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| 1 | Lingguizhugan Decoction, a Chinese herbal formula, improves insulin resistance in overweight/obese subjects with non-alcoholic fatty liver disease: a translational approach显示文摘Lingguizhugan Decoction(LGZG)has been investigated in basic studies,with satisfactory effects on insulin resistance in non-alcoholic fatty liver disease(NAFLD).This translational approach aimed to explore the effect and underlying mechanism of LGZG in clinical setting.A randomized,double-blinded,placebo-controlled trial was performed.A total of 243 eligible participants with NAFLD were equally allocated to receive LGZG(two groups:standard dose and low dose)or placebo for 12 weeks on the basis of lifestyle modifications.The primary efficacy variable was homeostasis model assessment of insulin resistance(HOMA-IR).Analyses were performed in two populations in accordance with body mass index(BMI;overweight/obese,BMI 24 kg/m^(2);lean,BMI<24 kg/m^(2)).For overweight/obese participants,low-dose LGZG significantly decreased their HOMA-IR level compared with placebo(0.19(1.47)versus 0.08(1.99),P=0.038).For lean subjects,neither dose of LGZG showed a superior effect compared with placebo.Methylated DNA immunoprecipitation sequencing and real-time qPCR found that the DNA N6-methyladenine modification levels of protein phosphatase 1 regulatory subunit 3A(PPP1R3A)and autophagy related 3(ATG3)significantly increased after LGZG intervention in overweight/obese population.Low-dose LGZG effectively improved insulin resistance in overweight/obese subjects with NAFLD.The underlying mechanism may be related to the regulation of DNA N6-methyladenine modification of PPP1R3A and ATG3.Lean subjects may not be a targeted population for LGZG. | Liang Dai Jingjuan Xu Baocheng Liu Yanqi Dang Ruirui Wang Lijie Zhuang Dong Li Lulu Jiao Jianying Wang Lei Zhang Linda LDZhong Wenjun Zhou Guang Ji | 2022 | Frontiers of Medicine2022，16，5： | 7 |
| 2 | The receptor-like cytoplasmic kinase RIPK regulates broad-spectrum ROS signaling in multiple layers of plant immune system显示文摘Production of reactive oxygen species(ROS)via the activity of respiratory burst oxidase homologs(RBOHs)plays a vital role in multiple layers of the plant immune system,including pathogen-associated molecular pattern-triggered immunity(PTI),damage-associated molecular pattern-triggered immunity(DTI),effector-triggered immunity(ETI),and systemic acquired resistance(SAR).It is generally established that RBOHD is activated by different receptor-like cytoplasmic kinases(RLCKs)in response to various immune elicitors.In this study,we showed that RPM1-INDUCED PROTEIN KINASE(RIPK),an RLCK VII subfamily member,contributes to ROS production in multiple layers of plant immune system.The ripk mutants showed reduced ROS production in response to treatment with all examined immune elicitors that trigger PTI,DTI,ETI,and SAR.We found that RIPK can directly phosphorylate the N-terminal region of RBOHD in vitro,and the levels of phosphorylated S343/S347 residues of RBOHD are sigfniciantly lower in ripk mutants compared with the wild type upon treatment with all tested immune elicitors.We further demonstrated that phosphorylation of RIPK is required for its function in regulating RBOHD-mediated ROS production.Similar to rbohd,ripk mutants showed reduced stomatal closure and impaired SAR,and were susceptible to the necrotrophic bacterium Pectobacterium carotovorum.Collectively,our results indicate that RIPK regulates broad-spectrum RBOHD-mediated ROS signaling during PTI,DTI,ETI,and SAR,leading to subsequent RBOHD-dependent immune responses. | Ping Li Lulu Zhao Fan Qi Nang Myint Phyu Sin Htwe Qiuying Li Dawei Zhang Fucheng Lin Keke Shang-Guan Yan Liang | 2021 | Molecular Plant2021，14，10： | 5 |
| 3 | An Efficient Bar Code Image Recognition Algorithm for Sorting System显示文摘In the sorting system of the production line,the object movement,fixed angle of view,light intensity and other reasons lead to obscure blurred images.It results in bar code recognition rate being low and real time being poor.Aiming at the above problems,a progressive bar code compressed recognition algorithm is proposed.First,assuming that the source image is not tilted,use the direct recognition method to quickly identify the compressed source image.Failure indicates that the compression ratio is improper or the image is skewed.Then,the source image is enhanced to identify the source image directly.Finally,the inclination of the compressed image is detected by the barcode region recognition method and the source image is corrected to locate the barcode information in the barcode region recognition image.The results of multitype image experiments show that the proposed method is improved by 5+times computational efficiency compared with the former methods,and can recognize fuzzy images better. | Desheng Zheng Ziyong Ran Zhifeng Liu Liang Li Lulu Tian | 2020 | Computers, Materials & Continua2020，，9： | 3 |
| 4 | A compact polarization-integrated long wavelength infrared focal plane array based on In As/GaSb superlattice显示文摘Real-time polarization imaging plays a vital role in target detection,recognition,and tracking in complex scenes.However,large optical crosstalk and the integration technology are difficult problems in the development of polarization-integrated infrared detectors.We demonstrate a monolithic long wavelength infrared(LWIR)In As/Ga Sb superlattice focal plane array(FPA)integrated with the polarizer.To obtain high performance and real-time polarization imaging devices,the parameters of the grating were optimized and the optical crosstalk between adjacent polarization bands was studied.We analyze the light diffraction depending on the distance between the polarizer and photosensitive elements and the coupling between oblique incident light and device.The fabrication process of the antireflective polarizer,the integration technology of the polarizer and the FPA composed of 512×4×3 pixels were explored.Finally,a polarization integrated focal plane array(PI-FPA)was fabricated to detect polarized light with different oscillating directions.The large response extinction ratio of corresponding polarization bands was measured as 50:1,49:1,and 44:1 of 0°,60°,and 120°,respectively. | Jian ZHOU Yi ZHOU Ying SHI Fangfang WANG Zhicheng XU Zhizhong BAI Min HUANG Lulu ZHENG Zhaoming LIANG Yihong ZHU Qingqing XU Yiming SHEN Xiangxiao YING Jianxin CHEN | 2022 | Science China(Information Sciences)2022，65，2： | 2 |
| 5 | Core clock component MtLUX controls shoot architecture through repression of MtTB1/MtTCP1A in Medicago truncatula显示文摘Plants are capable of regulating their shoot architecture in response to diverse internal and external environments.The circadian clock is an adaptive mechanism that integrates information from internal and ambient conditions to help plants cope with recurring environmental fluctuations.Despite the current understanding of plant circadian clock and genetic framework underlying plant shoot architecture,the intricate connection between these two adaptive mechanisms remains largely unclear.In this study,we elucidated how the core clock gene LUX ARRHYTHMO(LUX)regulates shoot architecture in the model legume plant Medicago truncatula.We show that mtlux mutant displays increased main stem height,reduced lateral shoot length,and decreased the number of lateral branches and biomass yield.Gene expression analysis revealed that Mt LUX regulated shoot architecture by repressing the expression of strigolactone receptor MtD14 and MtTB1/MtTCP1A,a TCP gene that functions centrally in modulating shoot architecture.In vivo and in vitro experiments showed that Mt LUX directly binds to a cis-element in the promoter of MtTB1/MtTCP1A,suggesting that Mt LUX regulates branching by rhythmically suppressing MtTB1/MtTCP1A.This work demonstrates the regulatory effect of the circadian clock on shoot architecture,offering a new understanding underlying the genetic basis towards the flexibility of plant shoot architecture. | Liping Wang Anqi Zhou Lulu Wang Jing Li Mingkang Yang Tingting Duan Jian Jin Liang Chen Liangfa Ge Wei Huang | 2023 | The Crop Journal2023，11，3： | 2 |
| 6 | Ultrasound-induced biophysical effects in controlled drug delivery显示文摘Ultrasound is widely used in biomedical engineering and has applications in conventional diagnosis and drug delivery.Recent advances in ultrasound-induced drug delivery have been summarized previously in several reviews that have primarily focused on the fabrication of drug delivery carriers.This review discusses the mechanisms underlying ultrasound-induced drug delivery and factors affecting delivery efficiency,including the characteristics of drug delivery carriers and ultrasound parameters.Firstly,biophysical effects induced by ultrasound,namely thermal effects,cavitation effects,and acoustic radiation forces,are illustrated.Secondly,the use of these biophysical effects to enhance drug delivery by affecting drug carriers and corresponding tissues is clarified in detail.Thirdly,recent advances in ultrasound-triggered drug delivery are detailed.Safety issues and optimization strategies to improve therapeutic outcomes and reduce side effects are summarized.Finally,current progress and future directions are discussed. | Lulu Zhang Zhuohua Lin Lan Zeng Fan Zhang Lihong Sun Suhui Sun Ping Wang Menghong Xu Jinxia Zhang Xiaolong Liang Huiyu Ge | 2022 | Science China(Life Sciences)2022，65，5： | 2 |
| 7 | BnVIR:bridging the genotype-phenotype gap to accelerate mining of candidate variations underlying agronomic traits in Brassica napus显示文摘Dear Editor,Genetic variations,which range from single nucleotide polymor-phisms(SNPs)and short insertion/deletions(InDels)to large-scale structural variations(SVs),are the basis of phenotypic diversity.Understanding the effect of genetic variations on traits is critical for uncovering the genetic architecture of various phe-notypes. | Zhiquan Yang Congyuan Liang LuLu Wei Shengbo Wang Feifan Yin Dongxu Liu Liang Guo Yongming Zhou Qing-Yong Yang | 2022 | Molecular Plant2022，15，5： | 2 |
| 8 | Solid-state electrolytes for solid-state lithium-sulfur batteries:Comparisons,advances and prospects显示文摘Compared with other secondary batteries,lithium-sulfur batteries(LSBs)have unparalleled advantages such as high energy density,low cost,etc.In liquid LSB systems,it is extremely easy to cause severe‘‘shuttle effecto and safety issues.Hence,the development of solid-state LSBs(SSLSBs)has been attracting much more attention.As the most essential part of the SSLSBs,the solid-state electrolyte(SSE)has received significant attention from researchers.In this review,we concentrate on discussing the core of SSLSBs,which is the SSE.Moreover,we also highlight the differences in the properties of the different SSEs,which are polymer-based electrolytes and ceramic-based electrolytes.In addition,the challenges and advances in different types of SSEs are also compared and described systematically.Furthermore,the prospects for new SSE systems and the design of effective SSE structures to achieve highperformance SSLSBs are also discussed.Thus,this review is expected to give readers a comprehensive and systematic understanding of SSEs for SSLSBs. | Xin Liang Lulu Wang Xiaolong Wu Xuyong Feng Qiujie Wu Yi Sun Hongfa Xiang Jiazhao Wang | 2022 | Journal of Energy Chemistry2022，31，10： | 2 |
| 9 | The potential distribution of adult Antarctic krill in the Amundsen Sea显示文摘Antarctic krill is the key species of ecological system in the Amundsen Sea.At present,the suitable distribution is unobtainable by scientifi c surveys or data from the fi shery.In this paper,the maximum entropy algorithm(Maxent)was used to obtain the potential distribution of adult Antarctic krill in order to provide useful information and reasonable reference for the policy on protecting potential krill habitats around the Amundsen Sea.Occurrence points and 17 environmental variables were used to simulate the distributions.Results show that the high and moderate suitable habitats lie between 65°S and 72°S in the Amundsen Sea.The high suitable habitat accounts for 8.1%of the total area of the Amundsen Sea.The sea ice persistence(ICE),total phytoplankton(PHYC),and the minimum value of dissolved iron(Fe_min)are the three dominant contributors to the model.Results from the response curves show that Antarctic krill preferred habitats with ICE of 0.42-0.93,PHYC of 2.48-2.77 mmol/m^(3) and Fe_min of(7.10×10^(-5))-(9.45×10^(-5))mmol/m 3.Positive trends existed in the PHYC of the high and moderate suitable habitat,and a positive trend existed in the Fe_min of moderate suitable habitat.However,the probability of presence of Antarctic krill will decrease if the increase of the PHYC and Fe_min continues. | Jianlong FENG Lulu LIU Qiulin LIU Liang ZHAO | 2022 | Journal of Oceanology and Limnology2022，40，4： | 1 |
| 10 | Rnf20 deficiency in adipocyte impairs adipose tissue development and thermogenesis显示文摘RNF20,an E3 ligase critical for monoubiquitination of histone H2B at lysine 120(H2Bub),has been implicated in the regulation of various cellar processes;however,its physiological roles in adipocytes remain poorly characterized.Here,we report that the adipocyte-specific knockout of Rnf20(ASKO)in mice led to progressive fat toss,organomegaly and hyperinsulinemia.Despite signs of hyperinsulinemia,normal insulin sensitivity and improved glucose tolerance were observed in the young and aged CD-fed ASKO mice.In addition,high-fat diet-fed ASKO mice developed severe liver steatosis.Moreover,we observed that the ASKO mice were extremely sensitive to a cold environment due to decreased expression levels of brown adipose tissue(BAT)selective genes,including uncoupling protein 1(l/cpf),and impaired mitochondrial functions.Significantly decreased levels of peroxisome proliterator-activated receptor gamma(Ppary)were observed in the gonadal white adipose tissues(gWAT)from the ASKO mice,suggesting that Rnf20 regulates adipogenesis,at least in part,through Ppary.Rosiglitazone-treated ASKO mice exhibited increased fat mass compared to that of the non-treated ASKO mice.Collectively,our results illustrate the critical role of RNF20 in control of white and brown adipose tissue development and physiological function. | Xiaojuan Liang Cong Tao Jianfei Pan Lilan Zhang Lulu Liu Ying Zhao Yiping Fan Chunwei Cao Jiali Liu Jin Zhang Sin Man Lam Guanghou Shui Wanzhu Jin Wei Li Jianguo Zhao Kui Li Yanfang Wang | 2021 | Protein & Cell2021，12，6： | 1 |
| 11 | High speed small gauge anterior vitrectomy cutter for scleral fixated intraocular lens implantation显示文摘● AIM: To report the outcomes of anterior vitrectomy using high speed cutter for scleral fixated intraocular lens(SFIOL) implantation in patients with posterior capsular rupture.● METHODS: Medical records of 51 patients with posterior capsular rupture who received high speed cutter anterior vitrectomy via limbal incision with SFIOL implantation from June 2011 to December 2013 were reviewed retrospectively for visual outcomes and complications.● RESULTS: Totally 51 eyes of 51 patients were identified(23 males and 28 females). Mean age at surgery was 67.2±15y(range 27-91y), with mean follow-up of 23±8.2mo(range 12-40mo). The 49(96.1%) eyes had improvement or unchanged of final postoperative visual acuity. The most common complication was vitreous haemorrhage(5.9%) and transient rise in intraocular pressure(5.9%) which all spontaneously resolved● CONCLUSION: High speed cutter anterior vitrectomy via limbal incision is a safe and effective method for those with posterior capsular rupture for SFIOL implantation. | Yuan Bo Liang Yoly Y.Y. FonG Lulu L. Cheng Alvin L. Young | 2017 | International Journal of Ophthalmology(English edition)2017，10，1： | 1 |
| 12 | Emergency medical rescue efforts after a major earthquake: lessons from the 2008 Wenchuan earthquake显示文摘 | Lulu Zhang Xu Liu Youping Li Yuan Liu Zhipeng Liu Juncong Lin Ji Shen Xuefeng Tang Yi Zhang Wannian Liang | 2012 | The Lancet2012，，9818： | 1 |
| 13 | Integrated strategies for chemotherapy cycles in nasopharyngeal carcinoma patients: Real-world data from two epidemic centers guiding decision-making显示文摘objective:Two cycles of induction chemotherapy(IC)followed by 2 cycles of platinum-based concurrent chemoradiotherapy(CCRT)(2IC+2CCRT)for locoregionally advanced nasopharyngeal carcinoma(LA-NPC)is widely adopted but not evidence-confirmed.This study aimed to determine the clinical value of 2IC+2CCRT regarding efficacy,toxicity and cost-effectiveness.Methods:This real-world study from two epidemic centers used propensity score matching(PSM)and inverse probability of treatment weighting(IPTW)analyses.The enrolled patients were divided into three groups based on treatment modality:Group A(2IC+2CCRT),Group B(3IC+2CCRT or 2IC+3CCRT)and Group C(3IC+3CCRT).Long-term survival,acute toxicities and cost-effectiveness were compared among the groups.We developed a prognostic model dividing the population into high-and low-risk cohorts,and survivals including overall survival(OS),progression-free survival(PFS),distant metastasis-free survival(DMFS)and locoregional relapse-free survival(LRRFS)were compared among the three groups according to certain risk stratifications.Results:Of 4,042 patients,1,175 were enrolled,with 660,419,and 96 included in Groups A,B and C,respectively.Five-year survivals were similar among the three groups after PSM and confirmed by IPTW.Grade 3-4 neutropenia and leukocytopenia were significantly higher in Groups C and B than in Group A(52.1%vs.41.5%vs.25.2%;41.7%vs.32.7%vs.25.0%)as were grade 3-4 nausea/vomiting and oral mucositis(29.2%vs.15.0%vs.6.1%;32.3%vs.25.3%vs.18.0%).Cost-effective analysis suggested that 2IC+2CCRT was the least expensive,while the health benefits were similar to those of the other groups.Further exploration showed that 2IC+2CCRT tended to be associated with a shorter PFS in high-risk patients,while 3IC+3CCRT potentially contributed to poor PFS in low-risk individuals,mainly reflected by LRRFS.Conclusions:In LA-NPC patients,2IC+2CCRT was the optimal choice regarding efficacy,toxicity and costeffectiveness;however,2IC+2CCRT and 3IC+3CCRT probably shortened LRRFS in high-and low-risk populations,respectively. | Zejiang Zhan Yingying Huang Jiayu Zhou Zhuochen Cai Haoyang Huang Ying Deng Wenze Qiu Xun Cao Xi Chen Chixiong Liang Lulu Zhang Xiang Guo Taize Yuan Xing Lyu | 2023 | Chinese Journal of Cancer Research2023，35，2： | 1 |
| 14 | A Bottom‐Up Approach to Build 3D Architectures from Nanosheets for Superior Lithium Storage显示文摘 | Yongji Gong Shubin Yang Liang Zhan Lulu Ma Robert Vajtai Pulickel M. Ajayan | 2014 | Adv Funct Mater2014，，1： | 1 |
| 15 | Ovarian cancer cells with the CD117 phenotype are highly tumorigenic and are related to chemotherapy outcome显示文摘 | Lijing Luo Jianfang Zeng Bing Liang Zhe Zhao Lulu Sun Dongyan Cao Jiaxin Yang Keng Shen | 2011 | Experimental and Molecular Pathology2011，，2： | 1 |
| 16 | Science with the 2.5-meter Wide Field Survey Telescope(WFST)显示文摘The Wide Field Survey Telescope(WFST) is a dedicated photometric surveying facility being built jointly by University of Science and Technology of China(USTC) and the Purple Mountain Observatory(PMO). It is equipped with a 2.5-meter diameter primary mirror, an active optics system, and a mosaic CCD camera with 0.73 gigapixels on the primary focal plane for highquality image capture over a 6.5-square-degree field of view. The installation of WFST near the summit of Saishiteng mountain in the Lenghu region is scheduled in summer of 2023, and the operation is planned to start three months later. WFST will scan the northern sky in four optical bands(u, g, r and i) at cadences from hourly/daily in the deep high-cadence survey(DHS) program, to semi-weekly in the wide field survey(WFS) program. During a photometric night, a nominal 30 s exposure in the WFS program will reach a depth of 22.27, 23.32, 22.84, and 22.31(AB magnitudes) in these four bands, respectively, allowing for the detection of a tremendous amount of transients in the low-z universe and a systematic investigation of the variability of Galactic and extragalactic objects. In the DHS program, intranight 90 s exposures as deep as 23(u) and 24 mag(g), in combination with target of opportunity follow-ups, will provide a unique opportunity to explore energetic transients in demand for high sensitivities, including the electromagnetic counterparts of gravitational wave events, supernovae within a few hours of their explosions,tidal disruption events and fast, luminous optical transients even beyond redshift of unity. In addition, the final 6-year co-added images, anticipated to reach g■25.8 mag in WFS or 1.5 mags deeper in DHS, will be of fundamental importance to general Galactic and extragalactic science. The highly uniform legacy surveys of WFST will serve as an indispensable complement to those of the Vera C. Rubin Observatory's Legacy Survey of Space and Time(LSST) that monitors the southern sky. | Tinggui Wang Guilin Liu Zhenyi Cai Jinjun Geng Min Fang Haoning He Ji-an Jiang Ning Jiang Xu Kong Bin Li Ye Li Wentao Luo Zhizheng Pan Xuefeng Wu Ji Yang Jiming Yu Xianzhong Zheng Qingfeng Zhu Yi-Fu Cai Yuanyuan Chen Zhiwei Chen Zigao Dai Lulu Fan Yizhong Fan Wenjuan Fang Zhicheng He Lei Hu Maokai Hu Zhiping Jin Zhibo Jiang Guoliang Li Fan Li Xuzhi Li Runduo Liang Zheyu Lin Qingzhong Liu Wenhao Liu Zhengyan Liu Wei Liu Yao Liu Zheng Lou Han Qu Zhenfeng Sheng Jianchun Shi Yiping Shu Zhenbo Su Tianrui Sun Hongchi Wang Huiyuan Wang Jian Wang Junxian Wang Daming Wei Junjie Wei Yongquan Xue Jingzhi Yan Chao Yang Ye Yuan Yefei Yuan Hongxin Zhang Miaomiao Zhang Haibin Zhao Wen Zhao | 2023 | Science China(Physics,Mechanics & Astronomy)2023，66，10： | 1 |
| 17 | Simulation-Guided Design of Bamboo Leaf-Derived Carbon-Based High-Efficiency Evaporator for Solar-Driven Interface Water Evaporation显示文摘Solar interface water evaporation has been demonstrated to be an advanced method for freshwater production with high solar energy utilization.The development of evaporators with lower cost and higher efficiency is a key challenge in the manufacture of practical solar interface water evaporation devices.Herein,a bamboo leaf-derived carbon-based evaporator is designed based on the light trace simulation.And then,it is manufactured by vertical arrangement and carbonization of bamboo leaves and subsequent polyacrylamide modification.The vertically arranged carbon structure can extend the light path and increase the light-absorbing area,thus achieving excellent light absorption.Furthermore,the continuous distribution of polyacrylamide hydrogel between these vertical carbons can support high-speed water delivery and shorten the evaporation path.Therefore,this evaporator exhibits an ultrahigh average light absorption rate of~96.1%,a good water evaporation rate of 1.75 kg m^(-2) h^(-1),and an excellent solar-to-vapor efficiency of 91.9%under one sun irradiation.Furthermore,the device based on this evaporator can effectively achieve seawater desalination,heavy metal ion removal,and dye separation while completing water evaporation.And this device is highly available for actual outdoor applications and repeated recycling. | Yitian Wu Rui Kong Chaoliang Ma Lanze Li Yu Zheng Yingzhuo Lu Lulu Liang Yajun Pang Qiang Wu Zhehong Shen Hao Chen | 2022 | Energy & Environmental Materials2022，5，4： | 1 |
| 18 | Effi- cient Event Detecting Protocol in Event-Driven Wire- less Sensor Networks 显示文摘 | Liang Lulu Gao Deyun Zhang Hongke | 2012 | Sensors Journal IEEE2012，12，6： | 1 |
| 19 | Combination of ultrasonication/mechanical refining with alkali treatment to improve the accessibility and porosity of bamboo cellulose fibers for the preparation of magnetic bionanocomposite cellulose beads显示文摘Ultrasonication and mechanical refining pretreatments were carried out to enhance alkali swelling of bamboo fibers to improve accessibility and porosity.Cellulose-based magnetic beads were synthesized with the alkali swollen bamboo fibers and Fe3O4 nanoparticles.Compared to the fibers treated with alkali alone,the water retention value(WRV)increased by 33.87%for the fibers treated by sonication and alkali,and by 94.58%for those treated by mechanical refining and alkali.The increased WRV was attributed to disruption of the crystalline region of fibers in the combined treatments which resulted in decreased crystallinity and degree of polymerization of cellulose.Furthermore,compared with the control sample which was treated by alkali alone,the specific surface area and pore volume of the samples treated by the combined processes increased markedly,which favored the adsorption of Fe3O4 nanoparticles in the synthesis of functional magnetic cellulose beads for the applications of protein immobilization,drug carrier and wastewater treatment. | Man Li Guigan Fang Zhaosheng Cai Long Liang Jing Zhou Lulu Wei | 2018 | Journal of Bioresources and Bioproducts2018，3，2： | 0 |
| 20 | Targeted drug delivery strategies for the treatment of rheumatoid arthritis显示文摘A chronic autoimmune disease named rheumatoid arthritis(RA)is characterized mainly by synovitis,which has high morbidity,disability and mortality rates.In addition,the aetiology and pathogenesis of RA have not been fully determined.RA is usually accompanied by persistent arthritic pain,swelling,stiffness,and functional disorders;in severe cases,it may result in cardiovascular,pulmonary,psychological and skeletal diseases(Scott et al.,2010). | Jinxia Zhang Ling Jiang Lihong Sun Ping Wang Suhui Sun Menghong Xu Lulu zhang Shumin Wang Xiaolong Liang Ligang Cui | 2021 | Science China(Life Sciences)2021，64，7： | 0 |
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