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| 1 | c‐Met represents a potential therapeutic target for personalized treatment in hepatocellular carcinoma显示文摘 | Hanning You Wei Ding Hien Dang Yixing Jiang C. Bart Rountree | 2011 | Hepatology2011，，： | 2 |
| 2 | Inverse uncertainty characteristics of pollution source identification for river chemical spill incidents by stochastic analysis显示文摘Identifying source information after river chemical spill occurrences is critical for emergency responses.However,the inverse uncertainty characteristics of this kind of pollution source inversion problem have not yet been clearly elucidated.To fill this gap,stochastic analysis approaches,including a regional sensitivity analysis method,identifiability plot and perturbation methods,were employed to conduct an empirical investigation on generic inverse uncertainty characteristics under a well-accepted uncertainty analysis framework.Case studies based on field tracer experiments and synthetic numerical tracer experiments revealed several new rules.For example,the release load can be most easily inverted,and the source location is responsible for the largest uncertainty among the source parameters.The diffusion and convection processes are more sensitive than the dilution and pollutant attenuation processes to the optimization of objective functions in terms of structural uncertainty.The differences among the different objective functions are smaller for instantaneous release than for continuous release cases.Small monitoring errors affect the inversion results only slightly,which can be ignored in practice.Interestingly,the estimated values of the release location and time negatively deviate from the real values,and the extent is positively correlated with the relative size of the mixing zone to the objective river reach.These new findings improve decision making in emergency responses to sudden water pollution and guide the monitoring network design. | Jiping Jiang Feng Han Yi Zheng Nannan Wang Yixing Yuan | 2018 | Frontiers of Environmental Science & Engineering2018，12，5： | 1 |
| 3 | Positive sputum culture of Candida spp.as a risk factor for 30-day mortality in patients with hospital-acquired pneumonia:A propensity-score matched retrospective clinical study显示文摘Background:Candida species(Candida spp.)are commonly isolated microorganisms from lower respiratory tract(LRT)specimens of patients with hospital-acquired pneumonia(HAP);however,the clinical significance remains controversial.This study aimed to investigate the correlation between Candida spp.in the LRT and the clinical features and prognosis of HAP.Methods:This retrospective analysis included eligible patients with HAP from the database of a prospective study carried out between 2018 and 2019 in nine Chinese hospitals.Data on demographics,clinical characteristics,and prognosis were collected and analyzed.Propensity score matching(PSM)was used to balance the baseline characteristics.Results:A total of 187 HAP patients were enrolled.After PSM of severity score,27 cases with positive sputum culture of Candida spp.were compared with the control group at a ratio of 1:1.The Candida-positive group had more bacterial isolates in blood culture than the Candida-negative group(39.1%[9/23]vs.7.7%[2/26],χ^(2)=6.928,effect size[ES]=0.38,95%CI:0.12-0.61,P=0.008).The proportion of patients with chronic lung diseases was significantly higher in the Candida-positive group(55.6%[15/27]vs.22.2%[6/27],χ^(2)=6.312,ES=0.34,95%CI:0.07-0.59,P=0.012).The 30-day prognosis of HAP was significantly different between the two groups(80.8%[21/26]vs.38.5%[10/26],χ^(2)=9.665,ES=0.43,95%CI:0.19-0.66,P=0.002).Univariable logistic regression analysis showed that LRT Candida spp.colonization was a risk factor for 30-day mortality of HAP(OR=6.720,95%CI:1.915-23.577,P=0.003).Conclusions:Candida spp.in the LRT was associated with 30-day mortality of HAP.Patients with chronic under-lying lung diseases tend to have Candida spp.colonization. | Yaopin Han Yihui Zuo Zhe Luo Minjie Ju Jianlan Hua Binfeng He Yixing Wu Jing Zhang | 2023 | Chinese Medical Journal Pulmonary and Critical Care Medicine2023，1，2： | 0 |
| 4 | Developmental systems biology flourishing on new technologies显示文摘Organism development is a systems level process. It has benefited greatly from the recent technological advances in the field of systems biology. DNA microarray, phenome, interactome and transcriptome mapping, the new generation of deep sequencing technologies, and faster and better computational and modeling approaches have opened new frontiers for both systems biologists and developmental biologists to reexamine the old developmental biology questions, such as pattern formation, and to tackle new problems, such as stem cell reprogramming. As showcased in the International Developmental Systems Biology Symposium organized by Chinese Academy of Sciences, developmental systems biology is flourishing in many perspectives, from the evolution of developmental systems, to the underly-ing genetic and molecular pathways and networks, to the genomic, epigenomic and noncoding levels, to the computational analysis and modeling. We believe that the field will continue to reap rewards into the future with these new approaches. | Jing-Dong J. Han Yi Liu Huiling Xue Kai Xia Hong Yu Shanshan Zhu Zhang Chen Wei Zhang Zheng Huang Chunyu Jin Bo Xian Jing Li Lei Hou Yixing Han Chaoqun Niu Timothy C. Alcon | 2008 | Journal of Genetics and Genomics2008，35，10： | 0 |
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