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| 1 | Role of microbial dysbiosis in the pathogenesis of esophageal mucosal disease:A paradigm shift from acid to bacteria?显示文摘Genomic sequencing,bioinformatics,and initial speciation(e.g.,relative abundance)of the commensal microbiome have revolutionized the way we think about the“human”body in health and disease.The interactions between the gut bacteria and the immune system of the host play a key role in the pathogenesis of gastrointestinal diseases,including those impacting the esophagus.Although relatively stable,there are a number of factors that may disrupt the delicate balance between the luminal esophageal microbiome(EM)and the host.These changes are thought to be a product of age,diet,antibiotic and other medication use,oral hygiene,smoking,and/or expression of antibiotic products(bacteriocins)by other flora.These effects may lead to persistent dysbiosis which in turn increases the risk of local inflammation,systemic inflammation,and ultimately disease progression.Research has suggested that the etiology of gastroesophageal reflux disease-related esophagitis includes a cytokine-mediated inflammatory component and is,therefore,not merely the result of esophageal mucosal exposure to corrosives(i.e.,acid).Emerging evidence also suggests that the EM plays a major role in the pathogenesis of disease by inciting an immunogenic response which ultimately propagates the inflammatory cascade.Here,we discuss the potential role for manipulating the EM as a therapeutic option for treating the root cause of various esophageal disease rather than just providing symptomatic relief(i.e.,acid suppression). | Steve M D'Souza Kevin Houston Lauren Keenan Byung Soo Yoo Parth J Parekh David A Johnson | 2021 | World Journal of Gastroenterology2021，27，18： | 8 |
| 2 | Astrocyte elevated gene-1 regulates hepatocellular carcinoma development and progression显示文摘 | Yoo Byoung Kwon Emdad Luni Su Zao-zhong Villanueva Augusto Chiang Derek Y Mukhopadhyay Nitai D Mills Alan Scott Waxman Samuel Fisher Robert A Llovet Josep M Fisher Paul B Sarkar Devanand | 2009 | Journal of Clinical Investigation2009，，3： | 2 |
| 3 | Phylogeny and diversificatoin of B-function MADS-box genes in angiosperms: Evolutionary and functional implications of a 260-million-year-old duplication显示文摘 | Kim S Yoo M J Albert V A | 2004 | Am J Bot2004，91，： | 1 |
| 4 | The control of neural cell-to-cell interactions through non- contact electrical field stimulation using graphene electrodes显示文摘 | Heo C Yoo J Lee S Jo A Jung S Yoo H Lee Y H Suh M | 2011 | Biomaterials2011，32，： | 1 |
| 5 | 查看详情显示文摘 | Fan W Snyder M A Kumar S Lee P S Yoo W C McCormick A V Penn R L Stein A Tsapatsis M | | 0，，： | 1 |
| 6 | Systematic characterization of the computed tomography angiography spot sign in primary intracerebral hemorrhage identifies patients at highest risk for hematoma expansion the spot sign score显示文摘 | Almandoz J E D Yoo A J Stone M J | 2009 | Stroke2009，40，9： | 1 |
| 7 | Enhanced control of integrating cascade processes with time delays using modified Smith predictor 显示文摘 | Uma S Chidarnbaram M Rao Seshagiri A Yoo C K | 2010 | Chemical Engineering Science2010，65，： | 1 |
| 8 | CT angiography of pul monary embolism: diagnostic criteria and causes of misdiagnosis 显示文摘 | Wittram C Maher M M Yoo A J | 2004 | RadioGraphics2004，24，5： | 1 |
| 9 | 查看详情显示文摘 | Nam K.T Kim D.W Yoo E J Chiang C.Y. Meethong N. Hammond P.T. Chiang Y.M. Belcher A M | | 0，，： | 1 |
| 10 | Tobacco and estrogen metabolic polymorpbisms and risk of non-small cell lung cancer in women显示文摘 | COTE M L YOO W WENZLAFF A S | 2009 | Carcinogenesis2009，30，4： | 1 |
| 11 | Induction of long - term protective immune responses by influenza I-IS N1 virus -like parti- cles显示文摘 | Kang S M Yoo D G Lipatov A S | 2009 | PLoS One2009，4，3： | 1 |
| 12 | The spot sign score in primary intracerebral hemorrhage identifies patients at highest risk of in-hospital mortality and poor outcome among survivors显示文摘 | Almandoz J E D Yoo A J Stone M J | 2010 | Stroke2010，41，1： | 1 |
| 13 | Sonic hedgehog pathway promotes metastasis and lymphangiogenesis via activation of Akt, EMT, and MMP-9 pathway in gastric cancer显示文摘 | Yoo Y A Kang M H Lee H J | 2011 | Cancer Res2011，71，22： | 1 |
| 14 | CT angiography of pulmonary embolism: diagnostic criteria and causes of misdiag- uosis 显示文摘 | Wittram C Mather M M Yoo A | 2004 | Radio Graphics2004，24，： | 1 |
| 15 | Sonic hedgehog pathway promotes metastasis and lymphangiogenesis via activation of Akt,EMT and MMP-9 pathway in gastric cancer显示文摘 | Yoo Y A Kang M H Lee H J | | 0，，22： | 1 |
| 16 | Application of texture simulation to understanding mechanical behavior of Mg and solid solution alloys containing Li or Y显示文摘 | AGNEW S R YOO M H HORTON J A | 2001 | Acta Materialia2001，49，20： | 1 |
| 17 | Design,test and model of a hybrid magnetostrictive hydraulic actuator显示文摘 | Chaudhuri A Yoo J H Wereley N M | 2009 | Smart Materials and Structures2009，18，8： | 1 |
| 18 | Systematic characterization of the computed tomography angiography spot sign in primary intracerebral hemorrhage identifies patients at highest risk for hematoma expansion:the spot sign score显示文摘 | Delgado AJE Yoo A J Stone M J | 2009 | Stroke2009，40，： | 1 |
| 19 | Viscoelastic Modeling and Field Validation of FlexiblePavements 显示文摘 | ELSEIFI M A AL-QADI I L YOO P J | 2006 | Journal of Engineering Mechanics2006，132，2： | 1 |
| 20 | Enhanced control of integrating cascade processes with time delays using modified Smith predictor显示文摘 | Uma S Chidambaram M Rao Seshagiri A Yoo C k | 2010 | Chemical Engineering Science2010，65，： | 1 |
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