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| 1 | Resveratrol provides neuroprotection by regulating the JAK2/STAT3/PI3K/AKT/mTOR pathway after stroke in rats显示文摘Ischemic stroke is a common disease with high mortality and morbidity worldwide.One of the important pathophysiological effects of ischemic stroke is apoptosis.A neuroprotective effect is defined as the inhibition of neuronal apoptosis to rescue or delay the infarction in the surviving ischemic penumbra.Resveratrol is a natural polyphenol that reportedly prevents cerebral ischemia injury by regulating the expression of PI3K/AKT/mTOR.Therefore,this study aimed to elucidate the neuroprotective effect of resveratrol on cerebral ischemia/reperfusion injury and to investigate the signaling pathways and mechanisms through which resveratrol regulates apoptosis in the ischemic penumbra.Rats were subjected to middle cerebral artery occlusion for 2 h followed by 24 h reperfusion.Cerebral infarct volume was measured using 2%TTC staining.TUNEL staining was conducted to evaluate neuronal apoptosis.Western blotting and immunohistochemistry were used to detect the proteins involved in the JAK2/STAT3/PI3K/AKT/mTOR pathway.The results suggested that resveratrol significantly improved neurological function,reduced cerebral infarct volume,decreased neuronal damage,and markedly attenuated neuronal apoptosis;these effects were attenuated by the inhibition of PI3K/AKT with LY294002 and JAK2/STAT3 with AG490.We also found that resveratrol significantly upregulated the expression of p-JAK2,p-STAT3,p-AKT,p-mTOR,and BCL-2 and downregulated expression of cleaved caspase-3 and BAX,which was partially reversed by LY294002 and AG490.These results suggested that resveratrol provides a neuroprotective effect against cerebral ischemia/reperfusion injury,which is partially mediated by the activation of JAK2/STAT3 and PI3K/AKT/mTOR.Resveratrol may indirectly upregulate the PI3K/AKT/mTOR pathway by activating JAK2/STAT3. | Yongying Hou Ke Wang Weijun Wan Yue Cheng Xia Pu Xiufeng Ye | 2018 | Genes & Diseases2018，5，3： | 60 |
| 2 | Adsorptive desulfurization over hierarchical beta zeolite by alkaline treatment显示文摘Hierarchical beta zeolites with SiO2 /Al2O3 molar ratios of 16 to 25 were obtained by alkaline treatment in NaOH solution. The effects of treatment temperature on crystallinity, textural properties and chemical composites were studied by XRD, N2 sorption, FT-IR and XRF techniques. The desulfurization performance of parent and alkaline-treated beta zeolites was investigated by static absorption in four model fuels, containing four sulfur compounds of different molecular sizes like thiophene (TP), 3-methylthiophene (3-MT), benzothiophene (BT) and dibenzothiophene (DBT), respectively. The crystallinity was observed to be successfully maintained when the treatment temperature was below 50 C. Mesoporosity of beta zeolite was evidently developed with alkaline treatment. The formation of mesopore remarkably improved the desulfurization performance for TP, 3-MT, BT and DBT, especially for DBT with larger molecular diameter. Though the addition of toluene in the model fuels resulted in a significant drop of the desulfurization performance of mesoporous beta zeolite, the introduction of cerium ions to some extent mitigated the effect of toluene, which means that both the adsorbents porous structure and the adsorption mode are responsible for the desulfurization performance. The adsorbent of cerium ion-exchanged mesoporous beta showed about 80% recovery of desulfurization after the first regeneration. | Fuping Tian Xiaojian Yang Yanchun Shi Cuiying Jia Yongying Chen | 2012 | Journal of Natural Gas Chemistry2012，21，6： | 11 |
| 3 | Recent progress of advanced anode materials of lithium-ion batteries显示文摘The rapid development of electric vehicles and mobile electronic devices is the main driving force to improve advanced high-performance lithium ion batteries(LIBs).The capacity,rate performance and cycle stability of LIBs rely directly on the electrode materials.As far as the development of the advanced LIBs electrode is concerned,the improvement of anode materials is more urgent than the cathode materials.Industrial production of anode materials superior to commercial graphite still faces some challenges.This review sets out the most basic LIBs anode material design.The reaction principles and structural design of carbon materials,various transition metal oxides,silicon and germanium are summarized,and then the progress of other anode materials are analyzed.Due to the rapid development of metal organic frameworks(MOFs)in energy storage and conversion in recent years,the synthesis process and energy storage mechanism of nanostructures derived from MOF precursors are also discussed.From the perspective of novel structural design,the progress of various MOFs-derived materials for alleviating the volume expansion of anode materials is discussed.Finally,challenges for the future development of advanced anode materials for LIBs will be considered. | Hui Cheng Joseph G.Shapter Yongying Li Guo Gao | 2021 | Journal of Energy Chemistry2021，30，6： | 10 |
| 4 | Effects of toluene on thiophene adsorption over NaY and Ce(IV)Y zeolites显示文摘Zeolites NaY and Ce(IV)Y were employed as adsorbents to remove organic sulfur compounds from model gasoline(MG) solutions with and without toluene in static adsorption experiments at room temperature(RT) and atmospheric pressure.The adsorbents were characterized by XRD,XRF and pyridine infrared spectrum(IR).The adsorption experiments show that the desulfurization performance of Ce(IV)Y is much better than that of NaY.The sulfur removal over both NaY and Ce(IV)Y decreases with the increase of toluene concentration in MG,however,the decline tendency on Ce(IV)Y is smooth,and it is steep on NaY.FT-IR spectra of thiophene adsorption indicate that thiophene molecules are mainly adsorbed on NaY via π electron interaction,but on Ce(IV)Y,in addition to the π electron interaction,both Ce4+-S direct interaction and protonation of thiophene also play important roles.Toluene molecules are adsorbed on NaY also via π electron interaction.Although the amount of Brnsted acid sites is increased due to the introduction of Ce4+ ions into NaY zeolite,it is not found to influence the adsorption mode of toluene over Ce(IV)Y.Compared with NaY zeolite,the improved desulfurization performance over Ce(IV)Y for removing organic sulfur compounds from MG solution,especially those containing large amount of aromatics,may be ascribed to the direct Ce(IV)-S interaction,which is much resistant to the influence resulted from toluene adsorption. | Yanchun Shi Xiaojian Yang Fuping Tian Cuiying Jia Yongying Chen | 2012 | Journal of Natural Gas Chemistry2012，21，4： | 9 |
| 5 | Preparation of a kind of mesoporous carbon and its performance in adsorptive desulfurization显示文摘Carbon materials were prepared using mesoporous silica HMS with different pore sizes as the hard templates and water-soluble phenolic resin as the carbon source.The obtained materials were characterized by powder X-ray diffraction,transmission electron microscopy and N2 physical adsorption,and were used in adsorptive desulfurization.It has been shown that the carbon material prepared using HMS with larger pore size(>3 nm) presented uniform wormlike mesopore of 2.3 nm and large BET surface area(1903 m2/g).The mesoporous carbon was an excellent adsorbent to remove the refractory sulfur compound in diesel,especially dibenzothiophene and 4,6-dimethyldibenzothiophene. | Haiyun Zhou Gang Li Xiaoxing Wang Changzi Jin Yongying Chen | 2009 | Journal of Natural Gas Chemistry2009，18，3： | 6 |
| 6 | The generation of PD-L1 and PD-L2 in cancer cells: From nuclear chromatin reorganization to extracellular presentation显示文摘The immune checkpoint blockade(ICB)targeting on PD-1/PD-L1 has shown remarkable promise in treating cancers.However,the low response rate and frequently observed severe side effects limit its broad benefits.It is partially due to less understanding of the biological regulation of PD-L1.Here,we systematically and comprehensively summarized the regulation of PD-L1 from nuclear chromatin reorganization to extracellular presentation.In PD-L1 and PD-L2 highly expressed cancer cells,a new TAD(topologically associating domain)(chr9:5,400,000-5,600,000)around CD274 and CD273 was discovered,which includes a reported super-enhancer to drive synchronous transcription of PD-L1 and PD-L2.The re-shaped TAD allows transcription factors such as STAT3 and IRF1 recruit to PD-L1 locus in order to guide the expression of PD-L1.After transcription,the PD-L1 is tightly regulated by mi RNAs and RNA-binding proteins via the long 3’UTR.At translational level,PD-L1 protein and its membrane presentation are tightly regulated by post-translational modification such as glycosylation and ubiquitination.In addition,PD-L1 can be secreted via exosome to systematically inhibit immune response.Therefore,fully dissecting the regulation of PD-L1/PD-L2 and thoroughly detecting PD-L1/PD-L2 as well as their regulatory networks will bring more insights in ICB and ICB-based combinational therapy. | Zhiwei Fan Changyue Wu Miaomiao Chen Yongying Jiang Yuanyuan Wu Renfang Mao Yihui Fan | 2022 | Acta Pharmaceutica Sinica B2022，12，3： | 4 |
| 7 | RHOBTB3 promotes proteasomal degradation of HIFa through facilitating hydroxylation and suppresses the Warburg effect显示文摘 | Chen-Song Zhang Qi Liu Mengqi Li Shu-Yong Lin Yongying Peng Di Wu Terytty Yang Li Qiang Fu Weiping Jia Xinjun Wang Teng Ma Yue Zong Jiwen Cui Chengfei Pu Guili Lian Huiling Guo Zhiyun Ye Sheng-Cai Lin | 2015 | Cell Research2015，25，9： | 2 |
| 8 | Generalized data reduction approach for aspheric testing in a non-null interferometer 显示文摘 | Chao Tian Yongying Yang Yongmo Zhuo | 2012 | Appl Opt2012，51，10： | 1 |
| 9 | Changing Medical Education and Medical Practice 显示文摘 | YongI I Kim | 1997 | Foreign Medical Sciences-medical Education1997，，1： | 1 |
| 10 | A practical design method of fuzzy control based on control surface 显示文摘 | Yongi Huang and Seiji Yasunobu | 1999 | Journal of Japan Society for Fuzzy Theory and System1999，11，5： | 1 |
| 11 | Polarization point-diffraction interferometer for high-precision testing of spherical surface 显示文摘 | WANG Daodang YANG Yongying CHEN Chen | 2010 | Proceedings of SPIE(S0277-786X)2010，7656，76： | 1 |
| 12 | Graphene-supported biomimetic catalysts with synergistic effect of adsorption and degradation for efficient dye capture and removal显示文摘Design and development of iron porphyrin-based artificial enzymes system have been attracting a lot of attention.Herein,without any toxic reductant and harsh processing,we present a facile one-pot method to fabricate bifunctional catalytic nanocomposites consisting of graphene and hemin by using vitamin C as a mild reduction reagent.The presence of graphene helps the formation of a high degree of highly active and stable hemin on the graphene surface in a monomeric form through theirπ-πstacking interaction.As a result,such nanocomposites possess a superior adsorption capacity and intrinsic peroxidase-like catalytic activity.Moreover,by the combination of their dye adsorption ability,RGOhemin nanocomposites can serve as a suitable candidate for efficient capture and removal of dyes via a synergistic effect.Our findings may pave the way to apply graphene-supported artificial enzymes in a variety of fields,such as environmental chemistry,bionics,medicine,and biotechnology. | Qin Li Xiaopei Wang Xueqing Xiong Shuihong Zhu Zhaohui Meng Yongying Hong Changxu Lin Xiangyang Liu Youhui Lin | 2020 | Chinese Chemical Letters2020，31，1： | 1 |
| 13 | Non-uniformity correction for SLM microscopic images显示文摘 | Pei Wei Zhu Yongying Liu Chong | 2008 | Image and Vision Computing2008，27，6： | 1 |
| 14 | Practical methods for retrace error correction in nonnu|| aspheric tes- ting显示文摘 | Liu Dong Yang Yongying Tian Chao | 2009 | Optics Express2009，17，9： | 1 |
| 15 | Isolationand characterization of phenol - degradation denitrifying bacteria 显示文摘 | PanlaM SchieL YongY | 1998 | Appl Environ Micrebid1998，64，7： | 1 |
| 16 | StudyofageinginAl-Mg-Sialloysbypositronannihilationspectroscopy显示文摘 | BanhartJ LiuM YongY etal | 2012 | PhysicaB:Condensed Matter2012，407，14： | 1 |
| 17 | Increased OX40 and soluble OX40 ligands in children with Henoch-Schonlein purpura : association with renal involvement 显示文摘 | Qin W Hongya W Yongiing C Fang X Yue M Xuekun Z | 2011 | Pediatr Allergy Immanol2011，22，11： | 1 |
| 18 | Point diffraction interferometer with adjustable fringe contrast for testing spherical sur- faces显示文摘 | Wang Daodang Yang Yongying Chen Chen | 2011 | Applied Optics2011，50，16： | 1 |
| 19 | A hybrid multiple damages detection method for plate structures显示文摘A hybrid method is proposed value to properly identify(SVD)multiple is applied damages reveal for plate structures in this work.and In the to stage detect of the damage damage(ACO)localization,locations.singular In decomposition damage to on singularities in modal shapes,hence colony the stage of to quantification,damage based the detected for location information ant optimization algorithm between is the introduced natural estimate severity by searching damage evaluation database,natural which reveals the relationship frequencies and the damage severity.The modal shapes and the frequencies required in damage localization and quantification carried are obtained the via the wavelet of finite hybrid element method multiple method.for The numerical simulation with and experimental damages.investigation are out to test performance the to free aluminum plates multiple with And the results indicate that the proposed method is effective identify damages of plate structures reasonable precision. | JIANG YongYing XIANG JiaWei LI Bing CHEN XueFeng LIN LiQu | 2017 | Science China(Technological Sciences)2017，60，5： | 1 |
| 20 | High-precision technique for in-situ testing of the PZT scanner based on fringe analysis 显示文摘 | Wang Daodang Yang Yongying Liu Dong | 2010 | Optics Communications2010，283，： | 1 |
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