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| 1 | Incidence and mortality of laryngeal cancer in China,2008–2012显示文摘Objective:To analyze the incidence and mortality rates of laryngeal cancer in China from 2008 to 2012.Methods:Incident and death cases of laryngeal cancer were retrieved from the National Central Cancer Registry(NCCR)database collecting from 135 cancer registries in China during 2008–2012.The crude incidence and mortality rates of laryngeal cancer were calculated by area(urban/rural),region(eastern,middle,western),gender and age group(0,1–4,5–9,…,85+).China census in 2000 and Segi’s world population were applied for age standardized rates.Join Point(Version 4.5.0.1)model was used for time trend analysis.Results:The crude incidence rate of laryngeal cancer was 1.86/100,000 ranked the 21st in overall cancers.The age-standardized incidence rates by China population(ASIRC)and by World population(ASIRW)were1.22/100,000 and 1.23/100,000,respectively.The crude mortality of laryngeal cancer in China was 1.01/100,000and it was the 21st cause of cancer-related death in overall cancers.Both the age-standardized mortality rates by Chinese standard population(ASMRC)and by world standard population(ASMRW)were 0.63/100,000.Incidence and mortality rates of laryngeal cancer were higher in males than in females and higher in urban areas than in rural areas.Middle areas had the highest incidence and mortality rates followed by eastern and western areas.Incidence and mortality rates of laryngeal cancer retained low level before age of 40 years old but increased greatly after and peaked in age group of 75.Incidence showed significant down trends in recent 10 years by 1.27%annually[95%confidence interval(95%CI):–2.2%,–0.3%].Mortality declined in females sharply by 5.18%per year although stable in males and both sexes combined.Conclusions:Appropriate targeted prevention,early detection and treatment programs should be carried out to control the local burden of laryngeal cancer. | Yuqin Liu Qin Zhao Gaoheng Ding Yitong Zhu Wenying Li Wanqing Chen | 2018 | Chinese Journal of Cancer Research2018，30，3： | 29 |
| 2 | Changes in progenitors and differentiated epithelial cells of neonatal piglets显示文摘This study aimed to assess the changes of small intestinal morphology,progenitors,differentiated epithelial cells,and potential mechanisms in neonatal piglets.Hematoxylin and eosin staining of samples from 36 piglets suggested that dramatic changes were observed in the jejunum crypts depth and crypt fission index of neonatal piglets(P<0.001).The number of intestinal stem cells(ISC)tended to increase(P<0.10),and a decreased number of enteroendocrine cells appeared in the jejunal crypt on d 7(P<0.05).Furthermore,the mRNA expression of jejunal chromogranin A(ChgA)was down-regulated in d 7 piglets(P<0.05).There was an up-regulation of the adult ISC marker gene of SPARC related modular calcium binding 2(Smoc2),and Wnt/b-catenin target genes on d 7(P<0.05).These results were further verified in vitro enteroid culture experiments.A mass of hollow spheroids was cultured from the fetal intestine of 0-d-old piglets(P<0.001),whereas substantial organoids with budding and branching structures were cultured from the intestine of 7-d-old piglets(P<0.001).The difference was reflected by the organoid budding efficiency,crypt domains per organoid,and the surface area of the organoid.Furthermore,spheroids on d 0 had more Ki67-positive cells and enteroendocrine cells(P<0.05)and showed a decreasing trend in the ISC and goblet cells(P<0.10).Moreover,the mRNA expression of spheroids differed markedly from that of organoids,with low expression of intestinal differentiation gene(Lysozyme;P<0.05),epithelial-specific markers(Villin,E-cadherin;P<0.05),and adult ISC markers(leucine-rich repeat-containing G protein-coupled receptor 5[Lgr5],Smoc2;P<0.001),and upregulation of fetal marker(connexin 43[Cnx43];P<0.05).The mRNA expression of relevant genes was up-regulated,and involved in Wnt/b-catenin,epidermal growth factor(EGF),Notch,and bone morphogenetic protein(BMP)signaling on d 7 organoids(P<0.05).Spheroids displayed low differentiated phenotype and high proliferation,while organoids exhibited strong differentiation potential.These results indicated that the conversion from the fetal progenitors(spheroids)to adult ISC(normal organoids)might largely be responsible for the fast development of intestinal epithelial cells in neonatal piglets. | Lanmei Yin Jun Li Yitong Zhang Qing Yang Cuiyan Yang Zhenfeng Yi Yuebang Yin Qiye Wang Jianzhong Li Nengshui Ding Zhigang Zhang Huansheng Yang Yulong Yin | 2022 | Animal Nutrition2022，，1： | 3 |
| 3 | Efficient Currency Determination Algorithms for Dynamic Data显示文摘Data quality is an important aspect in data application and management, and currency is one of the major dimensions influencing its quality. In real applications, datasets timestamps are often incomplete and unavailable,or even absent. With the increasing requirements to update real-time data, existing methods can fail to adequately determine the currency of entities. In consideration of the velocity of big data, we propose a series of efficient algorithms for determining the currency of dynamic datasets, which we divide into two steps. In the preprocessing step, to better determine data currency and accelerate dataset updating, we propose the use of a topological graph of the processing order of the entity attributes. Then, we construct an Entity Query B-Tree(EQB-Tree) structure and an Entity Storage Dynamic Linked List(ES-DLL) to improve the querying and updating processes of both the data currency graph and currency scores. In the currency determination step, we propose definitions of the currency score and currency information for tuples referring to the same entity and use examples to discuss methods and algorithms for their computation. Based on our experimental results with both real and synthetic data, we verify that our methods can efficiently update data in the correct order of currency. | Xiaoou Ding Hongzhi Wang Yitong Gao Jianzhong Li Hong Gao | 2017 | Tsinghua Science and Technology2017，22，3： | 2 |
| 4 | Study of ghost image suppression in polarized catadioptric virtual reality optical systems显示文摘Backgrounds This paper introduces a polarized catadioptric virtual reality optical system.With a focus on the issue of serious ghost image in the system,root causes are analyzed based on design principles and optical structure.Methods The distribution of stray light is simulated using Lighttools,and three major ghost paths are selected using the area of the diffuse spot,S d and the energy ratio of the stray light,K as evaluation means.A method to restrain the ghost image through optimization of the structure of the optical system by controlling the focal power of the ghost image path is proposed.Results/Conclusions The results show that the S_(d) for the ghost image path increases by 40%and K decreases by 40%after optimization.Ghost image is effectively suppressed,which provides the theoretical basis and technical support for ghost suppression in a virtual reality optical system. | Xu PENG Zhenyu GAO Yitong DING Dongfeng ZHAO Xiaoyu CHI | 2020 | Virtual Reality & Intelligent Hardware2020，2，1： | 0 |
| 5 | Achyranthes bidentata polypeptide k attenuates neuroinflammation by inhibiting PI3K/Akt pathway and promoting Nrf2 translocation in BV-2 microglia显示文摘Activated microglia play a critical role in regulating neuroinflammatory responses in central nervous system.Previous studies have shown that Ach yranthes bidentata polypeptide k's(ABPPk s)neuroprotective effects are partly due to its anti-inflammatory effect,but the mechanism remains unknown.Here we investigated the anti-inflam matory effects of ABPPk on LPSactivated BV2 microglia.The results showed that pretreated with ABPPk(0.2-5μg/mL)for 30 minutes reduced the iNOS mediated NO and COX-2 mediated PGE2 production significantly in LPS-activated BV2 microglia.ABPPk(1 and 5μg/mL)also suppressed the production of TNF-α,IL-6,glutamate and ROS significantly. | Cheng Qiong Ge Xiangyu Wang Yitong Zhao Yahong Gong Leilei Ding Fei | 2021 | 解剖学杂志2021，44，S01： | 0 |
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