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| 1 | Erianin,a novel dibenzyl compound in Dendrobium extract,inhibits lung cancer cell growth and migration via calcium/calmodulin-dependent ferroptosis显示文摘Ferroptosis,a novel form of programmed cell death,is characterized by iron-dependent lipid peroxidation and has been shown to be involved in multiple diseases,including cancer.Stimulating ferroptosis in cancer cells may be a potential strategy for cancer therapy.Therefore,ferroptosis-inducing drugs are attracting more attention for cancer treatment.Here,we showed that erianin,a natural product isolated from Dendrobium chrysotoxum Lindl,exerted its anticancer activity by inducing cell death and inhibiting cell migration in lung cancer cells.Subsequently,we demonstrated for the first time that erianin induced ferroptotic cell death in lung cancer cells,which was accompanied by ROS accumulation,lipid peroxidation,and GSH depletion.The ferroptosis inhibitors Fer-1 and Lip-1 but not Z-VAD-FMK,CQ,or necrostatin-1 rescued erianin-induced cell death,indicating that ferroptosis contributed to erianin-induced cell death.Furthermore,we demonstrated that Ca^(2+)/CaM signaling was a critical mediator of erianin-induced ferroptosis and that blockade of this signaling significantly rescued cell death induced by erianin treatment by suppressing ferroptosis.Taken together,our data suggest that the natural product erianin exerts its anticancer effects by inducing Ca^(2+)/CaMdependent ferroptosis and inhibiting cell migration,and erianin will hopefully serve as a prospective compound for lung cancer treatment. | Peng Chen Qibiao Wu Jiao Feng Lili Yan Yitian Sun Shuiping Liu Yu Xiang Mingming Zhang Ting Pan Xiaying Chen Ting Duan Lijuan Zhai Bingtao Zhai Wengang Wang Ruonan Zhang Bi Chen Xuemeng Han Yicong Li Liuxi Chen Ying Liu Xingxing Huang Ting Jin Wenzheng Zhang Hong Luo Xiaohui Chen Yongqiang Li Qiujie Li Guohua Li Qin Zhang Lvjia Zhuo Zuyi Yang Huifen Tang Tian Xie Xiaoping Ouyang Xinbing Sui | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 42 |
| 2 | Wnt/β-catenin signaling in cancers and targeted therapies显示文摘Wnt/β-catenin signaling has been broadly implicated in human cancers and experimental cancer models of animals.Aberrant activation of Wnt/β-catenin signaling is tightly linked with the increment of prevalence,advancement of malignant progression,development of poor prognostics,and even ascendence of the cancer-associated mortality.Early experimental investigations have proposed the theoretical potential that efficient repression of this signaling might provide promising therapeutic choices in managing various types of cancers.Up to date,many therapies targeting Wnt/β-catenin signaling in cancers have been developed,which is assumed to endow clinicians with new opportunities of developing more satisfactory and precise remedies for cancer patients with aberrant Wnt/β-catenin signaling. | Fanyuan Yu Changhao Yu Feifei Li Yanqin Zuo Yitian Wang Lin Yao Chenzhou Wu Chenglin Wang Ling Ye | 2021 | Signal Transduction and Targeted Therapy2021，6，9： | 8 |
| 3 | Effect of electroacpuncture of Neiguan(PC 6)and Tianquan(PC 2)on skin temperature,blood perfusion,and adrenoceptor response in rats with acute myocardial ischemia显示文摘OBJECTIVE: To investigate the effect of electroacupuncture(EA) of acupoints Neiguan(PC 6) and Tianquan(PC 2) on the skin temperature, blood perfusion, and alpha1-and beta2-adrenoreceptor(α1-AR and β2-AR) protein and m RNA level in rats with acute myocardial ischemia.METHODS: Thirty male adult Wistar rats [(230 ±20) g] were randomly assigned into five groups(n = 6 each): a control group, sham operation group, model group, model group treated with EA at low frequency(L-EA, 2 Hz, 1 m A) and model group treated with EA at high frequency(H-EA, 100 Hz, 1 m A). The rat model was prepared by ligating the left anterior descending coronary artery. Electroacupuncture was performed at the left Neiguan(PC 6) for 20 min daily for 3 d. After the 3 rd time of the treatment, measurements of skin blood perfusion and temperature in Neiguan(PC 6) and Tianquan(PC 2) in all groups were made by laser speckle contrast imaging and infrared thermal image instrument. Real-time PCR and ELISA were used to measure m RNA level and protein level of α1-AR andβ2-AR in the skin tissues of Neiguan(PC 6) and Tianquan(PC 2), respectively. Serum levels of c Tn T and electrocardiogram were used to identify the state of myocardium.RESULTS: In the group receiving electroacupunture at Neiguan(PC 6), compared with control group,the skin temperature, blood perfusion, and β2-AR m RNA and protein level of model group significantly decreased(P < 0.05), α1-AR m RNA and protein level of model group significantly increased(P < 0.05);compared with model group, the skin temperature,blood perfusion, and β2-AR m RNA and protein level of L-EA significantly increased(P < 0.05), α1-AR m RNA and protein level of L-EA and H-EA significantly decreased(P < 0.05). The same trend has taken place in the former four groups of the Tianquan(PC 2).CONCLUSION: Low-or high-frequency electroacupuncture can improve the skin temperature and blood perfusion which may be induced by decreasingthelevelofα1-ARandincreasingthelevelofβ2-AR of the Neiguan(PC 6) and Tianquan(PC 2) in the rat with acute myocaidial ischemia. | Wang Dan Ji Bo Zhao Guozhen Yan Mingna Bai Hongxin Sun Xiaomin Dai Jian Lu Yawen Liu Yitian You Min Wu Jiaojuan Ge Yunpeng Su Hang Cheng Kai | 2017 | Journal of Traditional Chinese Medicine2017，37，6： | 3 |
| 4 | 基于数值仿真的全箭动特性获取技术显示文摘and then in the absence of test data to establish the dynamic model.The issue was,how to accurately obtain the mode data of LM-8 with numerical simulations which directly affects the control reliability of flight.In this paper,various approaches to obtain the dynamic characteristics of LM-8 are described from the perspective of refined dynamic modeling and simulating,mode slope prediction,vertical modal test,etc.The numerical simulations were found to be in good agreement with the experimental data,and satisfied the requirements for the engineering application,which effectively supported the successful maiden flight mission of LM-8. | YANG Shutao YUAN He XU Shanshu WU Yitian SONG Zhengyu | 2021 | Aerospace China2021，22，2： | 2 |
| 5 | Fabrication and biological evaluation of 3D-printed calcium phosphate ceramic scaffolds with distinct macroporous geometries through digital light processing technology显示文摘Digital light processing(DLP)-based 3D printing technique holds promise in fabricating scaffolds with high precision.Here raw calcium phosphate(CaP)powders were modified by 5.5%monoalcohol ethoxylate phosphate(MAEP)to ensure high solid loading and low viscosity.The rheological tests found that photocurable slurries composed of 50wt%modified CaP powders and 2wt%toners were suitable for DLP printing.Based on geometric models designed by computer-aided design(CAD)system,three printed CaP ceramics with distinct macroporous structures were prepared,including simple cube,octet-truss and inverse face-centered cube(fcc),which presented the similar phase composition and microstructure,but the different macropore geometries.Inverse fcc group showed the highest porosity and compressive strength.The in vitro and in vivo biological evaluations were performed to compare the bioactivity of three printed CaP ceramics,and the traditional foamed ceramic was used as control.It suggested that all CaP ceramics exhibited good biocompatibility,as evidence by an even bone-like apatite layer formation on the surface,and the good cell proliferation and spreading.A mouse intramuscular implantation model found that all of CaP ceramics could induce ectopic bone formation,and foam group had the strongest osteoinduction,followed by inverse fcc,while cube and octet-truss had the weakest one.It indicated that macropore geometry was of great importance to affect the osteoinductivity of scaffolds,and spherical,concave macropores facilitated osteogenesis.These findings provide a strategy to design and fabricate high-performance orthopedic grafts with proper pore geometry and desired biological performance via DLP-based 3D printing technique. | Jing Wang Yitao Tang Quanle Cao Yonghao Wu Yitian Wang Bo Yuan Xiangfeng Li Yong Zhou Xuening Chen Xiangdong Zhu Chongqi Tu Xingdong Zhang | 2022 | Regenerative Biomaterials2022，9，1： | 2 |
| 6 | Inactivation efficiency of slightly acidic electrolyzed water against microbes on facility surfaces in a disinfection channel显示文摘Slightly acidic electrolyzed water(SAEW,pH 6.0-6.5)is an ideal and environmentally-friendly disinfectant,which was used to prevent and control bacterial infections on farms.This work aims to investigate the inactivation effectiveness of SAEW in inactivating microbes in a disinfection channel.The bactericidal efficiency of SAEW on equipment surfaces was compared to two commercial disinfectants,Kuei A bromide solution(KAS,5:1000 v/v)and Glutaraldehyde solution(GS,5:1000 v/v).The disinfection effectiveness of SAEW in inactivating Salmonella enteritidis(S.enteritidis)on equipment surfaces in the disinfection channel was evaluated,and a model was developed using multiple linear regression analysis.Results indicated that SAEW was significantly(p<0.05)more efficient than KAS and GS on kits and clothing in the disinfection channel at 1 min.The SAEW did not contribute as aggressively to respiratory difficulty as KAS and GS.Maximum reductions of 2.362 log10 CFU/cm^(2),2.613 log10 CFU/cm^(2) and 2.359 log10 CFU/cm^(2) for Salmonella enteritidis were obtained from clothing surfaces,iron materials,and kits treated with SAEW for 2.5 min at a chlorine concentration of 220 mg/L.Moreover,the established model had a good fit-quantified by the determination coefficient R^(2)(0.939)and a lack of fit test(p>0.05).In addition,available chlorine concentration(ACC)was an important factor than other factors,and the inactivation efficiency of Salmonella enteritidis sprayed by SAEW treatment was different between iron materials,kits and clothing surfaces(iron>kit>clothing). | Zang Yitian Li Baoming Shi Zhengxiang Sheng Xiaowei Wu Hongxiang Shu Dengqun | 2017 | International Journal of Agricultural and Biological Engineering2017，10，6： | 2 |
| 7 | Graphene oxide coated three-dimensional printed biphasic calcium phosphate scaffold for angiogenic and osteogenic synergy in repairing critical-size bone defect显示文摘The custom-tailored medicine requires a developmental strategy that integrates excellent osteogene-sis with mechanical stability to enhance the reconstruction of the critical-size bone defect(CSBD)and the healing process in weight-bearing bone.We prepared three-dimensional(3D)printed biphasic cal-cium phosphate(BCP)scaffolds composited with nano-graphene oxide(GO).The biological effects of the GO/BCP composite scaffolds could induce the differentiation of rat bone marrow stem cells(BM-SCs)and the migration of human umbilical vein endothelial cells(HUVECs)for bone repair.The proper ratio of GO in the composite scaffold regulated the composites’surface roughness and hydrophilicity to a suitable range for the adhesion and proliferation of BMSCs and HUVECs.Besides,the GO/BCP composite scaffold increased osteogenesis and angiogenesis by activating BMP-2,RUNX-2,Smad1/4,and VEGF.The customized intramedullary nail combined with GO/BCP scaffold was applied to repair CSBD(2.0 cm in length)in a beagle femur model.This fixation strategy was confirmed by finite element analysis.In vivo,the results indicated that the custom-made internal fixation provided sufficient stability in the early stage,ensuring bone healing in a considerable mechanical environment.At 9 months postoperatively,longitudi-nal bony union and blood vessels in osteon were observed in the CSBD area with partial degradation in the 0.3%GO/BCP group.In the three-point bending test,the ultimate load of 0.3%GO/BCP group reached over 50%of the normal femur at 9 months after repair.These results showed a promising application of osteogenic GO/BCP scaffold and custom-made intramedullary nails in repairing CSBD of the beagle femur.This effective strategy could provide an option to treat the clinical CSBD in weight-bearing bones. | Yitian Wang Yonghao Wu Yuqi Zhang Xiangfeng Li Li Min Quanle Cao Yi Luo Xiao Yang Minxun Lu Yong Zhou Xiangdong Zhu Chongqi Tu Xingdong Zhang | 2023 | Journal of Materials Science & Technology2023，，14： | 1 |
| 8 | Combined coal gasification and methane reforming for production of syngas in a fluidized-bed reactor显示文摘 | Wu Jinhu Fang Yitian Wang Yang Zhang Dongke | 2005 | Energy and Fuels2005，19，2： | 1 |
| 9 | Simulation-Guided Design of Bamboo Leaf-Derived Carbon-Based High-Efficiency Evaporator for Solar-Driven Interface Water Evaporation显示文摘Solar interface water evaporation has been demonstrated to be an advanced method for freshwater production with high solar energy utilization.The development of evaporators with lower cost and higher efficiency is a key challenge in the manufacture of practical solar interface water evaporation devices.Herein,a bamboo leaf-derived carbon-based evaporator is designed based on the light trace simulation.And then,it is manufactured by vertical arrangement and carbonization of bamboo leaves and subsequent polyacrylamide modification.The vertically arranged carbon structure can extend the light path and increase the light-absorbing area,thus achieving excellent light absorption.Furthermore,the continuous distribution of polyacrylamide hydrogel between these vertical carbons can support high-speed water delivery and shorten the evaporation path.Therefore,this evaporator exhibits an ultrahigh average light absorption rate of~96.1%,a good water evaporation rate of 1.75 kg m^(-2) h^(-1),and an excellent solar-to-vapor efficiency of 91.9%under one sun irradiation.Furthermore,the device based on this evaporator can effectively achieve seawater desalination,heavy metal ion removal,and dye separation while completing water evaporation.And this device is highly available for actual outdoor applications and repeated recycling. | Yitian Wu Rui Kong Chaoliang Ma Lanze Li Yu Zheng Yingzhuo Lu Lulu Liang Yajun Pang Qiang Wu Zhehong Shen Hao Chen | 2022 | Energy & Environmental Materials2022，5，4： | 1 |
| 10 | Effects of Different Modes of Returning Farmland to Forest on Physicochemical Properties of Soil in Bashang Area of Northern Hebei Province显示文摘[Objective]The research aimed to understand the change rules of physicochemical properties of soil in the different modes of returning farmland to forest.[Method]The physicochemical properties of soil in three different types of returning farmland to forest(Hippophae rhamnoides Linn.forest,Caragana korshinskii forest and Ulmus pumila L.forest)were analyzed by taking the enclosed grassland as comparison in Bashang area of northern Hebei Province.[Result]The results showed that there were significant differences among different types.Order of the bulk density of soil:H.rhamnoides Linn.forest(1.17 g/cm^3)U.pumila L.forest(52.55%)>C.korshinskii forest(51.93%)C.korshinskii forest(3.128%)>U.pumila L.forest(2.804%)>enclosed grassland(2.536%).[Conclusion]After returning farmland to forest,vegetation played a positive role in physicochemical properties of soil.There were significant differences in physicochemical properties of soil among different modes of returning farmland to forest,and the improvement effect of H.rhamnoides Linn.forest on physicochemical properties of soil was the best. | Yue YANG Yitian YANG Zhiyong WU Caiwu WU Yongjiao HAN | 2020 | Meteorological and Environmental Research2020，11，4： | 0 |
| 11 | NaHCO_(3)-induced porous PbI_(2) enabling efficient and stable perovskite solar cells显示文摘Driven by their many unique features,perovskite solar cells(PSCs)have become one of the most promising candidates in the photovoltaic field.Two-step preparation of perovskite film is advantageous for its higher stability and reproducibility compared to the one-step method,which is more suitable for practical application.However,the incomplete conversion of the dense lead iodide(PbI_(2))layer during the sequential spin-coating of formamidinium/methylammonium(FA^(+)/MA^(+))organic amine salts severely affect the performance of PSCs.Herein,sodium bicarbonate(NaHCO_(3))is used to induce the formation of porous PbI_(2),which facilitates the penetration of the FA^(+)/MA^(+)ions and the formation of a perovskite film with high crystallinity and large grain microstructure.Meanwhile,the introduction of Na^(+)not only improves the energetic alignment of the PSC,but also increases the conductivity via p-doping.As a result,the optimized NaHCO_(3)-modified PSC achieves a champion power conversion efficiency of 24.0% with suppressed hysteresis.Moreover,the significant reduction in defect density and ion migration as well as a mild alkaline environment enhance the stability of device.The unencapsulated NaHCO_(3)-modified PSCs maintain over 90% of their original efficiency upon storage in ambient air(30%–40% relative humidity)for 2160 h.We have demonstrated an ingenious strategy for controlling the quality of perovskite and improving the performance of device by low-temperature foaming of simple inorganic molecules of NaHCO_(3). | Yitian Du Ying Wang Jihuai Wu Qi Chen Chunyan Deng Ran Ji Liuxue Sun Lina Tan Xia Chen Yiming Xie Yunfang Huang Yana Vaynzof Peng Gao Weihai Sun Zhang Lan | 2023 | InfoMat2023，5，6： | 0 |
| 12 | Decentralized Heterogeneous Federal Distillation Learning Based on Blockchain显示文摘Load forecasting is a crucial aspect of intelligent Virtual Power Plant(VPP)management and ameans of balancing the relationship between distributed power grids and traditional power grids.However,due to the continuous emergence of power consumption peaks,the power supply quality of the power grid cannot be guaranteed.Therefore,an intelligent calculation method is required to effectively predict the load,enabling better power grid dispatching and ensuring the stable operation of the power grid.This paper proposes a decentralized heterogeneous federated distillation learning algorithm(DHFDL)to promote trusted federated learning(FL)between different federates in the blockchain.The algorithm comprises two stages:common knowledge accumulation and personalized training.In the first stage,each federate on the blockchain is treated as ameta-distribution.After aggregating the knowledge of each federate circularly,the model is uploaded to the blockchain.In the second stage,other federates on the blockchain download the trained model for personalized training,both of which are based on knowledge distillation.Experimental results demonstrate that the DHFDL algorithmproposed in this paper can resist a higher proportion of malicious code compared to FedAvg and a Blockchain-based Federated Learning framework with Committee consensus(BFLC).Additionally,by combining asynchronous consensus with the FL model training process,the DHFDL training time is the shortest,and the training efficiency of decentralized FL is improved. | Hong Zhu Lisha Gao Yitian Sha Nan Xiang Yue Wu Shuo Han | 2023 | Computers, Materials & Continua2023，76，9： | 0 |
| 13 | Effects of Nickel on the Microstructure,Mechanical properties and Corrosion Resistance of CoCrFeNi_(x)Al_(0.15)Ti_(0.1)High Entropy Alloy显示文摘The present work investigates the effect of Ni on the microstructure,mechanical properties,and corrosion resistance of CoCrFeNi_(x)Al_(0.15)Ti_(0.1)high-entropy alloys.It was found that the appropriate addition of Ni element in the alloy is beneficial to reduce the average grain size of the alloy.The yield strength and tensile strength of the alloy underfine-grain strengthening have also been increased,whilethe ductility of the system in this study has not been significantly affected.In terms of corrosion resistance,CoCrFeNi_(x)Al_(0.15)Ti_(0.1)high-entropy alloys form a dense passive film at open circuit potential,possessing good corrosion resistance.However,with the excessive addition of Ni content in the alloy,the pitting corrosion resistance of the alloy in the environment of chloride ions will decrease due to the relative decrease of the relative content of Cr element.This work also canprovide guidancesfor the design and development of new precipitation-strengthened CoCrFeNi-based high-entropy alloys with excellent comprehensive properties. | Wu QI Yitian SU Xiao YANG Guannan ZHANG Yi ZHAO Ya ZHANG Wenrui WANG | 2022 | Research and Application of Materials Science2022，4，2： | 0 |
| 14 | Surface passivation using pyridinium iodide for highly efficient planar perovskite solar cells显示文摘Perovskite solar cells have developed rapidly in the past decades.However,there are large amounts of ionic defects at the surface and grain boundaries of perovskte films which are detrimental to both the efficiency and stability of perovskite solar cells.Here,an organic halide salt pyridinium iodide(PyI) is used in cation-anion-mixed perovskite for surface defect passivation.Different from the treatment with Lewis base pyridine(Py) which can only bind to the under-coordinated Pb ions,zwitterion molecule PyI can not only fill negative charged iodine vacancies,but also interact with positive charged defects.Compared with Py treatment,PyI treatment results in smoother surface,less defect densities and nonradiative recombination in perovskite,leading to an improved VOC, negligible J-V hysteresis and stable performance of devices.As a result,the champion PyI-treated planar perovskite solar cell with a high VOC of 1.187 V achieves an efficiency of 21.42%,which is higher than 20.37% of Py-treated device,while the pristine device without any treatment gets an efficiency of 18.83% at the same experiment conditions. | Yitian Du Jihuai Wu Xinpeng Zhang Qianjin Zhu Mingjing Zhang Xuping Liu Yu Zou Shibo Wang Weihai Sun | 2021 | Journal of Energy Chemistry2021，30，1： | 0 |
| 15 | Vertically mounting molybdenum disulfide nanosheets on dimolybdenum carbide nanomeshes enables efficient hydrogen evolution显示文摘Designing hierarchical heterostructure to optimize the adsorption of hydrogen intermediate(H*)is impressive for hydrogen evolution reaction(HER)catalysis.Herein,we show that vertically mounting two-dimensional(2D)layered molybdenum disulfide(MoS_(2))nanosheets on 2D nonlayered dimolybdenum carbide(Mo_(2)C)nanomeshes to form a hierarchical heterostructure largely accelerates the HER kinetics in acidic electrolyte due to the weakening adsorption strength of H*on 2D Mo_(2)C nanomeshes.Our hierarchical MoS2/Mo2C heterostructure therefore gives a decrease of overpotential for up to 500 mV at-10 mA·cm^(-2)and an almost 200-fold higher kinetics current density compared with the pristine Mo2C nanomeshes and maintains robust stability with a small drop of overpotential for only 16 mV upon 5,000 cycles.We further rationalize this finding by theoretical calculations and find an optimized adsorption free energy of H*,identifying that the MoS_(2)featuring strong H*desorption plays a key role in weakening the strong binding of Mo_(2)C with H*and therefore improves the intrinsic HER activity on active C sites of Mo_(2)C.This present finding shines the light on the rational design of heterostructured catalysts with synergistic geometry. | Tingting Wang Pengyan Wang Yajun Pang Yitian Wu Jin Yang Hao Chen Xiaorui Gao Shichun Mu Zongkui Kou | 2022 | Nano Research2022，15，5： | 0 |
| 16 | NUMERICAL SIMULATION OF FLOOD DETENTION OPERATIONIN MULTIPLY CONNECTED RIVER CHANNEL NETWORK显示文摘Multiply connected network of river channels and lakes is the main feature of the Middle Yangtze River. The simulation of flood detention of the system is a subject of intensive research. This paper presents a numerical model based on a combination of hydrodynamic and hydrological methods, which is suitable for complex river channel network simulation, and is validated using hydrologic and topographic data from the river channel network of Dongting Lake region in the Middle Yangtze River Area Coordinated flood detention operation in the river channel network of Dongting Lake region has been simulated and the result shows that the model produces accurate predictions of the variation in water stage and discharge when flood diversion operation is carried out in enclosed low lands. | LI Yitian, WU Daoxi, CAO Zhifang (Wuhan University of Hydraulic and Electric Engineering, Wuhan, China) | 1999 | International Journal of Sediment Research1999，14，2： | 0 |
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