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| 1 | Phosphate removal from domestic wastewater using thermally modified steel slag显示文摘This study was performed to investigate the removal of phosphate from domestic wastewater using a modified steel slag as the adsorbent. The adsorption effects of alkalinity, salt, water,and thermal modification were investigated. The results showed that thermal activation at 800℃ for 1 hr was the optimum operation to improve the adsorption capacity. The adsorption process of the thermally modified slag was well described by the Elovich kinetic model and the Langmuir isotherm model. The maximum adsorption capacity calculated from the Langmuir model reached 13.62 mg/g. Scanning electron microscopy indicated that the surface of the modified slag was cracked and that the texture became loose after heating. The surface area and pore volume did not change after thermal modification. In the treatment of domestic wastewater, the modified slag bed(35.5 kg) removed phosphate effectively and operated for 158 days until the effluent P rose above the limit concentration of 0.5 mg/L. The phosphate fractionation method, which is often applied in soil research, was used to analyze the phosphate adsorption behavior in the slag bed. The analysis revealed that the total contents of various Ca–P forms accounted for 81.4%–91.1%, i.e., Ca10–P 50.6%–65.1%, Ca8–P 17.8%–25.0%,and Ca2–P 4.66%–9.20%. The forms of Al–P, Fe–P, and O–P accounted for only 8.9%–18.6%. The formation of Ca10–P precipitates was considered to be the main mechanism of phosphate removal in the thermally modified slag bed. | Jian Yu Wenyan Liang Li Wang Feizhen Li Yuanlong Zou Haidong Wang | 2015 | Journal of Environmental Sciences2015，27，5： | 13 |
| 2 | Interferon-armed RBD dimer enhances the immunogenicity of RBD for sterilizing immunity against SARS-CoV-2显示文摘Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)has caused a global crisis,urgently necessitating the development of safe,efficacious,convenient-to-store,and low-cost vaccine options.A major challenge is that the receptor-binding domain(RBD)-only vaccine fails to trigger long-lasting protective immunity if used alone for vaccination. | Shiyu Sun Yueqi Cai Tian-Zhang Song Yang Pu Lin Cheng Hairong Xu Jing Sun Chaoyang Meng Yifan Lin Haibin Huang Fang Zhao Silin Zhang Yu Gao Jian-Bao Han Xiao-Li Feng Dan-Dan Yu Yalan Zhu Pu Gao Haidong Tang Jincun Zhao Zheng Zhang Jiaming Yang Zhenxiang Hu Yang-Xin Fu Yong-Tang Zheng Hua Peng | 2021 | Cell Research2021，31，9： | 7 |
| 3 | A stiffness-matching based evaluation approach for compliance of mechanical systems in shield tunneling machines显示文摘As the most important performance,compliance of shield tunneling machines(STM) is defined as the capability to accommodate the sudden change of the load induced by the variable geological conditions during excavation.Owing to the different requirements of the compliant tasks,the existing methods in the robotic field cannot be utilized in the analysis and design of the mechanical system of shield tunneling machines.In this paper,based on the stiffness of the mechanical system and the equivalent contact stiffness of the tunnel face,the tunneling interface-matching index(IMI) is proposed to evaluate the compliance of the machine.The IMI is defined as a metric to describe the coincidence of the stiffness curves of the mechanical system and the tunnel face.Moreover,a tunneling case is investigated in the paper as an example to expound the validation of IMI and the analytical process.In conclusion,the IMI presented here can be served as an appraisement of the capability in conforming to the load fluctuation,and give instructions for the design of the thrust system of shield tunneling machines. | ZHAO Yong WANG Hao YU HaiDong LAI XinMin LIN ZhongQin | 2012 | Science China(Technological Sciences)2012，55，10： | 7 |
| 4 | Tim-3 promotes cell aggressiveness and paclitaxel resistance through NF-κB/STAT3 signalling pathway in breast cancer cells显示文摘Objective:Although T-cell immunoglobulin and mucin-domain containing molecule-3(Tim-3)has been recognized as a promising target for cancer immunotherapy,its exact role in breast cancer has not been fully elucidated.Methods:Tim-3 gene expression in breast cancer and its prognostic significance were analyzed.Associated mechanisms were then explored in vitro by establishing Tim-3-overexpressing breast cancer cells.Results:In a pooled analysis of The Cancer Genome Atlas(TCGA)database,Tim-3 gene expression levels were significantly higher(P<0.001)in breast cancer tissue,compared with normal tissues.Tim-3 was a prognosis indicator in breast cancer patients[relapse-free survival(RFS),P=0.004;overall survival(OS),P=0.099].Tim-3 overexpression in Tim-3 low breast cancer cells promoted aggressiveness of breast cancer cells,as evidenced by enhanced proliferation,migration,invasion,tight junction deterioration and tumor-associated tubal formation.Tim-3 also enhanced cellular resistance to paclitaxel.Furthermore,Tim-3 exerted its function by activating the NF-κB/STAT3 signalling pathway and by regulating gene expression[cyclin D1(CCND1),C-Myc,matrix metalloproteinase-1(MMP1),TWIST,vascular endothelial growth factor(VEGF)upregulation,concomitant with Ecadherin downregulation).Lastly,Tim-3 downregulated tight junction-associated molecules zona occludens(ZO)-2,ZO-1 and occludin,which may further facilitate tumor progression.Conclusions:Tim-3 plays an oncogenic role in breast cancer and may represent a potential target for antitumor therapy. | Yizi Cong Yuxin Cui Shiguang Zhu Jianqiao Cao Haidong Zou Tracey AMartin Guangdong Qiao Wenguo Jiang Zhigang Yu | 2020 | Chinese Journal of Cancer Research2020，32，5： | 7 |
| 5 | 肿瘤浸润髓系细胞上表达的共抑制分子B7S1抑制抗肿瘤CD8 T细胞的功能显示文摘文章简介近年来,肿瘤免疫治疗蓬勃发展,为人类战胜癌症带来了一线曙光。阻断PD-1/PD-L1通路的抗体药物可以提高CD8 T细胞的抗肿瘤活性,疗效显著优于传统治疗手段。然而,只有小部分实体瘤病人可以对PD-1/PD-L1免疫治疗产生应答. | 黎静 Younghee Lee Yanjian Li Yu Jiang Huiping Lu Wenjuan Zang Xiaohong Zhao Liguo Liu Yang Chen Haidong Tan 杨志英 Michael Q Zhang Tak W.Mak Ling Ni 董晨 | 2019 | 科学新闻2019，0，2： | 6 |
| 6 | High mobility group box 1 protein (HMGB1) as an immune-modulating factor for polarization of human T lymphocytes显示文摘Objective This study was performed to investigate the effect of high mobility group box-1 protein (HMGB1) on immune function of human T lymphocytes in vitro and explore its potential role in cell-mediated immune dysfunction. Methods Fresh blood was obtained from healthy adult volunteers and peripheral blood mononuclear cells (PBMCs) were isolated, then rhHMGB1 was added to PBMCs. Four-color flow cytometric (FCM) analysis was used for the measurement of intracellular cytokine including interleukin IL-4 and interferon IFN- ? ELISA kits were employed for the determination of IL-2 and sIL-2R protein levels in cell culture supernatants. Results (1) Different stimulating time and dosage of rhHMGB1 did not alter the number of IFN- αpositive cells (Th1). rhHMGB1 stimulation provoked a dose-dependent and time-dependent increase in Th2 subset and decrease in ratio of Th1 to Th2. (2) Compared with the untreated cells, when the cells were coincubated with rhHMGB1 (10-100ng/ml) for 12 hrs, protein release of IL-2 and sIL-2R were significantly up-regulated. At 48 hrs, in contrast, protein production was relatively lower in cells after exposure to 100-1000 ng/ ml rhHMGB1. Conclusions These findings demonstrated that HMGB1 has a dual influence on immune functions of human T lymphocytes. | Lifeng Huang Yongming Yao Haidong Meng Xiaodong Zhao Ning Dong Yan Yu | 2008 | Journal of Geriatric Cardiology2008，5，2： | 6 |
| 7 | Rapid health transition in China, 1990–2010: findings from the Global Burden of Disease Study 2010显示文摘 | Gonghuan Yang Yu Wang Yixin Zeng George F Gao Xiaofeng Liang Maigeng Zhou Xia Wan Shicheng Yu Yuhong Jiang Mohsen Naghavi Theo Vos Haidong Wang Alan D Lopez Christopher JL Murray | 2013 | The Lancet . 2013 (9882)2013，，9882： | 4 |
| 8 | Rapid health transition in China, 1990–2010: findings from the Global Burden of Disease Study 2010显示文摘 | Gonghuan Yang Yu Wang Yixin Zeng George F Gao Xiaofeng Liang Maigeng Zhou Xia Wan Shicheng Yu Yuhong Jiang Mohsen Naghavi Theo Vos Haidong Wang Alan D Lopez Christopher JL Murray | 2013 | The Lancet2013，，9882： | 3 |
| 9 | A MXene-functionalized paper-based electrochemical immunosensor for label-free detection of cardiac troponin I显示文摘Convenient,rapid,and accurate detection of cardiac troponin I(cTnI)is crucial in early diagnosis of acute myocardial infarction(AMI).A paper-based electrochemical immunosensor is a promising choice in this field,because of the flexibility,porosity,and cost-efficacy of the paper.However,paper is poor in electronic conductivity and surface functionality.Herein,we report a paper-based electrochemical immunosensor for the label-free detection of cTnI with the working electrode modified by MXene(Ti_(3)C_(2))nanosheets.In order to immobilize the bio-receptor(anti-cTnI)on the MXene-modified working electrode,the MXene nanosheets were functionalized by aminosilane,and the functionalized MXene was immobilized onto the surface of the working electrode through Nafion.The large surface area of the MXene nanosheets facilitates the immobilization of antibodies,and the excellent conductivity facilitates the electron transfer between the electrochemical species and the underlying electrode surface.As a result,the paper-based immunosensor could detect cTnI within a wide range of 5-100 ng/mL with a detection limit of 0.58 ng/mL.The immunosensor also shows outstanding selectivity and good repeatability.Our MXene-modified paper-based electrochemical immunosensor enables fast and sensitive detection of cTnI,which may be used in real-time and cost-efficient monitoring of AMI diseases in clinics. | Li Wang Yufeng Han Hongchen Wang Yaojie Han Jinhua Liu Gang Lu Haidong Yu | 2021 | Journal of Semiconductors2021，42，9： | 3 |
| 10 | Rapid health transition in China, 1990–2010: findings from the Global Burden of Disease Study 2010显示文摘 | Gonghuan Yang Yu Wang Yixin Zeng George F Gao Xiaofeng Liang Maigeng Zhou Xia Wan Shicheng Yu Yuhong Jiang Mohsen Naghavi Theo Vos Haidong Wang Alan D Lopez Christopher JL Murray | 2013 | 2013 (9882)2013，，9882： | 3 |
| 11 | Regulation of sister chromatid cohesion by nuclear PD-L1显示文摘Programmed death ligand-1(PD-L1 or B7-H1)is well known for its role in immune checkpoint regulation,but its function inside the tumor cells has rarely been explored.Here we report that nuclear PD-L1 is important for cancer cell sister chromatid cohesion.We found that depletion of PD-L1 suppresses cancer cell proliferation,colony formation in vitro,and tumor growth in vivo in immune-deficient NSG mice independent of its role in immune checkpoint.Specifically,PD-L1 functions as a subunit of the cohesin complex,and its deficiency leads to formation of multinucleated cells and causes a defect in sister chromatid cohesion.Mechanistically,PD-L1 compensates for the loss of Sororin,whose expression is suppressed in cancer cells overexpressing PD-L1.PD-L1 competes with Wing Apart-Like(WAPL)for binding to PDS5B,and secures proper sister chromatid cohesion and segregation.Our findings suggest an important role for nuclear PD-L1 in cancer cells independent of its function in immune checkpoint. | Jia Yu Bo Qin Ann MMoyer Somaira Nowsheen Xinyi Tu Haidong Dong Judy CBoughey Matthew PGoetz Richard Weinshilboum Zhenkun Lou Liewei Wang | 2020 | Cell Research2020，30，7： | 3 |
| 12 | Catalysis-based specific detection and inhibition of tyrosinase and their application显示文摘Tyrosinase is an important enzyme in controlling the formation of melanin in melanosome,and plays a key role in the pigmentation of hair and skin.The abnormal expression or activation of tyrosinase is associated with several diseases such as albinism,vitiligo,melanoma and Parkinson disease.Excessive deposition of melanin could cause diseases such as freckles and brown spots in the human body,and it is also closely related to browning of fruits and vegetables and insect molting.Detecting and inhibiting the activity of tyrosinase is of extraordinary value in the progress of diagnosis and treatment of these diseases.Therefore,many selective optical detection probes and small molecular inhibitors have been developed,and have made significant contributions to the basic and clinical research on these diseases.In this paper,the detection and inhibition of tyrosinase and their application in whitening products are reviewed,with special emphasis on development of fluorescent probes and inhibitors.Hopefully,this review will help design more efficient and sensitive tyrosinase probes and inhibitors,as well as shed light on novel treatment of diseases such as melanoma. | Yunwei Qu Qing Zhan Shubo Du Yang Ding Bin Fang Wei Du Qiong Wu Haidong Yu Lin Li Wei Huang | 2020 | Journal of Pharmaceutical Analysis2020，10，5： | 2 |
| 13 | Transition of Streamer, Corona and Glow Discharges in Needle-to-plane Dielectric Barrier Discharge at Atmospheric Pressure Air显示文摘To discuss the modes of dielectric barrier discharge(DBD) between needle-to-plane electrodes in air,DBD is generated and observed on a needle-to-plane device at atmospheric pressure air.Fast images of the DBD are taken by using a charge couple device(CCD) cinema with a macro lens,while the electrical and photo-electricity waveforms of the DBD are recorded.The current waveforms show that under an applied voltage of 3 kV,there are numerous short current pulses in both positive and negative half-periods of discharges.However,under 6 kV,there are still the numerous short current pulses in the positive half-periods,but only one wide current pulse in each negative half-period.This difference is also found in the photoelectric signals.The streamer,corona and glow discharges are observed from the images of the discharges at different applied voltages.The structure of glow discharge in the negative period is exactly the same as that of the low pressure glow discharge.However,in the positive period of discharge there is always a streamer.In the negative period of discharge,while the applied voltage increases,the transition from corona to glow discharge is observed.The progress of a transition between streamer and glow discharge at 6 kV during one period is analyzed.The glow discharge appearance is determined by two factors: the discharge current is limited to a certain extent by the dielectric layer; the charges deposited on the dielectric layer during the last half period enhance the intensity of the electric field.At an insufficient applied voltage,the cathode drop leads to no glow discharge,but Trichel pulses. | YU Zhe YANG Haidong DU Huan YAO Jing XU Shaojie ZHANG Zhitao | 2013 | 高电压技术2013，39，10： | 2 |
| 14 | Equality Testing for Soil Grid Unit Resolutions to Polygon Unit Scales with DNDC Modeling of Regional SOC Pools显示文摘Matching soil grid unit resolutions with polygon unit map scales is important to minimize the uncertainty of regional soil organic carbon(SOC) pool simulation due to their strong influences on the modeling.A series of soil grid units at varying cell sizes was derived from soil polygon units at six map scales,namely,1:50 000(C5),1:200 000(D2),1:500 000(P5),1:1 000 000(N1),1:4 000 000(N4) and 1:14 000 000(N14),in the Taihu Region of China.Both soil unit formats were used for regional SOC pool simulation with a De Nitrification-DeC omposition(DNDC) process-based model,which spans the time period from 1982 to 2000 at the six map scales.Four indices,namely,soil type number(STN),area(AREA),average SOC density(ASOCD) and total SOC stocks(SOCS) of surface paddy soils that were simulated by the DNDC,were distinguished from all these soil polygon and grid units.Subjecting to the four index values(IV) from the parent polygon units,the variations in an index value(VIV,%) from the grid units were used to assess its dataset accuracy and redundancy,which reflects the uncertainty in the simulation of SOC pools.Optimal soil grid unit resolutions were generated and suggested for the DNDC simulation of regional SOC pools,matching their respective soil polygon unit map scales.With these optimal raster resolutions,the soil grid units datasets can have the same accuracy as their parent polygon units datasets without any redundancy,when VIV < 1% was assumed to be a criterion for all four indices.A quadratic curve regression model,namely,y = – 0.80 × 10^(–6)x^2 + 0.0228 x + 0.0211(R^2 = 0.9994,P < 0.05),and a power function model R? = 10.394?^(0.2153)(R^2 = 0.9759,P < 0.05) were revealed,which describe the relationship between the optimal soil grid unit resolution(y,km) and soil polygon unit map scale(1:10 000x),the ratio(R?,%) of the optimal soil grid size to average polygon patch size(?,km^2) and the ?,with the highest R^2 among different mathematical regressions,respectively.This knowledge may facilitate the grid partitioning of regions during the investigation and simulation of SOC pool dynamics at a certain map scale,and be referenced to other landscape polygon patches' mesh partition. | YU Dongsheng PAN Yue ZHANG Haidong WANG Xiyang NI Yunlong ZHANG Liming SHI Xue-zheng | 2017 | Chinese Geographical Science2017，27，4： | 2 |
| 15 | Shipping emissions associated with increased cardiovascular hospitalizations显示文摘 | Linwei Tian Kin-fai Ho Peter K.K. Louie Hong Qiu Vivian C. Pun Haidong Kan Ignatius T.S. Yu Tze Wai Wong | 2013 | Atmospheric Environment2013，，： | 1 |
| 16 | Dynamic characteristic analysis of TBM tunnelling in mixed-face conditions 显示文摘 | ZHANG Kaizhi YU Haidong LIU Zhongpo | 2010 | Simulation Modelling Practice andTheory2010，18，7： | 1 |
| 17 | Maize Gene Regulatory Network for Phenolic Metabolism显示文摘 | Fan Yang Wei Li Nan Jiang Haidong Yu Kengo Morohashi Wilberforce Zachary Oumal Daniel E. Morales-Mantilla Fabio Andres Gomez-Canol Eric Mukundi Luis Daniel Prada-Salcedo Roberto Alers Velazquez Jasmin Valentin Maria Katherine Mejia-Guerra John Gray Andrea I. Doseff Erich Grotewold | 2017 | Molecular Plant2017，10，3： | 1 |
| 18 | Rate-dependent behavior and constitutive model ofDP600 steel at strain rate from 10–4 to 103 s–1显示文摘 | YU Haidong GUO Yongjin LAI Xinmin | 2009 | Materials&Design2009，30，7： | 1 |
| 19 | Enumeration and molecular characterization of circulating tumor cell using an in vivo capture system in squamous cell carcinoma of head and neck显示文摘Objective: Detection rate and isolation yield of circulating tumor cell(CTC) are low in squamous cell carcinoma of head and neck(SCCHN) with in vitro approaches due to limited sample volumes. In this study, we applied the Cell Collector to capture CTC in vivo from peripheral blood.Methods: In total, the study included 22 cases with 37 times of detection. All of the patients were newly diagnosed with locally advanced or metastatic SCCHN, including laryngocarcinoma(40.9%, 9/22) and hypopharyngeal carcinoma(59.1%, 13/22). All patients received CTC analysis before treatment. Three patients received induction chemotherapy. Sixteen patients received surgical therapy, of which 13 patients received postoperative detection. Two patients received both induction chemotherapy and surgery treatment. Patients underwent two successive Cell Collector applications 24 h before and 7 d after surgical therapy. Nine healthy volunteers were enrolled as the control group. Epidermal growth factor receptor variant type Ⅲ(EGFRⅧ)expression was analyzed with fluorescent dye labeled antibody.Results: With Cell Collector isolation, 72.7%(16/22) of the patients were positive for ≥1 CTC(CTC; range,1–17 cells) before treatments and 46.7%(7/15) of patients were CTC positive for ≥1 CTC(CTC; range, 1–29 cells) after surgical therapy. Moreover, the detection rate of Cell Collector(82.4%, 14/17; CTC count range, 0–17)in advanced SCCHN(stage Ⅲ–Ⅳ) was much higher than that in early stages(stage Ⅰ–Ⅱ, 40.0%, 2/5; CTC count range, 0–2)(P<0.05). EGFRⅧ expression of CTC was also analyzed with fluorescence staining. One CTCEGFRⅧ-positive patient was detected from six CTC-positive patients, and the positive expression of EGFRⅧ was also found in the tumor tissue of this patient.Conclusions: In vivo detection of CTCs had high sensitivity in SCCHN, which might improve CTC application in clinic. | Haidong Zhang Shanchun Gong Yaqun Liu Longjun Liang Shuangba He Qingxiang Zhang Mingyuan Si Zhenkun Yu | 2017 | Chinese Journal of Cancer Research2017，29，3： | 1 |
| 20 | A variational solution of 2-D sound-structure interaction problems显示文摘基于联合理论的液体结构,为从有弹性的结构分析健全放射的一个局部性的变化原则由于泛音刺激在水里沉没了被介绍。为结构声学的系统的稳定的反应提出各种各样的数字方法将是一个强大的工具。借助于一个混合元素方法,在大多数包围的水里有效的一个分析答案与有限元素在被合并在结构和它的附近的水散布了的这个变化原则,被设计。计算例子然后被给表明它的高精确性并且时间节省。 | Yuying Huang Haidong Su Yu Xiang | 2006 | Acta Mechanica Sinica2006，22，2： | 1 |
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