|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | SLC1A1-mediated cellular and mitochondrial influx of R-2-hydroxyglutarate in vascular endothelial cells promotes tumor angiogenesis in IDH1-mutant solid tumors显示文摘Muta nt isocitrate dehydrog en ase 1(mlDH1)drives tumorigenesis via produci ng on cometabolite R-2-hydroxyglutarate(R-2-HG)across various tumor types.However,mlDHl in hibitors appear only effective in hematological tumors.The therapeutic ben efit in solid tumors remains elusive,likely due to the complex tumor microenvironment.In this study,we discover that R-2-HG produced by IDH1-mutant tumor cells is preferentially imported into vascular endothelial cells and remodels mitochondrial respiration to promote tumor angiogenesis,conferring a therapeutic vulnerability in IDH1-mutant solid tumors.Mechanistically,SLC1 Alz a Na'-depe ndent glutamate tran sporter that is prefere ntially expressed in en dothelial cells,facilitates the in flux of R-2-HG from the tumor microenvironment into the endothelial cells as well as the intracellular trafficking of R-2-HG from cytoplasm to mitochondria.R-2-HG hijacks SLC1A1 to promote mitochondrial Na^(+)/Ca^(2+)exchange,which activates the mitochondrial respiratory chain and fuels vascular en dothelial cell migratio n in tumor an giogenesis.SLC1A1 deficiency in mice abolishes mlDHl-promoted tumor an giogenesis as well as the therapeutic benefit of mlDHl in hibitor in solid tumors.Moreover,we report that HH2301,a newly discovered mlDHl inhibitor,shows promising efficacy in treating IDH1-mutant cholangiocarcinoma in preclinical models.Together,we identify a new role of SLC1A1 as a gatekeeper of R-2-HG-mediated crosstalk between IDH1-mutant tumor cells and vascular en dothelial cells,and dem on strate the therapeutic potential of mlDHl in hibitors in treating IDH1-muta nt solid tumors via disrupting R-2-HG-promoted tumor angiogenesis. | Xiaomin Wang Ziqi Chen Jun Xu Shuai Tang Nan An Lei Jiang Yixiang Zhang Shaoying Zhang Qingli Zhang Yanyan Shen Shijie Chen Xiaojing Lan Ting Wang Linhui Zhai Siyuwei Cao Siqi Guo Yingluo Liu Aiwei Bi Yuehong Chen Xiameng Gai Yichen Duan Ying Zheng Yixian Fu Yize Li Liang Yuan Linjiang Tong Kun Mo Mingcheng Wang Shu-Hai Lin Minjia Tan Cheng Luo Yi Chen Jia Liu Qiansen Zhang Leping Li Min Huang | 2022 | Cell Research2022，32，7： | 2 |
| 2 | Deviation correction strategy for the earth pressure balance shield based on shield–soil interactions显示文摘The control system presently used in shield posture rectification is based on driver experience,which is marginally reliable.The study of the related theory is flawed.Therefore,a decision-making approach for the deviation correction trajectory and posture rectification load for an earth pressure balance(EPB)shield is proposed.A calculation model of posture rectification load of an EPB shield is developed by considering the interactions among the cutter head,shield shell,and ground.The additional position change during the shield attitude correction is highlighted.The posture rectification loads and shield behaviors results can be solved by the proposed method.The influences of the stratum distribution(i.e.,bedrock height in the upper-soft and lower-hard strata)on shield behaviors and posture rectification loads are analyzed.Results indicated that the increase of pitch angle in the upper-soft and lower-hard strata causes a sharp rise in vertical displacement.The bedrock height increases the magnitudes of the required posture rectification moments when hr/D>0.5.For a tunnel with hr/D≤0.5,the variation of hr/D has little effect on the posture rectification moments.Finally,the posture rectifying curves based on the theoretical model are compared with the target ones based on the double circular arc interpolation method.The required results can be obtained regardless of the soil–rock compound stratum distribution.The maximum rectification moment in the rock layer is almost 12.6 times that in the soil layer.Overall,this study provides a valuable reference for moment determination and the trajectory prediction of posture rectification in compound strata. | Liang TANG Xiangxun KONG Xianzhang LING Yize ZHAO Wenchong TANG Yifan ZHANG | 2022 | Frontiers of Mechanical Engineering2022，17，2： | 1 |
| 3 | Tailoring light on three-dimensional photonic chips: a platform for versatile OAM mode optical interconnects显示文摘Explosive growth in demand for data traffic has prompted exploration of the spatial dimension of lightwaves, which provides a degree of freedom to expand data transmission capacity. Various techniques basedon bulky optical devices have been proposed to tailor light waves in the spatial dimension. However, theirinherent large size, extra loss, and precise alignment requirements make these techniques relativelydifficult to implement in a compact and flexible way. In contrast, three-dimensional (3D) photonic chips withcompact size and low loss provide a promising miniaturized candidate for tailoring light in the spatialdimension. Significantly, they are attractive for chip-assisted short-distance spatial mode optical interconnectsthat are challenging to bulky optics. Here, we propose and fabricate femtosecond laser-inscribed 3D photonicchips to tailor orbital angular momentum (OAM) modes in the spatial dimension. Various functions on theplatform of 3D photonic chips are experimentally demonstrated, including the generation, (de)multiplexing,and exchange of OAM modes. Moreover, chip-chip and chip–fiber–chip short-distance optical interconnectsusing OAM modes are demonstrated in the experiment with favorable performance. This work paves the wayto flexibly tailor light waves on 3D photonic chips and offers a compact solution for versatile opticalinterconnects and other emerging applications with spatial modes. | Jue Wang Chengkun Cai Feng Cui Min Yang Yize Liang Jian Wang | 2023 | Advanced Photonics2023，5，3： | 0 |
| 4 | Remote Measurement of the Angular Velocity Vector Based on Vectorial Doppler Effect Using Air-Core Optical Fiber显示文摘Rotational Doppler effect has made tremendous development in both theoretical and applied research over the last decade.Different from the inertial thinking of focusing on the scalar field dominated by helical phase light,we have revealed a vectorial Doppler effect in our previous work,which is based on the spatially variant polarized light fields to simultaneously acquire the speed and direction of a target.Here,further,we propose a method to construct a flexible and robust velocimeter based on that novel effect by employing an air-core fiber with kilometer-length scale for remotely measuring the vectorial information of angular velocity in situ.In addition,we experimentally substantiate that the measurement system still has commendable accuracy in determining the direction of movement even when the air-core fiber is interfered by the external environment.The demonstrations prove the potential of vectorial Doppler effect in practical scenarios and remote measurements. | Zhenyu Wan Yize Liang Xi Zhang Ziyi Tang Liang Fang Zelin Ma Siddharth Ramachandran Jian Wang | 2023 | Research2023，，3： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员