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| 1 | Effectiveness of Catch-Up Vaccinations after COVID-19 Containment--China,2020显示文摘Introduction:In the early stages of the coronavirus disease 2019(COVID-19)epidemic in China,the highest level of public health emergency response(Level 1 Response)was launched in all province-level administrative divisions(PLADs)across the country.Provision of vaccination services was selectively suspended due to the physical distancing and gathering restrictions required of Level 1 Response.The purpose of this paper is to evaluate the impact of COVID-19 on vaccination services and the effectiveness of selective vaccination service suspension and catch-up vaccinations in China.Methods:Vaccine doses administered,routine vaccination coverage levels,catch-up vaccine doses administered,and coverage levels after the catch-up campaign were determined from individual vaccination records in sampled clinics,standard routine immunization administrative coverage reports,and catch-up vaccination activity reports submitted by PLADs between October 2019 and October 2020.Results:National Immunization Program(NIP)and non-NIP vaccine doses administered in sampled clinics decreased by 80% and 90%,respectively,compared with doses administered before the COVID-19 pandemic.Coverage with the birth dose of hepatitis B vaccine(HepB1)and the Bacillus Calmette-Guérin vaccine(BCG)—two vaccinations recommended to continue throughout the epidemic due to their timecritical nature—were maintained at over 85%,while coverage of other NIP vaccines decreased to below 60%by February 2020.Catch-up vaccination coverage of the 29 PLADs,excluding Xinjiang and Xizang(Tibet),began in April 2020 and exceeded 90%;Hubei catch-up coverage was 95% by October 2020.Conclusions and Implications for Public Health Practice:The COVID-19 pandemic had a great impact on China’s vaccination services.During the epidemic and time of local transmission of the coronavirus,HepB1,BCG,rabies vaccine for postexposure prophylaxis,and tetanus antitoxin(TAT)for wound prophylaxis were maintained at high levels.Of the 69 million vaccine doses postponed during the time of local transmission of the coronavirus,94% were administered in the catch-up campaign.China’s pandemic immunization practices may provide evidence for other countries’immunization programs. | Jing Wu Wenzhou Yu Lei Cao Lingsheng Cao Lance Rodewald Jiakai Ye Yifan Song Li Li Xiaoxue Liu Ning Wen Fuzhen Wang Lixin Hao Yixing Li Hui Zheng Keli Li Chao Ma Dan Wu Yanmin Liu Guomin Zhang Zhijie An Huaqing Wang Zundong Yin | 2020 | China CDC weekly2020，2，50： | 6 |
| 2 | DeST 3.0:A new-generation building performance simulation platform显示文摘Buildings contribute to almost 30%of total energy consumption worldwide.Developing building energy modeling programs is of great significance for lifecycle building performance assessment and optimization.Advances in novel building technologies,the requirements of high-performance computation,and the demands for multi-objective models have brought new challenges for building energy modeling software and platforms.To meet the increasing simulation demands,DeST 3.0,a new-generation building performance simulation platform,was developed and released.The structure of DeST 3.0 incorporates four simulation engines,including building analysis and simulation(BAS)engine,HVAC system engine,combined plant simulation(CPS)engine,and energy system(ES)engine,connected by air loop and water loop balancing iterations.DeST 3.0 offers numerous new simulation features,such as advanced simulation modules for building envelopes,occupant behavior and energy systems,cross-platform and compatible simulation kernel,FMI/FMU-based co-simulation functionalities,and high-performance parallel simulation architecture.DeST 3.0 has been thoroughly evaluated and validated using code verification,inter-program comparison,and case-study calibration.DeST 3.0 has been applied in various aspects throughout the building lifecycle,supporting building design,operation,retrofit analysis,code appliance,technology adaptability evaluation as well as research and education.The new generation building simulation platform DeST 3.0 provides an efficient tool and comprehensive simulation platform for lifecycle building performance analysis and optimization. | Da Yan Xin Zhou Jingjing An Xuyuan Kang Fan Bu Youming Chen Yiqun Pan Yan Gao Qunli Zhang Hui Zhou Kuining Qiu Jing Liu Yan Liu Honglian Li Lei Zhang Hong Dong Lixin Sun Song Pan Xiang Zhou Zhe Tian Wenjie Zhang Ruhong Wu Hongsan Sun Yu Huang Xiaohong Su Yongwei Zhang Rui Shen Diankun Chen Guangyuan Wei Yixing Chen Jinqing Peng | 2022 | Building Simulation2022，15，11： | 5 |
| 3 | Microscopy and Bioinformatic Analyses of Lipid Metabolism Implicate a Sporophytic Signaling Network Supporting Pollen Development in Arabidopsis显示文摘Arabidopsis sporophytic tapetum 经历一个规划退化过程分泌类脂化合物和另外的材料支持花粉开发。然而,调整退化过程的分子的机制是未知的。到进这分子的机制的获得卓见,我们首先决定为到支持花粉开发的 tapetal 分泌物的最批评的时期从有液泡的小孢子阶段到早 binucleate 花粉阶段。我们然后与可得到的 in-silico 数据分析了为类脂化合物生合成和降级负责的酶的表达式。为在雄蕊然而并非在并发的单核的小孢子和 binucleate 花粉被表示的这些酶的基因具有特别兴趣,当他们大概与 gametophytic 织物相比在 sporophytic 纸巾保持线索到唯一的分子的过程。为类脂化合物生合成的没有基因但是为类脂化合物动员多半编码象 patatin 一样蛋白质的单个基因基于选择标准被识别。为基因的搜索与这基因共同表示编码象充满白氨酸的重复受体 kinase,额外大的 G 蛋白质,另外的蛋白质 kinases,和抄写因素那样的典型信号 transduction 部件的识别另外的基因。另外,朊酶,房间墙降级酶,和另外的蛋白质也被识别。这些蛋白质可以因此是导致大量细胞的部件的降级的一个发信号的网络的部件。因为大量降级活动被期望在雄蕊仅仅在 tapetal 退化过程发生在这个阶段,它是进一步的假设发信号的网络在 tapetal 退化过程行动。 | Yixing Wang Hong Wu Ming Yang | 2008 | Molecular Plant2008，1，4： | 4 |
| 4 | Defects in nuclealar migration and synapsis in male prophase Ⅰ in the ask1 - 1mutant of Arabidopsis显示文摘 | YIXING Wang HONG Wu GENQING Liang | 2004 | Sex Plant Reprod2004，16，： | 1 |
| 5 | ROS is essential for initiation of energy deprivation-induced autophagy显示文摘Autophagy is a highly conserved degradation process in which intracellular components are engulfed into a double membrane structure,known as the autophagosomes,and then delivered to lysosomes/vacuoles for degradation(Ohsumi,2014).Recently,autophagy has been found to be responsible for maintaining glucose homeostasis in adult animals(Karsli-Uzunbas et al.,2014).However,the molecular mechanism underlying energy deprivation-induced autophagy remains relatively unclear. | Choufei Wu Yixing Li Shu Zhong Yingcong Chen Yu Xie Yuyao Feng Weijing Yao Suping Fu Yanlan Zhu Liefeng Wang Yuting Chen Liqin Zhang Jingjing Tong Cong Yi | 2021 | Journal of Genetics and Genomics2021，48，6： | 1 |
| 6 | New trends of suburbaniza- tion in Beijing since 1990: From government-led to market-ori- ented显示文摘 | Feng Jian Zhou Yixing Wu Fulong | 2008 | Regional Studies2008，42，1： | 1 |
| 7 | Vaccination Guidelines During and After the COVID-19 Epidemic in China显示文摘In late December 2019,clinicians in Hubei Province noticed and reported to health authorities a cluster of cases of pneumonia of unknown etiology(PUE)that turned out to be the start of the coronavirus disease 2019(COVID-19)pandemic(1).By January 29,2020,all provincial-level administrative divisions(PLADs)across the country had launched their highest public health emergency responses(Level 1 responses)(2-3). | Wenzhou Yu Yuanqiu Li Jing Wu Fuzhen Wang Ning Wen Lance Rodewald Lixin Hao Yixing Li Hui Zheng Keli Li Chao Ma Dan Wu Lei Cao Lingsheng Cao Jiakai Ye Yanmin Liu Guomin Zhang Wen Du Zhijie An Huaqing Wang Zundong Yin | 2020 | China CDC weekly2020，2，34： | 1 |
| 8 | Efficacy and safety of S-1 based adjuvant chemoradiotherapy for resected pancreatic ductal adenocarcinoma with high-risk pathological feature: a prospective, single-arm, interventional study显示文摘Objective: It remains unclear whether adjuvant chemoradiotherapy (CRT) improves survival outcome of pancreatic ductal adenocarcinoma (PDAC) patients after surgery. This study aimed to investigate the efficacy and safety of tegafur/gimeracil/oteracil (S-1)-based adjuvant concurrent chemoradiotherapy in resected PDAC patients with defined high-risk pathological features.Methods: We conducted a single-arm, prospective, and interventional study at Zhongshan Hospital Fudan University from December 2012 to December 2019 and the last follow-up was conducted in December 2021. This study was approved by the Ethics Committee of Zhongshan Hospital Fudan University on December 27, 2012 (approval No. B2012-139). Resected PDAC patients with high-risk pathological features, including positive resection margin, pathological T3-4N1-2M0 disease, peripancreatic fat invasion, microvascular invasion, and perineural invasion, were recruited. Primary endpoint was overall survival and secondary endpoints were disease-free survival, treatment toxicity, and 2-, 5-year survival rates.Results: A total of 54 patients were recruited. Mean age was 63.6 years old (±7.2). The distribution of T and N stages were 24.1% for T1, 46.3% for T2, 27.8% for T3, 1.9% for T4, 33.3% for N1, and 11.1% for N2. Seven patients had R1 resection. The median overall survival and disease-free survival were 27.1 and 13.7 months, respectively, while no fatal adverse events were recorded. Subgroup analyses showed differences in survival outcomes among patients with microvascular invasion, different N stages, and preoperative CA 19-9 levels. Further, a Cox proportional hazard model demonstrated associations of lymph node metastases, CA 19-9 level, and microvascular invasion with overall survival and disease-free survival.Conclusion: S-1 -based adjuvant CRT showed promising efficacy and manageable toxicity in resected PDAC patients with highrisk pathological features. | Lili Wu Yaolin Xu Zhaochong Zeng Yixing Chen Yuhong Zhou Dansong Wang Jing Sun Minzhi Lv Shisuo Du Wenhui Lou | 2022 | Journal of Pancreatology2022，5，1： | 1 |
| 9 | New Trends of Suburbanization in Beijing since 1990: From Government-led to Market-oriented显示文摘 | Feng Jian Zhou Yixing Wu Fulong | 2008 | Regional Studies2008，42，1： | 1 |
| 10 | New Trends of Suburbanization in Beijing since 1990: From Government-led to Market-oriented显示文摘 | Jian Feng Yixing Zhou Fulong Wu | 2008 | Regional Studies2008，，1： | 1 |
| 11 | Pluripotent factor lin-28 and its homologue lin-28b in epithelial ovarian cancer and their associations with disease outcomes and expression of let-7a and IGF-II显示文摘 | Lingeng Lu Dionyssios Katsaros Khvaramze Shaverdashvili Biyun Qian Yixing Wu Irene A. Rigault de la Longrais Mario Preti Guido Menato Herbert Yu | 2009 | European Journal of Cancer2009，，12： | 1 |
| 12 | Effectiveness of DTaP Against Pertussis in≤2-Year-Old Children—Linyi Prefecture,Shandong Province,China,2017–2019显示文摘Summary What is already known about this topic?Vaccine effectiveness(VE)is positively correlated with the number of administered co-purified diphtheria,tetanus,and acellular pertussis vaccine(DTaP)doses.A matched case-control study conducted in Zhongshan City revealed that the co-purified DTaP VE against pertussis-related illnesses in children aged 4–11 months was 42%for one dose,88%for two doses,and 95%for three doses,respectively.What is added by this report?The results of this study contribute to the current body of research.We found that the VE of co-purified DTaP against pertussis-related illness and hospitalization increased substantially,ranging from 24%–26%after one dose to 86%–87%after four doses. | Pinpin Zhu Dan Wu Yan Wang Xiaoxue Liu Lance ERodewald Yixing Li Hui Zheng Lei Cao Yifan Song Li Song Xiaodong Zhao Jianyi Yao Fuzhen Wang Mingshuang Li Qian Zhang Tingting Yan Zundong Yin | 2023 | China CDC weekly2023，5，17： | 0 |
| 13 | Optimization of the Open Degree of Key Valves Based on Relative Entropy and Pipeline Leakage显示文摘Based on information entropy theory, the definition of relative entropy, and the relative entropy minimum principle, this study establishes a multi-objective optimization model for a key valve opening of an urban water distribution network(WDN). Each node pressure is taken as the main research object to reduce pipeline leakage. Moreover, genetic algorithm is applied in the proposed model to solve the key valve opening of the actual WDN in a city in southern China. Using the proposed model, the relevant decision variables of a WDN can be optimized to provide a new manner of network dispatching. | Feiyu Li Zhenfeng Shi Chenguang Wu Yixing Yuan Yan Zhu | 2017 | Transactions of Tianjin University2017，23，5： | 0 |
| 14 | SYNTHESIS OF GUIDED CHAIN DRIVE MECHANISM WITH LINKAGE显示文摘SYNTHESISOFGUIDEDCHAINDRIVEMECHANISMWITHLINKAGEShanBaozhongWuKeyongChangchunInstituteofOpticsandFineMechanicsWangYixingChenEn... | Shan, Baozhong Wu, Keyong Wang, Yixing Chen, Entao | 1998 | Chinese Journal of Mechanical Engineering1998，11，1： | 0 |
| 15 | Stiffness and toughness of soft/stiff suture joints in biological composites显示文摘Biological composites can overcome the conflict between strength and toughness to achieve unprecedented mechanical properties in engineering materials.The suture joint,as a kind of heterogeneous architecture widely existing in biological tissues,is crucial to connect dissimilar components and to attain a tradeoff of all-sided functional performances.Therefore,the suture joints have attracted many researchers to theoretically investigate their mechanical response.However,most of the previous models focus on the sutural interface between two chemically similar stiff phases with(or without)a thin adhesive layer,which are under the framework of linear elasticity and small deformation.Here,a general model based on the finite deformation framework is proposed to explore the stiffness and toughness of chemically dissimilar suture joints connecting soft and stiff phases.Uniaxial tension tests are conducted to investigate the tensile response of the suture joints,and finite element simulations are implemented to explore the underlying mechanisms,considering both material nonlinearity and cohesive properties of the interface.Two failure modes are quantitively captured by our model.The stored elastic energy in the soft phase competes with the energy dissipation due to the interface debonding,which controls the transition among different failure modes.The toughness of the suture joints depends on not only the intrinsic strengths of the constituent materials and their cohesive strength,but also the interfacial geometry.This work provides the structureproperty relationships of the soft/stiff suture joints and gives a foundational guidance of mechanical design towards high-performance bioinspired composites. | Dong WU Yixing HUANG Ming LEI Zeang ZHAO Xiaogang GUO Daining FANG | 2022 | Applied Mathematics and Mechanics(English Edition)2022，43，10： | 0 |
| 16 | Positive sputum culture of Candida spp.as a risk factor for 30-day mortality in patients with hospital-acquired pneumonia:A propensity-score matched retrospective clinical study显示文摘Background:Candida species(Candida spp.)are commonly isolated microorganisms from lower respiratory tract(LRT)specimens of patients with hospital-acquired pneumonia(HAP);however,the clinical significance remains controversial.This study aimed to investigate the correlation between Candida spp.in the LRT and the clinical features and prognosis of HAP.Methods:This retrospective analysis included eligible patients with HAP from the database of a prospective study carried out between 2018 and 2019 in nine Chinese hospitals.Data on demographics,clinical characteristics,and prognosis were collected and analyzed.Propensity score matching(PSM)was used to balance the baseline characteristics.Results:A total of 187 HAP patients were enrolled.After PSM of severity score,27 cases with positive sputum culture of Candida spp.were compared with the control group at a ratio of 1:1.The Candida-positive group had more bacterial isolates in blood culture than the Candida-negative group(39.1%[9/23]vs.7.7%[2/26],χ^(2)=6.928,effect size[ES]=0.38,95%CI:0.12-0.61,P=0.008).The proportion of patients with chronic lung diseases was significantly higher in the Candida-positive group(55.6%[15/27]vs.22.2%[6/27],χ^(2)=6.312,ES=0.34,95%CI:0.07-0.59,P=0.012).The 30-day prognosis of HAP was significantly different between the two groups(80.8%[21/26]vs.38.5%[10/26],χ^(2)=9.665,ES=0.43,95%CI:0.19-0.66,P=0.002).Univariable logistic regression analysis showed that LRT Candida spp.colonization was a risk factor for 30-day mortality of HAP(OR=6.720,95%CI:1.915-23.577,P=0.003).Conclusions:Candida spp.in the LRT was associated with 30-day mortality of HAP.Patients with chronic under-lying lung diseases tend to have Candida spp.colonization. | Yaopin Han Yihui Zuo Zhe Luo Minjie Ju Jianlan Hua Binfeng He Yixing Wu Jing Zhang | 2023 | Chinese Medical Journal Pulmonary and Critical Care Medicine2023，1，2： | 0 |
| 17 | Modern Radiotherapy in the Multidisciplinary Management of Common Cancers显示文摘Radiotherapy(RT)is an indispensable treatment for nearly all cancer types.Rapid evolution of technology has progressively increased the safely deliverable radiation dose,minimizing the exposure of uninvolved normal tissue and thus improving the efficacy,safety,and accessibility of radiation therapy.Meanwhile,multidisciplinary team management that aims to define personalized,optimal treatment strategies through shared decision-making between healthcare professionals and patients is a fundamental aspect of high-quality cancer diagnosis and treatment and often includes radiation oncology.How to combine this with other anti-tumor modalities,especially immunotherapy,in the era of modern RT has been increasingly emphasized.Here,in this review,we introduce the innovations in RT technology,and aim to provide an outline of the role of contemporary RT in the multidisciplinary treatment of most common cancers,including non-small cell lung cancer,esophageal cancer,breast cancer,hepatocellular carcinoma,gastric/esophageal-gastric junction cancer,and colorectal cancer,focusing on the main areas of innovation that are conducive to a change toward the personalized application of RT.We also discuss the future research directions for combination with modern RT. | Shisuo DU Yixing CHEN Qian ZHANG Jing SUN Guifen MA Jian WANG Xian ZHANG Taiwei SUN Yang ZHANG Jianying ZHANG Qiqiao WU Zhaochong ZENG | 2022 | Clinical Cancer Bulletin2022，1，2： | 0 |
| 18 | Traditional Chinese Medicine constitution among patients with allergic rhinitis and its correlation with anxiety and depression显示文摘OBJECTIVE:To preliminary investigate the distribution of Traditional Chinese Medicine(TCM)constitution among patients with allergic rhinitis(AR)and reveal the related factors with anxiety and depression.METHODS:Between July 2020 and June 2021,specialist doctor recruited AR patients in Beijing and Shanghai.A total of 630 patients admitted to participate in the survey,and 516(81.9%)(male 54.3%,female 45.7%)participants completed the questionnaires.Three scales including Constitution in Chinese Medicine Questionnaire(CCMQ),Generalized Anxiety Disorder Questionnaire(GAD-7)and The Patient Health Queationaire-9(PHQ-9)were applied.Theχ^(2)and the Fisher’s exact test were used to evaluate the classification data,multivariate logistic regression was used to explore the related factors of anxiety and depression.RESULTS:According to 516 AR patients,the most commonly first-constitution was Yang-deficiency(22.1%)and frequent of all constitutions was inherited-special(21.6%).One third of AR patients(33.5%)suffered from anxiety,nearly half of AR patients(46.5%)were found to be depressive.Inherited-special(27.7%)was the most common constitution in patients with anxiety whereas Yang-deficiency(26.7%)was most common constitution in patients with depression.Sex,duration of symptoms,balanced,Qi-deficiency,phlegm-dampness,Qi-stagnation,and inherited-special constitutions were related with anxiety;Sex,income,duration of symptoms,balanced,Qi-deficiency,Yang-deficiency,phlegm-dampness,Qi-stagnation,and inherited-special constitutions were related with depression.CONCLUSIONS:According to our study,the commonly constitution types of AR were Yang-deficiency and inherited-special.We found that the prevalence value of anxiety and depression were high.People with Qi-deficiency,phlegm-dampness,Qi-stagnation,and inherited-special constitutions were more likely to have mental problems than the others.Controlling these influential factors might be beneficial for clinical health management of AR patients,and the government should apply appropriate mental health treatment services to offer psychiatric support. | WANG Yaqi ZHAO Weibo WANG Yixing ZHAO Haihong ZHOU Yaoyao YAN Yun WU Taotao LUO Bin WANG Ji | 2023 | Journal of Traditional Chinese Medicine2023，43，6： | 0 |
| 19 | Cancer Gene Extraction Based on Stepwise Regression显示文摘With the expansion of the gene expression profile database,in the case of as little as possible to lose information or to retain the most critical information,gene extraction has become a main direction for the scholars.This paper excludes 1561 irrelevant genes through the definition of weighted distance firstly,and then removes 252 redundant genes by Pearson's correlation coefficient.Finally by comparing the two methods,stepwise regression after clustering and only stepwise analysis,we obtain the best combination of 8 genes. | Jie Ni Fan Wu Meixiang Jin Yixing Bai Yunfei Guo | 2016 | 数学计算(中英文版)2016，5，1： | 0 |
| 20 | Cancer Gene Extraction Based on Ideal Gene Model显示文摘 | Jie Ni Fan Wu Meixiang Jin Yixing Bai Yunfei Guo | 2016 | 信息工程期刊(中英文版)2016，6，4： | 0 |
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