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| 1 | Mechanosignaling activation of TGFβmaintains intervertebral disc homeostasis显示文摘Intervertebral disc(IVD) degeneration is the leading cause of disability with no disease-modifying treatment.IVD degeneration is associated with instable mechanical loading in the spine, but little is known about how mechanical stress regulates nucleus notochordal(NC) cells to maintain IVD homeostasis. Here we report that mechanical stress can result in excessive integrin α_vβ_6-mediated activation of transforming growth factor beta(TGFβ), decreased NC cell vacuoles, and increased matrix proteoglycan production, and results in degenerative disc disease(DDD). Knockout of TGFβ type II receptor(TβRII) or integrin α_v in the NC cells inhibited functional activity of postnatal NC cells and also resulted in DDD under mechanical loading.Administration of RGD peptide, TGFβ, and α_vβ_6-neutralizing antibodies attenuated IVD degeneration. Thus,integrin-mediated activation of TGFβ plays a critical role in mechanical signaling transduction to regulate IVD cell function and homeostasis. Manipulation of this signaling pathway may be a potential therapeutic target to modify DDD. | Qin Bian Lei Ma Amit Jain Janet L Crane Khaled Kebaish Mei Wan Zhengdong Zhang X Edward Guo Paul D Sponseller Cheryle A Seguin Lee H Riley Yongjun Wang Xu Cao | 2017 | Bone Research2017，5，1： | 9 |
| 2 | Initiation and longterm slip history of the Altyn Tagh fault显示文摘 | Yue Yongjun Bradley D Ritts Stephan A Graham | 2001 | International Geology Review2001，43，： | 1 |
| 3 | Correlation of structural properties and film thickness to photocatalytic activity of thick TiO2 films coated on stainless steel显示文摘 | Chen Yongjun Dionysiou Dionysios D | 2006 | Applied Catalysis B: Environmental2006，69，12： | 1 |
| 4 | Pay-as-bid versus marginal pricing-part Ⅰ: Strategic generator offers显示文摘 | Yongjun Ren Galiana F D | 2004 | IEEE Transaction on Power Systems2004，19，4： | 1 |
| 5 | The Analysis of Industrial Xanthoceras sorbifolia Forest-Oil Integration'sProspects显示文摘 | Yongjun D Qiuliang Z Huijun A | 2012 | Procedia Environmental Sciences2012，，12： | 1 |
| 6 | Biocidal polystyrene hydantoin beads 2:control of chlorine loading显示文摘 | CHEN Yongjun WORLEY S D KIM Jangho | | 0，，： | 1 |
| 7 | TiO2 photocatalytic films on stainless steel:the role of degussa P-25 in modified sol-gel methods显示文摘 | Chen Yongjun Dionysiou D D | 2006 | Applied Catalysis B:Environmental2006，62，： | 1 |
| 8 | 显示文摘 | Chen Yongjun Dionysiou D D | 2006 | Applied Catalysis B:Environmental2006，62，： | 1 |
| 9 | Pay-as-bid versus marginal pricing-part Ⅰ: strategic generator offers 显示文摘 | Ren Yongjun Galiana Francisco D | 2004 | IEEE Trans on Power Systems2004，19，4： | 1 |
| 10 | Correlation of Structural Properties and Film Thickness to Photocatalytic Activity of Thick TiO2 Films Coated on Stainless Steel显示文摘 | Chen Yongjun Dionysiou Dionysios D | 2006 | Applied Catalysis B:Environmental2006，69，12： | 1 |
| 11 | Initiation and long-term slip history of the Altyn Tagh fault显示文摘 | Yue Yongjun Ritts B D Graham S A | 2001 | International Geology Review2001，43，12： | 1 |
| 12 | Control of grind-ing condition in the flotation of chalcopyrite and its separa-tion from pyrite显示文摘 | Peng Yongjun Rano S Fomasiero D | 2003 | Mineral Processing2003，69，14： | 1 |
| 13 | Control of grinding conditions in the flotation of chalcopyrite and its separation from pyrite显示文摘 | Peng Yongjun Grano S Fornasiero D | 2003 | Int J Miner Process2003，69，： | 1 |
| 14 | The prevalence of sexually transmitted and other lower reproductive tract infections among rural women in Sichuan Province, China显示文摘 | Yongjun T Samuelson J Qingsheng D | 2009 | Southeast Asian J Trop Med Public Health2009，40，5： | 1 |
| 15 | Reliability and validity of a Chinese version of the Quality of Life in Epilepsy Inventory (QOLIE-89) 显示文摘 | YONGQING Z H CHENGYUN D YONGJUN W | 2007 | Epilepsy & Behavior2007，11，： | 1 |
| 16 | Initiation and long-term slip history of the Altyn Tagh fault显示文摘 | Bradley D Ritts Stephan A Graham | 2001 | International Geology Review2001，43，： | 1 |
| 17 | The Use of Aligned Silver Nanorod Arrays Prepared by Oblique Vapor Deposition 显示文摘 | DRISKELL J D SHANMUKH S LIU Yongjun | 2008 | J Phys Chem C2008，112，4： | 1 |
| 18 | Exploiting the dual functions of polymer depressants in fine particle flotation 显示文摘 | Liu Qi Wannas D Peng Yongjun | 2006 | Int J Miner Process2006，80，24： | 1 |
| 19 | Genomic scanning enabling discovery of a new antibacterial bicyclic carbamate-containing alkaloid显示文摘Non-ribosomal peptides are a group of structurally diverse natural products with various important therapeutic and agrochemical applications.Bacterial pyrrolizidine alkaloids(PAs),containing a scaffold of two fused five-membered ring system with a nitrogen atom at the bridgehead,have been found to originate from a multidomain non-ribosomal peptide synthetase to generate indolizidine intermediates,followed by multistep oxidation,catalysed by single Bayer-Villiger(BV)enzymes,to yield PA scaffolds.Although bacterial PAs are rare in natural product inventory,bioinformatics analysis suggested that the biosynthetic gene clusters(BGCs)that are likely to be responsible for the production of PA-like metabolites are widely distributed in bacterial genomes.However,most of the strains containing PA-like BGCs are not deposited in the public domain,therefore preventing further assessment of the chemical spaces of this group of bioactive metabolites.Here,we report a genomic scanning strategy to assess the potential of PA metabolites production in our culture collection without prior knowledge of genome information.Among the strains tested,we found fifteen contain the key BV enzymes that are likely to be involved in the last step of PA ring formation.Subsequently one-strain-many-compound(OSMAC)method,supported by a combination of HR-MS,NMR,SMART 2.0 technology,and GNPS analysis,allowed identification and characterization of a new[5+7]heterobicyclic carbamate,legoncarbamate,together with five known PAs,bohemamine derivatives,from Streptomyces sp.CT37,a Ghanaian soil isolate.The absolute stereochemistry of legoncarbamate was determined by comparison of measured and calculated ECD spectra.Legoncarbamate displays antibacterial activity against E.coli ATCC 25922 with an MIC value of 3.1μg/mL.Finally,a biosynthetic model of legoncarbamate and other bohemamines was proposed based on the knowledge we have gained so far. | Qing Fang Linrui Wu Caroline Urwald Morgane Mugat Shan Wang Kwaku Kyeremeh Carol Philips Samantha Law d Yongjun Zhou Hai Deng | 2021 | Synthetic and Systems Biotechnology2021，6，1： | 1 |
| 20 | Pay-as-bid versus marginal pricing-part I : Strategic generator offers 显示文摘 | Ren Yongjun Galiana F D | 2004 | IEEE Trans on Power Systems2004，19，4： | 1 |
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