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| 1 | 帕博利珠单抗治疗伴脑转移NSCLC患者的一项非随机、开放Ⅱ期试验的长期随访结果和生物标志物分析显示文摘背景与目的我们开展了一项帕博利珠单抗用于伴未治疗脑转移的非小细胞肺癌(non-small cell lung cancer,NSCLC)或黑色素瘤患者的疗效和安全性的II期试验,旨在评估程序性死亡受体1(programmed cell death 1,PD-1)抑制剂在中枢神经系统(central nervous system,CNS)中的疗效。中期结果已发表,现报道对NSCLC队列的更新分析结果。方法这是一项开放性、单中心、II期试验。纳入标准:年龄≥18岁,诊断为晚期NSCLC并伴有≥1个5 mm-20 mm脑转移病灶,既往从未治疗或之前放疗后进展,无神经系统症状,不需要激素治疗且美国东部肿瘤协作组(Eastern Cooperative Oncology Group,ECOG)<2分。患者每2周接受一次帕博利珠单抗(10 mg/kg)治疗。队列1为程序性死亡配体1(programmed cell death ligand 1,PD-L1)≥1%的患者,队列2为PD-L1<1%或未评估的患者。主要终点是脑转移患者缓解比例。所有经治患者均纳入疗效与安全性终点的分析。该研究已结束入组,并于Clinicaltrials.gov登记注册,注册号为NCT02085070。结果2014年3月31日-2018年5月21日,共42例患者接受治疗。中位随访时间为8.3个月(IQR:4.5个月-26.2个月)。队列1的37例患者中11例有脑转移缓解[29.7%(95%CI:15.9%-47.0%)]。队列2未观察到缓解。治疗相关的3级-4级不良事件(adverse events,AEs)包括2例肺炎、1例全身症状、1例结肠炎、1例肾上腺皮质功能不全、1例高血糖症和1例低钾血症。6例(14%)患者发生了治疗相关的严重不良事件,包括肺炎、急性肾损伤、低钾血症和肾上腺皮质功能不全。没有观察到治疗相关死亡病例。结论帕博利珠单抗治疗PD-L1≥1%的NSCLC伴脑转移患者有效,且对所有纳入的未经治疗的脑转移患者安全。需要进一步探索免疫治疗用于NSCLC合并CNS转移。 | Sarah B GOLDBERG Kurt A SCHALPER Scott N GETTINGER Amit MAHAJAN Roy S HERBST Anne C CHANG Rogerio LILENBAUM Frederick H WILSON Sacit Bulent OMAY James B YU Lucia JILAVEANU Thuy TRAN Kira PAVLIK Elin ROWEN Heather GERRSH Annette KOMLO Richa GUPTA Hailey WYATT Matthew RIBEIRO Yuval KLUGER Geyu ZHOU Wei WEI Veronica L CHANG Harriet M KLUGER 董晓荣(翻译/校对) | 2021 | 中国肺癌杂志2021，24，9： | 34 |
| 2 | 体内腺相关病毒-常间回文重复序列丛集及其相关蛋白9介导的基因编辑可改善家族性高胆固醇血症的动脉粥样硬化显示文摘低密度脂蛋白受体(low-density lipoprotein receptor,Ldlr)基因突变是家族性高胆固醇血症的主要原因之一,可导致动脉粥样硬化,并具有很高的终生心血管病风险。常间回文重复序列丛集(clustered regularly interspaced short palindromic repeats,CRISPR)/CRISPR相关蛋白9(CRISPR-related protein 9,Cas9)系统是基因编辑纠正基因突变从而改善疾病的有效工具。该研究的目的是通过腺相关病毒(adeno-associated virus,AAV)携带的CRISPR/Cas9系统进行体内体细胞基因编辑,以确定其能否在小鼠模型中治疗由Ldlr突变体引起的家族性高胆固醇血症。 | 刘青(译) 叶鹏(审校) Zhao H Li Y He L Pu W Yu W Li Y Wu YT Xu C Wei Y Ding Q Song BL Huang H Zhou B | 2020 | 中华高血压杂志2020，28，3： | 22 |
| 3 | Femtojoule electro-optic modulation using a silicon– organic hybrid device显示文摘Energy-efficient electro-optic modulators are at the heart of short-reach optical interconnects,and silicon photonics is considered the leading technology for realizing such devices.However,the performance of all-silicon devices is limited by intrinsic material properties.In particular,the absence of linear electro-optic effects in silicon renders the integration of energy-efficient photonic–electronic interfaces challenging.Silicon–organic hybrid(SOH)integration can overcome these limitations by combining nanophotonic silicon waveguides with organic cladding materials,thereby offering the prospect of designing optical properties by molecular engineering.In this paper,we demonstrate an SOH Mach–Zehnder modulator with unprecedented efficiency:the 1-mm-long device consumes only 0.7 fJ bit^(-1) to generate a 12.5 Gbit s^(-1) data stream with a bit-error ratio below the threshold for hard-decision forward-error correction.This power consumption represents the lowest value demonstrated for a non-resonant Mach–Zehnder modulator in any material system.It is enabled by a novel class of organic electro-optic materials that are designed for high chromophore density and enhanced molecular orientation.The device features an electro-optic coefficient of r33<180 pm V^(-1) and can be operated at data rates of up to 40 Gbit s^(-1). | Sebastian Koeber Robert Palmer Matthias Lauermann Wolfgang Heni Delwin L Elder Dietmar Korn Markus Woessner Luca Alloatti Swen Koenig Philipp C Schindler Hui Yu Wim Bogaerts Larry R Dalton Wolfgang Freude Juerg Leuthold Christian Koos | 2015 | Light(Science & Applications)2015，4，1： | 4 |
| 4 | Cloning,Sequencing,and mapping of the human chromosome 14 Heat Shock Protein Gene (HSPA2)显示文摘 | Lori L C Bonnycastale Yu Chang-En | 1994 | Genomics1994，23，： | 2 |
| 5 | Properties of lead-free solder alloys with rare earth element additions显示文摘 | WU C M L YU D Q LAW C M T WANG L | 2004 | Materials Science and Engineering2004，44，1： | 2 |
| 6 | Fine mapping of a C-terminal linear epitope highly conserved among the major envelope gly coprotein E2 (gpS1 to gp54) of different pestiviruses显示文摘 | Yu M Wang L F Shiell B J Morrissy C J Westbury H A | 1996 | Virology1996，222，： | 1 |
| 7 | Standard CMOS implementation of a novel, fully differential optoelectronic integrated receiver 显示文摘 | YU C L MAO L H XIAO X D | 2009 | J of Optoelectronics Laser2009，20，4： | 1 |
| 8 | Mesotunnels on the silica wall of ordered SBA-15 to generate three-dimensional large-pore mesoporous networks显示文摘 | Yu C Wang L | 2001 | J Am Chem SCc2001，123，12： | 1 |
| 9 | Randomized, placebo-controlled, phase II study of sequential erlotinib and chemotherapy as first-line treatment for advanced non-small-cell lung cancer显示文摘 | Mok T S Wu Y L Yu C J | 2009 | J ClinOneol2009，27，30： | 1 |
| 10 | Tin nanoparticles encapsulated in porous multichannel carbon microtubes: Preparation by single -zozzle electrospinning and application as anode material for high-performance Li-based batteries 显示文摘 | Yu Y Gu L Zhu C et ol | 2009 | Journal of the American Chemical Society2009，131，15： | 1 |
| 11 | IgC, anti-melanocyte antibodies purified from patients with active vitiligo induce HLA-DR and intercellular adhesion molecule-1 expression and an increase in interleukin-8 release by melanocytes 显示文摘 | Li Y L Yu C L Yu H S | 2000 | J Invest Dermatol2000，115，6： | 1 |
| 12 | A metabolic labeling approach toward proteomic analysis of mucin-type O-linked glycosylation显示文摘 | Hang H C Yu C Kato D L | 2003 | Proc Natl Acad Sci USA2003，100，14： | 1 |
| 13 | Significance of serum uric acid levels on the risk of all-cause and cardiovascular mortality 显示文摘 | Kuo C F See L C Yu K H | 2013 | Rheumatology(Oxford)2013，52，1： | 1 |
| 14 | Replication ofavian and seasonal influenza viruses in human bronchus andlung显示文摘 | Chan R W Y Yuen K M Yu W C L | 2011 | Influenza Other Resp Viruses2011，5，： | 1 |
| 15 | Hierarchical streamline bundles显示文摘 | Shene C K Wang C L Yu H F | 2012 | IEEE Transactions on Visualization and Computer Graphics2012，18，8： | 1 |
| 16 | The effect of stealth liposomes onpharmacokinetics,tissue distribution and anti-tumor activity of oridonin显示文摘 | Wang C Wei Y Yu L | | 0，，05： | 1 |
| 17 | The properties of Sn-9Zn lead-free solder alloys doped with trace rare earth elements 显示文摘 | Wu C M L Yu D Q Law C M T | 2002 | Journal of electronic materials2002，31，9： | 1 |
| 18 | Experimental study on the NO and N20 formation characteristics during biomass com- bustion 显示文摘 | Bai J Yu C Li L | 2012 | Energy &Fuels2012，27，1： | 1 |
| 19 | Fast and Accurate Determination of K, Ca, and Mg in Human Serum by Sector Field ICP-MS 显示文摘 | Yu L L Davis W C Ordonez Y N | 2013 | Analytical and Bioanalytical Chemistry2013，405，27： | 1 |
| 20 | Hydrogen sulfide reduces serum triglyceride by activating liver autophagy via the AMPK-mTOR pathway显示文摘 | Sun L Zhang S Yu C | 2015 | Am J Physiol Endocrinol Metab2015，309，11： | 1 |
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