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| 1 | Geochemistry,Nd Isotopic Characteristics of Metamorphic Complexes in Northern Hebei:Implications for Crustal Accretion显示文摘北方中国古地台(NCC ) 的北边缘的中间的片断在 Damiao-Changshaoying 区域主要由变形太古代的 Dantazi 建筑群, Paleoproterozoic Hongqiyingzi 复杂 andunmetamorphosed gabbro-anorthosite-meta-alkaline 花岗石,以及变形迟了的 Paleozoicmafic 组成到 granitoid 岩石。~ 2 .49 Ga Dantazi 复杂 comprisesdioritic-trondhjemitic-granodoritic-monzogranitic 片麻岩在角闪岩变形了到 granulitefacies。石油化学的特征表明大多数岩石属于媒介--tohigh钾计算碱的系列,和显示Mg~#不到 40 ,衰退权利的 REE 模式没有到在使primitivemantle正常化的蜘蛛图的显然积极的 Eu 异例,显然否定的 Th , Nb , Ta 和 Ti 异例,到-0.03,和弄空的披风的ε_( Nd )(t) =+0.65 为agesT_( DM ) =2.78-2.71 Ga 建模。在岩石成因论的学习显示岩石从从在一个大陆人边缘背景的再循环的外壳的 mafic 岩石的部分融化从弄空的披风和 granitoid 岩浆在 mafic 岩浆之间混合的 magmatic 被形成。2.44-2.41 Ga Hongqiyingzi 建筑群被变形 mafic-granodioritic-monzogranitic 片麻岩统治,显示到 Dantazi 建筑群的类似的石油化学的特征,对高钾也就是中等计算碱的系列,和 mafic 岩石在 LILE,否定 Th, Nb, Ta, Zr 异例和积极 Panomalies 显示出明显的变化。并且另外的 granitiod 样品也展出否定 Th, Nb, Ta, P 和 Ti 异例。在 Hongqiyingzi 复杂表演的 Allrocks 没有 Eu 的衰退权利的 REE 模式异例。有ε _(Nd ) 的 Themetamorphic mafic 岩石(t)=-1.64 不能是有 granitoids 的一个相同 magmatic 系列有(t)+3.19 珍视到 +1.94 和 2.55-2.52 Ga 的 T_(DM ) 年龄的ε _(Nd ) 。Thesegranitic 岩石从在一个弧形列岛的外壳的 mafic 岩石设置的少年的部分融化从弄空的披风和岩浆从在 mafic 岩浆之间的混血儿发源。 11 妈 LatePaleozoic 变形 mafic 摇的所有 ~3 和相关花岗石的岩石显示出一个中等钾的 calc-alkalinemagmatic 进化系列,由高Mg~#,显然否定的 Th , Nb , Ta 异例和positive 描绘了 Sr 异例,从不到有ε_( Nd )的强烈否定的 Ti 异例和扁平的 REE 模式(t)= +8.42 ,暗示 mafic 岩浆从弄空的披风被导出。另外的花岗石的岩石不管多么被衰退权利的 REE 模式显然描绘没有到 positiveEu 异例,显著地低的ε_( Nd )(t)= -13.37 到-14.04,和T_( DM ) =1.97-1.96 Ga ,表明 granitoid 岩浆从在来自 ~3 的 mafic 岩浆之间的混血儿被导出 11 Madepleted 披风和 granitoid 岩浆从对早 Paleoproterozoic 太古代古老的外壳的再循环。象上述地质的 andgeochronological 结果一样的地球化学和 Nd 同位素的特征显示 NCC 的北边缘的中间的片断主要经历了四个外壳的生长事件从对太古代晚古生代,它被三个大陆人统治边缘的弧生长( ~2 .49 , ~2 .44 和 311 妈)除了与 post-collisional 扩展有关的 1.76-1.68 Gaepisode ,表明这的外壳的生长分割主要从弧生长和合并被产生到 NCC 大陆块。 | LIU Shuwen TIAN Wei Lü Yongjun LI Qiugen FENG Yonggang K. H. PARK Y. S. SONG | 2006 | Acta Geologica Sinica(English Edition)2006，80，6： | 21 |
| 2 | Mechanosignaling activation of TGFβmaintains intervertebral disc homeostasis显示文摘Intervertebral disc(IVD) degeneration is the leading cause of disability with no disease-modifying treatment.IVD degeneration is associated with instable mechanical loading in the spine, but little is known about how mechanical stress regulates nucleus notochordal(NC) cells to maintain IVD homeostasis. Here we report that mechanical stress can result in excessive integrin α_vβ_6-mediated activation of transforming growth factor beta(TGFβ), decreased NC cell vacuoles, and increased matrix proteoglycan production, and results in degenerative disc disease(DDD). Knockout of TGFβ type II receptor(TβRII) or integrin α_v in the NC cells inhibited functional activity of postnatal NC cells and also resulted in DDD under mechanical loading.Administration of RGD peptide, TGFβ, and α_vβ_6-neutralizing antibodies attenuated IVD degeneration. Thus,integrin-mediated activation of TGFβ plays a critical role in mechanical signaling transduction to regulate IVD cell function and homeostasis. Manipulation of this signaling pathway may be a potential therapeutic target to modify DDD. | Qin Bian Lei Ma Amit Jain Janet L Crane Khaled Kebaish Mei Wan Zhengdong Zhang X Edward Guo Paul D Sponseller Cheryle A Seguin Lee H Riley Yongjun Wang Xu Cao | 2017 | Bone Research2017，5，1： | 9 |
| 3 | Petrogenesis of the Paleoproterozoic Guandishan Granitoids in Shanxi Province:Constraints from Geochemistry and Nd Isotopes显示文摘The Guandishan granitoids consist mainly of various granitoid intrusions with different scales, including the Huijiazhuang intrusion, Shizhuang intrusion and Hengjian intrusion, which were formed between 1906 Ma and 1848 Ma. On the basis of geological and petrological characteristics, these granitoids can be classified into two groups: the earlier gneissic granodiorites and monzogranites, and the later massive leuco-monzogranites. Their geochemical and Nd isotopic features indicate that they could be derived from complicated partial melting of supracrustal rocks with an affinity of continental arc materials, such as sandy shale and pelite, and with garnet, pyroxene, hornblende and plagioclase as residual phases. Biotite, feldspar and other minerals were most likely fractionated during the magma evolution. Their source may have an affinity with continental arcs, and the granitoids could be derived from the main syn-collisional to late-orogenic tectonic environment, which may be related to the final amalgamation between the Eastern and Western continental blocks in the North China Craton. | LIU Chaohui LIU Shuwen LI Qiugen Lü Yongjun K. H. PARK Y. S. SONG | 2006 | Acta Geologica Sinica(English Edition)2006，80，6： | 5 |
| 4 | Effect of Tongxieyaofang decoction on colonic mucosal protein expression profiles in rats with visceral hypersensitivity显示文摘OBJECTIVE: To explore the underlying mechanism of action of Tongxieyaofang decoction in rats with visceral hypersensitivity using proteomics technology.METHODS: Twenty-four female Sprague-Dawley rats were randomly divided into three groups: control group, irritable bowel syndrome(IBS) group and Tongxieyaofang treatment group. An IBS model, characterized as visceral hypersensitivity, was established using the odour of mothballs as conditional stimulation and colorectal distension combined with classic physical restraint as non-conditional stimulation. Rats were intragastrically treated with Tongxieyaofang(2 or 4 m L · kg^(-1)· d^(-1))for 4 weeks. On the 45 th day, the rats were dissected and the colonic mucosal proteins were extracted. Differential protein spots were screened by fluorescent two-dimensional differential gel electrophoresis(2 D-DIGE), and identified by matrix-assisted laser desorption/ionisation time of flight mass spectrometry(MALDI-TOF-MS). Western blotting experiments were performed to verify the changes observed in 2 D-DIGE and MALDI-TOF-MS.RESULTS: It was found that the visceral sensitivity of rats in the Tongxieyaofang treatment group(4 m L/kg) was lower than that in the IBS group(P <0.01). Sixty-one protein spots were differentially expressed between the IBS group and the Tongxieyaofang treatment group. Of these, 23 spots were upregulated in the Tongxieyaofang treatment group, while 38 spots were downregulated. Three specific proteins were successfully identified from the five protein spots with the most obvious changes. The two upregulated proteins were transgelin(TAGLN) and acetaldehyde dehydrogenase 2(Aldh2) and the downregulated protein was cytokeratin 8(CK8).CONCLUSION: Tongxieyaofang can dose-dependently ameliorate visceral hypersensitivity in rats and the mechanism of action may involve the upregulation of TAGLN and Aldh2 and the downregulation of CK8. | Lin Yongjun Ding Ying Lü Bin Liu Nan | 2020 | Journal of Traditional Chinese Medicine2020，40，2： | 4 |
| 5 | A molecular dynamics study on melting point and specific heat of Ni_3Al alloy显示文摘Using the Embedding Atom Method(EAM)for highly undercooled Ni3Al alloy,the melting point and the specific heat were studied by a molecular dynamics simula-tion.The simulation of melting point was carried out by means of the sandwich method and the NVE ensemble method,and the results show a good agreement,whereas are larger than the experimental value of 1663 K.This difference is attrib-uted to the influence of surface melting on experimental results,which causes the smaller measurements compared with the thermodynamic melting point.The simulated specific heat of Ni3Al alloy weakly and linearly increases with the in-crease of undercooling in the temperature range from 800 K to 2000 K. | YANG Hong,Lü YongJun,CHEN Min & GUO ZengYuan Department of Engineering Mechanics,Tsinghua University,Beijing 100084,China | 2007 | Science China(Physics,Mechanics & Astronomy)2007，50，4： | 3 |
| 6 | Megacrysts in the Cenozoic basalt of the Tuoyun Basin,Southwest Tianshan显示文摘Abundant megacrysts of clinopyroxene, amphibole, anorthoclase, and phlogopite are found together with deep-seated xenoliths in the Cenozoic basalt of the Tuoyun Basin, Southwest Tianshan. The megacrysts are mainly in the cone sheet formed at the early stage of the volcanic activity. Clinopyrox-ene megacrysts are located in the lower part of the profile, with amphibole and phlogopite megacrysts in the middle part and anorthoclase megacrysts in the upper part. The crystal integrity, absence of de-formation fabric and their relation to the host basalt suggest that they were crystallized from the host magma and quickly transported to the surface. The mineralogical studies imply that the clinopyroxene megacrysts are of Al-augite with higher Al2O3 (>9%). Amphibole megacrysts are kaersutite rich in TiO2 (>4.5%). Sulfide inclusions such as pyrrhotite occur in some clinopyroxene and amphibole megacrysts. Thermodynamic calculations reveal that pyroxene megacrysts formed under the temperature of 1185.85―1199.85℃ and the pressure between 1.53 and 1.64 GPa comparable to the crust-mantle boundary and amphibole megacrysts crystallized under the pressure of around 0.85 GPa, temperature about 1000℃ comparable to the depth of 30 km. Anorthoclase megacrysts crystallized under the pressure between 0.8―1 GPa,temperature about 900℃.The absence of Ti-rich inclusions such as rutile can be considered as an evidence of quick magma ascending. The P-T conditions estimated via py-roxene megacrysts and phenocrysts compose a P-T path with a steep slope. It can be considered as another evidence of quick magma ascending. However, the estimated temperatures for amphibole megacrysts are markedly lower than those for pyroxene megacrysts given the same pressure. It probably shows that the amphiboles have crystallized at the vanguard of magma and under the vola-tile-rich condition. Thus, we can conclude that the Cenozoic basalts are produced in an extensional tectonic setting and the processes governing crystallization and ascending of the megacrysts are very complex. | LÜ YongJun LUO ZhaoHua REN ZhongBao LIANG Tao | 2007 | Science China Earth Sciences2007，50，1： | 2 |
| 7 | Geochemistry and Petrogenesis of Neoarchean Metamorphic Mafic Rocks in the Wutai Complex显示文摘Neoarchean metamorphic mafic rocks in the lower and the middle Wutai Complex mainly comprise metamorphic gabbros, amphibolites and chlorite schists. They can be subdivided into three groups according to chondrite normalized REE patterns. Rocks in Group #1 are characterized by nearly flat REE patterns (Lan/Ybn=0.86?1.3), the lowest total REEs (29?52 ppm), and weak negative to positive Eu anomalies (Eun/Eun*=0.84?1.02), nearly flat primitive mantle normalized patterns and strong negative Zr(Hf) anomalies. Their geochemical characteristics in REEs and trace elements are similar to those of ocean plateau tholeiite, which imply that this group of rocks can represent remnants of Archean oceanic crust derived from a mantle plume. Rocks in Group #2 are characterized by moderate total REEs (34?116 ppm), LREE-enriched (Lan/Ybn=1.76?4.34) chondrite normalized REE patterns with weak Eu anomalies (Eun/Eun*=0.76?1.16), and negative Nb, Ta, Zr(Hf), Ti anomalies in the primitive mantle normalized spider diagram. The REE and trace element characteristics indicate that they represent arc magmas originating from a sub-arc mantle wedge metasomatized by slab- derived fluids. Rocks in Group #3 are characterized by the highest total REEs (61?192 ppm), the strongest LREEs enrichment (Lan/Ybn=7.12?16) with slightly negative Eu anomalies (Eun/ Eun*=0.81?0.95) in the chondrite normalized diagram. In the primitive mantle normalized diagram, these rocks are characterized by large negative anomalies in Nb, Ta, Ti, negative to no Zr anomalies. They represent arc magmas originating from a sub-arc mantle wedge enriched in slab-derived melts. The three groups of rocks imply that the formation of the Neoarchean Wutai Complex is related to mantle plumes and island-arc interaction. | Lü Yongjun LIU Shuwen Guochun ZHAO LI Qiugen Jian ZHANG LIU Chaohui K. H. PARK Y. S. SONG | 2006 | Acta Geologica Sinica(English Edition)2006，80，6： | 2 |
| 8 | lmaging findings and clinical features of intracal lymphoplasmacyte-rich meningioma显示文摘 | Yongjun L Xin L Qiu S | 2015 | J Craniofae Surg2015，26，2： | 1 |
| 9 | Wide viewing angle dynam- ic holographic stereogram with a curved array of spatial light modula- tors显示文摘 | JOONKU H HW1 K YONGJUN L et at | 2008 | Optics Express2008，16，12： | 1 |
| 10 | Imaging findings and clinical features of intracal lymphoplasmacyte-rich meningioma显示文摘 | Yongjun L Xin L Qiu S | 2015 | J Craniofac Surg2015，，2： | 1 |
| 11 | High undercooling of bulk water during acoustic levitation显示文摘 | Yongjun Lü Chongde Cao Bingbo Wei | 2003 | Science in China Series G: Physics Mechanics and Astronomy2003，，3： | 1 |
| 12 | Two-stage evolution model for the Altyn Tagh Fault, China显示文摘 | YUE Yongjun JUHN G L | 1999 | Geology1999，27，3： | 1 |
| 13 | Nanoparticle as a new gene transferring vector in specific expression gene 显示文摘 | Heng G Yongjun L Yuehong Z | 2004 | Chin Med Sci J2004，17，4： | 1 |
| 14 | Human and mouse dendritic cell subtype显示文摘 | Yongjun L | 2002 | Nature Rev2002，21，9： | 1 |
| 15 | High undercooling of bulk water during acoustic levitation显示文摘 | Yongjun Lü Chongde Cao Bingbo Wei | 2003 | Science in China Series G: Physics Mechanics and Astronomy2003，，3： | 1 |
| 16 | Nanoparticle as a new gene transferring vector in specific expression gene显示文摘 | Yongjun L Yuehong Z | 2002 | Chin Med Sci J2002，17，4： | 1 |
| 17 | Human and mouse dendritic cell subtype显示文摘 | Shortman K Yongjun L | 2002 | Nature Rev2002，21，9： | 1 |
| 18 | Oxidative degradation of phenol in aqueous electrolyte induced by plasma from a direct glow discharge 显示文摘 | Jinzhang G Yongjun L Wu Y | 2003 | Plasma Sources Science and Technology2003，12，4： | 1 |
| 19 | Dietal vitamin C requirement and its effects on tissue antioxidant capacity of juvenile largemouth bass, Micropterus salmoides 显示文摘 | Yongjun C Ruimin Y Yongjian L | 2015 | Aquaculture2015，435，： | 1 |
| 20 | Immobi- lized penicillin G acylase on mesoporous silica: the influence of pore size, pore volume and mesophases显示文摘 | L~ Yongjun GUO Yanglong WANG Yanqin | 2008 | Microporous and mesoporous materials2008，1，13： | 1 |
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