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| 1 | Layer-by-layer deposition of bioactive layers on magnesium alloy stent materials to improve corrosion resistance and biocompatibility显示文摘Magnesium alloy is considered as one of the ideal cardiovascular stent materials owing to its good mechanical properties and biodegradability.However,the in vivo rapid degradation rate and the insufficient biocompatibility restrict its clinical applications.In this study,the magnesium alloy(AZ31B)was modified by combining the surface chemical treatment and in-situ self-assembly of 16-phosphonyl-hexadecanoic acid,followed by the immobilization of chitosan-functionalized graphene oxide(GOCS).Heparin(Hep)and GOCS were alternatively immobilized on the GOCS-modified surface through layer by layer(LBL)to construct the GOCS/Hep bioactive multilayer coating,and the corrosion resistance and biocompatibility were extensively explored.The results showed that the GOCS/Hep bioactive multilayer coating can endow magnesium alloys with an excellent in vitro corrosion resistance.The GOCS/Hep multilayer coating can significantly reduce the hemolysis rate and the platelet adhesion and activation,resulting in an excellent blood compatibility.In addition,the multilayer coating can not only enhance the adhesion and proliferation of the endothelial cells,but also promote the vascular endothelial growth factor(VEGF)and nitric oxide(NO)expression of the attached endothelial cells on the surfaces.Therefore,the method of the present study can be used to simultaneously control the corrosion resistance and improve the biocompatibility of the magnesium alloys,which is expected to promote the application of magnesium alloys in biomaterials or medical devices,especially cardiovascular stent. | Fan Gao Youdong Hu Guicai Li Sen Liu Li Quan Zhongmei Yang Yanchun Wei Changjiang Pan | 2020 | Bioactive Materials2020，5，3： | 12 |
| 2 | CFD Investigation of the Influence of Volute Geometrical Variations on Hydrodynamic Characteristics of Circulator Pump显示文摘Improper design of volute geometry can be the main cause that leads to unsteady pressure pulsation and radial force in pumps. Therefore, it is important to understand the influence of volute geometrical parameters on hydrodynamic characteristics of pump and the mechanism. However, the existing studies are limited to investigate the influence of only one or two volute geometrical parameters each time, and a systematic study of the influence of the combinations of different volute geometrical parameters on the pump's hydrodynamic characteristics is missing. In this paper, a study on the understanding of the influence of volute geometrical variations on hydrodynamic characteristics of a high speed circulator pump by using computational fluid dynamics(CFD) technology is presented. Five main volute geometrical parameters D_3, A_8, a_0, j_0 and Rt are selected and 25 different volute configurations are generated by using design of experiments(DOE) method. The 3D unsteady flow numerical simulations, which are based on the SST k-w turbulence model and sliding mesh technique provided by CFX, are executed on the 25 different volute configurations. The hydraulic performance, pressure pulsation and unsteady radial force inside the pump at design condition are obtained and analyzed. It has been found that volute geometrical parameters D_3 and A_8 are major influence factors on hydrodynamic characteristics of the pump, while a_0, j_0 and Rt are minor influence factors. The minimum contribution from both D_3 and A_8 is 58% on head, and maximum contribution from both D_3 and A_8 is 90% on pressure pulsation. Regarding the pressure pulsation intensity, two peaks can be found. One is in the tongue area and the other is in the diffusor area. The contributions are around 60% from tongue and 25% from diffusor, respectively. The amplitude of pressure pulsation has a quadratic polynomial functional relationship with respect to D_3/D_2 and A_8/A_(10), and fluctuating level of radial force has a quadratic polynomial functional relationship with respect to D_3/D_2. While for the other volute parameters a_0, j_0 and Rt, no special function has been found related to pressure pulsation and radial force. The presented work could be a useful guideline in engineering practice when designing a circulator pump with low hydrodynamic force. | WU Denghao YUAN Shouqi REN Yun MU Jiegang YANG Youdong LIU Jian | 2016 | Chinese Journal of Mechanical Engineering2016，29，2： | 11 |
| 3 | Multi-level assembly model for top-down design of mechanical products显示文摘 | Xiang Chen Shuming Gao Youdong Yang Shuting Zhang | 2012 | Computer-Aided Design2012，10，： | 1 |
| 4 | Extracorporeal membrane oxygenation in adult patients with sepsis and septic shock: Why, how, when, and for whom显示文摘Sepsis and septic shock remain the leading causes of death in intensive care units.Some patients with sepsis fail to respond to routine treatment and rapidly progress to refractory respiratory and circulatory failure,necessitating extracorporeal membrane oxygenation(ECMO).However,the role of ECMO in adult patients with sepsis has not been fully established.According to existing studies,ECMO may be a viable salvage therapy in carefully selected adult patients with sepsis.The choice of venovenous,venoarterial,or hybrid ECMO modes is primarily determined by the patient’s oxygenation and hemodynamics(distributive shock with preserved cardiac output,septic cardiomyopathy(left,right,or biventricular heart failure),or right ventricular failure caused by acute respiratory distress syndrome).Veno-venous ECMO can be used in patients with sepsis and severe acute respiratory distress syndrome when conventional mechanical ventilation fails,and early application of veno-arterial ECMO in patients with sepsis-induced refractory cardiogenic shock may be critical in improving their chances of survival.When ECMO is indicated,the choice of an appropriate mode and determination of the optimal timing of initiation and weaning are critical,particularly in an experienced ECMO center.Furthermore,some special issues,such as ECMO flow,anticoagulation,and antibiotic therapy,should be noted during the management of ECMO support. | Hongling Zhang Youdong Xu Xin Huang Shunyin Yang Ruiting Li Yongran Wu Xiaojing Zou Yuan Yu You Shang | 2024 | Journal of Intensive Medicine2024，4，1： | 0 |
| 5 | STUDY ON ADSORPTION OF HUMIC AND PHYIC ACIDS USING RESINS显示文摘1. INTRODUCTION Humic acid (HA) and Phytic acid (PA) are present in environment as a result of the decomposition of plant biomass, they are the major components of natural dissolved | WANG Jinnan LI Aimin ZHOU Youdong YANG Zhou LI Xu | 2008 | Chinese Journal of Reactive Polymers2008，17，1： | 0 |
| 6 | Prevention and Treatment of COVID-19 and Rehabilitation of Kidney,Liver and Cardiovascular Diseases with Kyllinga brevifolia Rottb.显示文摘The COVID-19 epidemic is raging,and the virus damages the lung,kidney,liver,and cardiovascular system.Medicine for prevention and treatment of COVID-19 requires three properties:being able to efficiently inhibit COVID-19 from infecting cells;being able to quickly repair lung damage;non-toxic.Kyllinga brevifolia Rottb.is found to have the three properties mentioned above and can be used for prevention,treatment and rehabilitation.In terms of rehabilitation of lung,kidney,liver,and cardiovascular diseases,K.brevifolia Rottb.shows remarkable efficacy when combined with other medicinal materials.This is instructive and useful for the rehabilitation of lung,liver,kidney,and cardiovascular damage caused by COVID-19. | Leng NIE Youdong LIANG Xinwei YANG Xiaohao HUANG Shumei WANG Jianfei CHEN Ni ZENG | 2021 | Medicinal Plant2021，12，2： | 0 |
| 7 | Steric hindrance effect of Schiff-base ligands on magnetic relaxation dynamics and emissive behavior of two dinuclear dysprosium complexes显示文摘The self-assembly reactions between mixed-ligand and tetrahydrate dysprosium acetate in the presence of mixed organic solvents lead to two structural similar dinuclear dysprosium complexes with composition formulas of Dy_(2)(L_1)_(2)(L_(2))_(2)(CH_(3)OH)_(2)·CH_(2)Cl_(2)·CH_(3)OH(1) and Dy_(2)(L_1)_(2)(L_(3))_(2)(CH_(3)OH)_(2)·CH_(3)CN(2),where L_1,L_(2) and L_(3) represent the deprotonated form of 4-tert-butyl-2-(7-methoxybenzo[d]oxazol-2-yl)phenol,(E)-1-(((3,5-di-tert-butyI-2-hydroxyphenyI)imino)methyl)naphthalen-2-ol and(E)-2,4-di-tertbutyl-6-((2-hydroxybenzylidene)amino)phenol.The tiny difference of the core structure of 1 and 2 is derived from the steric hindrance of Schiff base ligands L_(2) and L_(3).Dynamic magnetic measurements reveal that 1 and 2 show frequency-dependent out-of-phase alternating-current susceptibility signal peaks at different temperatures under zero dc field,diagnostic of single-molecule magnet behavior.The experimental derived energy barrier to magnetization reversal for 1 and 2 is 108(1),47(2) and 33(3) K.Ab initio CASSCF calculations performed on 1 and 2 suggest that the origin of the difference in magnetic properties originates from the variation in the single-ion anisotropy that arises due to minor structural variation.Further,the equation to calculate the effective energy barrier for Dy_(2) proposed earlier is found to yield an excellent agreement with the experimental results.Solid state fluorescence measurements performed on 1 and 2 demonstrate that both exhibit two ligands centered components of fluorescent emissive,in addition,with different emitting colors and chromaticity coordinates.The discrepancy of fluorescence and single molecule magnet behavior showed by 1 and 2 can be attributed to the steric hindrance effect of Schiff base ligands. | Youdong Jiang Sourav Dey Hongshan Ke Yongsheng Yang Lin Sun Gang Xie Sanping Chen Gopalan Rajaraman | 2023 | Journal of Rare Earths2023，41，7： | 0 |
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