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| 1 | Regulation of inflammation and tumorigenesis by the FIPE family of phospholipid transfer proteins显示文摘 | Jason R Goldsmith Youhai H Chen | 2017 | Cellular & Molecular Immunology2017，14，6： | 15 |
| 2 | 在由巨噬细胞并且从而的增加的 IL-10 表示的规划房间死亡 4 结果的缺乏在 hyperlipidemic 鼠标稀释动脉粥样硬化显示文摘(Pdcd4 ) 规划房间死亡 4 是抄写和翻译和肿瘤 suppressor 的一个最新定义的禁止者。最近的研究建议了 Pdcd4 可以也涉及一些煽动性的疾病。然而,它在动脉粥样硬化的角色,动脉的墙的长期的发炎,尚待被调查。这里,我们发现在老鼠的那 Pdcd4 缺乏在巨噬细胞增加了 IL-10 的表示并且减少在 T 房间的 IL-17 的表示面对在 vitro 并且在高导致脂肪的动脉粥样硬化患者匾的一个联系动脉粥样硬化的激发器。重要地,击倒 Pdcd4 在喂的 Apoe −/− 老鼠在动脉粥样硬化患者损害导致了减少一本高胖的食谱。这效果能被与抵销的抗体堵住 IL-10 然而并非由外长的 IL-17 的申请部分颠倒。进一步机械学的研究表明 Pdcd4 否定地以一种 ERK1/2 依赖、 p38 依赖的方式调整了 IL-10 的表示。这些结果证明那 Pdcd4 缺乏通过反煽动性的 cytokine IL-10 的 upregulation 部分地在 hyperlipidemic 老鼠稀释动脉粥样硬化。这显示内长的 Pdcd4 支持动脉粥样硬化因此与动脉粥样硬化为病人代表一个潜在的治疗学的目标。 | Yang Jiang Qi Gao Liyang Wang Chun Guo Faliang Zhu Bo Wang Qun Wang Fei Gao Youhai Chen Lining Zhang | 2016 | Cellular & Molecular Immunology2016，13，4： | 8 |
| 3 | Regulation of inflammation and tumorigenesis by the TIPE family of phospholipid transfer proteins显示文摘In this article,the name of an author was listed incorrectly.The author names should have been listed as Jason R Goldsmith,Svetlana Fayngerts and Youhai H Chen.The authors regret the errors. | Jason R Goldsmith Youhai H Chen | 2017 | Cellular & Molecular Immunology2017，14，12： | 8 |
| 4 | Hepatitis B virus X protein modulates the apoptosis of hepatoma cell line induced by TRAIL显示文摘The purpose of this study is to observe the effects of HBx on the apoptosis of hepatoma cells induced by TNF-related apoptosis-inducing ligand (TRAIL) and to study prelimi- nary molecular mechanisms for its effects. In order to set up a model in vitro, BEL7402-HBx cell line, stably expressing HBx mRNA, was established by stable transfection of pcDNA-HBx, which contains HBx gene, into hepatoma cell line BEL7402. Control cell line BEL7402-cDNA3, stably transfected with pcDNA3, was set up simultaneously as a control. Trypan blue exclusion test, caspase 3 activity detection and TUNEL assay were performed to detect the apoptosis of BEL7402, BEL7402-cDNA3, BEL7402-HBx induced by TRAIL. The expression of TRAIL recep- tors in three groups was analyzed by Flow cytometry. In addition, phosphorothioated antisense oligonucleotide against the translation initial region of HBx gene (PS-asODNs/HBx) was used to block the expression of HBx in HepG2.2.15 cells and to further confirm the effects of HBx on TRAIL-induced apoptosis. Trypan blue exclusion test indicated that TRAIL had a dose-dependent cytotoxicity on BEL7402, BEL7402-cDNA3 and BEL7402-HBx cells. Under treatment of the same concentration of TRAIL, BEL7402-HBx had a higher apoptosis rate and a higher level of Caspase 3 activation than BEL7402 and BEL7402-cDNA3. TUENL assay showed that the apoptosis rate of BEL7402-HBx induced by 10 μg/L TRAIL was 41.4%±7.2%, signifi- cantly higher than that of BEL7402 and BEL7402-cDNA3 cells. Blockade of HBx expression in Hep G2.2.15 cells partly inhibited the apoptosis induced by TRAIL. The introduction or blockade of HBx did not change the expression pattern of TRAIL receptors. The present study firstly con- firms the effects of HBx on TRAIL- induced apoptosis from two different points and it is not re- lated with the expression level of TRAIL receptors. This would be useful to further clarify the roles of imbalanced apoptosis in pathogenesis of Hepatitis B and related hepatocellular carcinoma. | LIANG Xiaohong 1 , SUN Wensheng 1 , GAO Lifen 1 , MA Chunhong 1 , HAN Lihui 1 & CHEN Youhai 2 1. Institute of Immunology, Medical School of Shandong University, Jinan 250012, China 2. Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia PA19104, USA | 2005 | Science China(Life Sciences)2005，48，3： | 7 |
| 5 | COVID-19:immunopathogenesis and Immunotherapeutics显示文摘The recent novel coronavirus disease(COVID-19)outbreak,caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),is seeing a rapid increase in infected patients worldwide.The host immune response to SARS-CoV-2 appears to play a critical role in disease pathogenesis and clinical manifestations.SARS-CoV-2 not only activates antiviral immune responses,but can also cause uncontrolled inflammatory responses characterized by marked pro-inflammatory cytokine release in patients with severe COVID-19,leading to lymphopenia,lymphocyte dysfunction,and granulocyte and monocyte abnormalities.These SARS-CoV-2-induced immune abnormalities may lead to infections by microorganisms,septic shock,and severe multiple organ dysfunction.Therefore,mechanisms underlying immune abnormalities in patients with COVID-19 must be elucidated to guide clinical management of the disease.Moreover,rational management of the immune responses to SARSCoV-2,which includes enhancing anti-viral immunity while inhibiting systemic inflammation,may be key to successful treatment.In this review,we discuss the immunopathology of COVID-19,its potential mechanisms,and clinical implications to aid the development of new therapeutic strategies against COVID-19. | Li Yang Shasha Liu Jinyan Liu Zhixin Zhang Xiaochun Wan Bo Huang Youhai Chen Yi Zhang | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 4 |
| 6 | Maintaining immunological tolerance with Foxp3显示文摘在胸腺的中央忍耐是为删除汽车的主要机制反应 T 房间。尽管有这,进圆周的自我反应的 T 淋巴细胞的逃跑揭示汽车免疫的威胁。补偿它的瑕疵,胸腺也与镇压功能生产 Foxp3+CD4+CD25+ 规章的 T 房间的一个自然地发生的子集,能够控制汽车反应房间。Foxp3 (叉头框 P3 ) ,为房间的这个子集的系特定的标记,对他们的 thymic 开发和外部功能关键,并且还 Foxp3 驾驶的 transcriptional 程序直到现在大部分未定义。新兴的证据提供了卓见进它的角色:从 Foxp3 到的能力与象 NFAT 那样的另外的抄写因素合作,到目标的染色体宽的描述,基因直接由 Foxp3 跳了并且调整。这里,我们讨论自然地发生的规章的 T 房间的发现 - 他们的显型,发展,维护,和功能 - 大部分当他们被系特定的标记定义, Foxp3。 | Lauren E Mays Youhai H Chen | 2007 | Cell Research2007，17，11： | 3 |
| 7 | The Anti-inflammatory TIPE2 Is an Inhibitor of the Oncogenic Ras显示文摘 | Yael Gus-Brautbar Derek Johnson Li Zhang Honghong Sun Peng Wang Shirley Zhang Lining Zhang Youhai H. Chen | 2012 | Molecular Cell2012，，5： | 2 |
| 8 | TIPE2, a Negative Regulator of Innate and Adaptive Immunity that Maintains Immune Homeostasis显示文摘 | Honghong Sun Shunyou Gong Ruaidhri J. Carmody Anja Hilliard Li Li Jing Sun Li Kong Lingyun Xu Brendan Hilliard Shimin Hu Hao Shen Xiaolu Yang Youhai H. Chen | 2008 | Cell2008，，： | 2 |
| 9 | Heavy metal contamination in western Xiamen Bay sediments and its vicinity, China显示文摘 | Luoping Zhang Xin Ye Huan Feng Youhai Jing Tong Ouyang Xingtian Yu Rongyuan Liang Chengtie Gao Weiqi Chen | 2007 | Marine Pollution Bulletin2007，，7： | 1 |
| 10 | Analysis of TRAIL receptor expression using a novel anti - TRAIL death receptor 5 monoclonal antibody 显示文摘 | Ma Yuanfang Chen Yiguang Chen Youhai | 2003 | CMJ2003，16，： | 1 |
| 11 | TIPE2, a Negative Regulator of Innate and Adaptive Immunity that Maintains Immune Homeostasis显示文摘 | Honghong Sun Shunyou Gong Ruaidhri J. Carmody Anja Hilliard Li Li Jing Sun Li Kong Lingyun Xu Brendan Hilliard Shimin Hu Hao Shen Xiaolu Yang Youhai H. Chen | 2008 | Cell2008，，3： | 1 |
| 12 | Dissociation between source and item memory in Parkinson's disease显示文摘 | Hu Panpan Li Youhai Ma Huijuan Xi Chunhua Chen Xianwen Wang Kai | 2014 | Chinese Medical Journal2014，，18： | 1 |
| 13 | Analysis of TRAIL receptor expression using a novel anti-TRAIL death receptor5 monoclonal antibody 显示文摘 | Ma Yuanfang Chen Yiguang Chen Youhai | 2003 | CMJ2003，16，： | 1 |
| 14 | Blocking TRAIL-DR5 signaling with soluble DR5 reduces delayed neuronal damage after transient global cerebral ischemia显示文摘 | Min Cui Limei Wang Xiaohong Liang Xuelian Ma Yugang Liu Mingfeng Yang Kejing Liu Xinbing Wei Zhiqiang Zhou Youhai H. Chen Wensheng Sun | 2010 | Neurobiology of Disease2010，，2： | 1 |
| 15 | Ectopic osteogenesis and scaffold biodegradation of tissue engineering bone composed of chitosan and osteo-induced bone marrow mesenchymal stem cells in vivo显示文摘 | He Yiqun Dong Youhai Chen Xujun Lin Rongqiang | 2014 | Chinese Medical Journal2014，，2： | 1 |
| 16 | Research on High-Efficiency Cyclone Separators and Their Optimum Design显示文摘ResearchonHighEficiencyCycloneSeparatorsandTheirOptimumDesignShiMingxian,JinYouhai,WuXiaolin,ChenJianyi,LiuJunren(UnitedRese... | Shi Mingxian, Jin Youhai, Wu Xiaolin, Chen Jianyi, Liu Junren (United Research Institute of Applied Chemistry and Chemical Engineering, University of Petroleum, Beijing 100083) | 1997 | 石油学报(石油加工)1997，13，S1： | 1 |
| 17 | Regulation of TH2 response 显示文摘 | Youhai chen | 1997 | Immunology1997，92，： | 1 |
| 18 | PDCD4 Deficiency Aggravated Colitis and Colitis-associated Colorectal Cancer Via Promoting IL-6/STAT3 Pathway in Mice显示文摘 | Liyang Wang Mingsheng Zhao Chun Guo Guannan Wang Faliang Zhu Jianing Wang Xiaoyan Wang Qun Wang Wei Zhao Yongyu Shi Youhai H. Chen Lining Zhang | 2016 | Inflammatory Bowel Diseases2016，，： | 1 |
| 19 | Heavy vicinity, China 显示文摘 | Zhang Luoping Ye Xin Feng Huan Jing Youhai Ouyang Tong Yu Xingtian Liang Rongyuan Gao Chengtie Chen Weiqi | 2007 | Mar Pollut Bull2007，54，7： | 1 |
| 20 | Roles of TIPE2 in hepatitis B virus-induced hepatic inflammation in humans and mice显示文摘 | Wenjin Xi Yejia Hu Yugang Liu Jiao Zhang Lei Wang Yunwei Lou Zhonghua Qu Jian Cui Guizhong Zhang Xiaohong Liang Chunhong Ma Chengjiang Gao Youhai Chen Suxia Liu | 2011 | Molecular Immunology2011，，9： | 1 |
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