar App mutations and humanized Aβsequence knocked into the rat App gene.Without altering the levels of full-length APP and other APP fragments,this model exhibits pathologies and disease progression resembling those in human patients:deposit of Aβplaques in relevant brain regions,microglia activation and gliosis,progressive synaptic degeneration and AD-relevant cognitive deficits.Interestingly,we have observed tau pathology,neuronal apoptosis and necroptosis and brain atrophy,phenotypes rarely seen in other APP models.This App knock-in rat model may serve as a useful tool for AD research,identifying new drug targets and biomarkers,and testing therapeutics. | Keliang Pang Richeng Jiang Wei Zhang Zhengyi Yang Lin-Lin Li Makoto Shimozawa Simone Tambaro Johanna Mayer Baogui Zhang Man Li Jiesi Wang Hang Liu Ailing Yang Xi Chen Jiazheng Liu Bengt Winblad Hua Han Tianzi Jiang Weiwen Wang Per Nilsson Wei Guo Bai Lu | 2022 | Cell Research2022，32，2： | 6 |
| 7 | Source apportionment of ambient PM_(10) in urban areas of Wuxi,China显示文摘A total of 168 PM_(10)samples were collected during the year of 2005 at eight sites in the city of Wuxi in China.Fifteen chemical elements,three water-soluble ions,total carbon and organic carbon were analyzed.Six source categories were identified and their contributions to ambient PM_(10)in Wuxi were estimated using a nested chemical mass balance method that reduces the effects of colinearity on the chemical mass balance model.In addition,the concentrations of secondary aerosols,such as secondary organic carbon,sulfate and nitrate,were quantified.The spatially averaged PM_(10)was high in the spring and winter(123μg·m^(-3)and low in the summer-fall(90μg·m^(-3)).According to the result of source apportionment,resuspended dust was the largest contributor to ambient PM_(10),accounting for more than 50%of the PM_(10)mass.Coal combustion(14.6%)and vehicle exhaust(9.4%)were also significant source categories of ambient PM_(10).Construction and cement dust,sulfates,secondary organic carbon,and nitrates made contributions ranging between 4.1%and 4.9%.Other source categories such as steel manufacturing dust and soil dust made low contributions to ambient PM_(10). | Bo HAN Xiaohui BI Yonghua XUE Jianhui WU Tan ZHU Baogui ZHANG Jianqing DING Yuanxin DU | 2011 | Frontiers of Environmental Science & Engineering2011，5，4： | 5 |
| 8 | Outbreaks of Acute Respiratory Disease Associated with Human Adenovirus Infection in Closed Camps,China,December 2011–March 2014显示文摘Summary What is already known on this topic?Human adenovirus(HAdV)was frequently associated with acute respiratory disease(ARD)outbreaks in military camps.What is added by this report?HAdV-B7,HAdV-B14,and HAdV-B55 were determined to be responsible for 3,2,and 4 ARD outbreaks in military camps,China,respectively,with a total attack rate of 28.0%during 2011 to 2014. | Juan Du Xiaodong Zhao Fang Tang Doudou Huang Guangqian Pei Xiaoai Zhang Baogui Jiang Qingbin Lu Wei Liu Yigang Tong | 2021 | China CDC weekly2021，3，38： | 4 |
| 9 | Regional gravity field modeling based on rectangular harmonic analysis显示文摘Regional gravity field modeling with high-precision and high-resolution is one of the most important scientific objectives in geodesy,and can provide fundamental information for geophysics,geodynamics,seismology,and mineral exploration.Rectangular harmonic analysis(RHA)is proposed for regional gravity field modeling in this paper.By solving the Laplace’s equation of gravitational potential in local Cartesian coordinate system,the rectangular harmonic expansions of disturbing potential,gravity anomaly,gravity disturbance,geoid undulation and deflection of the vertical are derived,and so are the formula for signal degree variance and error degree variance of the rectangular harmonic coefficients(RHC).We also present the mathematical model and detailed algorithm for the solution of RHC using RHA from gravity observations.In order to reduce the edge effects caused by periodic continuation in RHA,we propose the strategy of extending the size of computation domain.The RHA-based modeling method is validated by conducting numerical experiments based on simulated ground and airborne gravity data that are generated from geopotential model EGM2008 and contaminated by Gauss white noise with standard deviation of 2 mGal.The accuracy of the 2.5′×2.5′geoid undulations computed from ground and airborne gravity data is 1 and 1.4cm,respectively.The standard error of the gravity disturbances that downward continued from the flight height of 4 km to the geoid is only 3.1 mGal.Numerical results confirm that RHA is able to provide a reliable and accurate regional gravity field model,which may be a new option for the representation of the fine structure of regional gravity field. | JIANG Tao LI JianCheng DANG YaMin ZHANG ChuanYin WANG ZhengTao KE BaoGui | 2014 | Science China Earth Sciences2014，57，7： | 4 |
| 10 | Heinrich layer in Antarctic marine sediments and its significance to global changes显示文摘Results of grain size analysis and rock magnetic measurements of core NP95-1 from Prydz Bay, Antarctica revealed two series of ice-rafted detritus layers, which correspond to cold climatic events, Younger Dryas and Heinrich event 1, occurring at about 11.7-10.3 and 14.3-13.6 kaB.P. respectively. Studies also show that the sequence of paleoclimatic changes in Antarctica can be correlated with that in other parts of the world, and that the millennial climate of the earth could change synchronously and globally. In addition, magnetic fabric analysis also shows a close relationship between paleoclimatic change and ocean circulation re-assemblage. | Hongrning Hou Youlang Luo Honghan Zheng Baogui Wang Xianzan Tang | 1998 | Chinese Science Bulletin1998，43，21： | 3 |
| 11 | Influence of Perioperative Blood Transfusion on Prognosis in Patients with Colon Cancer显示文摘客观:探索起作用的仙子的影响有结肠癌的病人的手术后的幸存上的输血。方法:Univariate 和 multivariateretrospective 分析总共在 10 年的一个时期期间通过手术被对待的 723 个结肠癌病人的在幸存上被执行。结果:Kaplan-Meier 估计显示出起作用的那超过 800 mL 仙子输血幸存预言者。输血显著地影响了病人的预后 40 岁并且更年轻,那些 undergoinghelicoloectomy 左边,那些与乳头状腺癌,那些与大肿瘤(直径≥ 8cm ) ,那些与阶段Ⅰ肿瘤,那些与没有肝转移的淋巴的节点转移和那些。在里面多变量分析仅仅肿瘤地点,操作的 radicality,淋巴的侵略,肝转移,肿瘤侵略的深度和 TNM 舞台保留了他们的 significance.Conclusion:Perioperative 输血是为有到某程度的结肠癌的病人的预示的因素。输血的指示必须严格地被限制,特殊比 40 岁年轻的住院病人与右边损害,乳头状腺癌,大肿瘤(直径≥ 8 厘米) ,阶段Ⅰ肿瘤和淋巴的节点转移或没有肝转移。Butperioperative 输血不能为有阶段Ⅳ疾病并且与远转移的病人是有害的。 | LIANG Han WANG Xiaona WANG Baogui PAN Yuan LIU Ning WANG Dianchang HAO Xishan | 2006 | The Chinese-German Journal of Clinical Oncology2006，5，4： | 3 |
| 12 | Mating System of Tricholoma giganteum显示文摘Microscopical examination demonstrated that Tricholoma giganteum basidia bear 4 basidiospores. Mating tests revealed that T. giganteum has a tetra-polar, heterothallic mating system. New types of factor B (Br) occurred as a result of recombination within the B-type mating factor. | FU Junsheng CAI Yanshan KE Lina LIN Shaoxia DENG Youjin XIE Baogui | 2007 | 食用菌学报2007，14，3： | 3 |
| 13 | Antihepatofibrotic effect of Guizhifuling pill(桂枝茯苓丸) on carbon tetrachloride-induced liver fibrosis in mice显示文摘OBJECTIVE: To evaluate the protective effects and the underlying mechanism of Guizhifuling pill(桂枝茯苓丸, GZFL) on carbon tetrachloride(CCl4)-induced hepatic fibrosis in mice. METHODS: Male ICR mice by intraperitoneally administered with 20% CCl4(mixed 1∶4 in soybean oil) to induce liver fibrosis. Mice that underwent CCl4 were orally with GZFL. Using hematoxylin and eosin and Masson staining to examine the pathological changes in liver tissue. Serum biochemical parameters, antioxidant enzyme activity and proinflammatory cytokines was assessed. Nuclear factor-kappa B(NF-κB) pathway and nuclear factor-erythroid 2-related factor 2(Nrf2) family members were evaluated by Western blotting. RESULTS: Our findings indicated that GZFL could effectively suppress the progression of liver fibrosis in mice, which was determined based on the improvement in liver function and reduction of collagen deposition. GZFL treatment also decreased the level of cytokines and increased the activity of antioxidant enzymes in liver tissue. Moreover, GZFL exerted anti-inflammatory and antioxidant effects through regulating the Nrf2-mediated antioxidant system and inhibiting the NF-κB pathway. CONCLUSIONS: GZFL may prevent the progression of liver fibrosis by regulating the Nrf2/heme oxygenase-1 and NF-κB signaling pathways, thereby highlighting its role in the management of liver fibrosis. | XU Baogui ZHENG Jiawen TIAN Xiaoxiao YUAN Falei LIU Zhongliang YANG Zuisu DING Xianjun | 2022 | Journal of Traditional Chinese Medicine2022，42，5： | 2 |
| 14 | Fine-Grained Topography and Modularity of the Macaque Frontal Pole Cortex Revealed by Anatomical Connectivity Profiles显示文摘The frontal pole cortex(FPC)plays key roles in various higher-order functions and is highly developed in non-human primates.An essential missing piece of information is the detailed anatomical connections for finer parcellation of the macaque FPC than provided by the previous tracer results.This is important for understanding the functional architecture of the cerebral cortex.Here,combining cross-validation and principal component analysis,we formed a tractography-based parcellation scheme that applied a machine learning algorithm to divide the macaque FPC(2 males and 6 females)into eight subareas using high-resolution diffusion magnetic resonance imaging with the 9.4 T Bruker system,and then revealed their subregional connections.Furthermore,we applied improved hierarchical clustering to the obtained parcels to probe the modular structure of the subregions,and found that the dorsolateral FPC,which contains an extension to the medial FPC,was mainly connected to regions of the default-mode network.The ventral FPC was mainly involved in the social-interaction network and the dorsal FPC in the metacognitive network.These results enhance our understanding of the anatomy and circuitry of the macaque brain,and contribute to FPC-related clinical research. | Bin He Long Cao Xiaoluan Xia Baogui Zhang Dan Zhang Bo You Lingzhong Fan Tianzi Jiang | 2020 | Neuroscience Bulletin2020，36，12： | 2 |
| 15 | Geodynamic settings of Mesozoic large-scale mineralization in North China and adjacent areas显示文摘 | Jingwen Mao Yitian Wang Zuoheng Zhang Jinjie Yu Baogui Niu | 2003 | Science in China Series D: Earth Sciences2003，，8： | 1 |
| 16 | Floristic composition and biogeography of tropical montane rain forest in southern Yunnan of China显示文摘 | Zhu Hua Wang Hong Li Baogui | 2006 | Gardens′ Bulletin Singapore2006，58，： | 1 |
| 17 | Biogeography and floristic affinity of the Limestone flora in southern Yunnan, China显示文摘 | Zhu Hua Wang Hong Li Baogui | 2003 | Annals of the Missouri Botanical Garden2003，90，3： | 1 |
| 18 | High Efficiency Hypocrellin Production by a Novel Mutant Isolated from Shiraia bambusicola显示文摘The fungus Shiraia bambusicola GZ19 M1 is biotechnologically important due to its ability to biosynthesis the pigment hypocrellins.Results showed that ethyl methane sulfonate( EMS) was effective mutagenic agent for strain and potentially produced large numbers of random mutations broadly and uniformly over the whole genome to generate unique strains. Wild-type cultures of S. bambusicola GZ19 were subjected to EMS( 80 mM) induction targeted at approximately 20% spores' survival. When surviving spores were selected in sufficient numbers and cultured on PDA medium for 7 d at 26℃,five novel mutagenized S. bambusicola strains were obtained. A mutant GZ19 M1 that exhibited an activity of more than two times over the wild strain was obtained. Also,batch experiments were carried out to achieve the suitable conditions for hypocrellin. Glucose and rice extract were the most favorable carbon and nitrogen sources for hypocrellin production by submerged culture of S. bambusicola GZ19 M1,and initial glucose and rice extract concentrations were at 35 and 250 g/L,respectively. The optimal surfactant were found to be 0. 008 V/V Tween 80,it was added into cultivation medium at 24 h. Hypocrellin concentration reached 498. 89 mg/L under optimal nutritional conditions,an increment of about 8. 70 times of hypocrellins production was observed compared with that of in non-optimized medium by the wild strain. | Wen DU Baogui WANG | 2019 | Asian Agricultural Research2019，11，2： | 1 |
| 19 | Cretaceous-early tertiary paleolatitude migration in the Sanshui basin of South China and the evolution of the South China Sea显示文摘 | Yuan Youren Wang Baogui Tang Xianzan | 1994 | Tectonophysics1994，，235： | 1 |
| 20 | Effects of precipitant on microstructure and luminescent properties of Lu2O3 : Eu^3+ nanopowders and ceramics 显示文摘 | Wang Zhifang Zhang Weiping You Baogui | 2008 | Spectrochimica Acta Part A2008，70，4： | 1 |
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